Leukemia Research Reports最新文献_第10页

Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations 髓系/淋巴肿瘤伴ZMYM2: FGFR1重排:复杂的三代表型和克隆进化与相关的基因组改变

Leukemia Research Reports Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100370

Dong Chen , Guang Liu , Michael R. Lewis , Xia Li , Matthew Ulrickson , Rajneesh Nath , Weina Chen

引用次数: 0

Location, location, location: A mini-review of CEBPA variants in patients with acute myeloid leukemia 位置，位置，位置:急性髓性白血病患者CEBPA变异的小型回顾

Leukemia Research Reports Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100386

Muhammad Salman Faisal , Pamela J. Sung

引用次数: 0

Corrigendum to Acute pancreatitis following L-asparaginase in acute lymphoblastic leukemia 急性淋巴细胞白血病中l -天冬酰胺酶引起的急性胰腺炎的勘误表

Leukemia Research Reports Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100375

Aziza Elouali , Soulaimane M'harzi , Karim Lahrache , Ayad Ghanam , Abdeladim Babakhouya , Maria Rkain , Noufissa Benajiba

引用次数: 0

Newly onset cytopenias not always indicate a relapsing AML after allogeneic HSCT, a case of non-destructive post transplant lymphoproliferative disorder 新发作的细胞减少并不总是表明同种异体造血干细胞移植后复发的AML，这是一种非破坏性移植后淋巴细胞增生性疾病

Leukemia Research Reports Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100369

Süreyya Yiğit Kaya , Abdullah Emre Askin , Sebnem Bektas , Aslı Çakır , Ömür Gökmen Sevindik

引用次数: 0

Aggressive chronic lymphocytic leukemia masked by extensive marrow fibrosis 侵袭性慢性淋巴细胞白血病被广泛的骨髓纤维化所掩盖

Leukemia Research Reports Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100390

Hareem Farooq , Ke Li , Talha Badar

{"title":"Aggressive chronic lymphocytic leukemia masked by extensive marrow fibrosis","authors":"Hareem Farooq , Ke Li , Talha Badar","doi":"10.1016/j.lrr.2023.100390","DOIUrl":"10.1016/j.lrr.2023.100390","url":null,"abstract":"<div><p>Chronic lymphocytic leukemia (CLL) is one of the most common B-cell leukemias, occurring because of abnormal proliferation of non-functional B-lymphocytes. Progressive disease is commonly complicated by anemia, thrombocytopenia, infections as well as secondary malignancies. Bone marrow fibrosis is infrequently co-occurred along with CLL. Although multiple explanations have been proposed for this association, the etiology remains unclear in most cases. Bone marrow fibrosis occurring as a complication of CLL itself, however, is a rare entity. We present an uncommon case of a patient initially diagnosed with primary myelofibrosis but later revealed to have aggressive CLL leading to bone marrow fibrosis upon re-evaluation. Treatment for CLL resolved the bone marrow fibrosis completely, confirming our suspicion of fibrosis being secondary to CLL. This sheds light on the importance of understanding the etiology of bone marrow fibrosis in patients with CLL owing to its therapeutic implications. The utility of bone marrow biopsy in not only helping understand the etiology of the fibrosis but also providing prognostic information merits reconsideration of performing it in all cases of CLL.</p></div>","PeriodicalId":38435,"journal":{"name":"Leukemia Research Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/56/main.PMC10480308.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10559774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Membranous nephropathy in chronic lymphocytic leukemia responsive to ibrutinib: A case report 慢性淋巴细胞白血病膜性肾病对伊鲁替尼反应:1例报告

Leukemia Research Reports Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100377

Anna-Eve Turcotte , William F. Glass , Jamie S. Lin , Jan A. Burger

引用次数: 0

A rare case of aCML associated with CNS involvement and with aggressive clinical course 罕见的aCML伴中枢神经系统受累及侵袭性临床病程

Leukemia Research Reports Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100361

Dorela Lame, Michelangelo Pianelli, Erika Morsia, Alberto Carturan, Gaia Goteri, Stefania Mancini, Attilio Olivieri, Antonella Poloni

{"title":"A rare case of aCML associated with CNS involvement and with aggressive clinical course","authors":"Dorela Lame, Michelangelo Pianelli, Erika Morsia, Alberto Carturan, Gaia Goteri, Stefania Mancini, Attilio Olivieri, Antonella Poloni","doi":"10.1016/j.lrr.2023.100361","DOIUrl":"10.1016/j.lrr.2023.100361","url":null,"abstract":"<div><p>The presence of neutrophilic leukocytosis may underlie a wide variety of diseases. Some rare causes of neutrophilia might be chronic neutrophilic leukemia (CNL) and myelodysplastic/myeloproliferative neoplasm with neutrophilia (MDS with neutrophilia). Here we report a case of a 78-year-old woman who came to our ER due to severe leukocytosis and anemia on a routine check-up. The patient was asymptomatic and the last exams available showed a mild leukopenia and thrombocytopenia. The abdominal echography showed mild splenomegaly The patient underwent bone marrow (BM) examinations. One week later, the patient presented mental deterioration. The patient underwent a cranial CT and RMN that showed multiple lesions of 11 mm in the brain parenchyma, cerebellum and encephalic trunk. Another week later, the clinical presentations worsened: she was in a comatous state and feverish 40 °C unresponsive to steroid therapy. Autopsy showed a leukemic and hemorrhage infiltration in multiple organs and in the BM a cellularity of 100% represented by myeloid elements with a slowdown maturation with blasts 5%. According to WHO 2016 this case can be reported as an aCML, an MDS/MPN overlap syndrome that is difficult to differentiate from a CNL.</p></div>","PeriodicalId":38435,"journal":{"name":"Leukemia Research Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c8/32/main.PMC9867965.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9190559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A case series of therapy-related leukemias: A deadly ricochet 一系列与治疗相关的白血病病例:致命的反弹

Leukemia Research Reports Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100382

Ronit Juthani , Ashish Ranjan Singh , Debdatta Basu

引用次数: 0

Allogeneic stem cell transplant for multiple myeloma & myelofibrosis with split-dose busulfan, fludarabine & cyclophosphamide 同种异体干细胞移植治疗多发性骨髓瘤和骨髓纤维化，分剂量布磺胺、氟达拉滨和环磷酰胺

Leukemia Research Reports Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100388

Andrew D. Trunk, Sagar S. Patel, Josef T. Prchal, Douglas W. Sborov, Axel R. Zander, Catherine J. Lee

引用次数: 0

Contribution of rare and common coding variants to haematological malignancies in the UK biobank 在英国生物库中，罕见和常见的编码变异对血液系统恶性肿瘤的贡献

Leukemia Research Reports Pub Date : 2023-01-01 DOI: 10.1016/j.lrr.2023.100362

Bengt Zöller , Eric Manderstedt , Christina Lind-Halldén , Christer Halldén

引用次数: 0