{"title":"由超级增强子控制的 IGLL5 影响成熟 B 细胞淋巴瘤中细胞的存活和 MYC 的表达","authors":"Hiroki Hosoi , Shotaro Tabata , Hideki Kosako , Yoshikazu Hori , Tadashi Okamura , Yusuke Yamashita , Kota Fujimoto , Daiki Kajioka , Kentaro Suzuki , Motomi Osato , Gen Yamada , Takashi Sonoki","doi":"10.1016/j.lrr.2024.100451","DOIUrl":null,"url":null,"abstract":"<div><p><em>IGLL5</em> is shown to be located near super-enhancer (SE) in B-cell tumors, and this gene is frequently mutated and a target of translocation in B-cell tumors. These results suggest roles of the <em>IGLL5</em> in tumorigenesis; however, its functional properties have been unclear. We found that two mature B-cell lymphoma cell lines expressed <em>IGLL5</em> mRNA with <em>Cλ1</em> segment. JQ1 treatment resulted in down-expression of <em>IGLL5</em>, indicating that <em>IGLL5</em> is controlled by SE. <em>IGLL5</em> knockdown induced cell death with down-expression of <em>MYC</em>. Our results suggested that <em>IGLL5</em> might have a role in survival of mature B-cell tumors and involvement in <em>MYC</em> expression. (100 words)</p></div>","PeriodicalId":38435,"journal":{"name":"Leukemia Research Reports","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213048924000414/pdfft?md5=1e4f34f4af678dbfb8cd62fea439eaed&pid=1-s2.0-S2213048924000414-main.pdf","citationCount":"0","resultStr":"{\"title\":\"IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma\",\"authors\":\"Hiroki Hosoi , Shotaro Tabata , Hideki Kosako , Yoshikazu Hori , Tadashi Okamura , Yusuke Yamashita , Kota Fujimoto , Daiki Kajioka , Kentaro Suzuki , Motomi Osato , Gen Yamada , Takashi Sonoki\",\"doi\":\"10.1016/j.lrr.2024.100451\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><em>IGLL5</em> is shown to be located near super-enhancer (SE) in B-cell tumors, and this gene is frequently mutated and a target of translocation in B-cell tumors. These results suggest roles of the <em>IGLL5</em> in tumorigenesis; however, its functional properties have been unclear. We found that two mature B-cell lymphoma cell lines expressed <em>IGLL5</em> mRNA with <em>Cλ1</em> segment. JQ1 treatment resulted in down-expression of <em>IGLL5</em>, indicating that <em>IGLL5</em> is controlled by SE. <em>IGLL5</em> knockdown induced cell death with down-expression of <em>MYC</em>. Our results suggested that <em>IGLL5</em> might have a role in survival of mature B-cell tumors and involvement in <em>MYC</em> expression. (100 words)</p></div>\",\"PeriodicalId\":38435,\"journal\":{\"name\":\"Leukemia Research Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2213048924000414/pdfft?md5=1e4f34f4af678dbfb8cd62fea439eaed&pid=1-s2.0-S2213048924000414-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Leukemia Research Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213048924000414\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Leukemia Research Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213048924000414","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
在 B 细胞肿瘤中，IGLL5 位于超级增强子（SE）附近，而且该基因经常发生突变，是 B 细胞肿瘤的易位靶点。这些结果表明了 IGLL5 在肿瘤发生中的作用，但其功能特性尚不清楚。我们发现两种成熟的 B 细胞淋巴瘤细胞系表达带有 Cλ1 片段的 IGLL5 mRNA。JQ1处理导致IGLL5表达量下降，表明IGLL5受SE控制。敲除 IGLL5 会导致细胞死亡，同时降低 MYC 的表达。我们的研究结果表明，IGLL5 可能在成熟 B 细胞肿瘤的存活中发挥作用，并参与 MYC 的表达。(100字)
IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma
IGLL5 is shown to be located near super-enhancer (SE) in B-cell tumors, and this gene is frequently mutated and a target of translocation in B-cell tumors. These results suggest roles of the IGLL5 in tumorigenesis; however, its functional properties have been unclear. We found that two mature B-cell lymphoma cell lines expressed IGLL5 mRNA with Cλ1 segment. JQ1 treatment resulted in down-expression of IGLL5, indicating that IGLL5 is controlled by SE. IGLL5 knockdown induced cell death with down-expression of MYC. Our results suggested that IGLL5 might have a role in survival of mature B-cell tumors and involvement in MYC expression. (100 words)
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