血糖范围对1型糖尿病患者并发症发生的预测价值

Q4 Medicine
K. Moshenets
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引用次数: 1

摘要

背景与目的:建立1型糖尿病(T1DM)患者微血管病变风险的预后数学模型。材料与方法:62例T1DM患者根据НвА1с水平分为两组:1组(n=18) НвА1с≤7.0%,2组(n=44) НвА1с > = 7.0%。测定HbA1c、肽、血肌酐、肾小球滤过率(eGFR)、CKD-EPI、晨尿白蛋白排泄(AU)。采用连续血糖监测系统(CGMS)测定血糖水平。所有患者随访3个月。采用秩相关法。结果:HbA1c与AU水平直接相关,3个月后ρ=0.4 (ρ= 0.021),开始时ρ=0.29 (ρ <0.016)。AU水平与血糖范围有直接的相关性,开始时ρ=0.51(<0.001), 3个月后ρ=0.48(< 0.004)。我们用数学方法描述了这种依赖关系。血糖范围每增加一个单位,AU水平平均增加0.4816 mg/l。结论:我们的AU水平与血糖范围相关性的数学方程为预测T1DM患者糖尿病肾病的进展提供了机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictive Value of Blood Glucose Range for Onset of Complications in Patients with Diabetes Mellitus Type 1
Abstract Background and aims: to develop a prognostic mathematical model for risk of microangiopathy in patients with diabetes mellitus type 1 (T1DM). Materials and methods: 62 T1DM patients were divided into 2 groups according to НвА1с level: group 1 (n=18) with НвА1с ≤ 7.0% and group 2 (n=44) with НвА1с > of 7.0%. HbA1c, Cpeptide, blood creatinine, estimated glomerular filtration rate (eGFR) CKD-EPI, first morning urinary albumin excretion (AU) were determined. Blood glucose levels were conducted by CGMS (Continuous Glucose Monitoring System). All patients were followed for 3 months. Rank correlation method was used. Results: We established the direct correlation between HbA1c the AU level ρ=0.29 (р<0.016) at the beginning and ρ=0.4 (р=0.021) after 3 months. AU level has a direct correlation with blood glucose range, at the beginning ρ=0.51 (р<0.001) and after 3 months ρ=0.48 (р=0.004) visits. We made the mathematical description of this dependence. Each additional unit of blood glucose range is accompanied by increasing an average level AU level by 0.4816 mg/l. Conclusion: our mathematical equation of dependence between AU level and blood glucose range gives the opportunities to predict diabetic kidney disease progression in T1DM patients.
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
49
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