Semir Vranic, Gargi D Basu, David W Hall, Zoran Gatalica
{"title":"Tumor-Type Agnostic, Targeted Therapies: BRAF Inhibitors Join the Group.","authors":"Semir Vranic, Gargi D Basu, David W Hall, Zoran Gatalica","doi":"10.5644/ama2006-124.392","DOIUrl":"https://doi.org/10.5644/ama2006-124.392","url":null,"abstract":"<p><p>In the present review, we briefly discuss the breakthrough advances in precision medicine using a tumor-agnostic approach and focus on BRAF treatment modalities, the mechanisms of resistance and the diagnostic approach in cancers with BRAF mutations. Tumor-type agnostic drug therapies work across cancer types and present a significant novel shift in precision cancer medicine. They are the consequence of carefully designed clinical trials that showed the value of tumor biomarkers, not just in diagnosis but in therapy guidance. Six tumor-agnostic drugs (with seven indications) have been approved through October 2022 by FDA. The first tumor-agnostic treatment modality was pembrolizumab for MSI-H/dMMR solid tumors, approved in 2017. This was followed by approvals of larotrectinib and entrectinib for cancers with NTRK fusions without a known acquired resistance mutation. In 2020, pembrolizumab was approved for all TMB-high solid cancers, while a PD-L1 inhibitor dostarlimab-gxly was approved for dMMR solid cancers in 2021. A combination of BRAF/MEK inhibitors (dabrafenib/trametinib) was approved as a tumor-agnostic therapy in June 2022 for all histologic types of solid metastatic cancers harboring BRAFV600E mutations. In September 2022, RET inhibitor selpercatinib was approved for solid cancers with RET gene fusions. CONCLUSION: Precision cancer medicine has substantially improved cancer diagnostics and treatment. Tissue type-agnostic drug therapies present a novel shift in precision cancer medicine. This approach rapidly expands to provide treatments for patients with different cancers harboring the same molecular alteration.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 3","pages":"217-231"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/18/AMA-51-217.PMC10116180.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christos Lyrtzis, George Tsakotos, Michael Kostares, Maria Piagkou, Chrysovalantis Mariorakis, Konstantinos Natsis
{"title":"The Prevalence and Morphometry of the Atlas Vertebra Retrotransverse Foramen.","authors":"Christos Lyrtzis, George Tsakotos, Michael Kostares, Maria Piagkou, Chrysovalantis Mariorakis, Konstantinos Natsis","doi":"10.5644/ama2006-124.388","DOIUrl":"https://doi.org/10.5644/ama2006-124.388","url":null,"abstract":"<p><strong>Objective: </strong>The current study records the prevalence of the accessory foramen, located posterior to the transverse foramen (TF), the so-called the retrotransverse foramen (RTF), its morphometry, exact location, and coexistence with ossified posterior bridges. Additionally, factors associated with the length of the RTF are investigated.</p><p><strong>Materials: </strong>One-hundred and forty-one dried atlas vertebrae were examined.</p><p><strong>Results: </strong>Thirty-seven out of the 141 vertebrae (26.2%) had at least one RTF. The RTF was unilateral in 67.6% and bilateral in 32.4%. The mean RTF anteroposterior diameter (length) was 4.2±1.4 mm on the right and 3.8±1.0 mm on the left side. The mean RTF laterolateral diameter (width) was 2.6±1.2 mm on the right and 2.5±0.8 mm on the left side. Both dimensions were symmetrical. The RTF was symmetrically located from the TF, at a mean distance of 4.6±1.1 mm on the right and of 4.5±0.9 mm on the left side. For the given TF-RTF distance, laterality, and presence of posterior bridges, each mm increase in the RTF width was associated with a 0.74 mm increase in the relevant length.</p><p><strong>Conclusion: </strong>The estimated prevalence was higher than most of those reported in other studies. However, the between-studies prevalence varies to a significant degree. Hence, a systematic review and meta-analysis should be performed to identify a more precise estimate due to the clinical importance of the RTF.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 3","pages":"189-198"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/40/AMA-51-189.PMC10116178.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anatomical Variations of Vascular Anatomy in Meckel's Diverticulum.","authors":"Dimitrios Malligiannis Ntalianis, Rami N Maloula, Konstantinos Malligiannis Ntalianis, Panagiotis Giavopoulos, Eirini Solia, Dimosthenis Chrysikos, Vasileios Karampelias, Theodore Troupis","doi":"10.5644/ama2006-124.394","DOIUrl":"https://doi.org/10.5644/ama2006-124.394","url":null,"abstract":"<p><strong>Objective: </strong>The objective of the current study was to describe the anatomical variations of vessels observed in patients with Meckel's Diverticulum.</p><p><strong>Methods: </strong>A narrative review of the literature was undertaken by means of the PubMed database, using the terms: \"Meckel's Diverticulum AND vessels\", \"Meckel's Diverticulum AND anatomical variation\" and \"Meckel's Diverticulum variation\". Classical anatomical textbooks were also used for normal anatomy. Additional articles provided useful information in relation to the aim of this review. Hence, the articles that met the inclusion criteria were included in this review, and the collected data were categorized into a single table.</p><p><strong>Results: </strong>The majority of studies indicated the presence of an abnormal vitelline artery. Other angiographic findings concerned variations of the ileal and the iliac arteries. However, the literature revealed the presence of vascular variations without the existence of Meckel's Diverticulum, whereas a remnant of the vitelline vein may be present, but it is very rare.</p><p><strong>Conclusion: </strong>The detection of vascular variations accompanying Meckel's Diverticulum is not always easy and requires the correct choice of imaging method to prevent misdiagnosis.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 3","pages":"243-248"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/55/8f/AMA-51-243.PMC10116170.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michail Anastasakis, Ioanna Gkalonaki, Charalampos Doitsidis, Ioannis Patoulias
{"title":"A Remarkably Rare Position of a Cutaneous Ciliated Cyst in a 16 Month-old Female: A Case Report.","authors":"Michail Anastasakis, Ioanna Gkalonaki, Charalampos Doitsidis, Ioannis Patoulias","doi":"10.5644/ama2006-124.390","DOIUrl":"https://doi.org/10.5644/ama2006-124.390","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the work was to show a Cutaneous Ciliated Cyst (CCC) in an unusual location in a 16-month-old girl.</p><p><strong>Case report: </strong>We present the case of a 16-month otherwise healthy girl presented to our hospital, with a report of a palpable mass in the left suprascapular region. Physical examination revealed a soft-textured, fluctuating, mobile and painless entity, with no further indications of local inflammation. The mass was totally excised, under general anesthesia, for both diagnostic and therapeutic purposes. According to the histopathological findings, the cystic lesion was covered by a pseudostratified ciliary epithelium, resembling the epithelium of a normal fallopian tube, surrounded by a smooth muscle layer. Immunohistochemical studies identified the cyst epithelium as having cytokeratin (CKAE1/AE3) expression, despite the negative immunostaining findings on Estrogen and Progesterone Receptors.</p><p><strong>Conclusion: </strong>Our case report concerns a CCC in an unusual position, in the suprascapular area. After a thorough review of the international literature, we concluded that this is the second published case regarding this specific location. To our knowledge our patient is the youngest ever diagnosed with CCC.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 3","pages":"209-211"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/26/a6/AMA-51-209.PMC10116175.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9389035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachmat Hidayat, Patricia Wulandari, Muhammad Reagan
{"title":"The Potential of Cinnamon Extract (Cinnamomum burmanii) as Anti-insomnia Medication through Hypothalamus Pituitary Adrenal Axis Improvement in Rats.","authors":"Rachmat Hidayat, Patricia Wulandari, Muhammad Reagan","doi":"10.5644/ama2006-124.375","DOIUrl":"https://doi.org/10.5644/ama2006-124.375","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the efficacy of cinnamon extract as an anti-insomnia medication in experimental animals by evaluating the levels of hormones and neurotransmitters related to insomnia.</p><p><strong>Materials and methods: </strong>A total of 30 male Wistar rats were divided into six groups. Induction of insomnia in animal models was done by administration of p-chloro-phenylalanine (PCPA) compounds. Estazolam was administrated to the positive control group. Cinnamon extract administration was divided into 3 doses, namely: 25 mg/kg BW, 50 mg/kg BW and 100 mg/kg BW. Evaluation of the organ coefficient was conducted to evaluate drug toxicity to the organs. The enzyme-linked-immunoassay method assessed hormones and neurotransmitters in the serum and hypothalamus related to insomnia.</p><p><strong>Results: </strong>There was a decrease in the adrenal coefficient in the cinnamon extract group compared to the PCPA group (0.011+0.001, P<0.05). In addition, there was a decrease in the corticotropin-releasing hormone, adrenocorticotropin hormone, and corticosterone levels in the serum of animals who received cinnamon extract. Our study found a dose of cinnamon extract of 50 mg/kg BW was the best dose to balance neurotransmitter levels in insomniac rats.</p><p><strong>Conclusion: </strong>The cinnamon extract increased serotonin and melatonin levels and decreased norepinephrine levels in the insomnia-induced group. Cinnamon extract has potential as an anti-insomnia medication through hypothalamus-pituitaryadrenal axis improvement and brain neurotransmitter regulation in an animal model of insomnia.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 2","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/47/AMA-51-79.PMC9982853.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9106996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spyros Laskaris, Dimosthenis Chrysikos, Ioannis Koutrafouris, Maria Piagkou, Vasileios Protogerou, Vasileios Karampelias, Filippos Bekos, Dimitrios Kotzias, Theodore Troupis
{"title":"Partial Superficial Parotidectomy Versus Extracapsular Anatomical Dissection for the Treatment of Benign Parotid Tumors.","authors":"Spyros Laskaris, Dimosthenis Chrysikos, Ioannis Koutrafouris, Maria Piagkou, Vasileios Protogerou, Vasileios Karampelias, Filippos Bekos, Dimitrios Kotzias, Theodore Troupis","doi":"10.5644/ama2006-124.376","DOIUrl":"https://doi.org/10.5644/ama2006-124.376","url":null,"abstract":"<p><strong>Objectives: </strong>Superficial benign parotid tumors are a common neoplasm of the salivary glands. Different surgical procedures have been applied for partial superficial parotidectomy (PSP) and extracapsular dissection (ECD), which are the two predominant surgical techniques. Our study aimed to evaluate PSP versus ECD for benign parotid tumors, in relation to post-operative complications and recurrence rates.</p><p><strong>Materials and methods: </strong>266 patients who underwent parotidectomies of benign superficial parotid tumors were evaluated retrospectively. The first group (PSP group) was composed of 143 patients who underwent PSP, and the second group (ECD group) was composed of 123 patients who underwent ECD.</p><p><strong>Results: </strong>In the ECD group the rate of patients presenting with total postoperative permanent facial nerve paralysis, House-Brackmann grade III, was 0.8%, whereas in the PSP group it was 1.4%. Frey's syndrome was only reported in the PSP group. Salivary fistula occurred in both groups at similar rates. Sensation dysfunction due to greater auricular nerve division occurred in 72% patients in the PSP group and 10.6% in the ECD group. No statistical difference regarding recurrence rates was found between the two groups.</p><p><strong>Conclusions: </strong>Both ECD and PSP procedures are safe surgical options for superficial parotidectomy in the treatment of benign tumors, with similar recurrence rates and post-surgical complications, apart from sensation abnormalities due to more extensive auricular nerve division.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 2","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b7/fa/AMA-51-85.PMC9982861.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9102510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dionysios Galatis, Konstantina Kalopita, Ioannis Grypiotis, Ioannis Flessas, Nikolaos Kiriakopoulos, Georgia Micha
{"title":"Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review.","authors":"Dionysios Galatis, Konstantina Kalopita, Ioannis Grypiotis, Ioannis Flessas, Nikolaos Kiriakopoulos, Georgia Micha","doi":"10.5644/ama2006-124.379","DOIUrl":"https://doi.org/10.5644/ama2006-124.379","url":null,"abstract":"<p><p>This narrative review aims to summarize all the latest studies published between 2015-2021 concerning the management protocols adopted for poor ovarian response (POR) cases. Patients defined as \"poor responders\" show minimal response to controlled ovarian hyperstimulation, although there is no standard definition for POR. Although infertility specialists are endeavoring to improve cycle outcomes in poor responders by adopting multiple management strategies, still the estimated risk of cycle cancellation is about 20%. All the studies performed during this study period were evaluated and their results were recorded. The latest published protocols to improve oocyte retrieval in poor responders include: anti-Mϋllerian hormone, clomiphene citrate, co-enzyme Q10, corifollitropin, dehydroepiandrosterone, double stimulation, Follicle Stimulation Hormone, Growth Hormone, Gonadotropin-releasing hormone agonists, letrozole, human chorionic gonadotropin, Luteinizing Hormone, progesterone and testosterone. CONCLUSION: Although many strategies have been suggested to manage POR, none has been proven superior to the others. Further large-scale randomized studies are needed to validate experimental techniques leading towards successful individualized treatment regimens.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 2","pages":"108-122"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3a/e3/AMA-51-108.PMC9982854.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9102513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alma Voljevica, Elvira Talović, Maida Šahinović, Amna Pleho-Kapić
{"title":"Morphometric Analysis of the Supraorbital Foramen and Notch in the Population of Bosnia and Herzegovina.","authors":"Alma Voljevica, Elvira Talović, Maida Šahinović, Amna Pleho-Kapić","doi":"10.5644/ama2006-124.377","DOIUrl":"https://doi.org/10.5644/ama2006-124.377","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to learn about the morphological characteristics of the supraorbital foramen and to determine its precise position in relation to the surrounding anatomical landmarks in the adult population of Bosnia and Herzegovina.</p><p><strong>Material and methods: </strong>For this purpose, 60 skulls from the Bosnia and Herzegovina population of known sex (32 males and 28 females), taken from the osteological collection of the Department of Human Anatomy of the Medical Faculty in Sarajevo, were subjected to morphological and morphometric analysis. Morphometric measurements were performed using a digital vernier caliper (Mitutoyo Corporation, Japan).</p><p><strong>Results: </strong>The study showed that most supraorbital nerves exit the orbit through the supraorbital notch (73.8%) and the rest through the foramen (26.2%). Of this number, bilateral supraorbital notches were recorded in 58.33% of cases, a bilateral supraorbital foramen in 18.34% of cases, while in 23.33% of cases a notch was recorded on one side and a foramen on the contralateral side. Morphometric measurements performed to determine the exact position of the supraorbital foramen relative to the surrounding landmarks showed different values in males and females. An accessory foramen was also observed on the examined skulls in 16.67% of cases.</p><p><strong>Conclusion: </strong>Detailed knowledge of anatomical variations of the supraorbital foramen is required for safe and successful administration of regional anesthesia, in order to avoid iatrogenic nerve injuries during orbitofacial region surgery.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 2","pages":"92-98"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/a6/AMA-51-92.PMC9982859.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9106999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Text Neck Syndrome: Disentangling a New Epidemic.","authors":"Alexandra-Regina Tsantili, Dimosthenis Chrysikos, Theodore Troupis","doi":"10.5644/ama2006-124.380","DOIUrl":"https://doi.org/10.5644/ama2006-124.380","url":null,"abstract":"<p><p>The aim of this report is to provide a brief review of the predisposing factors for Text Neck Syndrome, along with diagnostic and therapeutic approaches in young and adult populations. Text neck pain is a worldwide public health problem, largely reported nowadays. Currently, data have shown that the erroneous use of personal computers and cell phones might be correlated with the development of various clinical symptoms that are defined as \"text neck syndrome\". Modified radical changes in everyday life may ameliorate the powerful forces on the cervical spine that can lead to cervical degeneration, along with other developmental, medical, psychological, and social complications that are attributed to text neck syndrome. CONCLUSION: New technologies and the potentially harmful addiction to cell phones and computers while reading or texting are inducing an epidemic of text neck syndrome. By focusing on postural correction, both pain alleviation and a better quality of life can be achieved for the patient. The predisposing factors and therapeutic approaches for this syndrome that affects public health remain to be further elucidated.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 2","pages":"123-127"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/17/fd/AMA-51-123.PMC9982850.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9102514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On Measuring Vaccine Effectiveness with Observational Study Designs.","authors":"Farrokh Habibzadeh, Parham Habibzadeh, Mahboobeh Yadollahie","doi":"10.5644/ama2006-124.383","DOIUrl":"https://doi.org/10.5644/ama2006-124.383","url":null,"abstract":"Herein, we present a bird’s eye view of common observational study designs utilized for measurement of vaccine effectiveness. Assessing vaccines effectiveness is an integral part of vaccine research, particularly for the newly developed vaccines. A cohort study is prospective, directing from an exposure to one or more outcomes. The design is the best method to ascertain the attack rate of an infectious disease. A traditional case-control study is retrospective, directing from a given outcome to one or more exposures. The design cannot provide the relative risk, but it can provide the odds ratio, which is a good estimation of the relative risk when the attack rate is low. Critically depending on laboratory test results and performance, the test-negative case-control study design is another type of observational study commonly used nowadays for the evaluation of the vaccine effectiveness. Comparing to cohort and traditional case-control designs, conducting a test-negative case-control study is relatively cheaper and faster. Herein, we describe each of the above-mentioned study designs through examples generated by a Monte-Carlo simulation program assuming real-world conditions. Conclusion. The simulation shows that regardless of the study design employed, the diagnostic test specificity is of utmost importance in providing a valid estimate of the vaccine effectiveness.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"51 2","pages":"134-146"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/85/AMA-51-134.PMC9982864.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9102512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}