Romanian Journal of Diabetes, Nutrition and Metabolic Diseases最新文献

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Metabolic Syndrome and Pulmonary Function Indices 代谢综合征与肺功能指标
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-09-01 DOI: 10.2478/rjdnmd-2018-0030
G. Pouryaghoub, R. Mehrdad, M. Mehraban
{"title":"Metabolic Syndrome and Pulmonary Function Indices","authors":"G. Pouryaghoub, R. Mehrdad, M. Mehraban","doi":"10.2478/rjdnmd-2018-0030","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0030","url":null,"abstract":"Abstract Background and aims: Metabolic syndrome (MetS) is a collection of metabolic risk factors including increased waist circumference (WC), elevated blood pressure (BP), increased triglyceride (TG), decreased high density lipoprotein (HDL-C) and increased fasting blood sugar (FBS). We aimed to examine the relevance between the MetS and its components with reduced lung functions in adult men. Material and method: A total of 3899 adult men underwent screening examination between 2015-2016 in a cross-sectional survey. Results: The mean (± SD) age of our population was 37.25 (± 4.9) years. The overall prevalence of MetS was 7.6%. The total prevalence of reduced lung function in men with MetS was 13.8%. The most common type of reduced lung function was the restrictive pattern (7.1%). The forced expiratory volume of first second (FEV1) and forced vital capacity (FVC) values were significantly lower in men with MetS (both p<0.001). Also these values were significantly lower in diabetic men compared to non-diabetics and those with impaired fasting glucose (IFG). WC and HDL were the most potent predictors of reduced FEV1 and FVC. Conclusions: We obtained a positive independent association between MetS and reduced lung function in adult men which may be related mainly due to increased WC and decreased HDL.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"261 - 269"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46836859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatty Acid Metabolism Disorder as a Factor in Atherogenesis 脂肪酸代谢紊乱是动脉粥样硬化的一个因素
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-09-01 DOI: 10.2478/rjdnmd-2018-0028
A. Osipenko
{"title":"Fatty Acid Metabolism Disorder as a Factor in Atherogenesis","authors":"A. Osipenko","doi":"10.2478/rjdnmd-2018-0028","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0028","url":null,"abstract":"Abstract Background and aims: The study aims to analyze of fatty acid (FA) composition of arteries and blood plasma in atherosclerosis. Material and method: The blood plasma in patients with coronary atherosclerosis was studied, the blood from healthy volunteers was used as control. There were also analyzed arteries of patients with severe atherosclerotic lesions and arteries of people with significantly less atherosclerotic changes. Results: The received data indicates that there is a rather active penetration of FA from blood plasma lipoproteins into intima of arteries. Penetration of FA from blood lipoproteins into the depth of atherosclerotic aorta and an atherosclerotic plaque appears to be small and does not effect on their fatty acid composition, which is similar to that of free FA of blood plasma. The evidence of the increased activity of desaturases and fatty acid synthases in atherosclerotic and intact arteries in patients with severe atherosclerotic vascular lesions was obtained. This increase in activity may be related by relatively low content of polyunsaturated linoleic acid in blood plasma in atherosclerosis. Conclusions: The increased activity of desaturases and fatty acid synthases as well as arterial wall hypoxia must promote accumulation of lipids in vascular wall by increasing the synthesis and inhibition of FA oxidation including free FA coming from blood.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"243 - 252"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68796400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Removable Dentures Treatment Satisfaction of Patients with Type-2 Diabetes 2型糖尿病患者活动义齿治疗满意度分析
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-09-01 DOI: 10.2478/rjdnmd-2018-0032
L. Goguţă, D. Lungeanu, A. Jivănescu
{"title":"Removable Dentures Treatment Satisfaction of Patients with Type-2 Diabetes","authors":"L. Goguţă, D. Lungeanu, A. Jivănescu","doi":"10.2478/rjdnmd-2018-0032","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0032","url":null,"abstract":"Abstract Background and aims: The aim of this study was to find out which was the impact of the treatment with removable dentures on the satisfaction of the type 2 diabetes patients. Material and method: 50 patients, 27 females (54%) and 23 males (46%) were included in the study. 37 were treated by using a partial removable denture and 13 were receiving a complete denture. Each patient included in the study had answered to a questionnaire after the first year of wearing the dentures and the blood glycemic level and the salivary flux were assessed. Chi-square test was applied to investigate the statistical significance of observed differences in proportions. Kruskal-Wallis test was applied to compare distributions across the groups. Results The age of the enrolled patients was between 40 and 85 years, with a mean of 64.3 years (standard deviation = 9.77). The mean values of the glucose levels were decreasing proportional with the age of the patients until 85 years and were inconstant for the group 81-90 years. The saliva at 5min was significantly decreasing with the age (p<0.001). The most satisfied patients with the removable dentures were in the group 61-70 years. Conclusions: The prosthodontic treatment of the type -2 diabetic patients with removable denture should be started after stabilizing the blood glycemic levels and treating the xerostomia, when present.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"277 - 282"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44993115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Effect of Fiber-Rich Snacks on C-Reactive Protein and Atherogenic Index in Type 2 Diabetes Patients 富含纤维的零食对2型糖尿病患者C反应蛋白和动脉粥样硬化指数的影响
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-09-01 DOI: 10.2478/rjdnmd-2018-0031
Sunarti, S. Rini, Hemi Sinorita, D. Ariani
{"title":"Effect of Fiber-Rich Snacks on C-Reactive Protein and Atherogenic Index in Type 2 Diabetes Patients","authors":"Sunarti, S. Rini, Hemi Sinorita, D. Ariani","doi":"10.2478/rjdnmd-2018-0031","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0031","url":null,"abstract":"Abstract Background and aims: High levels of non-HDL and atherogenic cholesterol can induce inflammation, and as risk factor for cardiovascular diseases. This study was to evaluate the effects of fiber-rich snacks on non-HDL cholesterol, atherogenic index, and C-reactive protein (CRP) levels in type 2 diabetes patients (T2DM). Material and Methods: Twenty T2DM patients, were recruited from the Policlinic of Endocrine, Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The subjects received daily 32g fiber-rich snacks made of Dioscorea esculenta, arrowroot, cassava and pumpkin for 4 weeks. Fasting non-HDL cholesterol, atherogenic index, CRP and HbA1c levels were measured before and after intervention. Paired t-test was used to evaluate the results. Results: The fiber-rich snack intervention in T2DM patients significantly reduced levels of non-HDL cholesterol and CRP levels (p<0.05), but the decreased the atherogenic index was not significant (p>0.05). The intervention also significantly reduced the CRP levels (p<0.05) but did not affect HbA1c levels. Body weight, body mass index (BMI), waist circumference decreased significantly after consuming the snacks (p<0.05). Conclusions: This study showed fiber-rich snack has a positive effect in improving non-HDL cholesterol, atherogenic index and CRP levels but does not affect HbA1c levels in T2DM patients.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"271 - 276"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41972787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Gender and Physical Activity: Are they Associated with Body Mass Index in Elderly Jordanian People? 性别和体育活动:它们与约旦老年人的体重指数有关吗?
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-09-01 DOI: 10.2478/rjdnmd-2018-0027
Safaa A. Al-Zeidaneen, Maha T. Hdaib, Yahya W Najjar, Marwa A. Al-Zidaneen
{"title":"Gender and Physical Activity: Are they Associated with Body Mass Index in Elderly Jordanian People?","authors":"Safaa A. Al-Zeidaneen, Maha T. Hdaib, Yahya W Najjar, Marwa A. Al-Zidaneen","doi":"10.2478/rjdnmd-2018-0027","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0027","url":null,"abstract":"Abstract Background: The number of elderly people is increasing worldwide, and elevated body mass index is a common problem that occur with elderly people, which can be directly or indirectly affected by level of physical activity and gender. So, it is essential to study the effect of both physical activity and gender on body mass index in elderly people. Material and methods: A cross-sectional, observational study was conducted on 120 elderly Jordanian people who live in Amman (62 women; 58 men) and evaluated for body mass index. Those participants were 40 elderly persons who attended the gym at least twice a week for the last 2 years, and 80 elderly who were home resident or physically inactive. A structured questionnaire was used to collect data about personal, social, health and life-style information including the daily activities and the anthropometric measurements for the study participants. Results: The results of this study showed that as elderly people become physically inactive, their body mass index will increase to become as overweight or obese. The results of this study also showed that body mass index of 30 and more was associated with gender, with majority of female elderly (50%) having body mass index of 30 or more. Conclusion: Physical activity should be maintained by both genders in order to prevent obesity, primarily in women as they are more likely to become obese that men. Furthermore, body mass index should not exceed 30 in elderly. Physical activity is essential in order to obtain healthy weight.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"237 - 242"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48361080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Type 2 Diabetes and Hashimoto Thyroiditis-Possible Associations and Clinical Correlations - Preliminary Results 2型糖尿病和桥本甲状腺炎-可能的关联和临床相关性-初步结果
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-09-01 DOI: 10.2478/rjdnmd-2018-0035
Oana-Andreea Parlițeanu, D. Cheța
{"title":"Type 2 Diabetes and Hashimoto Thyroiditis-Possible Associations and Clinical Correlations - Preliminary Results","authors":"Oana-Andreea Parlițeanu, D. Cheța","doi":"10.2478/rjdnmd-2018-0035","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0035","url":null,"abstract":"Abstract Background and aims: The primary objective is to evaluate the possible relationship between Type 2 Diabetes (T2DM) and Hashimoto Thyroiditis (HT), since the only correlation described until now is between Type 1 Diabetes and HT based on the autoimmune mechanism. The secondary end-point is to evaluate if there is a correlation between the characteristics of Type 2 Diabetes and autoimmune thyroiditis and if the metabolic component may be a factor of association. Material and method: We designed a retrospective, observational research, enrolling patients from “Sanamed” Hospital from Bucharest. Between 2016 and 2017 in our clinic a number of 150 patients were enrolled, in the following groups: 50 only with T2DM, 50 only with HT and 50 with both T2DM and HT. Results: The main observations of the study were the following: the prevalence of obesity was higher in patients with T2DM (p<0.001) than in the group with HT (p<0.001); Dyslipidemia was higher in the HT group (p<0.001) than in the group of T2DM (p<0.001); Ischemic cardiac disease was more frequent in the HT group (p<0.001) than in the Diabetes group (p<0.001); in the group that had both T2DM and HT, the HbA1c was correlated with pre-existing Thyroid pathology (p<0.001), also Dyslipidemia was associated with hepatic steatosis (p<0.001). Conclusions: After assessing all the parameters we have reached the conclusion that there is an association between the characteristics of T2DM and HT, as well as an interaction between these two diseases, considering their metabolic component.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"297 - 301"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44148825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Endothelial Dysfunction and 24-Hour Ambulatory Blood Pressure Monitoring in Patients with Diabetes 糖尿病患者内皮功能障碍和24小时动态血压监测
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-06-01 DOI: 10.2478/rjdnmd-2018-0016
N. Pertseva, D. Chub
{"title":"Endothelial Dysfunction and 24-Hour Ambulatory Blood Pressure Monitoring in Patients with Diabetes","authors":"N. Pertseva, D. Chub","doi":"10.2478/rjdnmd-2018-0016","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0016","url":null,"abstract":"Abstract Arterial hypertension in patients with diabetes plays a main role in the earlier development of diabetic kidney disease (DKD), and endothelial dysfunction is considered to be a process involved in the development of diabetic complications. It is important to study the markers which gives the opportunity to identify DKD in early stage. In this article is presented a study of 24-hour Ambulatory Blood Pressure Monitoring (24hABPM) data in patients with diabetes and its interconnection with estimated glomerular filtration rate and endothelial dysfunction. The endothelial function was determined using the levels of TGF-b1(transforming growth factor-beta1) and VCAM-1 (vascular cell adhesion molecule-1). In our study, we obtained convincing results that complex including endothelial dysfunction and results of 24hABPM can be considered as early signs of DKD progression in patients with diabetes.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"141 - 147"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42743316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Macrosomia. A Systematic Review of Recent Literature 巨大胎儿。最近文献的系统回顾
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-06-01 DOI: 10.2478/rjdnmd-2018-0022
Delia Monica Glodean, D. Miclea, A. Popa
{"title":"Macrosomia. A Systematic Review of Recent Literature","authors":"Delia Monica Glodean, D. Miclea, A. Popa","doi":"10.2478/rjdnmd-2018-0022","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0022","url":null,"abstract":"Abstract Background and aims: The obesity and overweight rate among women of childbearing age and fetal macrosomia associated with different birth injuries are very frequent all over the world and with an increasing incidence. The huge amount of published literature on this topic in the last decade is putting the practioners in a very challenging position. Material and method: We have done a systematic review on the recent literature (last five years) based on science direct database. Results: A total of 5990 articles were identified and after successive exclusion of some of them, 48 were deeply analyzed. The results were grouped in following topics: risk factors for fetal macrosomia, the pathophysiology of macrosomia, prenatal clinical and lab diagnosis and prevention of macrosomia. Conclusions: Considering the maternal, fetal and neonatal complications of macrosomia, the counseling, and monitoring of the pregnant women risk group are of particular importance for adopting a low calorie / low glycemic diet and avoiding a sedentary behaviour. Long-term follow-up of the mother and the macrosomic baby is required because of the risk of obesity, diabetes, hypertension, and metabolic syndrome later in life.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"20 1","pages":"187 - 195"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/rjdnmd-2018-0022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68796343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Subclinical Diastolic Dysfunction and Its Correlation with Laboratory Parameters in Type 2 Diabetes Mellitus in India: A Case Control Study 印度2型糖尿病亚临床舒张功能障碍及其与实验室参数的相关性:一项病例对照研究
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-06-01 DOI: 10.2478/rjdnmd-2018-0018
Ravichandran, R. Meena, Sourabh Sharma, Soumya Sudharsan, Priyanka Kumari
{"title":"Subclinical Diastolic Dysfunction and Its Correlation with Laboratory Parameters in Type 2 Diabetes Mellitus in India: A Case Control Study","authors":"Ravichandran, R. Meena, Sourabh Sharma, Soumya Sudharsan, Priyanka Kumari","doi":"10.2478/rjdnmd-2018-0018","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0018","url":null,"abstract":"Abstract Background: This study was conducted to evaluate left ventricular dysfunction in diabetics and to find correlation with glycemic control and biochemical parameters compared to non-diabetic population. Methods: Thirty type 2 diabetics and thirty nondiabetic controls were recruited. Age, sex, body mass index of the controls were matched. Results: Mean duration of diabetes mellitus in study population was 10.97± 4.01years. Among study population both cases and controls had ejection fraction >55%( no systolic dysfunction). Among cases(n=16) 53.3% were having mean E/A ratio <1 and(n=14) 46.67% were had mean E/A ratio >1. In controls all of them had mean E/A ratio above 1. This difference of mean E/A ratio among cases and controls was statistically significant (p<0.001). Among patients with diabetes, 9.09% cases with a HbA1cbetween 6-7%, 33.33% between 7.1-8%, respectively 100% of cases with HbA1c>8.1% had diastolic dysfunction the differences between groups being statistically significant (p<0.001). Low density lipoprotein( LDL) was weakly and negative correlated with E/A ratio (r = - 0.38) while fasting blood sugar (r = -0.53) respectively Hemoglobin A1c (r = -0.66) were moderately and negatively correlated. All these correlations were statistically significant. Conclusion: Subclinical diastolic dysfunction is prevalent among diabetic population. Diastolic dysfunction in patients with diabetes was correlated with FBS, HbA1C and LDL.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"157 - 164"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41507470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Editorial: Heart Failure in Type 2 Diabetes – The “Forgotten” Complication 社论:2型糖尿病的心力衰竭——“被遗忘”的并发症
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2018-06-01 DOI: 10.2478/rjdnmd-2018-0014
C. Guja, R. Dănciulescu Miulescu
{"title":"Editorial: Heart Failure in Type 2 Diabetes – The “Forgotten” Complication","authors":"C. Guja, R. Dănciulescu Miulescu","doi":"10.2478/rjdnmd-2018-0014","DOIUrl":"https://doi.org/10.2478/rjdnmd-2018-0014","url":null,"abstract":"Diabetes, particularly type 2 diabetes (T2DM), was recognized as the new “worldwide pandemic” of the 21 st century, with an estimated 8.8% of the adult population (~425 million subjects) afflicted by this condition in 2017 [1]. In the same time, diabetes represents a massive public health issue, being one of the major causes of morbidity and mortality in the modern societies, with high social and economic costs. It is estimated that chronic diseases (including diabetes) have surpassed infectious diseases as the first cause of premature mortality worldwide [2]. In addition, healthcare expenditure related to diabetes in USA reached a staggering 322-377 billion USD [1,2], with a worldwide estimate of 727 billion USD in 2017 according to the latest IDF data [1]. It was long time established that cardiovascular disease (CVD) represents the first cause of death and probably the main cause of disability in subjects with T2DM, with some estimates indicating an 80% excess mortality due to CVD in T2DM [3]. Progresses in the treatment of T2DM and associated CVD risk factors (especially hypertension and dyslipidemia) have led to a continuous decline in the CVD associated morbidity and mortality in diabetes subjects [4,5]. Still, a recent analysis of data from the Swedish National Diabetes Register have shown that T2DM subjects continue to have a 2-4 fold increased risk of death from any cause, death from CVD and death from coronary heart disease (CHD) compared with non-diabetic subjects [4]. This could be explained by the fact that frequently T2DM subjects have asymptomatic / unrecognized CVD, including silent myocardial ischemia and heart failure (HF).","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"25 1","pages":"123 - 130"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47532703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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