Ceska a Slovenska Farmacie最新文献_第8页

Colour and antioxidant activity of honey. 蜂蜜的颜色和抗氧化活性。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Jan Šubert, Jozef Kolář, Jozef Čižmárik

引用次数: 0

Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico. 有前途的抗惊厥药N-[(2,4-二氯苯基)甲基]-2-(2,4-二氧基- 1h -喹唑啉-3-基)乙酰胺:体内和硅体内抗惊厥作用谱的剂量依赖性研究和评价。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Sergiy Shtrygol, Sergiy Zalevskyi, Mariia Mishchenko, Diana Shtrygol, Hanna Severina, Wassim El Kayal, Victoriya Georgiyants

{"title":"Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.","authors":"Sergiy Shtrygol, Sergiy Zalevskyi, Mariia Mishchenko, Diana Shtrygol, Hanna Severina, Wassim El Kayal, Victoriya Georgiyants","doi":"","DOIUrl":"","url":null,"abstract":"The anticonvulsant spectrum of the original promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide was studied. The compound had a pronounced anticonvulsant effect, significantly reducing the mortality of mice in models of seizures induced by pentylenetetrazole, picrotoxin, strychnine, and caffeine. In the thiosemicarbazideinduced seizure model, the test compound did not reduce mortality. The obtained results indicated that the mechanism of anticonvulsant action involved GABA-ergic (effective in models of pentylenetetrazole and picrotoxin-induced seizures), glycinergic (efficiency in the strychnine model of paroxysms), and adenosinergic (effectiveness in the model of caffeine induced seizures). Molecular docking of a promising anticonvulsant to anticonvulsant biotargets follow the mechanisms of chemo-induced seizures, namely GABA, glycine, and adenosine receptors type A2A, GABAAT, and BCAT enzymes. The conformity between in vivo and in silico studies results was revealed.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 5","pages":"224-233"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40709004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicinal mushrooms Ophiocordyceps sinensis and Cordyceps militaris. 药用蘑菇:冬虫夏草和蛹虫草。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Lucia Ungvarská Maľučká, Anna Uhrinová, Patricia Lysinová

{"title":"Medicinal mushrooms Ophiocordyceps sinensis and Cordyceps militaris.","authors":"Lucia Ungvarská Maľučká, Anna Uhrinová, Patricia Lysinová","doi":"","DOIUrl":"","url":null,"abstract":"The main component of Ophiocordyceps sinensis and Cordyceps militaris extracts are polysaccharides. These are natural biopolymers that represent a large class of biologically active components. These contribute to their pharmacological activity and effect on health. They contain monosaccharides that include rhamnose, ribose, arabinose, xylose, mannose, glucose, galactose, mannitol, fructose, and sorbose. The exopolysaccharide fraction has a large number of pharmacological effects, the two most important of which are immunomodulatory and antitumour. Among the contained polysaccharides is also mannoglucan, which shows weak cytotoxic activity against the SPC-I1) cancer cell line. More than ten nucleosides and their related compounds, including adenine, adenosine, inosine, cytidine, cytosine, guanine, uridine, thymidine, uracil, hypoxanthine, and guanosine, have been successively isolated from Ophiocordyceps sinensis. It contains many amino acids and polypeptides that are thought to affect the cardiovascular system. They also have a sedative and hypnotic effect, with tryptophan being the most effective component among them. Polysaccharides were extracted from four samples: sample 1 (grown on the substrate Oryza sativa indica, strain Ophiocordyceps sinensis), sample 2 (grown on the substrate Oryza sativa japonica, strain Ophiocordyceps sinensis), sample 3 (grown on the substrate Oryza sativa indica, strain Cordyceps militaris), sample 4 (grown on Oryza sativa japonica substrate, strain Cordyceps militaris). Through NMR spectroscopy and subsequent comparison with the literature, the majority of a chemical compound in deproteinized extracts 1 and 4 was found to be a hydrophilic polyglucan referred to as CBHP2).","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 6","pages":"259-265"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10337704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico. 有前途的抗惊厥药N-[(2,4-二氯苯基)甲基]-2-(2,4-二氧基- 1h -喹唑啉-3-基)乙酰胺:体内和硅体内抗惊厥作用谱的剂量依赖性研究和评价。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01 DOI: 10.5817/csf2022-5-224

S. Shtrygol’, S. Zalevskyi, M. Mishchenko, D. Shtrygol’, H. Severina, Wassim El Kayal, V. Georgiyants

{"title":"Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.","authors":"S. Shtrygol’, S. Zalevskyi, M. Mishchenko, D. Shtrygol’, H. Severina, Wassim El Kayal, V. Georgiyants","doi":"10.5817/csf2022-5-224","DOIUrl":"https://doi.org/10.5817/csf2022-5-224","url":null,"abstract":"The anticonvulsant spectrum of the original promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide was studied. The compound had a pronounced anticonvulsant effect, significantly reducing the mortality of mice in models of seizures induced by pentylenetetrazole, picrotoxin, strychnine, and caffeine. In the thiosemicarbazideinduced seizure model, the test compound did not reduce mortality. The obtained results indicated that the mechanism of anticonvulsant action involved GABA-ergic (effective in models of pentylenetetrazole and picrotoxin-induced seizures), glycinergic (efficiency in the strychnine model of paroxysms), and adenosinergic (effectiveness in the model of caffeine induced seizures). Molecular docking of a promising anticonvulsant to anticonvulsant biotargets follow the mechanisms of chemo-induced seizures, namely GABA, glycine, and adenosine receptors type A2A, GABAAT, and BCAT enzymes. The conformity between in vivo and in silico studies results was revealed.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 5 1","pages":"224-233"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71344518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of triazavirin (riamilovir)-based treatment for coronavirus disease 2019 (COVID-19) in clinical trials and preliminary practical experiences. 以三唑韦林(利阿米洛韦)为主治疗冠状病毒病2019 (COVID-19)的临床试验及初步实践经验

Ceska a Slovenska Farmacie Pub Date : 2022-01-01 DOI: 10.5817/csf2022-6-239

I. Malík, Gustáv Kováč, L. Hudecová

{"title":"The efficacy of triazavirin (riamilovir)-based treatment for coronavirus disease 2019 (COVID-19) in clinical trials and preliminary practical experiences.","authors":"I. Malík, Gustáv Kováč, L. Hudecová","doi":"10.5817/csf2022-6-239","DOIUrl":"https://doi.org/10.5817/csf2022-6-239","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has plagued the human population as 2019 turned into 2020, when first cases were confirmed to be infected with the pathogen in Wuhan City, the largest mega-city and capital of Hubei Province in Central China. Since this time, many pharmacotherapeutic modalities were suggested and used to treat the patients suffering from COVID-19. Triazavirin (TZV; riamilovir) is a synthetic non-toxic broad-spectrum antiviral drug belonging into an azolotriazine class. Several hypotheses and suggestions based on the knowledge about morphology, structure of virion, genome, replication cycle and functions of particular proteins within SARS-CoV-2 as well as in silico analyzes were published aiming to employ TZV for the treatment of COVID-19. Results and conclusions from a well-known randomized controlled trial registered under the Registration No. ChiCTR2000030001, which was carried out in China in 2020, indicated not only the anti-SARS-CoV-2 efficacy of given aza analogue of guanine but also some limitations of these outcomes in the context of their general interpretability and applicability. Thus, a primary aim of this review article was to provide more complex view on pharmacotherapeutic interventions based on TZV against COVID-19/SARS-CoV-2. The focus was on relevant results and conclusions from clinical trials as well as practical experiences with given antiviral agent considering not only real benefits of chosen therapeutic strategies but also several obstacles connected with them.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 6 1","pages":"239-244"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71344639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of Aronia melanocarpa extract on the phospholipid composition of the rat myocardium during stress. 黑荆芥提取物对应激大鼠心肌磷脂组成的影响。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Volodymyr Shvets, Hanna Maslak, Vadim Davydov, Halyna Berest, Inna Nosulenko

引用次数: 0

Medicinal mushrooms Ophiocordyceps sinensis and Cordyceps militaris. 药用蘑菇:冬虫夏草和蛹虫草。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01 DOI: 10.5817/csf2022-5-259

Lucia Ungvarská Maľučká, A. Uhrinová, Patricia Lysinová

{"title":"Medicinal mushrooms Ophiocordyceps sinensis and Cordyceps militaris.","authors":"Lucia Ungvarská Maľučká, A. Uhrinová, Patricia Lysinová","doi":"10.5817/csf2022-5-259","DOIUrl":"https://doi.org/10.5817/csf2022-5-259","url":null,"abstract":"The main component of Ophiocordyceps sinensis and Cordyceps militaris extracts are polysaccharides. These are natural biopolymers that represent a large class of biologically active components. These contribute to their pharmacological activity and effect on health. They contain monosaccharides that include rhamnose, ribose, arabinose, xylose, mannose, glucose, galactose, mannitol, fructose, and sorbose. The exopolysaccharide fraction has a large number of pharmacological effects, the two most important of which are immunomodulatory and antitumour. Among the contained polysaccharides is also mannoglucan, which shows weak cytotoxic activity against the SPC-I1) cancer cell line. More than ten nucleosides and their related compounds, including adenine, adenosine, inosine, cytidine, cytosine, guanine, uridine, thymidine, uracil, hypoxanthine, and guanosine, have been successively isolated from Ophiocordyceps sinensis. It contains many amino acids and polypeptides that are thought to affect the cardiovascular system. They also have a sedative and hypnotic effect, with tryptophan being the most effective component among them. Polysaccharides were extracted from four samples: sample 1 (grown on the substrate Oryza sativa indica, strain Ophiocordyceps sinensis), sample 2 (grown on the substrate Oryza sativa japonica, strain Ophiocordyceps sinensis), sample 3 (grown on the substrate Oryza sativa indica, strain Cordyceps militaris), sample 4 (grown on Oryza sativa japonica substrate, strain Cordyceps militaris). Through NMR spectroscopy and subsequent comparison with the literature, the majority of a chemical compound in deproteinized extracts 1 and 4 was found to be a hydrophilic polyglucan referred to as CBHP2).","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 6 1","pages":"259-265"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71344594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Beliefs and knowledge related to nutritional supplements among pharmacy students. 药学专业学生对营养补充品的认知与信念。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01 DOI: 10.5817/csf2022-2-57

C. Triantis, E. Asimakopoulou, Konstantina Konidari, A. Filotheidou, P. Nobelos

{"title":"Beliefs and knowledge related to nutritional supplements among pharmacy students.","authors":"C. Triantis, E. Asimakopoulou, Konstantina Konidari, A. Filotheidou, P. Nobelos","doi":"10.5817/csf2022-2-57","DOIUrl":"https://doi.org/10.5817/csf2022-2-57","url":null,"abstract":"A variety of supplement-drug interactions has been identified, and therefore health scientists should be aware of the proper usage of nutritional supplements. The main aim of this study was to assess beliefs and knowledge related to nutritional supplements among pharmacy students. A cross-sectional study was conducted in order to assess beliefs and knowledge related to nutritional supplements among pharmacy students. A literature review on nutritional supplements was conducted in order to develop a 24-item questionnaire, and expert indications established its face and content validity. Τhe sample was comprised of 142 pharmacy students in Cyprus, whose results are presented. The majority of the participants was receiving nutritional supplements (66.9%) and believed that nutritional supplements may interact and may have toxic effects. Those in the higher years of study scored higher in knowledge than those in the lower ones. The mean scores (mean ± SD) on the knowledge about nutritional supplements by the years of study were 9.14 ± 2.67, 8.71 ± 2.92, 9.91 ± 2.08, 11.16 ± 3.00, and 15.76 ± 2.67 and compared using one-way ANOVA followed by Bonferroni correction. The level of statistical significance was set at p < 0.05. The study showed that pharmacy students are adequately informed about nutritional supplements and that this subject is essential for the curriculum of pharmaceutical studies.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 2 1","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71344777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digoxin at sub-cardiotonic dose modulates the anticonvulsive potential of valproate, levetiracetam and topiramate in experimental primary generalized seizures. 地高辛在亚心脏强直剂量下调节丙戊酸、左乙拉西坦和托吡酯在实验性原发性全身性癫痫发作中的抗惊厥电位。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01 DOI: 10.5817/csf2022-2-76

V. Tsyvunin, S. Shtrygol’, M. Mishchenko, D. Shtrygol’

{"title":"Digoxin at sub-cardiotonic dose modulates the anticonvulsive potential of valproate, levetiracetam and topiramate in experimental primary generalized seizures.","authors":"V. Tsyvunin, S. Shtrygol’, M. Mishchenko, D. Shtrygol’","doi":"10.5817/csf2022-2-76","DOIUrl":"https://doi.org/10.5817/csf2022-2-76","url":null,"abstract":"The prevalence of epilepsy in the world population together with a high percentage of patients resistant to existing antiepileptic drugs (AEDs) stimulates the constant search for new approaches to the treatment of the disease. Previously a significant anticonvulsant potential of cardiac glycoside digoxin has been verified by enhancing a weak activity of AEDs in low doses under screening models of seizures induced by pentylenetetrazole and maximal electroshock. The aim of the present study is to investigate the influence of digoxin at a sub-cardiotonic dose on the anticonvulsant activity of valproate, levetiracetam, and topiramate in models of primary generalized seizures with different neurochemical mechanisms. A total of 264 random-bred male albino mice have been used. AEDs were administered 30 min before seizure induction once intragastrically at conditionally effective (ED50) and sub-effective (½ ED50) doses: sodium valproate and topiramate - at doses of 300 and 150 mg/kg; levetiracetam - at doses of 100 and 50 mg/kg. Digoxin was administered once subcutaneously at a dose of 0.8 mg/kg body weight (1/10 LD50) 10-15 min before seizure induction. Picrotoxin (aqueous solution 2.5 mg/kg, subcutaneously), thiosemicarbazide (aqueous solution 25 mg/kg, intraperitoneally), strychnine (aqueous solution 1.2 mg/kg, subcutaneously), camphor (oil solution 1000 mg/kg, intraperitoneally) have been used as convulsive agents for seizure induction. It was found that under the conditions of primary generalized seizures induced by picrotoxin, thiosemicarbazide, strychnine, and camphor, digoxin not only shows its own strong anticonvulsant activity but also significantly enhances the anticonvulsant potential of classical AEDs sodium valproate, levetiracetam, and topiramate. The obtained results substantiate the expediency of further in-depth study of digoxin as an anticonvulsant drug, in particular, the in-depth study of neurochemical mechanisms of its action.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 2 1","pages":"78-88"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71344784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Safety of drug administration from the perspective of hospitalized patients in selected hospitals of the South Bohemia Region. 从南波希米亚地区选定医院住院患者的角度看药物给药安全。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Hana Hajduchová, Iva Brabcová, Radka Prokešová, Valérie Tóthová, Ivana Chloubová, Květoslava, Slabáková, Dana Velimská, Edita Klavíková, Hana Kubešová, Martin Doseděl, Josef Malý

{"title":"Safety of drug administration from the perspective of hospitalized patients in selected hospitals of the South Bohemia Region.","authors":"Hana Hajduchová, Iva Brabcová, Radka Prokešová, Valérie Tóthová, Ivana Chloubová, Květoslava, Slabáková, Dana Velimská, Edita Klavíková, Hana Kubešová, Martin Doseděl, Josef Malý","doi":"","DOIUrl":"","url":null,"abstract":"Drug administration is one of the riskiest areas of healthcare provision, accompanied by several possible mistakes. Patient and family involvement is crucial for patient safety in a hospital environment. The research study aimed to evaluate the subjective perception of the safety of the drug administration process from hospitalized patients point of view and their involvement in drug administration. A structured questionnaire of its own design was used to obtain data. Three hundred twenty-nine respondents from 4 hospitals in the South Bohemian Region in the Czech Republic were included in the research, including patients hospitalized in the internal medicine, surgery, and follow-up and rehabilitation care departments. We found different perceptions and individual understandings of the safety of the drug delivery process by other groups of patients. Interest in participating in drug administration also varies between groups of patients. Women control the medication given to them by the nurse to a much greater extent than men. Patients under the age of 60, patients with higher professional and university education, and patients from the surgical department would like to be more involved in deciding which aplikovadrugs to use. Patients with a low level of education want to involve their family members more in their treatment decisions. Both healthcare professionals and patients should be led by hospital management to increase patient involvement in the hospitalization process.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 5","pages":"179-189"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40515562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0