Acta medica academica最新文献

{"title":"P53/MDM2 Complex-Based Targeted Strategies in Colon Adenocarcinoma.","authors":"Athanasios Niotis,&nbsp;Evangelos Tsiambas,&nbsp;Dimitrios Dimitroulis,&nbsp;Helen Sarlanis,&nbsp;Evangelos Falidas,&nbsp;Nikolaos Kavantzas,&nbsp;Constantinos A Constantinides","doi":"10.5644/ama2006-124.398","DOIUrl":"https://doi.org/10.5644/ama2006-124.398","url":null,"abstract":"<p><p>In the current molecular review, we describe the mechanisms of TP53/MDM2 deregulation and their impact on the colon adenocarcinoma molecular substrate and phenotype. Among the genes that are critically altered in carcinogenesis, the TP53 tumor suppressor gene is of major importance. The TP53 gene (gene locus: 17p13.1) regulates the cell cycle by controlling the G1/S and G2/M checkpoints securing the normal sequence of cell cycle phases. Furthermore, it is involved in apoptosis programmed cell death. The gene is mutated or epigenetically altered in all epithelial malignancies, including colon adenocarcinoma. Additionally, Mouse Double Minute 2 Homolog (MDM2), a proto-oncogene (12q14.3), acts as a major negative regulator for p53 expression in the p53-MDM2 auto-regulatory pathway. MDM2 binds directly to p53 and represses its transcriptional activity, promoting p53 degradation. CONCLUSION: In colon adenocarcinoma, MDM2 oncogene overexpression directly influences p53 oncoprotein expression levels.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"24-29"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c7/8f/AMA-52-24.PMC10316079.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and Attitudes regarding Covid-19 Vaccination among Medical and Non-medical Students in Bosnia and Herzegovina.","authors":"Adaleta Softić,&nbsp;Elma Omeragić,&nbsp;Martin Kondža,&nbsp;Nahida Srabović,&nbsp;Aida Smajlović,&nbsp;Esmeralda Dautović,&nbsp;Nataša Bubić Pajić,&nbsp;Tamer Bego,&nbsp;Žarko Gagić,&nbsp;Ivica Brizić,&nbsp;Anđelka Račić,&nbsp;Ervina Bečić,&nbsp;Belma Pehlivanović,&nbsp;Šejla Šabić,&nbsp;Edin Suljagić,&nbsp;Adnan Hukić,&nbsp;Daria Pavlić,&nbsp;Andrea Lučić","doi":"10.5644/ama2006-124.396","DOIUrl":"https://doi.org/10.5644/ama2006-124.396","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate students' knowledge, attitudes and hesitancy regarding COVID-19 vaccination.</p><p><strong>Methods: </strong>A cross-sectional questionnaire-based survey was conducted among a total of 1282 medical students and 509 non-medical students at four public universities in Bosnia and Herzegovina: Tuzla, Sarajevo, Banja Luka, and Mostar.</p><p><strong>Results: </strong>A significantly higher rate of vaccination was observed in the group of medical students as well as a higher level of knowledge about vaccination in general and vaccines against the COVID-19 disease. Students who received the COVID-19 vaccine had a higher level of knowledge about vaccination in general and COVID-19 vaccines in particular compared to the non-vaccinated students in the medical and non-medical groups, respectively. Furthermore, vaccinated students, regardless of the course they are taking, showed generally stronger positive attitudes compared to non-vaccinated students, regarding the safety and effectiveness of the COVID-19 vaccine. Both groups of students believe that the rapid development of the vaccine is contributing to refusal or hesitancy to receive a vaccine against COVID-19. Social media/networks were the main sources of information about the COVID-19 vaccine. We did not find any contribution of social media to the reduced level of COVID-19 vaccine coverage.</p><p><strong>Conclusion: </strong>Education of students about the benefits of the COVID-19 vaccine will lead to its better acceptance as well as the development of more positive attitudes towards vaccination in general, especially having in mind that students are the future population of parents, who will make decisions about vaccinating their children.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/d1/AMA-52-1.PMC10316077.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. Isak Samokovlija: Life in a White Coat.","authors":"Jovan Dimitrijević","doi":"10.5644/ama2006-124.406","DOIUrl":"https://doi.org/10.5644/ama2006-124.406","url":null,"abstract":"No abstract available.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"73-75"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/44/AMA-52-73.PMC10316068.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Facial Artery as a Branch of the External Carotid Artery in Thomas Turner's (1793-1873) Treatise on the Arterial System (1825) and a Comparison with Modern Anatomy.","authors":"Amir Shihada, Maria Sioula, Panagiotis Georgakopoulos, Evaggelos Mavrommatis","doi":"10.5644/ama2006-124.405","DOIUrl":"10.5644/ama2006-124.405","url":null,"abstract":"<p><p>The aim of the present paper is to contribute to the understanding of the history of the anatomical study of the facial artery. The facial artery plays a fundamental role in the study of the anatomy of the face, and in maxillofacial and vascular surgery. The debate on the understating of this vessel is essential in the educational process, with special focus on the historical development of topographical and descriptive ideas about it. The comparison between the study of facial artery in the work of Thomas Turner (1793-1873) and modern anatomical concepts serves as an excellent educational paradigm. The documentary research method was used this short historical survey. CONCLUSION: Thomas Turner laid the scientific foundation for the accurate anatomical study of the facial artery.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"67-72"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/17/AMA-52-67.PMC10316073.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. Maša Živanović: A Pioneer in Health Care for Women and Children in Bosnia and Herzegovina.","authors":"Husref Tahirović,&nbsp;Maša Miloradović,&nbsp;Jelena Jovanović Simić","doi":"10.5644/ama2006-124.395","DOIUrl":"https://doi.org/10.5644/ama2006-124.395","url":null,"abstract":"<p><p>The aim of the article is to present, primarily to the medical world and also the general public, the personality and work of Maša Živanović (1890-1960), a pioneer in the health care of children and mothers in Bosnia and Herzegovina (BH), a health educator and one of the leaders of the Yugoslav Women's Rights Movement in the period between the two world wars. She was born in Croatia (then part of the Austro-Hungarian Empire) as Maria Skopszyński, in a family of Polish-Czech origin. After studying at the Temporary Women's Lyceum in Zagreb and passing the matriculation exam at the boy's High School (1909), she obtained the title of Doctor of Medicine in Vienna (1916). Her activity in the Women's Rights Movement has so far generally attracted more attention from researchers than her medical work. However, this work was very important because the general and health education of women, expectant mothers and mothers, after the two World Wars was very poor in BH, and the rates of child morbidity and mortality were high. Maša Živanović spent almost her entire working life in Sarajevo. For 30 years, she was the head of the Dispensary for Mothers and the Children, later the Institute for Maternal and Child Health Care, into which the previous institution grew in 1931. She was among the first followers of the new concept of \"comprehensive paediatrics\", which included social care for children, disease prevention and treatment of the sick. She successfully connected the medical mission with the mission of a women's rights activist, also trying to act as a health educator through articles published in the Women's Movement magazine (Ženski pokret). For a time, she was the president of the Society for the Education of Woman and Protection of her Rights, i.e. the Women's Movement, and a delegate at conferences of international feminist organizations. CONCLUSION: Maša Živanović was a physician, a pioneer in the health care of children and mothers in BH, a long-time director of the Institute for Health Care of Mothers and Children in Sarajevo, and one of the leaders of the Yugoslav Women's Rights Movement.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 3","pages":"249-263"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/76/AMA-51-249.PMC10116176.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9688950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Hypertrophic Anterior Scalene Muscle and the Passage of a Subclavian Artery Through its Fibres: The Location of Possible Entrapment.","authors":"George Tsakotos,&nbsp;Vasilios Karampelias,&nbsp;Ilenia Chatziandreou,&nbsp;Dimitrios Philippou,&nbsp;Trifon Totlis,&nbsp;Maria Piagkou","doi":"10.5644/ama2006-124.391","DOIUrl":"https://doi.org/10.5644/ama2006-124.391","url":null,"abstract":"<p><strong>Objective: </strong>The presence of cervical ribs, 1st rib anomalies, cervical muscle hypertrophy and repetitive motion are possible aetiologies of subclavian artery (SCA) entrapment and/or compression. Thoracic outlet syndrome of the arterial type may appear with symptoms of hand pain due to the aneurismal part of the compressed SCA. The current cadaveric case describes a hypertrophic right-sided anterior scalene muscle (ASM) and the possible entrapment of the right SCA (RSCA) passing through its fibres. Furthermore, the branching pattern of the entrapped vessel is analysed.</p><p><strong>Case report: </strong>A hypertrophic ASM was identified in the right infraclavicular area of a male Greek donated cadaver (70 years of age). The RSCA passed through the ASM belly, and some deeply situated fibres extended posteriorly to the RSCA. The ASM compressed the RSCA against the superior part of the 1st rib.</p><p><strong>Conclusion: </strong>Knowledge of such variants may be important in the diagnosis of upper limb muscle atrophy or neurosensory loss.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 3","pages":"212-216"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/bd/AMA-51-212.PMC10116174.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Superficial Temporal Artery: Anatomy and Clinical Significance in the Era of Facial Surgery and Aesthetic Medicine.","authors":"Dimitra Daskalopoulou,&nbsp;Alkis Matsas,&nbsp;Dimosthenis Chrysikos,&nbsp;Theodore Troupis","doi":"10.5644/ama2006-124.393","DOIUrl":"https://doi.org/10.5644/ama2006-124.393","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this review was to present the vascular pattern of the STA, as well as anatomical variations, and to accentuate the areas which should be taken into consideration during manipulations along the course of the artery.</p><p><strong>Background: </strong>The STA may be encountered during several aesthetic procedures on the face, and iatrogenic trauma could be an incriminating factor of diverse sequelae. The constant increase in demand for facial aesthetic procedures has rendered it imperative to maximize safety and patient satisfaction.</p><p><strong>Methods: </strong>We conducted a narrative literature review using the electronic databases of PubMed and Google Scholar, retrieving studies concerning the anatomy and variations of the STA. Moreover, we identified registered clinical cases presenting complications which involved the artery.</p><p><strong>Discussion: </strong>The anatomic morphology of the STA is described and classification systems summarized, on the basis of the studies retrieved. In addition, the STA is related to defined landmarks, and specific danger zones are emphasized. Finally, the clinical significance of the artery is reflected in registered cases of adverse events following specific aesthetic surgeries.</p><p><strong>Conclusion: </strong>Thorough knowledge of the anatomical variability of the STA, and awareness of the danger zones involved in aesthetic procedures, combined with intraoperative vigilance could increase safety and minimize the advent of relevant sequelae.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 3","pages":"232-242"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/bc/AMA-51-232.PMC10116177.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Flow Nasal Cannula Versus Noninvasive Positive Pressure Ventilation as Initial Respiratory Support in Patients with Chronic Obstructive Pulmonary Disease and Covid-19: Exploratory Analysis in Two Intensive Care Units.","authors":"Aida Mujaković,&nbsp;Tijana Kovačević,&nbsp;Edin Begić,&nbsp;Almir Fajkić,&nbsp;Goran Barić,&nbsp;Anida Jamakosmanović,&nbsp;Nermin Ismić,&nbsp;Peđa Kovačević","doi":"10.5644/ama2006-124.389","DOIUrl":"https://doi.org/10.5644/ama2006-124.389","url":null,"abstract":"<p><strong>Objective: </strong>To identify the type of the non-invasive ventilatory treatment for patients diagnosed with chronic obstructive pulmonary disease (COPD), with respiratory status deteriorated by COVID-19 pneumonia, and in need of treatment in the Intensive Care Unit (ICU).</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted over a one-year period in the medical intensive care units of two hospitals. As the patients' clinical condition deteriorated and the parameters of the arterial blood gas (ABG) analysis worsened, oxygen support was applied via a high flow nasal cannula (HFNC) or by non-invasive positive pressure ventilation (NPPV). According to the control values of the arterial oxygen saturation (SaO2) and the parameters of ABG, the patients were enabled to be transferred between the two types of non-invasive ventilatory support. The primary outcome was the length of hospital stay, while secondary outcomes were the rate of intubation, the mortality rate, and respiratory supportfree days.</p><p><strong>Results: </strong>Out of 21 critical patients with COPD and COVID-19, 11 (52.4%) were initially treated with NPPV and 10 (47.6%) with HFNC. The ages (67±9.79 in NPPV group vs. 70.10±10.25 in HFNC group) and severity of illness (SOFA score 5 (3.5) in NPPV group vs. 5 (2.8) in HFNC group) were similar between the two groups. Switching the mode of respiratory support was more common in NPPV (58.3% in survivor group vs. 41.7% in non-survivor group). Patients treated with NPPV compared to HFNC had a nominally longer length of stay (15 (11) vs. 11.5 (4.25)), and higher risk of intubation (66.7% vs. 33.3%) and mortality (66.7% vs. 33.3%), but the comparisons did not reach statistical significance. Survivors had significantly longer Medical Intensive Care Unit and hospital stays, but significantly lower FiO2 (0.60 vs.1) and higher values of PaO2/FiO2 (78(32.4) vs. 56.3(17.8)) than non-survivors. All patients were treated with corticosteroids, and the duration of treatment was similar between groups.</p><p><strong>Conclusion: </strong>In critically ill patients with COPD and COVID-19, both HFNC and NPPV were commonly used as the initial mode of ventilation. Switching to a different mode and adverse patient outcomes were more frequent in patients initially treated with NPPV. Survivors had higher values of PaO2/FiO2 than non-survivors.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 3","pages":"199-208"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/6f/AMA-51-199.PMC10116172.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9688433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy and Tolerability of a Fixed Combination of Perindopril and Indapamide in the Treatment of Unregulated Essential Hypertension - a Postmarketing Study.","authors":"Aziz Šukalo,&nbsp;Jasna Džananović Jaganjac,&nbsp;Amna Tanović Avdić,&nbsp;Una Glamočlija,&nbsp;Željka Popović,&nbsp;Alis Boloban,&nbsp;Merita Tirić Čampara,&nbsp;Meliha Mehić","doi":"10.5644/ama2006-124.385","DOIUrl":"https://doi.org/10.5644/ama2006-124.385","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this non-interventional post-marketing clinical trial was to analyze the antihypertensive effect and safety of a fixed combination of perindopril and indapamide in the treatment of unregulated essential hypertension.</p><p><strong>Patients and methods: </strong>The prospective clinical trial included patients aged 20 to 75 years with essential hypertension and blood pressure values ≥ 140/90 mmHg at baseline. On the basis of the investigator's decision, patients received 2 mg perindopril + 0.625 mg indapamide (group 2+0.625) or 4 mg perindopril + 1.25 mg indapamide (group 4+1.25).</p><p><strong>Results: </strong>The study included 1173 patients (426 patients in group 2+0.625 and 747 patients in group 4+1.25) at 27 investigational centers in Bosnia and Herzegovina. Mean blood pressure values at baseline and visits after nine months were significantly higher in the 4+1.25 group compared to the 2+0.625 group. There was a significant drop in systolic and diastolic blood pressure in both groups. The target values of systolic and diastolic blood pressure, according to the European Society of Cardiology (2018), were reached after nine months of therapy by more than 80% of patients in the 2+0.625 group, and this number was significantly higher compared to the 4+1.25 group where more than 60% of patients reached target values. Newly diagnosed patients had a better response to therapy. The percentage of patients receiving additional antihypertensive therapy decreased by the end of the study. Age, gender and the existence of diabetes mellitus were identified as negative predictors of target blood pressure achievement. The therapy showed a good safety profile.</p><p><strong>Conclusion: </strong>A fixed combination of perindopril and indapamide was effective and safe in the treatment of unregulated essential hypertension.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 3","pages":"163-174"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/b1/AMA-51-163.PMC10116171.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9688434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and the Reliability of the ACIC Questionnaire in the Primary Health Care Setting: a Study from Bosnia and Herzegovina.","authors":"Natasa Pilipovic-Broceta,&nbsp;Nadja Vasiljevic,&nbsp;Nevena Todorovic,&nbsp;Maja Racic","doi":"10.5644/ama2006-124.387","DOIUrl":"https://doi.org/10.5644/ama2006-124.387","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to carry out the cultural adaptation and validation of the Assessment of Chronic Illness Care questionnaire (ACIC) in the Republika Srpska, Bosnia and Herzegovina.</p><p><strong>Methods: </strong>A validation study was conducted in two randomly selected primary health care centers in the Republika Srpska, Bosnia and Herzegovina, during March and April 2016. The study participants were all physicians working in family medicine departments during the study. Translation of the ACIC questionnaire version 3.5 was performed following the guidelines of the World Health Organization. The validity and reliability of the questionnaire were tested with face validity, construct validity, and internal consistency.</p><p><strong>Results: </strong>The questionnaire was distributed to 66 family physicians. Missing values were negligible, therefore the criteria for factor analysis were met. Exploratory factor analysis confirmed that the questionnaire measured one factor. The Cronbach alpha coefficient (0.970) showed the excellent level of internal consistency of the questionnaire. The intraclass correlation coefficient (0.802) confirmed the good reliability of the questionnaire.</p><p><strong>Conclusion: </strong>The ACIC questionnaire can be used to assess the quality of chronic care in family medicine practice in Bosnia and Herzegovina. Further research is needed to explore how changes in healthcare care delivery impact changes in the Chronic Care Model domain.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 3","pages":"181-188"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/a8/AMA-51-181.PMC10116173.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}