Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial.

Q3 Pharmacology, Toxicology and Pharmaceutics
Ceska a Slovenska Farmacie Pub Date : 2024-01-01
Sadeel A Shanshal, Mohammad H Alsaaty, Harith Al-Qazaz, Radhwan N Al-Zidan
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Abstract

Alleviating the symptoms of irritable bowel syndrome (IBS) through the addition of probiotics to the treatment of IBS patients appears to be promising. The present randomized clinical trial seeks to assess the efficacy of a multi-strain probiotic product combining two Lactobacillus (L.) strains: L. acidophilus and L. plantarum, in diarrhea-predominant IBS (IBS-D) patients. A randomized, single-blinded clinical trial design was adopted to randomly assign 100 patients into two groups. Patients in group A received standard IBS treatment, whereas Group B patients were treated with probiotics besides the standard treatment. Both groups were treated for up to 12 weeks. The patients were assessed clinically by using IBS - Symptom Severity Scale (IBS-SSS) before starting the treatment and then at the end of the treatment period to evaluate the actual effect of probiotic intervention in treating IBS-D. Both treatments resulted in significant reductions in the total IBS-SSS score, but the reduction in Group B was significantly higher than in Group A. The reduction was significant in the number of days with pain, the severity of abdominal distension, satisfaction with bowel symptoms, and the effect of IBS on patients' life. The standard treatment showed a reduction of 241 points in the overall IBS-SSS score, while adding the probiotic resulted in 307 points reduction. Before treatment, all patients had severe IBS symptoms, but after treatment, 100% of patients in group B either achieved complete remission or had mild symptoms, while 14.3% of patients in group A still had moderate IBS. The patients on probiotics exhibited higher reductions in IBS-SSS overall scores as well as scores of individual sections. The probiotics also improved the severity of the disease and its symptoms when added to standard treatment. The results of this trial could support the addition of probiotics to the guidelines for managing IBS.

用两种乳酸菌株辅助治疗肠易激综合征:随机对照试验。
通过在肠易激综合征(IBS)患者的治疗中添加益生菌来缓解其症状似乎很有前景。本随机临床试验旨在评估一种多菌株益生菌产品的疗效,该产品结合了两种乳酸杆菌(L:嗜酸乳杆菌和植物乳杆菌对腹泻为主的肠易激综合征(IBS-D)患者的疗效。采用随机、单盲临床试验设计,将 100 名患者随机分为两组。A 组患者接受标准的 IBS 治疗,而 B 组患者则在标准治疗的基础上接受益生菌治疗。两组患者均接受长达 12 周的治疗。在开始治疗前和治疗期结束时,使用肠易激综合征-症状严重程度量表(IBS-SSS)对患者进行临床评估,以评价益生菌干预治疗肠易激综合征-D 的实际效果。两种治疗方法都能明显降低 IBS-SSS 总分,但 B 组的降低幅度明显高于 A 组;在疼痛天数、腹胀严重程度、肠道症状满意度以及 IBS 对患者生活的影响方面,B 组的降低幅度都很明显。标准治疗显示,IBS-SSS 总分降低了 241 分,而添加益生菌后则降低了 307 分。治疗前,所有患者都有严重的肠易激综合征症状,但治疗后,B 组 100%的患者症状完全缓解或症状轻微,而 A 组 14.3%的患者仍有中度肠易激综合征。服用益生菌的患者的肠易激综合征-SSS 总分和单个部分的分数都有较大幅度的降低。在标准治疗的基础上,益生菌还能改善疾病的严重程度和症状。这项试验的结果有助于将益生菌纳入肠易激综合征治疗指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ceska a Slovenska Farmacie
Ceska a Slovenska Farmacie Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
0.90
自引率
0.00%
发文量
22
期刊介绍: Přehledový článek je zaměřen zejména na metody přípravy, charakterizaci mikročástic a dále na charakteristiku a příklady jejich možného využití ve farmakoterapii. Mikročástice jako...
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