Romanian Journal of Diabetes, Nutrition and Metabolic Diseases最新文献

Pitfalls in establishing type of diabetes and optimal therapy: Clinical cases series 确定糖尿病类型的陷阱和最佳治疗：临床病例系列

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2021-06-30 DOI: 10.46389/rjd-2021-1027

Florentina Cristina Matei, Nicoleta Alexandra Şonei, A. Simion, S. Popa

{"title":"Pitfalls in establishing type of diabetes and optimal therapy: Clinical cases series","authors":"Florentina Cristina Matei, Nicoleta Alexandra Şonei, A. Simion, S. Popa","doi":"10.46389/rjd-2021-1027","DOIUrl":"https://doi.org/10.46389/rjd-2021-1027","url":null,"abstract":"Type 1 diabetes is an autoimmune disease characterized by absolute endogenous insulin deficiency. \u0000We report three clinical cases which highlight the particularities of diagnosis and evolution of patients with type 1 diabetes. \u0000These three cases have been diagnosed in different circumstances. The first case with symptoms of hyperglycemia and inaugural diabetic ketoacidosis, without detecting a precipitating factor; the second case accidentally diagnosed, in the absence of hyperglycemia symptoms; and the last case in the context of symptoms of hyperglycemia and ketosis precipitated by a respiratory infection. The cases are characterized by the presence of autoimmunity markers (anti-GAD positive antibodies) and C peptide within normal range. In dynamics, with the initiation of insulin therapy and the remission of glucotoxicity, the insulin requirement decreased progressively, in all patients therapeutic regimen being represented by a low dose of basal insulin, in the conditions of a C peptide still within normal limits at 4 years (first case), one year (second case), respectively 2 years (third case) from the diagnosis and without significant glycemic variability registered on the continuous glycemic monitoring system. \u0000In the third case, there is a lack of regression of insulin requirements after remission of SARS COV-2 infection, and in the second case, the maintenance of prandial insulin secretion sufficient to induce hypoglycemia after administration of a minimal dose of prandial insulin, but insufficient to control postprandial glycemia in the conditions of omitting the administration of prandial insulin. \u0000In each of the cases previously presented we highlight the existing pitfalls in establishing the diagnosis and especially the challenges in choosing the optimal therapy in patients with type 1 diabetes, as the evolution can sometimes be atypical.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"28 1","pages":"170-177"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42832525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shoulder disorders in patients with diabetes mellitus 糖尿病患者肩部疾病

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2021-03-31 DOI: 10.46389/RJD-2021-1002

K. Kamath, S. Kamath

{"title":"Shoulder disorders in patients with diabetes mellitus","authors":"K. Kamath, S. Kamath","doi":"10.46389/RJD-2021-1002","DOIUrl":"https://doi.org/10.46389/RJD-2021-1002","url":null,"abstract":"Background and Aims: Shoulder disorders are common manifestations of musculoskeletal issues affecting patients with diabetes,but get relatively little attention. The aim of the study was to evaluate prevalence of shoulder disorders and its association with glycemic control, duration, and certain epidemiological factors in a section of population with type II diabetes. Material and Method: We conducted a prospective study including 32 consecutive patients with type II diabetes and 32 consecutive patients without diabetes attending the outpatient department for shoulder symptoms. Patients underwent physical examination and the proforma and UCLA-m (modified University of California at Los Angeles) Shoulder Rating Scale form were filled. Data was compiled on frequency and contingency tables. Central tendency was measured by mean and standard deviation. For determining the co-relation unpaired t test and chi-square test were used. Results: We observed that as the fasting blood glucose and HbA1c values decrease, the UCLA scores increase. Hence, proper glycemic control may help in reducing shoulder pain and complications. There was no relation between the UCLA score and diabetic duration or the age of the patient. Conclusions: We conclude frozen shoulder was the most common shoulder disorder in the diabetic group. It is more prevalent in diabetics when comparedto non-diabetics. Evaluation of upper limb manifestations in diabetics must include estimation of glycemic control and an examination for other diabetic complications.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"28 1","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46126002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging evidence on the association between COVID-19 and Type 2 Diabetes 关于COVID-19与2型糖尿病之间关联的新证据

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2020-12-30 DOI: 10.46389/RJD-2020-1059

Nasreem Bibi, Bahta Wara, H. Morrissey, P. Ball

{"title":"Emerging evidence on the association between COVID-19 and Type 2 Diabetes","authors":"Nasreem Bibi, Bahta Wara, H. Morrissey, P. Ball","doi":"10.46389/RJD-2020-1059","DOIUrl":"https://doi.org/10.46389/RJD-2020-1059","url":null,"abstract":"Objective: Published studies demonstrate that diagnosis with T2DM places patients at risk of severe symptoms and increased mortality from COVID-19. The literature was reviewed to understand emerging evidence. \u0000Method: A review of published studies on COVID-19 in patients with diabetes was conducted to identify the needs and optimal practice for the local population diagnosed with diabetes at risk of Covid-19. \u0000Key Findings: The combined sample was n=18746 where all patients were diagnosed with T2DM and COVID-19. The severity of symptoms was reported in n=7646. Most reported were fever, (32%) cough (26%) chest tightness (8%). The causes of death were reported in n=3260. The main causes of death were: COVID-19 (76%), Acute respiratory distress (5%). Other comorbidities were reported in n= 6968. The most reported comorbidities were hypertension (38%) cardiovascular (10%), pulmonary disease (3%). Other risk factors were reported in n= 6968. Those most reported were diabetes, (80%) cardiovascular abnormalities (10%), hyperglycaemia not previously diagnosed as diabetes (9%). The reported effects of antidiabetic medications on COVID-19 disease was reviewed for emerging evidence. \u0000Conclusions: Published studies underline the importance of maintaining weight, glycaemic control, good hydration and exercising as much as possible. Patients need to be informed to present to hospital promptly if developing COVID-19 symptoms. Normal T2DM therapy can be maintained in patients with no, or mild symptoms. On presentation to hospital with severe COVID-19 disease, diabetes control maybe maintained with insulin, concurrent with hydration and metabolic parameters maintenance until the patient is recovered.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"27 1","pages":"410-418"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41497281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Quercetine Containing Drugs in Pharmacological Correction of Experimental Diabetes with Myocardial Injury 槲皮素类药物对实验性糖尿病心肌损伤的药理矫正作用

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-12-01 DOI: 10.2478/rjdnmd-2019-0042

I. Stechyshyn, B. Pavliuk

{"title":"The Quercetine Containing Drugs in Pharmacological Correction of Experimental Diabetes with Myocardial Injury","authors":"I. Stechyshyn, B. Pavliuk","doi":"10.2478/rjdnmd-2019-0042","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0042","url":null,"abstract":"Abstract Background and aims: The prevalence of diabetes mellitus is becoming an epidemic. The diversity of etiological factors contributes to the fact that both types of diabetes mellitus occur among different age groups and among different segments of the population. Activation of various types of processes that lead to oxidative stress, endothelial dysfunction, the development of atherosclerotic changes, increases the risk of macro- and microvascular complications in diabetes mellitus. Material and methods: The experiments were performed on 172 white Wistar rats weighing 120–150 g. All animals were kept on a standard I. Horbachevsky Ternopil National Medical University (TNMU), vivarium diet. In our studies, for the first time was established a distinct cardioprotective effect of quercetin-containing drugs, Corvitin and Lipoflavon, for the purpose of normalizing disorders in type 1 and type 2 diabetes mellitus coupled with obesity, which opens wide opportunities for the introduction of these drugs into diabetic cardiomyopathy. Results: The results obtained are an experimental rationale for extending the indications of clinical use of Corvitin and Lipoflavon. Conclusion: Lipoflavon in the experimental type 1 and type 2 diabetes mellitus coupled with obesity significantly outperforms Corvitin in terms of TBA-active products and diene conjugates.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"393 - 399"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44543481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Assessment of Common Risk Factors and Lifestyle Habits Associated with Atherogenic Risk and Lipid-Lowering Therapy in Men with Type 2 Diabetes 男性2型糖尿病患者与动脉粥样硬化风险和降脂治疗相关的常见危险因素和生活习惯的评估

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-12-01 DOI: 10.2478/rjdnmd-2019-0045

Zakia Hadj-Benali, M. Diaf, Méghit Boumédiène Khaled

{"title":"Assessment of Common Risk Factors and Lifestyle Habits Associated with Atherogenic Risk and Lipid-Lowering Therapy in Men with Type 2 Diabetes","authors":"Zakia Hadj-Benali, M. Diaf, Méghit Boumédiène Khaled","doi":"10.2478/rjdnmd-2019-0045","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0045","url":null,"abstract":"Abstract Background and aims: Our objective was to determine common risk factors and lifestyle habits associated with atherogenic risk and with the use of lipid-lowering therapy in men with type 2 diabetes. Material and Methods: A comparative cross-sectional study was performed in the northwestern Algeria during eleven months on adult men patients with type 2 diabetes. Anthropometric parameters, blood pressures and lipid profile were evaluated. Data of common risk factors and lifestyle habits associated to atherosclerosis were compared between two groups according to the lipid lowering therapy use based on statins. Results: 147 adult men patients with type 2 diabetes were involved in the study, 68 (46.26%) were under statins therapy and 79 (53.74%) were not. Significant associations with statins use were observed regarding the age group of 61-70 years (OR: 0.156 [0.043-0.570]; p=0.005), a salary of less than 30000 Algerian dinars (≈250.60$) (OR: 5.758 [1.299-25.512]; p=0.021), age of diabetes of 2-3 years (OR: 0.105 [0.013-0.867]; p=0.036) as well as with lipid ratios and body mass index (BMI). However, no significant associations were noted regarding the other studied parameters (marital status, educational level, occupation, salary, and family history, smoking status, alcohol consumption and sports practices) with lipid lowering therapy. Conclusion: Age of patients, diabetes duration, lipid ratios and the low income of patients are the strongest factors associated with the use of lipid lowering therapy (statins). However, largest longitudinal studies are needed to determine whether modifiable lifestyle habits could influence the lipid lowering therapies prescription in diabetic patients over time.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"425 - 434"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46637460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-Term Consumption of Probiotic Yogurt Improved HDL-C of Type 2 Diabetes Mellitus Patients: A Double-Blind Randomized Controlled Trial 短期食用益生菌酸奶可改善2型糖尿病患者的HDL-C:一项双盲随机对照试验

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-12-01 DOI: 10.2478/rjdnmd-2019-0041

L. Lestari, D. Ratnasari, E. F. Azizah, I. N. Farida, F. Nuriannisa, K. Yuliani, R. Kusuma, E. Huriyati, N. Kertia

{"title":"Short-Term Consumption of Probiotic Yogurt Improved HDL-C of Type 2 Diabetes Mellitus Patients: A Double-Blind Randomized Controlled Trial","authors":"L. Lestari, D. Ratnasari, E. F. Azizah, I. N. Farida, F. Nuriannisa, K. Yuliani, R. Kusuma, E. Huriyati, N. Kertia","doi":"10.2478/rjdnmd-2019-0041","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0041","url":null,"abstract":"Abstract Background and aims: Cardiovascular disease is the main complication and cause of morbidity and mortality in type 2 diabetes mellitus (T2DM) patients. The main cause of complication in T2DM is oxidative stress caused by insulin resistance, hence it can increase lipid profiles (cholesterol, LDL, and triglycerides) which exacerbates endothelial dysfunction. Among various functional foods with antioxidant effects, probiotic foods have been reported to suppress oxidative stress, and also improve the fasting blood glucose (FBG) and lipid profile in patients with T2DM. The aim of this clinical trial is to study the effects of probiotics and conventional yogurt on FBG and lipid profile in patients with T2DM. Material and method: Thirty-eight patients with T2DM, aged 30 to 60 years old, were assigned to two groups in this randomized, doubleblind, controlled clinical trial. The subjects in the intervention group consumed 100 ml/day probiotic yogurt containing Lactobacillus acidophilus La-5 and Bifidobacterium lactis BB-12, whereas subjects in the control group consumed 100 ml/day conventional yogurt for four weeks. Anthropometric indices, dietary intake, physical activity, serum FBG, and lipid profile were evaluated at the beginning and end of the intervention. Results: Consumption of 100 mL/day conventional yogurt could significantly reduce the fasting blood glucose (FBG) level, whereas probiotic yogurt could not reduce FBG significantly. Although the total cholesterol and triglyceride were not improved after yogurt consumption, both type of yogurt could improve HDL-C level. Conclusion: Both conventional yogurt or probiotic yogurt could be used as functional food since it improved the HDL-C in type 2 DM patients.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"381 - 392"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48157038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Antiglycation Effect of Monomethyl Branched Chained Fatty Acid and Phytochemical Compounds and their Synergistic Effect on Obesity Related Colorectal Cancer Cell Panel 单甲基支链脂肪酸和植物化学化合物的抗糖化作用及其对肥胖相关结直肠癌癌症细胞株的协同作用

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-12-01 DOI: 10.2478/rjdnmd-2019-0039

Moath Alqaraleh, V. Kasabri

{"title":"The Antiglycation Effect of Monomethyl Branched Chained Fatty Acid and Phytochemical Compounds and their Synergistic Effect on Obesity Related Colorectal Cancer Cell Panel","authors":"Moath Alqaraleh, V. Kasabri","doi":"10.2478/rjdnmd-2019-0039","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0039","url":null,"abstract":"Abstract Background and aims: monomethyl branched chain fatty acids (mmBCFA) and phytochemicals including: Hydroxycitric Acid, Chlorogenic Acid and Piperine have been considered as an interesting agent for researches due to their role in diabetes and cancer. The present study examines the antiglycation effect of mmBCFA and phytochemicals and investigate their Synergistic effect on different colorectal cancer cell lines. Methods: This study was carried out by using murine monocyte-macrophage cell line and Methylglyoxal (MGO) to enhance the glycation process, furthermore to examine the antiproliferative effect of both the mmBCFA and phytochemicals we use Sulforhodamine B (SRB) assay against obesity related-colorectal cancer cell line panel. Results: Both phytochemicals and mmBCFA have a higher antiglycation effect than Aminoguanidine (AMG) significantly, moreover, all of the phytochemicals and mmBCFA have antiproliferative against SW620, CACO2 and SW480, nevertheless none of these agents was equipotent to Cisplatin, furthermore, the synergetic effect observed only when we co-incubate Piperine with mmBCFA. Conclusions: phytochemicals such as Hydroxycitric Acid, Chlorogenic Acid and Piperine and mmBCFA could be used as treatment to prevents the accumulation of advanced glycation end-products (AGEs) in diabetes. Furthermore, the co-incubation between these compounds can inhibit cancer growth, as alternative therapeutic strategy against obesity related-colorectal cancer.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"361 - 369"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41866847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Relationships Between Serum Expression of IGF-1 and Metabolic Syndrome Metrics in Syrian Women with Breast Cancer 叙利亚癌症妇女血清IGF-1表达与代谢综合征指标的关系

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-12-01 DOI: 10.2478/rjdnmd-2019-0046

Husseina Khaddour, Y. Elshimali, R. Dǎnciulescu-Miulescu, D. Gradinaru

{"title":"Relationships Between Serum Expression of IGF-1 and Metabolic Syndrome Metrics in Syrian Women with Breast Cancer","authors":"Husseina Khaddour, Y. Elshimali, R. Dǎnciulescu-Miulescu, D. Gradinaru","doi":"10.2478/rjdnmd-2019-0046","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0046","url":null,"abstract":"Abstract Background and aims: Insulin-like Growth Factors (IGF-1) plays as mediator between metabolic syndrome (MetS), oxidative stress and breast cancer (BrCa) progression. The objective of this study was to examine the relationships between IGF-1 serum levels and metabolic profile biomarkers in a population group of BrCa patients. Material and methods: 126 Syrian women with breast lesions were assigned in 3 study groups: I. Malignant breast tumor group, II. Benign breast tumor group and a Normal (control) group. The following biochemical parameters were measured: IGF-1, HDL-cholesterol, LDL-cholesterol, triglycerides (TG) and glucose. Results: The mean levels of serum IGF- 1 in patients with breast cancer was significantly higher than those with benign tumors but we did not find any correlation between IGF-1 serum levels and tumor stage or lymph nodes metastases. Total cholesterol and LDL-cholesterol levels, along with TG were significantly higher in patients with BrCa versus benign and normal subjects. Conclusion: Results support the link of metabolic dysregulation and oxidative stress in BrCa progression as elevation of serum IGF-1 levels in BrCa patients are associated with metabolic syndrome markers which eventually adds more risk in cancer progression.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"435 - 443"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49389339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relative Risk of Developing Type 2 Diabetes Mellitus in Young Adults with Schizophrenia Treated with Different Atypical Antipsychotic 不同非典型抗精神病药物治疗青年精神分裂症患者患2型糖尿病的相对风险

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-12-01 DOI: 10.2478/rjdnmd-2019-0047

Nicolae-Marius Cason, P. Babeș, Enikő Béres, K. Babeș

{"title":"The Relative Risk of Developing Type 2 Diabetes Mellitus in Young Adults with Schizophrenia Treated with Different Atypical Antipsychotic","authors":"Nicolae-Marius Cason, P. Babeș, Enikő Béres, K. Babeș","doi":"10.2478/rjdnmd-2019-0047","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0047","url":null,"abstract":"Abstract Background and aim: While the link between antipsychotic treatment and metabolic adverse events, including type 2 diabetes mellitus (T2DM) are clear in adults with schizophrenia, in young this association is not so well studied although the use of secondgeneration antipsychotics (SGA) is more and more frequent. Material and methods: The local diabetes register was compared with the list of all registered young adults (18-35 years) with schizophrenia 2 years retrospective and 2 years prospective. Cumulative incidence, rate of incidence and relative risk was calculated knowing the number of persons in this age group within this region. Results: Cumulative incidence for exposed group was 0.7% with a rate of incidence of 6.27 (95%CI: 4.1-10.5) per 1,000 patientyears, when in normal population was 0.2%, respectively 2.01 (95%CI: 0.72-3.79). This means a relative risk of 3.4736 (95%CI: 1.79-6.72), p=0.0002 and NNH=202 (95%CI: 134-404). Multivariate analysis showed that gender male (OR=1.83; 95%CI: 0.9-2.7; p=0.002) and olanzapine prescription (OR=4.76; 95%CI: 1.7-7.7; p=0.0001) were independent risk factors for T2DM. Conclusions: The metabolic risk should be taken in account every time introducing or changing a SGA in young schizophrenic patient, balancing the benefits and negative metabolic effects (especially with olanzapine). Healthy nutrition and physical activities are necessary components of these patients lifestyle to avoid early onset of T2DM.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"445 - 453"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45693426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Usage of Lasso, Ridge, and Linear Regression to Explore the Most Influential Metabolic Variables that Affect Fasting Blood Sugar in Type 2 Diabetes Patients Lasso、Ridge和线性回归法探讨影响2型糖尿病患者空腹血糖的最具影响的代谢变量

Romanian Journal of Diabetes, Nutrition and Metabolic Diseases Pub Date : 2019-12-01 DOI: 10.2478/rjdnmd-2019-0040

Arash Farbahari, Tania Dehesh, M. Gozashti

{"title":"The Usage of Lasso, Ridge, and Linear Regression to Explore the Most Influential Metabolic Variables that Affect Fasting Blood Sugar in Type 2 Diabetes Patients","authors":"Arash Farbahari, Tania Dehesh, M. Gozashti","doi":"10.2478/rjdnmd-2019-0040","DOIUrl":"https://doi.org/10.2478/rjdnmd-2019-0040","url":null,"abstract":"Abstract Background and aims: To explore the most influential variables of fasting blood sugar (FBS) with three regression methods, to identify the existence chance of type 2 diabetes based on influential variables with logistic regression (LR), and to compare the three regression methods according to Mean Squared Error (MSE) value. Material and Methods: In this cross-sectional study, 270 patients suffering from type 2 diabetes for at least 6 months and 380 healthy people were participated. The Linear regression, Ridge regression, and Least Absolute Shrinkage and Selection Operator (Lasso) regression were used to find influential variables for FBS. Results: Among 15 variables (8 metabolic, 7 characteristic), Lasso regression selected HbA1c, Urea, age, BMI, heredity, and gender, Ridge regression selected HbA1c, heredity, gender, smoking status, and drug use, and Linear regression selected HbA1c as the most effective predictors for FBS. Conclusion: HbA1c is the most influential predictor of FBS among 15 variables according to the result of three regression methods. Controlling the variation of HbA1c leads to a more stable FBS. Beside FBS that should be checked before breakfast, maybe HbA1c could be helpful in diagnosis of Type 2 diabetes.","PeriodicalId":38700,"journal":{"name":"Romanian Journal of Diabetes, Nutrition and Metabolic Diseases","volume":"26 1","pages":"371 - 379"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46534397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5