Ceska a Slovenska Farmacie最新文献_第10页

Neuroactive steroids - new possibilities in the treatment of postpartum depression. 神经活性类固醇-产后抑郁症治疗的新可能性。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Lucia Žigová, Petra Massarová, Katarína Vranecová, Orsolya Hrubá, Adriana Adamičková, Andrea Gažová

{"title":"Neuroactive steroids - new possibilities in the treatment of postpartum depression.","authors":"Lucia Žigová, Petra Massarová, Katarína Vranecová, Orsolya Hrubá, Adriana Adamičková, Andrea Gažová","doi":"","DOIUrl":"","url":null,"abstract":"Pregnancy and postpartum period are associated with demanding physical and psychological changes that often lead to the development of psychological disorders. Depression is diagnosed in more than one in six women after childbirth. However, the prevalence of postpartum depression can be much higher because many cases are undiagnosed. In the case of severe depression, the patient is switched to pharmacological treatment, with sertraline being the most commonly used for this diagnosis. A new drug used in the treatment of postpartum depression is brexanolone, which was registered by FDA in 2019. The advantage over conventional therapy is its rapid onset of action. The structure represents the neuroactive steroid - allopregnanolone, which acts as an agonist on the δ-subunit of the GABA receptor and improves the symptoms of postpartum depression. In addition to the registered brexanolone, another steroidal drug, zuranolone, is available in the third phase of the clinical trial. The steroid structure was chemically altered to improve bioavailability and create an oral dosage form. Another synthetic analogue of neuroactive allopregnanolone, known as ganaxolone, did not show a significant reduction in depressive symptoms in the second phase of the clinical trial compared to placebo. Nevertheless, it has great therapeutic potential in the treatment of various types of epilepsy.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 4","pages":"142-150"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33513741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and evaluation of novel collagen/ carboxymethylcellulose blend film wound dressing. 新型胶原/羧甲基纤维素混合膜创面敷料的研制与评价。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01 DOI: 10.5817/csf2022-5-190

Kateřina Tenorová, Jana Kurfürstová, R. Masteiková, S. Pavloková, Jurga Bernatonien

{"title":"Formulation and evaluation of novel collagen/ carboxymethylcellulose blend film wound dressing.","authors":"Kateřina Tenorová, Jana Kurfürstová, R. Masteiková, S. Pavloková, Jurga Bernatonien","doi":"10.5817/csf2022-5-190","DOIUrl":"https://doi.org/10.5817/csf2022-5-190","url":null,"abstract":"Films are thin, flexible, and transparent wound dressings. They can be prepared from both synthetic and natural materials. In practice, synthetic polyurethane dominates, but research is mainly focused on substances of natural origin. An endogenous substance with excellent filmforming properties, which is involved in the wound healing process, is collagen. However, collagen films themselves have weak mechanical properties, which can be improved by, among other things, combining collagen with other materials. Such material could be carboxymethylcellulose, which has been shown to affect wound healing positively. Films consisting only of CMC also have weak mechanical properties, so combining both materials seems to be a suitable solution to the given problems, and a wound dressing with many beneficial properties for wound healing could be created. Therefore, our experiment aimed to prepare composite films for wound therapy consisting of a combination of collagen and CMC. The films were prepared by the solvent evaporation method, and their properties were compared with those formed only by CMC. In both cases, films with suitable organoleptic, physicochemical, and application properties for wound therapy were produced. The composite films showed lower absorption capacity and better mechanical resistance compared to those formed only by CMC. The combination of collagen and CMC in composite films intended for wound therapy has thus resulted in improved properties of the resulting dressing and holds potential for further research.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 5 1","pages":"190-199"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71344873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dose dumping of modified-release solid oral dosage forms. 缓释固体口服剂型的剂量倾倒。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Tomáš Bílik, Miroslava Pavelková, Kateřina Kubová, Jakub Vysloužil

引用次数: 0

Colour and content of some biologically active substances in honey. 蜂蜜中某些生物活性物质的颜色和含量。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Jan Šubert, Jozef Kolář, Jozef Čižmárik

引用次数: 0

Beliefs and knowledge related to nutritional supplements among pharmacy students. 药学专业学生对营养补充品的认知与信念。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Charalampos Triantis, Evanthia Asimakopoulou, Konstantina Konidari, Anna Filotheidou, Panagiotis Theodosis Nobelos

{"title":"Beliefs and knowledge related to nutritional supplements among pharmacy students.","authors":"Charalampos Triantis, Evanthia Asimakopoulou, Konstantina Konidari, Anna Filotheidou, Panagiotis Theodosis Nobelos","doi":"","DOIUrl":"","url":null,"abstract":"A variety of supplement-drug interactions has been identified, and therefore health scientists should be aware of the proper usage of nutritional supplements. The main aim of this study was to assess beliefs and knowledge related to nutritional supplements among pharmacy students. A cross-sectional study was conducted in order to assess beliefs and knowledge related to nutritional supplements among pharmacy students. A literature review on nutritional supplements was conducted in order to develop a 24-item questionnaire, and expert indications established its face and content validity. Τhe sample was comprised of 142 pharmacy students in Cyprus, whose results are presented. The majority of the participants was receiving nutritional supplements (66.9%) and believed that nutritional supplements may interact and may have toxic effects. Those in the higher years of study scored higher in knowledge than those in the lower ones. The mean scores (mean ± SD) on the knowledge about nutritional supplements by the years of study were 9.14 ± 2.67, 8.71 ± 2.92, 9.91 ± 2.08, 11.16 ± 3.00, and 15.76 ± 2.67 and compared using one-way ANOVA followed by Bonferroni correction. The level of statistical significance was set at p < 0.05. The study showed that pharmacy students are adequately informed about nutritional supplements and that this subject is essential for the curriculum of pharmaceutical studies.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 2","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40150636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of triazavirin (riamilovir)-based treatment for coronavirus disease 2019 (COVID-19) in clinical trials and preliminary practical experiences. 以三唑韦林(利阿米洛韦)为主治疗冠状病毒病2019 (COVID-19)的临床试验及初步实践经验

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Ivan Malík, Gustáv Kováč, Lucia Hudecova

{"title":"The efficacy of triazavirin (riamilovir)-based treatment for coronavirus disease 2019 (COVID-19) in clinical trials and preliminary practical experiences.","authors":"Ivan Malík, Gustáv Kováč, Lucia Hudecova","doi":"","DOIUrl":"","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has plagued the human population as 2019 turned into 2020, when first cases were confirmed to be infected with the pathogen in Wuhan City, the largest mega-city and capital of Hubei Province in Central China. Since this time, many pharmacotherapeutic modalities were suggested and used to treat the patients suffering from COVID-19. Triazavirin (TZV; riamilovir) is a synthetic non-toxic broad-spectrum antiviral drug belonging into an azolotriazine class. Several hypotheses and suggestions based on the knowledge about morphology, structure of virion, genome, replication cycle and functions of particular proteins within SARS-CoV-2 as well as in silico analyzes were published aiming to employ TZV for the treatment of COVID-19. Results and conclusions from a well-known randomized controlled trial registered under the Registration No. ChiCTR2000030001, which was carried out in China in 2020, indicated not only the anti-SARS-CoV-2 efficacy of given aza analogue of guanine but also some limitations of these outcomes in the context of their general interpretability and applicability. Thus, a primary aim of this review article was to provide more complex view on pharmacotherapeutic interventions based on TZV against COVID-19/SARS-CoV-2. The focus was on relevant results and conclusions from clinical trials as well as practical experiences with given antiviral agent considering not only real benefits of chosen therapeutic strategies but also several obstacles connected with them.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 6","pages":"239-244"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10337701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution to the concept of polypharmacy I. Etymological notes and characteristics. 对多药概念的贡献1 .词源学注释和特征。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Jozef Kolář, Tünde Ambrus, Dominik Grega, Lenka Smejkalová

引用次数: 0

Investigation of the antimicrobial and antifungal activities of some 1,2,4-triazole derivatives. 一些1,2,4-三唑类衍生物的抑菌活性研究。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Yuliia Frolova, Andrii Kaplaushenko, Sameliuk Yurii, Daria Romanina, Liubov Morozova

{"title":"Investigation of the antimicrobial and antifungal activities of some 1,2,4-triazole derivatives.","authors":"Yuliia Frolova, Andrii Kaplaushenko, Sameliuk Yurii, Daria Romanina, Liubov Morozova","doi":"","DOIUrl":"","url":null,"abstract":"This article presents the results of the study of the antimicrobial and antifungal properties among 1,2,4-triazole derivatives synthesized at the Department of Physical and Colloidal Chemistry of the Zaporizhzhia State Medical University. Previous studies have established the antimicrobial and antifungal activity of 1,2,4-triazole derivatives. Therefore, it was reasonable to investigate highly effective substances with antimicrobial and antifungal properties among synthesized compounds. In the first stage of our research, acute toxicity prediction was performed. The antimicrobial and antifungal properties were carried out by the method of “serial dilutions” on a liquid nutrient. Forty-seven compounds of the different classes were studied for these types of activities. According to our research, derivatives of 3-amino-1,2,4-triazole showed better performance than 3-thio-1,2.4-triazoles for Staphylococcus aureus and Candida albicans. 5-(1Н-tetrazole-1-іl)methyl-4Н- -1,2,4-triazole-3-yl-1-(5-nitrofuran-2-yl)methanimin (11.6) was showed the greatest antimicrobial and antifungal activity. Deeper research for compound 11.6 was done by diffusion in agar (method of “wells”). Studies have shown that molecule 11.6 showed antimicrobial and antifungal action to the studied test strains at a concentration of 2 μg/ml. Hence, this compound can be developed as a helpful therapeutic agent after establishing its safety pharmacology and toxicity.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"71 4","pages":"151-160"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33513742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metronomic therapy in the treatment of cancer. 节拍疗法在癌症治疗中的应用。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Dana Mazánková, Veronika Bárková, Pavel Mazánek

引用次数: 0

Pulsed electric field energy calculation to damage red galangal (Alpinia purpurata, K. Scumm) rhizome slices and its essential oil yield and quality with hydrodistillation. 脉冲电场能量计算对红高良姜(Alpinia purpurata, K. Scumm)根茎片的损伤及其精油得率和品质的影响。

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Sukardi Sukardi, Maimunah Hindun Pulungan, Sang Norma Lintang Asmara

引用次数: 0