IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma

IF 0.7 Q4 HEMATOLOGY

Leukemia Research Reports Pub Date : 2024-01-01 DOI:10.1016/j.lrr.2024.100451

Hiroki Hosoi , Shotaro Tabata , Hideki Kosako , Yoshikazu Hori , Tadashi Okamura , Yusuke Yamashita , Kota Fujimoto , Daiki Kajioka , Kentaro Suzuki , Motomi Osato , Gen Yamada , Takashi Sonoki

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Abstract

IGLL5 is shown to be located near super-enhancer (SE) in B-cell tumors, and this gene is frequently mutated and a target of translocation in B-cell tumors. These results suggest roles of the IGLL5 in tumorigenesis; however, its functional properties have been unclear. We found that two mature B-cell lymphoma cell lines expressed IGLL5 mRNA with Cλ1 segment. JQ1 treatment resulted in down-expression of IGLL5, indicating that IGLL5 is controlled by SE. IGLL5 knockdown induced cell death with down-expression of MYC. Our results suggested that IGLL5 might have a role in survival of mature B-cell tumors and involvement in MYC expression. (100 words)

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由超级增强子控制的 IGLL5 影响成熟 B 细胞淋巴瘤中细胞的存活和 MYC 的表达

在 B 细胞肿瘤中，IGLL5 位于超级增强子（SE）附近，而且该基因经常发生突变，是 B 细胞肿瘤的易位靶点。这些结果表明了 IGLL5 在肿瘤发生中的作用，但其功能特性尚不清楚。我们发现两种成熟的 B 细胞淋巴瘤细胞系表达带有 Cλ1 片段的 IGLL5 mRNA。JQ1处理导致IGLL5表达量下降，表明IGLL5受SE控制。敲除 IGLL5 会导致细胞死亡，同时降低 MYC 的表达。我们的研究结果表明，IGLL5 可能在成熟 B 细胞肿瘤的存活中发挥作用，并参与 MYC 的表达。(100字)

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