Acta medica academica最新文献

{"title":"Family Physicians' Perceptions of Primary Health Care Use in Bosnia and Herzegovina during the Covid-19 Pandemic, a Cross-sectional Study.","authors":"Zaim Jatić,&nbsp;Eman Smlatic,&nbsp;Madelynne McGowan,&nbsp;Hasiba Erkočević,&nbsp;Elvira Hasanović,&nbsp;Nataša Trifunović","doi":"10.5644/ama2006-124.397","DOIUrl":"https://doi.org/10.5644/ama2006-124.397","url":null,"abstract":"<p><strong>Objectives: </strong>The main objective of this paper was to examine the perceptions of family physicians on the use of primary health care in Bosnia and Herzegovina during the COVID-19 pandemic.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted using a short online questionnaire that was sent to primary care physicians in Bosnia and Herzegovina from April 20th, 2022, to May 20th, 2022.</p><p><strong>Results: </strong>The research sample consisted of 231 doctors of primary health care from Bosnia and Herzegovina, with an average age of 45 years and 85% women. About 70% of participants reported having COVID-19 at least once from March 2020 to March 2022. Participants had an average of 1,986 registered patients and approximately 50 encounters per day. The study revealed a high degree of reliability between test-retest measurements, with a single measure Intraclass correlation coefficient of 0.801, and internal consistency determined using Cronbach's alpha of 0.89. Participants reported that the following health services were most affected during the COVID-19 pandemic: care for patients with chronic diseases, home visits, navigating the health system with patients making appointments with specialists, cancer screening, and preventive health services. The study also found statistically significant perceived differences in the use of these health services based on age, gender, postgraduate education in family medicine, participation in COVID-19 clinics, and personal history of Covid-19.</p><p><strong>Conclusion: </strong>There were significant disturbances to the use of primary health care during the COVID-19 pandemic. Future research could investigate patient outcomes compared to family physician perceptions.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"13-23"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/f9/AMA-52-13.PMC10316076.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Predictive of In-Hospital Mortality in Patients with Systemic Lupus Erythematosus: A Single-Centre Retrospective Analysis.","authors":"Sujin Lertwises,&nbsp;Attapon Rattanasupar,&nbsp;Arunchai Chang","doi":"10.5644/ama2006-124.400","DOIUrl":"https://doi.org/10.5644/ama2006-124.400","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to investigate the causes and factors predictive of in-hospital death among patients with systemic lupus erythematosus (SLE) admitted to a tertiary care hospital in Thailand.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed the records of patients with SLE admitted between 2017 and 2021. We collected data related to age, sex, body mass index, comorbidities, disease duration, medication usage, clinical symptoms, vital signs, laboratory results, evidence of infection, presence of systemic inflammatory response syndrome, quick sepsis-related organ assessment scores, and SLE disease activity on the date of admission. The length of hospitalization, treatment administered, and subsequent clinical outcomes (including in-hospital complications and death) were also recorded.</p><p><strong>Results: </strong>Among 267 enrolled patients, the overall in-hospital mortality rate was 25.5%, and infection was the most common cause of death (75.0%). Multivariate analysis revealed that prior hospitalization within 3 months (odds ratio [OR]: 2.311; 95% confidence interval [CI]: 1.002-5.369; P=0.049), initial infection on admission (OR: 2.764; 95% CI: 1.006-7.594; P=0.048), use of vasopressor drugs (OR: 2.940; 95% CI: 1.071-8.069; P=0.036), and mechanical ventilation (OR: 5.658; 95% CI: 2.046-15.647; P=0.001) were independent risk factors for in-hospital mortality.</p><p><strong>Conclusion: </strong>Infection was the major cause of mortality in patients with SLE. Prior hospitalization within 3 months, initial infection on admission, vasopressor use, and mechanical ventilation during admission are independent risk factors for in-hospital mortality in patients with SLE.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/19/AMA-52-37.PMC10316072.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Coexistence of an Incomplete Superficial Palmar Arch and a Berrettini Anastomosis: A Case Report.","authors":"Ioannis Antonopoulos,&nbsp;Panagiotis Giavopoulos,&nbsp;Dimosthenis Chrysikos,&nbsp;Dimitrios Filippou,&nbsp;Theodore Troupis","doi":"10.5644/ama2006-124.401","DOIUrl":"https://doi.org/10.5644/ama2006-124.401","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to present a relatively rare case of the coexistence of an incomplete superficial palmar arch and a Berrettini anastomosis, identified in a cadaveric specimen, and further discuss the potential clinical implications of such anatomical variations.</p><p><strong>Case report: </strong>The variation was found in the left hand of a formalin-fixed male cadaver of Greek origin, that was dissected under an operating microscope (×4, ×10 magnification) in our Anatomy Department. In the specimen, we found an incomplete superficial palmar arch, formed only by the superficial branch of the ulnar artery, and a Type 1 Berrettini Anastomosis, originating from the ulnar nerve and joining a branch of the median nerve.</p><p><strong>Conclusion: </strong>To avoid iatrogenic damage and permanent loss of sensation, hand surgeons and microsurgeons should be aware of the presence of a BA, and the potential coexistence of this variation with vascular abnormalities in the hand that may complicate surgical procedures.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"47-50"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/46/AMA-52-47.PMC10316074.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When to Attend a Webinar?","authors":"Farrokh Habibzadeh","doi":"10.5644/ama2006-124.404","DOIUrl":"https://doi.org/10.5644/ama2006-124.404","url":null,"abstract":"<p><strong>Objective: </strong>To determine the most appropriate delay to start a webinar.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on weekly general staff scientific webinars held by the Institute of Human Virology (IHV), University of Maryland School of Medicine, Baltimore, USA. 35 observations were made at arbitrary chosen times of three consecutive IHV webinars. After standardizing the number of participants, a 4th-degree polynomial fit was applied to the data. A cost function was defined as the sum of the time wasted for those who attended the webinar early and the lost for those who attend with delay. The cost function was minimized to compute the most appropriate delay to start the webinar.</p><p><strong>Results: </strong>The model could explain almost 95% of the observed variance in the number of participants. Normally, half of the participants attended the meeting at the webinar set starting time. The cost was a minimum if the webinar was delayed for about 3 minutes.</p><p><strong>Conclusion: </strong>It seems that the most appropriate time for starting the IHV general staff meetings is around 3 minutes after the webinar set starting time.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"63-66"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/89/7d/AMA-52-63.PMC10316075.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Brachiocephalic Trunk Variant Origin and High-Riding Course: Two Cadaveric Cases.","authors":"George Tsakotos,&nbsp;Theano Demesticha,&nbsp;Vasilios Karampelias,&nbsp;Konstantinos Natsis,&nbsp;Vasilios Protogerou,&nbsp;Dimitrios Schizas,&nbsp;Ilenia Chatziandreou,&nbsp;Georgia Kostare,&nbsp;Maria Piagkou","doi":"10.5644/ama2006-124.402","DOIUrl":"https://doi.org/10.5644/ama2006-124.402","url":null,"abstract":"<p><strong>Objective: </strong>The current report describes two rare cadaveric findings of a left sided brachiocephalic trunk (BCT) in relation to the trachea, and its high-riding course above the suprasternal notch (SN).</p><p><strong>Cases description: </strong>In two elderly body donors dissected after death, a left-sided BCT was identified with a high-riding course (0.5 and 0.8 cm above the SN). The BCT originated from the aortic arch, in common with the left common carotid artery, more distally than the typical left-side location and crossed in front of the trachea. In the 1st case, the ascending and descending aortae, and the left subclavian artery had aneurysmal dilatation. In both cases, the trachea was displaced to the right side and had a stenosis due to the chronic compression.</p><p><strong>Conclusion: </strong>A high-riding BCT is of paramount clinical importance, as it may complicate tracheotomy, thyroid surgery and mediastinoscopy, leading to fatal complications. BCT injury leads to a massive bleeding during neck dissection (level VI), when the vessel crosses the anterior tracheal wall.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"51-55"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/03/8c/AMA-52-51.PMC10316069.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 Vaccination IgG Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Single Center Observation.","authors":"Fieke W Hoff,&nbsp;Suleyman Y Goksu,&nbsp;Naveen Premnath,&nbsp;Prapti A Patel,&nbsp;Ruth Ikpefan,&nbsp;Gurbakhash Kaur,&nbsp;Madhuri Vusirikala,&nbsp;Taha Bat,&nbsp;Weina Chen,&nbsp;Praveen Ramakrishnan Geethakumari,&nbsp;Larry D Anderson,&nbsp;Farrukh T Awan,&nbsp;Robert H Collins,&nbsp;Olga K Weinberg,&nbsp;Alagarraju Muthukumar,&nbsp;Stephen S Chung,&nbsp;Yazan F Madanat","doi":"10.5644/ama2006-124.399","DOIUrl":"https://doi.org/10.5644/ama2006-124.399","url":null,"abstract":"<p><strong>Objective: </strong>Patients diagnosed with hematologic malignancies are at increased risk for severe SARS-CoV-2 infection. We evaluated the serological IgG response following two doses of the SARS-CoV-2 vaccine in patients with hematologic malignancies.</p><p><strong>Methods: </strong>Patients treated at UT Southwestern Medical Center with a diagnosis of a myeloid or lymphoid neoplasm were included. SARS-CoV-2 vaccination response was defined as a positive quantifiable spike IgG antibody titer.</p><p><strong>Results: </strong>Sixty patients were included in the study and 60% were diagnosed with a myeloid neoplasm. The majority (85%) of the patients with a myeloid malignancy and 50% of the patients with a lymphoid malignancy mounted a serological response after receiving two doses of the vaccine.</p><p><strong>Conclusion: </strong>Vaccination should be offered irrespective of ongoing treatment or active disease. Findings require validation in a larger cohort of patients.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"30-36"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/59/2b/AMA-52-30.PMC10316070.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P53/MDM2 Complex-Based Targeted Strategies in Colon Adenocarcinoma.","authors":"Athanasios Niotis,&nbsp;Evangelos Tsiambas,&nbsp;Dimitrios Dimitroulis,&nbsp;Helen Sarlanis,&nbsp;Evangelos Falidas,&nbsp;Nikolaos Kavantzas,&nbsp;Constantinos A Constantinides","doi":"10.5644/ama2006-124.398","DOIUrl":"https://doi.org/10.5644/ama2006-124.398","url":null,"abstract":"<p><p>In the current molecular review, we describe the mechanisms of TP53/MDM2 deregulation and their impact on the colon adenocarcinoma molecular substrate and phenotype. Among the genes that are critically altered in carcinogenesis, the TP53 tumor suppressor gene is of major importance. The TP53 gene (gene locus: 17p13.1) regulates the cell cycle by controlling the G1/S and G2/M checkpoints securing the normal sequence of cell cycle phases. Furthermore, it is involved in apoptosis programmed cell death. The gene is mutated or epigenetically altered in all epithelial malignancies, including colon adenocarcinoma. Additionally, Mouse Double Minute 2 Homolog (MDM2), a proto-oncogene (12q14.3), acts as a major negative regulator for p53 expression in the p53-MDM2 auto-regulatory pathway. MDM2 binds directly to p53 and represses its transcriptional activity, promoting p53 degradation. CONCLUSION: In colon adenocarcinoma, MDM2 oncogene overexpression directly influences p53 oncoprotein expression levels.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"24-29"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c7/8f/AMA-52-24.PMC10316079.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and Attitudes regarding Covid-19 Vaccination among Medical and Non-medical Students in Bosnia and Herzegovina.","authors":"Adaleta Softić,&nbsp;Elma Omeragić,&nbsp;Martin Kondža,&nbsp;Nahida Srabović,&nbsp;Aida Smajlović,&nbsp;Esmeralda Dautović,&nbsp;Nataša Bubić Pajić,&nbsp;Tamer Bego,&nbsp;Žarko Gagić,&nbsp;Ivica Brizić,&nbsp;Anđelka Račić,&nbsp;Ervina Bečić,&nbsp;Belma Pehlivanović,&nbsp;Šejla Šabić,&nbsp;Edin Suljagić,&nbsp;Adnan Hukić,&nbsp;Daria Pavlić,&nbsp;Andrea Lučić","doi":"10.5644/ama2006-124.396","DOIUrl":"https://doi.org/10.5644/ama2006-124.396","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate students' knowledge, attitudes and hesitancy regarding COVID-19 vaccination.</p><p><strong>Methods: </strong>A cross-sectional questionnaire-based survey was conducted among a total of 1282 medical students and 509 non-medical students at four public universities in Bosnia and Herzegovina: Tuzla, Sarajevo, Banja Luka, and Mostar.</p><p><strong>Results: </strong>A significantly higher rate of vaccination was observed in the group of medical students as well as a higher level of knowledge about vaccination in general and vaccines against the COVID-19 disease. Students who received the COVID-19 vaccine had a higher level of knowledge about vaccination in general and COVID-19 vaccines in particular compared to the non-vaccinated students in the medical and non-medical groups, respectively. Furthermore, vaccinated students, regardless of the course they are taking, showed generally stronger positive attitudes compared to non-vaccinated students, regarding the safety and effectiveness of the COVID-19 vaccine. Both groups of students believe that the rapid development of the vaccine is contributing to refusal or hesitancy to receive a vaccine against COVID-19. Social media/networks were the main sources of information about the COVID-19 vaccine. We did not find any contribution of social media to the reduced level of COVID-19 vaccine coverage.</p><p><strong>Conclusion: </strong>Education of students about the benefits of the COVID-19 vaccine will lead to its better acceptance as well as the development of more positive attitudes towards vaccination in general, especially having in mind that students are the future population of parents, who will make decisions about vaccinating their children.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/d1/AMA-52-1.PMC10316077.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. Isak Samokovlija: Life in a White Coat.","authors":"Jovan Dimitrijević","doi":"10.5644/ama2006-124.406","DOIUrl":"https://doi.org/10.5644/ama2006-124.406","url":null,"abstract":"No abstract available.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"73-75"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/44/AMA-52-73.PMC10316068.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Facial Artery as a Branch of the External Carotid Artery in Thomas Turner's (1793-1873) Treatise on the Arterial System (1825) and a Comparison with Modern Anatomy.","authors":"Amir Shihada, Maria Sioula, Panagiotis Georgakopoulos, Evaggelos Mavrommatis","doi":"10.5644/ama2006-124.405","DOIUrl":"10.5644/ama2006-124.405","url":null,"abstract":"<p><p>The aim of the present paper is to contribute to the understanding of the history of the anatomical study of the facial artery. The facial artery plays a fundamental role in the study of the anatomy of the face, and in maxillofacial and vascular surgery. The debate on the understating of this vessel is essential in the educational process, with special focus on the historical development of topographical and descriptive ideas about it. The comparison between the study of facial artery in the work of Thomas Turner (1793-1873) and modern anatomical concepts serves as an excellent educational paradigm. The documentary research method was used this short historical survey. CONCLUSION: Thomas Turner laid the scientific foundation for the accurate anatomical study of the facial artery.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 1","pages":"67-72"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/17/AMA-52-67.PMC10316073.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}