Romanian Journal of Diabetes, Nutrition and Metabolic Diseases最新文献_第8页

Comparative Study of the Effect of Various Forms of Quercetin on Experimental Diabetes 不同形式槲皮素对实验性糖尿病影响的比较研究

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-12-01 DOI: 10.2478/rjdnmd-2018-0046

K. Posokhova, I. Stechyshyn, I. Krynytska, M. Marushchak, Inna Birchenko, I. Klishch

{"title":"Comparative Study of the Effect of Various Forms of Quercetin on Experimental Diabetes","authors":"K. Posokhova, I. Stechyshyn, I. Krynytska, M. Marushchak, Inna Birchenko, I. Klishch","doi":"10.2478/rjdnmd-2018-0046","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0046","url":null,"abstract":"Abstract Background and aims: Diabetes mellitus (DM) is a multifactorial metabolic disorder characterized by hyperglycaemia caused by insulin deficiency or insulin resistance. It is a global public health problem. This study aimed to determine specific pharmacological effect of quercetin in water soluble and liposomal preparations in experimental diabetes mellitus. Material and methods: We examined the effect of Corvitin and Lipoflavone (at the dose of 10 mg / kg body weight) in a comparative study in white rats with type 1 diabetes and type 2 diabetes coupled with obesity. To simulate the forms of diabetes mellitus most analogous to those in humans we used Streptozotocin at the doses of 30 mg / kg and 50 mg / kg. We tested the levels of glucose, glycosylated hemoglobin, C-reactive protein, and interleukins 6 and 4 in the blood. Results: In animals with type 1 and type 2 diabetes Lipoflavone significantly reduces glucose and glycosylated hemoglobin levels compared to the rats treated with Corvitin. When administered to animals with diabetes, the effect of quercetin in liposomal form on the concentrations of IL-6, IL-4 and Creactive protein is also larger compared to the water-soluble form. Conclusions: Water soluble quercetin preparation Corvitin and to a larger extent liposomal preparation of this flavonoid, Lipoflavone, show anti-inflammatory effect and restore key parameters of carbohydrate metabolism in experimental type 1 diabetes mellitus and type 2 diabetes coupled with obesity, reducing blood glucose and glycosylated hemoglobin levels.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"383 - 388"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41333537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Editorial. Shifting the Paradigm in Type 2 Diabetes Treatment. A Pragmatic Approach of the ADA/EASD 2018 Consensus: The Diabetes Decalogue 社论。2型糖尿病治疗模式的转变ADA/EASD 2018共识的务实途径:糖尿病十诫

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-12-01 DOI: 10.2478/rjdnmd-2018-0041

D. Gaita, B. Timar

引用次数: 0

Markers of Endogenous Intoxication in Rats with Diabetes Mellitus Combined with Carrageenan-Induced Enterocolitis 糖尿病合并卡拉胶性小肠结肠炎大鼠内源性中毒标志物的研究

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-12-01 DOI: 10.2478/rjdnmd-2018-0048

І. Krynytska, M. Marushchak, Inna Birchenko, I. Klishch

{"title":"Markers of Endogenous Intoxication in Rats with Diabetes Mellitus Combined with Carrageenan-Induced Enterocolitis","authors":"І. Krynytska, M. Marushchak, Inna Birchenko, I. Klishch","doi":"10.2478/rjdnmd-2018-0048","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0048","url":null,"abstract":"Abstract Background and aims: Diabetes mellitus (DM) is a significant public health issue, being one of the major contributors to morbidity and mortality in the modern societies. Chronic hyperglycemia produces significant physiological, biochemical, and histological changes in the affected organisms. This study aims to evaluate the markers of endogenous intoxication in rats with diabetes mellitus combined with carrageenan-induced enterocolitis. Materials and methods: Diabetes mellitus was induced by a single intraperitoneal administration of streptozotocin (Sigma Aldrich, USA, at a dose of 60 mg/kg body weight). Carrageenan-induced enterocolitis was modeled by giving the animals free access to 1.0 % solution of carrageenan in drinking water for 1 month. The syndrome of endogenous intoxication was assessed by quantification of low and medium molecular weight substances in blood plasma, red blood cell suspension and urine using extraction-spectrophotometric method. Results: The increase in endogenous intoxication in streptozotocin-induced diabetes combined with chronic enterocolitis can mainly be attributed to the catabolic pool of blood plasma substances of low and medium molecular weight. The index of distribution of low- and medium-molecular-weight substances between blood plasma proteins and glycocalyx of erythrocytes in the experimental groups increased simultaneously with the quantities of investigated fractions in the erythrocyte suspension measured at the wavelengths of 242, 254 and 280 nm. Conclusions: We observed upsurge of endogenous intoxication markers in the rats with diabetes mellitus. Endotoxicosis became even more evident in the rats with diabetes mellitus combined with carrageenan-induced enterocolitis.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"399 - 407"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42801856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effect of Fiber-Rich Snacks on C-Reactive Protein and Atherogenic Index in Type 2 Diabetes Patients 富纤维零食对2型糖尿病患者c反应蛋白及动脉粥样硬化指数的影响

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-12-01 DOI: 10.2478/rjdnmd-2018-0042

Nartyr Sunarti, Sri Lestari Sulistyo Rini, Hemi Sinorita, D. Ariani

{"title":"Effect of Fiber-Rich Snacks on C-Reactive Protein and Atherogenic Index in Type 2 Diabetes Patients","authors":"Nartyr Sunarti, Sri Lestari Sulistyo Rini, Hemi Sinorita, D. Ariani","doi":"10.2478/rjdnmd-2018-0042","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0042","url":null,"abstract":"Abstract Background and aims: High levels of non-HDL and atherogenic cholesterol can induce inflammation, and as risk factor for cardiovascular diseases. This study was to evaluate the effects of fiber-rich snacks on non-HDL cholesterol, atherogenic index, and Creactive protein (CRP) levels in type 2 diabetes patients (T2DM). Material and Methods: Twenty T2DM patients, were recruited from the Policlinic of Endocrine, Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The subjects received daily 32g fiber-rich snacks made of Dioscorea esculenta, arrowroot, cassava and pumpkin for 4 weeks. Fasting non-HDL cholesterol, atherogenic index, CRP and HbA1c levels were measured before and after intervention. Paired t-test was used to evaluate the results. Results: The fiber-rich snack intervention in T2DM patients significantly reduced levels of non-HDL cholesterol and CRP levels (p<0.05), but the decreased the atherogenic index was not significant (p>0.05). The intervention also significantly reduced the CRP levels (p<0.05) but did not affect HbA1c levels. Body weight, body mass index (BMI), waist circumference decreased significantly after consuming the snacks (p<0.05). Conclusions: This study showed fiber-rich snack has a positive effect in improving non-HDL cholesterol, atherogenic index and CRP levels but does not affect HbA1c levels in T2DM patients.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"357 - 362"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44773552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Omega-3 Polyunsaturated Fatty Acids Improved Arterial Stiffness Parameters in Type 2 Diabetic Patients with Cardiac Autonomic Neuropathy Omega-3多不饱和脂肪酸改善2型糖尿病合并心脏自主神经病变患者动脉僵硬参数

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-12-01 DOI: 10.2478/rjdnmd-2018-0043

V. Serhiyenko, Ludmila Serhiyenko, A. Serhiyenko

{"title":"Omega-3 Polyunsaturated Fatty Acids Improved Arterial Stiffness Parameters in Type 2 Diabetic Patients with Cardiac Autonomic Neuropathy","authors":"V. Serhiyenko, Ludmila Serhiyenko, A. Serhiyenko","doi":"10.2478/rjdnmd-2018-0043","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0043","url":null,"abstract":"Abstract Background and Aims: Diabetic cardiac autonomic neuropathy (DCAN) in type 2 diabetes (T2D) is among the strongest and independent risk markers for future global and cardiac mortality. Material and Methods: Thirty-six patients suffering from T2D and confirmed DCAN were enrolled in this investigation. Depending on the prescribed therapy, patients were allocated into two groups: group 1 was comprised of 15 patients to whom standard hypoglycemic treatment was prescribed (control group), the second received standard hypoglycemic treatment and omega-3 polyunsaturated fatty acids (ω-3 PUFAs, n = 21). The duration of the study was three month. Results: In subjects with T2D and DСAN prescription of ω-3 PUFAs was associated with a significant decrease of aorta augmentation index (AIxao), pulse wave velocity (PWV) during the active period of the day and decrease of AIxao, brachial augmentation index and PWV during the passive period of the day compared with the control group. Therefore, three month of ω-3 PUFAs supplementation to patients with confirmed DCAN and T2D promotes to improvement of arterial stiffness indices. Conclusions: In patients with T2D and СAN treatment with ω-3 PUFAs improved arterial stiffness parameters. The effectiveness of ω-3 PUFAs is not connected with optimization of glycemic control, but is rather the result of a direct drug action on the studied parameters.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"363 - 368"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42346671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Therapeutic Characteristics of Patients with Type 2 Diabetes Mellitus in Romania – Mentor Study 罗马尼亚2型糖尿病患者的临床和治疗特点——导师研究

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-12-01 DOI: 10.2478/rjdnmd-2018-0049

C. Serafinceanu, V. Elian, D. Catrinoiu, C. Guja, B. Mihai, M. Moța, G. Roman, R. Timar

{"title":"Clinical and Therapeutic Characteristics of Patients with Type 2 Diabetes Mellitus in Romania – Mentor Study","authors":"C. Serafinceanu, V. Elian, D. Catrinoiu, C. Guja, B. Mihai, M. Moța, G. Roman, R. Timar","doi":"10.2478/rjdnmd-2018-0049","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0049","url":null,"abstract":"Abstract Background and aims: PREDATORR Study estimated diabetes mellitus (DM) prevalence in Romania at 11.7%. MENTOR is the first national major study trying to determine the quality of the metabolic control in patients with type 2 diabetes (T2DM), the therapeutic options used, and the microvascular and macrovascular complications prevalence in order to achieve a better management for Romanian patients with T2DM. Material and methods: The study was designed as an observational analytical, multicenter, prospective study. Study population was selected from T2DM patients stratified by: age, diabetes duration and gender. Data was collected in an eCRF: demographics, physical examination, cardiovascular evaluation, blood tests, known pathology, treatment. Results: There were 54.80% women, mean age was 60.53±7.39 years. The average BMI is over 30 kg/m2 with a decreasing trend over the age. 60% had their HbA1c over the threshold of 7%. Average blood pressure was less than 140/80 mmHg. 76,66% of T2DM subjects have at least one chronic complication. On oral therapy we have 55.44% of patients, on insulin only therapy 12.99% and on a combination of oral and insulin therapy 22.51%. Conclusions: This study showed a high prevalence of diabetes complications and metabolic alterations (obesity, hypertension, dyslipidemia, etc.). Age, male gender and diabetes duration were associated with a higher risk for poor metabolic control and complications. Further data will be collected over a 3 years period to obtain a better image over T2DM evolution in Romanian population.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"409 - 418"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43495359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Association of Vitamin D Status with Body Mass Index in Adolescents in Ukraine 乌克兰青少年维生素D状况与体重指数的关系

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-12-01 DOI: 10.2478/rjdnmd-2018-0045

V. Pankiv, I. Pankiv

{"title":"Association of Vitamin D Status with Body Mass Index in Adolescents in Ukraine","authors":"V. Pankiv, I. Pankiv","doi":"10.2478/rjdnmd-2018-0045","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0045","url":null,"abstract":"Abstract Background and aims: Vitamin D status in many health managements have been researched extensively, but its dependence with obesity still remains controversial. This article is devoted to examination of blood cholecalciferol levels in Ukrainian population with establishment the association of cholecalciferol levels and body mass index (BMI). Materials and methods: For this observed investigation, data were collected during the summer 2017, over a period of one week from three township areas in Carpathian region, Ukraine from 304 adults aged 19-78 years. Measured variables contained 25(OH)D level, weight and weight applied to check BMI degree. The average level of vitamin D among adolescents presented 23.1 ± 8.2 ng/ml. Female gender was associated with lower vitamin D concentrations (22.9 ± 9.3 ng/ml vs. 26.2 ± 8.5 ng/ml for men). Among the participants, 74.4% had a BMNI of 25 kg/m2 and over, and in 27.3% of them the number was 30 kg/m2 and over. Results: Violation of vitamin D status was detected in 90.5% persons. 1.8% people had been identified as severe 25(OH)D deficiency. Measurement of cholecalciferol demonstrated meaningful connection between its level and BMI only in persons with BMI 25-29.9 kg/m2. Average vitamin D concentrations in persons with BMI over30 kg/m2 did not vary to a significant range from data in persons with normal body weight. Conclusions: Vitamin D status among the adolescents in Ukraine is far from optimum. Our results confirm reliable association between cholecalciferol level and BMI in persons with overweight. Interchange between conservation of vitamin D and BMI needs additional surveys.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"377 - 381"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44710859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Predictive Value of Blood Glucose Range for Onset of Complications in Patients with Diabetes Mellitus Type 1 血糖范围对1型糖尿病患者并发症发生的预测价值

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-12-01 DOI: 10.2478/rjdnmd-2018-0047

K. Moshenets

{"title":"Predictive Value of Blood Glucose Range for Onset of Complications in Patients with Diabetes Mellitus Type 1","authors":"K. Moshenets","doi":"10.2478/rjdnmd-2018-0047","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0047","url":null,"abstract":"Abstract Background and aims: to develop a prognostic mathematical model for risk of microangiopathy in patients with diabetes mellitus type 1 (T1DM). Materials and methods: 62 T1DM patients were divided into 2 groups according to НвА1с level: group 1 (n=18) with НвА1с ≤ 7.0% and group 2 (n=44) with НвА1с > of 7.0%. HbA1c, Cpeptide, blood creatinine, estimated glomerular filtration rate (eGFR) CKD-EPI, first morning urinary albumin excretion (AU) were determined. Blood glucose levels were conducted by CGMS (Continuous Glucose Monitoring System). All patients were followed for 3 months. Rank correlation method was used. Results: We established the direct correlation between HbA1c the AU level ρ=0.29 (р<0.016) at the beginning and ρ=0.4 (р=0.021) after 3 months. AU level has a direct correlation with blood glucose range, at the beginning ρ=0.51 (р<0.001) and after 3 months ρ=0.48 (р=0.004) visits. We made the mathematical description of this dependence. Each additional unit of blood glucose range is accompanied by increasing an average level AU level by 0.4816 mg/l. Conclusion: our mathematical equation of dependence between AU level and blood glucose range gives the opportunities to predict diabetic kidney disease progression in T1DM patients.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"389 - 397"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44044651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Impact of Low Caloric Diet and Exercise on Atherogenic Indices in Obese Hypertensive Adults 低热量饮食和运动对肥胖高血压成人动脉粥样硬化指数的影响

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-12-01 DOI: 10.2478/rjdnmd-2018-0044

Mohamed Abdelhaq Abbes, K. Bereksi-Reguig

{"title":"Impact of Low Caloric Diet and Exercise on Atherogenic Indices in Obese Hypertensive Adults","authors":"Mohamed Abdelhaq Abbes, K. Bereksi-Reguig","doi":"10.2478/rjdnmd-2018-0044","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0044","url":null,"abstract":"Abstract Background and aims: The influence of a low caloric diet with exercise were studied on several biochemical parameters including the lipid profile and atherogenic indices in overweight subjects including obesity with hypertension. Material and method: The study focused on 327 patients (144 men and 183 women) aged 54-73 years selected randomly, We chose hypertensives who live in the city of Tiaret and are over 50 years old, because it is the age group most affected by hypertension in Algeria and even in the world. We invited the subjects of our study to follow a program involving a low caloric diet, which was characterized by the suppression of the consumption of sucrose and refined white flour and by the choice of low-fat products, especially dairy products. Results: We observed a decrease in the mean value of blood pressure with its two components, systolic and diastolic. Systolic blood pressure ranged from 13.06 ± 1.40 cm Hg for the overall sample to 13.01 ± 1.12 cm Hg after the six-month program. The same finding is made for diastolic pressure, which decreased by 1.58% for the study population. For biochemical parameters, we observe a decrease in the mean value of all parameters after participation in the low-calorie diet and physical activity program, with the exception of HDL-c, which experienced an increase of 6.25%. Conclusions: The hypocaloric diet with exercise that we proposed to a group of hypertensives showed its effectiveness. A healthy lifestyle including a healthy and balanced diet with physical activity therefore allow better management of the hypertensive subject and could actually prevent atherosclerosis.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"369 - 375"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47493632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Web of Causation between Dietary Patterns and Childhood Obesity: Applying Hill's Criteria 饮食模式与儿童肥胖之间的因果关系网:应用希尔标准

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-12-01 DOI: 10.2478/rjdnmd-2018-0052

C. Șerban, D. Șerban, Ștefania Ioana Butica, D. Lungeanu

{"title":"Web of Causation between Dietary Patterns and Childhood Obesity: Applying Hill's Criteria","authors":"C. Șerban, D. Șerban, Ștefania Ioana Butica, D. Lungeanu","doi":"10.2478/rjdnmd-2018-0052","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0052","url":null,"abstract":"Abstract Since their publication in 1965, the Bradford Hill criteria for causality have been largely used as a framework for causal inference in epidemiology. We aim at employing this classical approach to shed new light onto the web of causation of childhood obesity. Although the fundamental cause of obesity is the long-term imbalance between energetic need and intake, this medical condition is multifactorial in its origin, influenced by genetic, behavioral, socioeconomic, and environmental factors. This imbalance leads to accumulation of excessive adipose tissue. Observational studies tend to mostly quantify association between dietary factors and accumulation of adipose tissue. On the other hand, multivariate analysis proved some of these associations to be spurious, therefore prospective trials are needed to demonstrate causality. Short term experimental studies have been conducted to identify unique dietary pattern changes on specific outcomes, but long term, community-based studies would offer more comprehensive answers on dietary pattern effects. We conducted a literature review on PubMed, Scopus, Web of Science, and Google Scholar. From a total of 323 papers identified at first stage, we further discuss the applicability of Bradford Hill criteria for 31 articles, by examples of dietary patterns and accumulation of excess body fat as exposure-response associations. We also put forward and analyzed the evidence prospective studies would bring, as foundation for future interventions.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"431 - 438"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45765746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1