{"title":"A novel passive micromixer with trapezoidal blades for high mixing efficiency at low Reynolds number flow","authors":"H. L. The, H. Le-Thanh, N. Tran-Minh, F. Karlsen","doi":"10.1109/MECBME.2014.6783199","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783199","url":null,"abstract":"In this paper, we propose a novel passive micromixer structure based on the effect of stretching-folding in both vertical and horizontal directions. The channel depth of the micromixer is tightened at two ends each mixing unit. The fluid flows are repeatedly twisted and bent from left to right and vice versa. With this special structure, our proposed micromixer can create vortices and transversal flow even at low Reynolds number. Therefore, it can efficiently mix low speed liquid flows, making it easy to be built into micro-devices. We conduct intensive simulation to evaluate the performance of our proposed mixer by using COMSOL Multiphysics package with Navier-Stokes, convection-diffusion equation and particle tracking method. The simulation results demonstrated that our micromixer may be the first device that is able to operate with high mixing efficiency independent of the Reynolds number in the range of 0.5 to 60. Especially, at very low Reynolds number the mixing efficiency of our proposed micromixer is 220-240% higher compared with those of rhombic mixer with branch channels and pure rhombic mixer.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122182514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving relaxant effect of contracted airway smooth muscles","authors":"A. Al-Jumaily, M. Mathur","doi":"10.1109/MECBME.2014.6783210","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783210","url":null,"abstract":"Treatments for asthma are largely pharmaceutical, with some therapies also utilizing alternative breathing techniques. The objective of both medical and alternative methods is to relax contracted airway smooth muscle (ASM). As a means of investigating more-effective alternative treatment methods for contracted airways, we analyze the combined effects of bronchodilators and length oscillations on isolated, contracted ASM. This work suggests that relaxation of isolated, contracted ASM is enhanced by combining oscillations with pharmaceutical relaxant.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122475903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Dynamic Decision Support System based on temporal association rules","authors":"F. Kammoun, Mounir Ben Ayed","doi":"10.1109/MECBME.2014.6783261","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783261","url":null,"abstract":"Nosocomial Infections (NI) have been the major causes of morbidity and mortality of patients in intensive care units (ICUs) particularly in developing countries. Intensive surveillance and preventive measures is an effective element to fight against NI. Based on the temporal data recorded daily in the intensive care unit (ICU) and the help of some physicians, we plan to develop a Clinical Dynamic Decision Support System (CDDSS) based on knowledge discovery in databases (KDD) to help Physicians to predict and prevent NI. The CDDSS aims to the daily estimation of the NI occurrence probability, in the ICU patient hospitalization. The goal is to be able to anticipate if the association of some factors will support the appearance of the infections on the basis of patient histories. We propose to develop an algorithm for mining temporal association rules to extract temporal information. The discovery of temporal pattern would help them to take measures at time.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121455431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the genetics underlying autoimmune diseases with network analysis and link prediction","authors":"Gregorio Alanis-Lobato, C. Cannistraci, T. Ravasi","doi":"10.1109/MECBME.2014.6783232","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783232","url":null,"abstract":"Ever since the first Genome Wide Association Study (GWAS) was carried out we have seen an important number of discoveries of biological and clinical relevance. However, there are some scientists that consider that these research outcomes and their utility are far from what was expected from this experimental design. We instead believe that the thousands of genetic variants associated with complex disorders by means of GWASs are an extremely valuable source of information that needs to be mined in a different way. Based on this philosophy, we followed a holistic perspective to analyze GWAS data and explored the structural properties of the network representation of one of these datasets with the aim to advance our understanding of the genetic intricacies underlying autoimmune human diseases. The simplicity, computational efficiency and precision of the tools proposed in this paper represent a new means to address GWAS data and contribute to the better exploitation of these rich sources of information.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116353340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficient walking of a simple biped with a torso","authors":"Amur S. Al Yahmedi, Mohamed A. Sayari","doi":"10.1109/MECBME.2014.6783284","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783284","url":null,"abstract":"Locomotion in general and legged locomotion in particular has stirred a great deal of interest in the last few years. In this paper, we focus on the energetic aspect of a bipedal robot with a torso walking on level ground.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"186 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124723746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Augmented Reality based Illusion System with biofeedback","authors":"Y. Aung, Adel Al-Jumaily","doi":"10.1109/MECBME.2014.6783255","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783255","url":null,"abstract":"This paper presents the Augmented Reality based Illusion System (ARIS) with biofeedback for upper limb rehabilitation. It aims for fast recovery of motor deficit with motivational approach over traditional upper limb rehabilitation methods. The system incorporates with Augmented Reality (AR) technology to develop upper limb rehabilitation exercise and computer vision with color recognition technique to create “Fool-the-Brain” concept for fast recovery of neural impairment due to various motor injuries. The rehabilitation exercise in ARIS is aiming to increase the shoulder joint range of motions by performing reaching movements and to strengthen the associated muscles. “Fool-the-Brain” concept is introduced during performing rehabilitation exercise to perceive artificial visual feedback where user's real impaired arm is covered by Virtual Arm (VA). When the real arm cannot perform the required task, VA will take over the job of real one and will make the user perceives the sense that is still be able to accomplish the task with own effort. Evaluation has performed and results indicate that ARIS with biofeedback is a potential upper limb rehabilitation system for people with upper limb motor deficit.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121659566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigating effects of copy number alterations on targeted therapy response using a conditioning-based model","authors":"Fang-Han Hsu, E. Serpedin","doi":"10.1109/MECBME.2014.6783231","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783231","url":null,"abstract":"Emerging targeted therapies have shown benefits such as less toxicity and higher effectiveness in specific types of cancer treatment; however, the accessibility of these advantages may rely on sufficient understanding of mechanisms causing resistance and correct identification of suitable patients, which remain highly immature. Based on the fact that copy number alterations (CNAs) may affect expression levels and regulatory activities, CNAs are assumed to be capable of interfering with signal transduction and influence targeted drug effectiveness. Considering the mechanism of action (MOA) of trastuzumab in the ERBB2-ERK signaling pathway, a conditioning-based model in which copy number alterations (CNAs) serve as latent parents modifying signal transduction is applied. Using mathematical induction, the upstream and downstream CNAs are found to have equal influence on drug effectiveness. Two scoring functions, M-score and R-value, are further proposed to provide qualitative and quantitative information regarding the unfavorableness of a CNA on drug utility and thereby shed light on personalized therapy.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116782517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MFC peak based segmentation for continuous Arabic audio signal","authors":"M. S. Abdo, A. Kandil, S. Fawzy","doi":"10.1109/MECBME.2014.6783245","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783245","url":null,"abstract":"This paper presents an algorithm for segmenting a subset of emphatic and non-emphatic sounds automatically from continuously spoken Arabic speech. The important contribution of this paper is to generate rules for automatic segmentation of these sounds which can be extended to the rest of Arabic sounds. In addition, the findings can be used for other speech analysis problems such as data training for speech recognizers, continuous speech segmentation systems, or to build and label Arabic databases. This study has been done in context of recited principles of the Holy Quran which commonly known as recitation rules. The method developed is based on peaks detection from delta function of Mel Frequency Cepstral Coefficients “MFCC”. The peaks position is used for boundaries locating of the target sounds within the speech signal. Medium vocabulary speech database was used to evaluate the system performance. The test database contained 80 recited words. Each word was recorded from six different speakers constituting total of 480 words. A significant increase in accuracy rate has been achieved compared to the prior work of [1, 2] by enhancing the developed algorithm. Results show that the enhanced algorithm achieved a segmentation accuracy of up to 90%.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114905976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Computer assisted to determine the influence of connector design and stress distribution in Incoris TZI (Zirconia) fixed partial denture","authors":"T. M. Nassef, M. F. Khalil, S. A. Kader","doi":"10.1109/MECBME.2014.6783207","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783207","url":null,"abstract":"In dentistry, computer assisted systems have been used to simulate and navigate the treatment planes i.e. computer-assisted design (CAD), which assists in minimizing the high costs of the product development process and allows the developers to simulate the same conditions that would take place under physical standards and conditions. In addition to the cost and time reduction benefits, CAD allows the product to be modified immediately before building prototypes and the final product. Finite element analysis (FEA) is another computer system, which used to determine stress distribution on teeth and jaw bones. Researchers also used FEA to analyze the effects of occlusal loads on crown margins and core materials of variable thickness. Finally the three dimensional (3-D) software packages are integrated with specific hardware systems to design and mill fixed partial dentures (FPDs). The present study are used all of the previous computer systems tools to assist the dentist and researchers to evaluate the effect of two connector designs on the fracture resistance and the stress distribution of the newly introduced monolithic full contoured Zirconia FPDs. The study concludes that radius of curvature at the occlusal embrasure had no significant effect on the fracture resistance and stress concentration of zirconia FPDs.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"31 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132062546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Combining long and short axis myocardial contours for accurate reconstruction of the left ventricular surface","authors":"Hossam El-Rewaidy, A. Khalifa, A. Fahmy","doi":"10.1109/MECBME.2014.6783215","DOIUrl":"https://doi.org/10.1109/MECBME.2014.6783215","url":null,"abstract":"Reconstruction of the left ventricular (LV) surface is required in a number of applications including modeling the LV shape and computing the LV volume. In this work, a new method is presented for accurately reconstructing the LV surface from magnetic resonance images of the heart. The method depends on novel technique for combining the long-axis (LAX) and short-axis (SAX) myocardium contours. A crucial step to achieve this goal is to properly reconstruct the LV surface from the long-axis (LAX) and short-axis (SAX) myocardium contours. This is done using three steps: (1) register the LAX and SAX contours to compensate the patient respiratory motion; (2) non-parametric interpolation of the LV surface at the gaps between SAX slices. To evaluate the proposed methods, out-of-place LAX and SAX myocardial contours was simulated to represent the respiratory motion effect. Then, the LV volume is calculated using the proposed method. The results are compared to the ground truth obtained by the modified Simpson's method. The significance of the methods was proved by calculating its error in calculating the LV volume when only few slices are available, i.e. reduced acquisition. In addition, the method was compared to other available methods using a dataset of 5 patients.","PeriodicalId":384055,"journal":{"name":"2nd Middle East Conference on Biomedical Engineering","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134022330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}