Ceska a Slovenska Farmacie最新文献_第2页

Bile acids in the treatment of hepatobiliary diseases: rational use of UDCA. 胆汁酸治疗肝胆疾病：UDCA的合理应用。

Ceska a Slovenska Farmacie Pub Date : 2026-01-01 DOI: 10.36290/csf.2026.014

Petra Halvová

引用次数: 0

Tirzepatide. Tirzepatide。

Ceska a Slovenska Farmacie Pub Date : 2026-01-01 DOI: 10.36290/csf.2026.020

Jan Brož, Marika Koželuhová, Juraj Michalec, Ondřej Lukáč

引用次数: 0

Pharmacokinetic changes and approach to drug dosing in patients with obesity and after bariatric surgery. 肥胖患者和减肥手术后的药代动力学变化和给药方法。

Ceska a Slovenska Farmacie Pub Date : 2026-01-01 DOI: 10.36290/csf.2026.004

Alena Pilková

{"title":"Pharmacokinetic changes and approach to drug dosing in patients with obesity and after bariatric surgery.","authors":"Alena Pilková","doi":"10.36290/csf.2026.004","DOIUrl":"10.36290/csf.2026.004","url":null,"abstract":"Introduction: Obesity is a chronic disease associated with multiple comorbidities and can affect drug pharmacokinetics. Appropriate dosing in obese patients is essential to ensure therapeutic efficacy and safety.Objective: To summarize the impact of obesity and bariatric surgery on drug pharmacokinetics and provide recommendations for individualized dosing.Methods: Review of available literature and clinical guidelines addressing changes in drug absorption, distribution, metabo-lism, and excretion in obese patients and after bariatric procedures.Results: Obesity is associated with nonlinear changes in volume of distribution and heterogenous changes in clearance: modification of certain CYP enzyme activity (notably CYP3A4, CYP2C19, CYP2E1), and alteration of renal function. Anatomical and functional chages of gastrointestinal tract (GIT) following bariatric surgery variably modify absorption area, pH, GIT motility and lead to improvement in metabolic comorbidities. Dose adjustments are particularly important for drugs with a narrow therapeutic range, weight-based dosing regimens, and highly lipophilic substances. An individualized approach and therapeutic drug monitoring are recommended in clinical practice.Conclusion: Universal drug dosing regimens for obese patients or those after bariatric surgery are unavailable for most drugs. Body composition and other patient-specific factors, as well as drug pharmacokinetics should be considered. Clinical pharmacists can contribute to optimal pharmacotherapy in this heterogeneous population.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"75 1","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sinusitis self-treatment. 自我治疗鼻窦炎。

Ceska a Slovenska Farmacie Pub Date : 2026-01-01 DOI: 10.36290/csf.2026.008

Tomáš Hammer

引用次数: 0

Idiopathic interstitial lung diseases - treatment options. 特发性间质性肺疾病-治疗方案。

Ceska a Slovenska Farmacie Pub Date : 2026-01-01 DOI: 10.36290/csf.2026.003

Martina Šterclová

引用次数: 0

Foot mycoses - treatment with over-the-counter preparations based on clinical recommendations. 足真菌病-基于临床建议的非处方制剂治疗。

Ceska a Slovenska Farmacie Pub Date : 2026-01-01 DOI: 10.36290/csf.2026.022

Ivana Kuklová

引用次数: 0

Pelargonium sidoides DC. vs. Pelargonium reniforme (Andrews) Curtis - active constituents and medicinal effects. 天竺葵。与reniformme (Andrews) Curtis - perargonium - active components and medicinal effect。

Ceska a Slovenska Farmacie Pub Date : 2026-01-01 DOI: 10.36290/csf.2026.007

Zdeňka Navrátilová

引用次数: 0

Justification of a medicinal form development based on the api dimethylammonium 3-methyl-2-(2-((e)-styryl)quinazolin-4-ylthio)butanoate with hepatoprotective and antioxidant effects for the needs of military medicine. 基于原料药3-甲基-2-（2-(e)-苯乙烯基）喹唑啉-4-基硫代)丁酸二甲基铵开发具有保肝和抗氧化作用的 药物剂型的论证

Ceska a Slovenska Farmacie Pub Date : 2026-01-01 DOI: 10.36290/csf.2026.023

Antonina Avramenko, Andrii Kaplaushenko, Volodymyr Salionov

{"title":"Justification of a medicinal form development based on the api dimethylammonium 3-methyl-2-(2-((e)-styryl)quinazolin-4-ylthio)butanoate with hepatoprotective and antioxidant effects for the needs of military medicine.","authors":"Antonina Avramenko, Andrii Kaplaushenko, Volodymyr Salionov","doi":"10.36290/csf.2026.023","DOIUrl":"https://doi.org/10.36290/csf.2026.023","url":null,"abstract":"Objective: The study aims to substantiate the development of an oral dosage form for military medicine based on the API dimethylammonium 3-methyl-2-(2-((E)-styryl)quinazolin-4-ylthio)butanoate, which demonstrates antioxidant and hepatoprotective activity. The molecule's physicochemical properties and dissociation constant were evaluated.Materials and methods: Computer modelling was used to assess lipophilicity, physicochemical parameters, and ADME characteristics via the SwissADME service. Drug-likeness was evaluated according to Lipinski's Rule of Five. Conductometric studies of API solutions (0.0625-0.5 M) were performed with a Konduktometr N 5721 M to determine χ, λv, λ∞, α, and the dissociation constant (7.45 × 10-8-9.2 × 10-8). The ionization constant was used to calculate pK = 7.13, indicating the pH range of optimal absorption.Results: ADME analysis showed high gastrointestinal absorption and suitable solubility, supporting the feasibility of an oral dosage form. Conductometric data confirmed the API to be a weak electrolyte with increasing dissociation at lower concentrations. The pK value suggests preferential absorption in the neutral to slightly alkaline environment of the small intestine. Considering its pharmacological activity, the API is promising for further development of tablets or capsules for military and clinical use.Conclusions: The findings justify designing a gastro-resistant oral dosage form ensuring API stability in gastric acid and efficient intestinal absorption. Such a form is particularly valuable for military medicine due to its stability, portability, and suitability for emergency and rehabilitation settings.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"75 2","pages":"100"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary delivery of monoclonal antibodies: challenges, limitations,and modern formulation strategies. 单克隆抗体肺递送：挑战、限制和现代配方策略。

Ceska a Slovenska Farmacie Pub Date : 2026-01-01 DOI: 10.36290/csf.2026.018

Paula Čermáková, Juraj Piešťanský

{"title":"Pulmonary delivery of monoclonal antibodies: challenges, limitations,and modern formulation strategies.","authors":"Paula Čermáková, Juraj Piešťanský","doi":"10.36290/csf.2026.018","DOIUrl":"https://doi.org/10.36290/csf.2026.018","url":null,"abstract":"Biopharmaceuticals, particularly monoclonal antibodies, represent a key therapeutic class in modern pharmacotherapy for the treatment of autoimmune, inflammatory, oncological, and rare diseases. Despite their high efficacy and specificity, their clinical use is largely limited to parenteral administration, which may negatively affect patient comfort and long-term treatment adherence. In recent years, the inhalation route of administration has emerged as a promising, non-invasive alternative, especially for respiratory diseases. This is due to the large absorptive surface area of the lungs, their rich vascularization, and the possibility of achieving high local drug concentrations while minimizing systemic adverse effects. This review summarizes and critically evaluates current knowledge and emerging trends in the field of inhaled monoclonal antibodies. The text focuses on the specific features of pulmonary physiology, as well as the anatomical, physiological, and immunological barriers influencing the deposition, stability, and absorption of biological therapeutics. Particular attention is given to advanced formulation strategies aimed at improving pulmonary retention and the systemic bioavailability of protein-based drugs. Inhaled administration of biologics may significantly expand the therapeutic potential of monoclonal antibodies in the future and contribute to more effective and targeted treatment strategies.","PeriodicalId":38771,"journal":{"name":"Ceska a Slovenska Farmacie","volume":"75 2","pages":"101-107"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148309877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin hydration: How to increase the water content in the skin with dermocosmetics? 皮肤补水：如何用护肤品增加皮肤含水量？

Ceska a Slovenska Farmacie Pub Date : 2026-01-01 DOI: 10.36290/csf.2026.002

Andrej Kováčik, Barbora Vraníková, Robert Čáp

引用次数: 0