Ceska a Slovenska Farmacie最新文献

Preparation and evaluation of spray-dried inhalable microparticles from carrier mixtures. 利用载体混合物制备喷雾干燥可吸入微颗粒并对其进行评估。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01

Andrea Peštálová, Karolína Molatová, Jan Gajdziok

{"title":"Preparation and evaluation of spray-dried inhalable microparticles from carrier mixtures.","authors":"Andrea Peštálová, Karolína Molatová, Jan Gajdziok","doi":"","DOIUrl":"","url":null,"abstract":"The formulation of microparticles composed of a mixture of carriers represents an innovative approach for lung drug delivery of dry powder. The carriers used can significantly influence the properties of the microparticles, such as size, shape, surface area, hygroscopicity, or aggregation, thus improving the aerosolization of the drugs after inhalation. The properties mentioned above are crucial for effective pulmonary therapy. The combination of carriers of a carbohydrate nature and gelling agents is advantageous for controlled drug release. The experimental work aimed to prepare by spray drying and subsequently evaluate ten batches of microparticles composed of sugar-based carriers (mannitol, maltodextrin, dextran) and gelling polymers (chitosan, chondroitin sulfate) and to select a suitable combination for follow-up experimental work aimed at drug incorporation into the microparticle matrix. The most suitable parameters were exhibited by batches whose aerodynamic diameter was close to 5 µm, particles prepared from a combination of mannitol and dextran, chitosan and chondroitin, or maltodextrin and chondroitin. These batches also showed the highest fine particle fraction value (> 43%). From a processability point of view, the batch with maltodextrin and chondroitin is preferable due to the lower viscosity of the dispersion and the more regular shape of the final microparticles.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"73 1","pages":"214-222"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What should we know about the skin as an application site for (not only) dermo-cosmetic products? 关于皮肤作为（不仅仅是）护肤化妆品的应用部位，我们应该知道些什么？

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.014

Andrej Kováčik, Barbora Vraníková, Robert Čáp

引用次数: 0

Hyperferritinemia as a factor associated with poor prognosis in COVID-19 patients. 高铁蛋白血症是 COVID-19 患者预后不良的一个相关因素。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01

Nuhad Mohammed Al-Dulaimi, Mahmood Jassim Mohammed, Saad T Mutlk, Khalid F Al-Rawi, Hameed Hussein Ali, Bilal J M Aldahham, Faisal Al-Ani, Osamah Al-Ani, Yaqout A Hamed, Aus T Ali

{"title":"Hyperferritinemia as a factor associated with poor prognosis in COVID-19 patients.","authors":"Nuhad Mohammed Al-Dulaimi, Mahmood Jassim Mohammed, Saad T Mutlk, Khalid F Al-Rawi, Hameed Hussein Ali, Bilal J M Aldahham, Faisal Al-Ani, Osamah Al-Ani, Yaqout A Hamed, Aus T Ali","doi":"","DOIUrl":"","url":null,"abstract":"Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to assess the relationship between the severity of Covid-19 and different clinical and laboratory parameters. A total number of 466 Arabs have willingly joined this prospective cohort. Out of the total number, 297 subjects (63.7%) had negative COVID-19 tests, and thus, they were recruited as controls, while 169 subjects (36.3%) who tested positive for COVID-19 were enrolled as cases. Out of the total number of COVID-19 patients, 127 (75.15%) presented with mild symptoms, and 42 (24.85%) had severe symptoms. The age range for the participants was 20 to 82 years. Compared with controls, the severity of the disease was associated with significantly high ferritin levels (P < 0.001). The severity of the disease was also associated with a significant increase in C-reactive protein (P < 0.001), D-dimer (P < 0.001), white blood cell count (WBC) (P < 0.01), IgM (P < 0.001), and Granulocytes (P < 0.01). In addition, severe COVID-19 symptoms in the current study were associated with a significant decrease in lymphocytes (P < 0.01). There was a four-fold increase in serum ferritin levels in COVID-19 patients presented with severe symptoms upon admission. The former was associated with significantly high levels of CRP and D-dimer. Thus, hyperferritinemia, together with high CRP and D-dimer concentrations, may serve as reliable predictors for disease severity and poor prognosis in Arabs with COVID-19.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"73 1","pages":"223-232"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pain and possibilities of its self-treatment - what can be recommended in a pharmacy? 疼痛和自我治疗的可能性-药房可以推荐什么？

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.029

Markéta Pitrová, Anna Koubová

引用次数: 0

Safety of injectable dosage forms during their preparation and administration by nurses in hospitals: a literature review. 医院护士在配制和给药过程中注射剂型的安全性：文献综述。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.005

Ondřej Tesař, Lucie Malečová, Klára Kubíková, Josef Malý

{"title":"Safety of injectable dosage forms during their preparation and administration by nurses in hospitals: a literature review.","authors":"Ondřej Tesař, Lucie Malečová, Klára Kubíková, Josef Malý","doi":"10.36290/csf.2024.005","DOIUrl":"10.36290/csf.2024.005","url":null,"abstract":"Safety of injectable dosage forms during their preparation and administration by nurses in hospitals: a literature review Introduction and Aim: Medication errors in hospitals are still frequent and significant for patient safety and associated healthcare costs. Especially, injectable dosage forms pose the high risk. The aim of this study was to review the current literature focused on medication errors related to injectable drug forms during their preparation and administration by nurses in hospitals.Methods: Databases Medline and Scopus were used for the literature review. Papers dealing with intravenous (i. v.), intramuscular (i. m.), or subcutaneous (s. c.) administration by nurses in hospitals using direct observation method for data collection were searched. Original papers, systematic reviews or meta-analyses published in English by the end of 2022 were included.Results: A total of 334 papers were retrieved, of which 21 studies met the inclusion criteria. 17 studies were observational (8 descriptive, 9 analytical) and 4 interventional. Medication errors were very common, moreover, critical steps of the medication process and possible interventions were identified.Conclusion: The results showed that the process of preparing and administering injectable dosage forms is a high-risk process. In the provision of healthcare, relevant measures must be set up to maximise patient safety.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"73 1","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omega-3 fatty acids in nutrition and supplementation. Omega-3脂肪酸的营养和补充。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.025

Miloslav Hronek, Miroslav Kovařík

引用次数: 0

The importance of neurotropic vitamins in the prevention and adjuvant therapy of peripheral neuropathy - A pharmacist's comprehensive view. 促神经维生素在周围神经病变预防和辅助治疗中的重要性——一个药剂师的综合观点。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.011

Ondřej Šimandl

{"title":"The importance of neurotropic vitamins in the prevention and adjuvant therapy of peripheral neuropathy - A pharmacist's comprehensive view.","authors":"Ondřej Šimandl","doi":"10.36290/csf.2024.011","DOIUrl":"10.36290/csf.2024.011","url":null,"abstract":"The importance of neurotropic vitamins in the prevention and adjuvant therapy of peripheral neuropathy - A pharmacist's comprehensive view Peripheral neuropathy is one of the most common neurological diseases of the peripheral nervous system. According to current statistics, it affects 2.4% of the Czech population, and its prevalence continues to increase with age. The possibilities of its treatment are to a large extent limited, and its effectiveness and the patient's tolerance of pharmacotherapy are individual. Neurotropic vitamins, which support the function of neurons and contribute to their protection and regeneration, represent a promising possibility for prevention and use in adjuvant therapy for patients suffering from this disease. Despite the fact that the diagnosis and treatment of peripheral neuropathy belong to the doctor, the role of the pharmacist can be crucial not only in the area of ensuring effective and safe pharmacotherapy and adherence to it, but also in pre-screening of at-risk persons visiting pharmacies. The primary aim of the article is therefore to familiarize readers with the significance of neurotropic vitamins in the prevention and adjunct therapy of peripheral neuropathy, as well as the role of the pharmacist in the care of patients suffering from this condition.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"73 2","pages":"80-87"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive and Rational Approach to Photoprotection. 综合合理的光防护方法。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.017

Kateřina Tenorová, Ruta Masteiková

引用次数: 0

Oral supplementation of sodium, potassium and phosphate ions in extemporaneous preparation. 即席制剂中钠、钾、磷离子的口服补充。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.006

Markéta Petrželová, Jana Hénková

引用次数: 0

Current pharmacotherapy of rosacea. 目前酒渣鼻的药物治疗。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.024

Magdalena Ryšavá, Renata Žáková

引用次数: 0