Ceska a Slovenska Farmacie最新文献_第9页

Available diagnostic tests in the pharmacy and the role of the pharmacist. 药房可用的诊断测试和药剂师的角色。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.030

Eliška Kolmanová, Ondřej Tesař

引用次数: 0

Medical devices in wound healing V: Special types of wound plasters II. 创面愈合用医疗器械V：特殊类型创面膏药II。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.045

Barbora Vraníková, Andrej Kováčik

引用次数: 0

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.015

Zuzana Juhásová, Martina Maříková, Jiří Vlček

{"title":"Drug-related hospitalizations - insights from the Czech Republic.","authors":"Zuzana Juhásová, Martina Maříková, Jiří Vlček","doi":"10.36290/csf.2024.015","DOIUrl":"10.36290/csf.2024.015","url":null,"abstract":"Drug-related hospitalizations - insights from the Czech Republic Background and objective: Drug-related hospitalizations represent a significant burden on healthcare. The aim of the study was to determine the prevalence of drug-related hospitalizations and identify medications and clinical manifestations associated with drug-related hospitalizations in patients admitted to hospital through the emergency department.Methods: This cross-sectional study examined unplanned hospitalizations at the University Hospital Hradec Kralove through the Department of Emergency Medicine between August and November 2018. Data were obtained from electronic health records. The methodology for identifying drug-related hospitalizations was based on the guideline of the European project OPERAM. This article focuses on a subgroup of drug-related problems related to the medication safety.Results: Of the total 1252 hospitalizations analyzed, 145 cases were identified as drug-related. The prevalence of drug-related hospitalizations was 12% (95% confidence interval 10-13). In 62% of cases, medications only contributed to the cause of hospitalization. Antithrombotics, cytostatics, diuretics, and systemic corticosteroids were the most common medication classes leading to drug-related hospitalizations. Gastrointestinal bleeding was the most common cause of drug-related hospitalizations. The potential preventability of drug-related hospitalizations was 34%.Conclusion: Drug-related hospitalizations remain relatively common, while some of them could be potentially prevented. Pharmacists can contribute to enhancing patient safety by detecting drug-related problems and proposing measures to minimize risks.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"73 2","pages":"93-102"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmaceutical care for patients with sore throat not requiring medical attention. 不需要医疗护理的喉咙痛患者的药物护理。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.044

Lenka Ťupová, Tereza Hendrychová, Josef Malý

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Chronic spontaneous urticaria, treatment with antihistamines. 慢性自发性荨麻疹，抗组胺药治疗。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.002

Iva Karlová

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Pharmaceutical care in the self-treatment of common urological problems. 药学护理在泌尿科常见问题自我治疗中的作用。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.009

Jana Šolínová

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New approaches to the issue of pyrogens in parenteral preparations. 肠外制剂中热原问题的新探讨。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.026

Michal Janů

{"title":"New approaches to the issue of pyrogens in parenteral preparations.","authors":"Michal Janů","doi":"10.36290/csf.2024.026","DOIUrl":"10.36290/csf.2024.026","url":null,"abstract":"New approaches to the issue of pyrogens in parenteral preparations The article provides a basic understanding of the pathophysiology of exogenous and endogenous pyrogens, particularly in the context of parenteral administration of drugs and the use of medical devices. It explains that pyrogens cause an increase in body temperature by activating the thermoregulatory center in the hypothalamus, with bacterial lipopolysaccharides being the most common source of pyrogenic burden. Contamination of pharmaceuticals with pyrogenic substances can lead to adverse effects, including life-threatening conditions. The text focuses on modern methods for identifying pyrogens, specifically endotoxins, and selecting suitable analytical procedures for their determination. These include in vivo tests on rabbits and the bacterial endotoxin tests, as well as in vitro tests such as the monocyte activation test and the recombinant Factor C test. The work includes a detailed description how to perform these tests, their advantages and disadvantages, and the development of methods for detecting pyrogens in pharmaceuticals. The author explains the reasons of false positive and negative test results, and ilusrates the calculations of threshold endotoxin limits. Information is provided on the new strategy of the European and Czech Pharmacopoeias on this issue, emphasizing efforts to reduce pyrogenic burden and the need to control both microbiological and endotoxin contamination levels.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"73 3","pages":"169-174"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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1,8-cineole (eucalyptol) in a therapy of respiratory diseases. 1,8-蒎烯（桉叶油醇）在呼吸系统疾病治疗中的应用。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.028

Zdeňka Navrátilová

引用次数: 0

Rising consumption of anticoagulants in Central and Eastern European countries in the period 2007-2019. 2007-2019年期间中欧和东欧国家抗凝血剂消费量的上升。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.036

Kateřina Malá-Ládová, Helena Štastná Koblihová, Eva Zimčíková, Anna Oleárová, Ria Benko, Maria Matuz, Reka Viola, Katarina Gvozdanovic, Pero Draganic, Irina Iaru, Josef Malý

{"title":"Rising consumption of anticoagulants in Central and Eastern European countries in the period 2007-2019.","authors":"Kateřina Malá-Ládová, Helena Štastná Koblihová, Eva Zimčíková, Anna Oleárová, Ria Benko, Maria Matuz, Reka Viola, Katarina Gvozdanovic, Pero Draganic, Irina Iaru, Josef Malý","doi":"10.36290/csf.2024.036","DOIUrl":"10.36290/csf.2024.036","url":null,"abstract":"Introduction and aim: Due to the growing incidence of thromboembolic disease and atrial fibrillation, increasing trends in anticoagulants consumption can be expected. The aim of this study was to analyse the consumption of anticoagulants in the Czech Republic, Croatia, Hungary, Romania, and Slovakia between 2007 and 2019.Methods: A retrospective analysis of anticoagulants comprising B01AA, B01AB, B01AE, B01AF and B01AX was performed using ATC/DDD methodology. The analysis was initiated in the year before the launch of the first non-vitamin K oral anticoagulant (NOAC). The consumption of each drug was assessed based on annual data and was expressed as DDD per 1,000 population per day (DDD/TID).Results: The overall rates of anticoagulant consumption increased in all countries. Specifically, doubled in the Czech Republic, Croatia, and Slovakia, more than tripled in Hungary and more than quadrupled in Romania. Parenteral anticoagulant consumption remained stable or decreased, while the proportion of oral anticoagulants increased from an average of 61.41% in 2009 to 66.95% in 2019. The use of vitamin K antagonists declined, with the highest rate in the Czech Republic (11.16 DDD/TID in 2019). NOAC consumption showed substantial growth: from 0.002 to 8.33 DDD/TID in the Czech Republic, 0.001 to 6.73 in Croatia, 0.009 to 8.31 in Hungary, 0.0005 to 5.40 in Romania, and 0.03 to 10.77 in Slovakia. By 2019, rivaroxaban was the most commonly used NOAC in all countries, apart from Romania.Conclusion: The study showed an overall increase in the anticoagulant consumption. However, specific characteristics of individual countries need to be further analysed to better understand the different factors influencing utilization patterns.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"73 E4","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmaceutical company Norgine in Ústí nad Labem (Aussig). 制药公司Norgine在Ústí和Labem （Aussig）。

Ceska a Slovenska Farmacie Pub Date : 2024-01-01 DOI: 10.36290/csf.2024.034

Tomáš Arndt

{"title":"Pharmaceutical company Norgine in Ústí nad Labem (Aussig).","authors":"Tomáš Arndt","doi":"10.36290/csf.2024.034","DOIUrl":"10.36290/csf.2024.034","url":null,"abstract":"Norgine was founded in 1909 and began operations in Ústí nad Labem. Its founder was Doctor of Chemistry Victor Stein. The company originally produced sodium alginate and chemical preparations from imported seaweed (which gave it its name). Her first drugs included the laxative Normacol and the canker sore tincture Pyralvex (both still in production today). After the First World War, the company focused on the group of medicines. The principal part of its portfolio was insulins. The company also collaborated with prominent German pharmacologists from the German University in Prague, first with Professor Wilhelm Wiechowski (1873-1928) and Professor Emil Starkenstein (1884-1942). These were, for example, the spasmolytic Apasmon or the anti-anemic Ferrostabil. 1934 Victor Stein died. His son Walter took over the company's management. During the Munich crisis, the company's share of its owners (Petschek banking house) transferred to London. After October 1938, German concern Schering AG \"appropriated\" the Norgine factory. After the end of the war in 1946, the company was nationalized and incorporated into the state enterprise United Pharmaceutical Works (the well-known abbreviation SPOFA was more commonly used). It was later renamed Chemopharm. In the period of socialism, it produced plasters (Spofaplast), pharmaceutical substances and medicines. After 1989, it was privatized and continued to make plasters and other purely chemical products. Abroad after 1945, Norgine continued to operate as a pharmaceutical company with production. It successfully exists in this form to this day.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"73 E3","pages":"23-26"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0