Spiros Delis, Nikolaos Taprantzis, Dimosthenis Chrysikos, Amir Shihada, Theodore Troupis
{"title":"Surgical Re-Resection for Isolated Local Recurrence of Pancreatic Cancer: A Case Series of 3 Patients and Literature Review.","authors":"Spiros Delis, Nikolaos Taprantzis, Dimosthenis Chrysikos, Amir Shihada, Theodore Troupis","doi":"10.5644/ama2006-124.495","DOIUrl":"10.5644/ama2006-124.495","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective case series study aims to assess the clinical role of surgical re-resection for isolated local recurrence of pancreatic cancer, integrating detailed case presentations with current evidence to clarify patient selection criteria, operative feasibility, and oncologic outcomes.</p><p><strong>Case presentations: </strong>We present three patients with locally recurrent pancreatic cancer who underwent repeat pancreatic resection. Patient 1, who previously underwent distal pancreatectomy for an Intraductal Papillary Mucinous Neoplasm (IPMN)-associated adenocarcinoma, developed a new pancreatic head lesion three years later and underwent pylorus-preserving pancreaticoduodenectomy; histopathology confirmed a small invasive IPMN, and the patient remains alive 8 years after the initial diagnosis and 5 years after the reoperation. Patient 2, who had previously undergone Pylorus-Preserving Pancreaticoduodenectomy for distal bile duct adenocarcinoma, developed recurrent disease in the pancreatic body and tail three years later. He underwent distal pancreatectomy but developed liver recurrence due to hematogenous metastasis one month postoperatively and succumbed 6 months later from generalized widespread disease. Patient 3, who previously underwent a Whipple procedure for IPMN-associated adenocarcinoma, developed a recurrent mass at the pancreatojejunostomy five years later and underwent distal pancreatectomy, with an uneventful recovery.</p><p><strong>Conclusion: </strong>Our findings suggest that repeat pancreatic resection may be feasible in carefully selected patients with isolated local recurrence, potentially offering a survival benefit. Strict selection criteria, including the absence of distant metastases, good performance status, and technically resectable disease, appear essential to optimize outcomes, supporting the consideration of surgical re-resection as an option within a multidisciplinary management framework.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"77-85"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment Stability of Warfarin and Acenocoumarol in Patients With Mechanical Heart Valves and Atrial Fibrillation: A One-Year Cohort Study.","authors":"Šahza Hajdari Toskić, Asija Mević, Aida Kulo Ćesić","doi":"10.5644/ama2006-124.497","DOIUrl":"10.5644/ama2006-124.497","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate which of the two vitamin K antagonists, warfarin or acenocoumarol, provides more stable anticoagulation control in patients with mechanical heart valves and atrial fibrillation.</p><p><strong>Patients and methods: </strong>This was a prospective, one-year clinical cohort study. In total, 73 outpatients with mechanical heart valves and atrial fibrillation who were already treated with warfarin or acenocoumarol were recruited from the Blood Transfusion Institute of the Federation of Bosnia and Herzegovina. The prothrombin time target values, expressed as the international normalized ratio (INR), were 2.0-3.0/4.0. Numerical data between the treatment groups were summarized descriptively.</p><p><strong>Results: </strong>Patients in the warfarin (N=35) and acenocoumarol (N=38) treatment groups were similar in terms of sex, age, body mass index, body surface area, and number of concomitant drugs known to interact with vitamin K antagonists. The number of INR measurements per patient, number of INR measurements within the therapeutic range per patient, mean time interval between successive INR measurements, and mean INR values across consecutive measurements were similar in both groups. However, compared to acenocoumarol, warfarin treatment seemed to be associated with more stable anticoagulation, i.e., with a higher mean time in the therapeutic range (TTR) (76.1±24.2 vs. 69.1±21.5%) and a smaller proportion of patients below all predefined TTR thresholds (<60%, <65%, and <70%).</p><p><strong>Conclusion: </strong>Our unadjusted descriptive results suggested that warfarin, compared to acenocoumarol, may provide more stable and therefore safer anticoagulation control in patients with mechanical heart valves and atrial fibrillation. To confirm this, larger prospective clinical studies are needed in patients with mechanical heart valves with or without atrial fibrillation.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Grigorios Stefanou, Dimosthenis Chrysikos, Dimitrios Filippou, George Tsakotos, Theodore Troupis
{"title":"Gastrocolic Trunk: Anatomical Variations and Surgical Significance.","authors":"Grigorios Stefanou, Dimosthenis Chrysikos, Dimitrios Filippou, George Tsakotos, Theodore Troupis","doi":"10.5644/ama2006-124.501","DOIUrl":"10.5644/ama2006-124.501","url":null,"abstract":"<p><strong>Objective: </strong>This review aims to summarize the Henle trunk configurations and tributary patterns presented in cadaveric, intraoperative, and imaging studies.</p><p><strong>Background: </strong>The Henle gastrocolic trunk is a highly variable venous structure formed by the confluence of the gastric, colic, and pancreatic veins. It has notable surgical importance, particularly during laparoscopic procedures, such as right colectomy and pancreaticoduodenectomy.</p><p><strong>Methods: </strong>A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was conducted using the PubMed/MEDLINE and Google Scholar databases.</p><p><strong>Discussion: </strong>Twenty-one publications comprising 2,454 cases were analyzed to classify Henle trunk configurations and tributary patterns. The trunk was identified in 92.5% of the cases, with the gastropancreatocolic (GPC) type being the most prevalent (73.1%). A total of 38 unique venous confluences were recorded, highlighting the considerable anatomical complexity and variability of the trunk. The Henle gastrocolic trunk is a common anatomical structure with significant heterogeneity in its venous configurations. The GPC type, most frequently formed by the confluence of the right gastroepiploic vein, the anterior superior pancreaticoduodenal vein, and either the right colic vein or the superior right colic vein, predominates across cadaveric, intraoperative, and imaging studies. Understanding this variability is crucial for ensuring safe dissection during pancreatic and colorectal resections.</p><p><strong>Conclusion: </strong>Comprehensive knowledge of the Henle trunk anatomy and its variations enhances operative planning, minimizes the risk of vascular injury, and supports safer and more efficient minimally invasive abdominal surgery.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"60-71"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgios Paraskevas, Christos Lyrtzis, Georgios Trikoilis, Alexia Maistrellis, Maria Piagkou
{"title":"A Rare Cadaveric Case Report of the Median Nerve Passing Through the Brachialis Muscle.","authors":"Georgios Paraskevas, Christos Lyrtzis, Georgios Trikoilis, Alexia Maistrellis, Maria Piagkou","doi":"10.5644/ama2006-124.503","DOIUrl":"10.5644/ama2006-124.503","url":null,"abstract":"<p><strong>Objective: </strong>To describe a rare cadaveric topographical variation of the median nerve (MN) involving an atypical relationship with the brachialis muscle (BM). Such variations, although uncommon, may complicate surgical procedures, regional anesthesia, and imaging interpretation. This report documents a variation in which the MN traverses the BM without providing motor innervation.</p><p><strong>Case report: </strong>During the routine dissection of the right upper limb of a 75-year-old male donated cadaver, a unilateral (right-sided) topographical variation of the MN was identified. The MN diverged from its usual close association with the brachial artery (BA) and followed a medial and posterior course toward the BM. Within the middle third of the arm, the nerve penetrated a macroscopically distinct bundle of BM fibers, traversed the muscle belly, and exited in its distal third. Distally, the MN resumed a superficial course, re-approached the BA, and continued normally through the cubital fossa. No motor or accessory branches from the MN to the BM were identified during its intramuscular course. The surrounding muscle fibers closely encircled the nerve along its intramuscular segment, indicating a restricted anatomical corridor. The musculocutaneous nerve, BA, and the remaining neurovascular structures followed their typical anatomical pathways.</p><p><strong>Conclusion: </strong>This anatomical configuration may represent a potential anatomical substrate for proximal MN irritation or compression and may clinically resemble pronator teres syndrome. Awareness of such variants is important for clinicians evaluating MN neuropathies and for surgeons, anesthesiologists, and radiologists working in the anterior compartment of the arm.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"86-91"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cervical Cytology and Age in HPV-Infected Women in North Macedonia: A Cross-Sectional Study.","authors":"Vjollca Shabani, Mije Reçi, Vesna Veselievska Stojkovska","doi":"10.5644/ama2006-124.498","DOIUrl":"10.5644/ama2006-124.498","url":null,"abstract":"<p><strong>Objective: </strong>HPV infection is a key etiological factor in cervical epithelial alterations and neoplasia. Its prevalence and cytological impact vary with age, co-infections, and screening practices. This study investigated the association between HPV infection, age, and cervical cytological findings in women from North Macedonia.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 300 women aged 26-66 years, who were screened over a 13-month period (June 2023-July 2024). The participants were divided into two age groups (26-36 and 37-66 years). All participants underwent Pap testing, HPV screening, and microbiological evaluation. Ordinal regression analysis was used to examine the associations between age, microbial factors, and HPV positivity.</p><p><strong>Results: </strong>HPV prevalence was higher in the 37-66 group (12.33%) than in the 26-36 group (6.0%). However, younger age showed a stronger statistical association with HPV positivity (OR=2.10; P<0.1). Cytological abnormalities, particularly LSIL/CIN I, were more prevalent in HPV-positive participants. The use of conventional Pap smears was associated with lower HPV detection (OR=0.16; P<0.05). Co-infection with Candida spp. and atrophic inflammation were inversely associated with HPV positivity.</p><p><strong>Conclusion: </strong>This study confirmed the association between HPV infection and cytological changes, particularly in younger age groups. These results highlight the importance of age-tailored screening approaches and support the continued use of conventional Pap smears as cost-effective tools. Integrating virological and microbiological assessments may further refine cervical cancer prevention strategies, particularly in transitional healthcare systems across the Western Balkans.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"21-29"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Developmental Trajectories and Outcomes of Online Child Sexual Abuse: A Systematic Review of Longitudinal Studies.","authors":"Krešimir Prijatelj","doi":"10.5644/ama2006-124.500","DOIUrl":"10.5644/ama2006-124.500","url":null,"abstract":"<p><strong>Background: </strong>OCSA includes adult grooming or solicitation and peer electronic sexual coercion. Due to its negative consequences, it has become a public mental health concern. While prevalence is well established, the developmental timing of onset, predictors, and outcomes can only be clarified through longitudinal studies.</p><p><strong>Objective: </strong>This review synthesizes longitudinal evidence on online child sexual abuse (OCSA) in minors, with an emphasis on developmental timing, prospective risk and protective factors, and downstream outcomes.</p><p><strong>Methods: </strong>A systematic review was conducted according to the PRISMA 2020 guidelines. Eligible studies enrolled participants under 18 years of age at baseline, used a longitudinal design, and examined OCSA. Twelve studies were identified through database searches (2000-2025) and citation chasing, all of which were published from 2013 onwards.</p><p><strong>Discussion: </strong>The narrative synthesis identified that the risk for OCSA was concentrated in mid-adolescence. Peer electronic coercion rose through early-mid adolescence and plateaued around the age of 16-17. The cumulative onset reached approximately one in three by age 18. The predictors included depressive symptoms, maltreatment, adverse childhood experiences, and risky digital behaviors. Protective parental monitoring buffered escalation, especially in early adolescence. In terms of consequences, adult solicitation predicted poorer quality of life and emotional distress, whereas peer coercion increased depression and delinquency. Bidirectional feedback loops emerged between adolescent sexting and adult solicitation. A school-based trial demonstrated that even brief prevention efforts can reduce the risk of OCSA.</p><p><strong>Conclusion: </strong>Longitudinal evidence suggests that OCSA follows an age-graded developmental pattern and is associated with potentially modifiable risk and protective factors. Prevention should focus on mid-adolescent hazard windows, minority-sensitive support, family-based monitoring, and digital safety education. The proposed Developmental-Online-Trajectories of Sexual abuse (DOTS) framework integrates these findings to guide future research, practice, and prevention.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"92-109"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danela Relić, Ivica Matić, Livia Puljak, Marta Čivljak
{"title":"Workplace Violence Against Nurses in Croatia: A Cross-Sectional Study on Its Frequency, Impact, and Solutions.","authors":"Danela Relić, Ivica Matić, Livia Puljak, Marta Čivljak","doi":"10.5644/ama2006-124.505","DOIUrl":"10.5644/ama2006-124.505","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the frequency of workplace violence against nurses in Croatia, its psychological consequences, and existing institutional measures to address this issue.</p><p><strong>Materials and methods: </strong>A cross-sectional online survey was conducted among Croatian nurses in October and November 2023 using a convenience sample recruited via a social media platform. The questionnaire included 38 closed-ended questions covering socio-demographic data, experiences of physical, verbal, and sexual violence, and measures implemented to prevent or address workplace violence.</p><p><strong>Results: </strong>A total of 318 nurses participated in the study. Most participants (70%) reported experiencing some form of workplace violence in the past 12 months. Verbal violence was most frequent (66%), followed by physical (21%) and sexual violence (13%). Patients were the most common perpetrators of physical violence (84%), followed by relatives and healthcare staff. No statistically significant differences were found between the reporting of violent incidents and the level of nurses' education, nor between the intensity of psychological consequences and years of nurses' work experience. Nearly half of the participants (48%) stated that no formal measures existed in their workplace to prevent or respond to violence.</p><p><strong>Conclusion: </strong>Among nurses participating in this study, workplace violence was frequently reported, while work experience was not associated with psychological consequences. The findings indicate that workplace violence remains a relevant issue and may inform future efforts to improve preventive measures in healthcare settings.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"39-59"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maja Ban, Toni Ćosić, Irena Canjuga, Ivica Matić, Vesna Mijoč
{"title":"Criterion Validity of the Yale Physical Activity Survey (YPAS) in Croatian Older Adults.","authors":"Maja Ban, Toni Ćosić, Irena Canjuga, Ivica Matić, Vesna Mijoč","doi":"10.5644/ama2006-124.504","DOIUrl":"10.5644/ama2006-124.504","url":null,"abstract":"<p><strong>Objective: </strong>The Yale Physical Activity Survey (YPAS) is one of the most commonly used questionnaires to assess physical activity (PA) levels in older adults. Although previous studies have explored its validity properties against accelerometry, to date, no evidence has been provided in Croatian older adults. Therefore, the primary purpose of this study was to examine whether the YPAS is a valid tool for measuring PA levels.</p><p><strong>Materials and methods: </strong>A total of 46 older women (mean age 72.3±1.2 years) were recruited from three randomly selected public residential aged-care facilities. During the first stage, all participants wore a triaxial GENEActiv accelerometer on their non-dominant hand for 7 consecutive days. After the wearing period, the participants completed the YPAS questionnaire. The correlations between the YPAS and GENEActiv data were calculated using Spearman's order-rank coefficients.</p><p><strong>Results: </strong>The YPAS total PA was positively and moderately correlated with the number of steps, light and moderate PA, and moderate-to-vigorous PA (MVPA; ρ=0.48-0.64), yet a low positive correlation was found with vigorous PA (ρ=0.33). The YPAS total energy expenditure (EE) and the number of stairs performance showed similar correlation patterns with GENEActiv accelerometry data as the total PA (ρ=0.33-0.64). The summary index score exhibited moderate and positive correlations with the number of steps, light, moderate, and vigorous PA and MVPA (ρ=0.28-0.49).</p><p><strong>Conclusion: </strong>This study shows that the YPAS is a valid tool for assessing PA patterns in older Croatian adults.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"30-38"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pejana Rastović, Marko Pavlović, Josip Kvesić, Ana Džidić Bevanda, Maja Pandža Topić
{"title":"Sociodemographic Characteristics of Patients with Schizophrenia: A Comparative Study with Healthy Controls.","authors":"Pejana Rastović, Marko Pavlović, Josip Kvesić, Ana Džidić Bevanda, Maja Pandža Topić","doi":"10.5644/ama2006-124.499","DOIUrl":"10.5644/ama2006-124.499","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess selected sociodemographic characteristics of patients with schizophrenia and compare them with those of a healthy control group, as well as within the group of patients with schizophrenia.</p><p><strong>Patients and methods: </strong>A retrospective observational study was conducted involving 400 patients with schizophrenia and 200 healthy controls from the Herzegovina-Neretva Canton. The diagnosis of schizophrenia was made according to ICD-10 criteria, and sociodemographic data were obtained through structured interviews.</p><p><strong>Results: </strong>Individuals with schizophrenia are more likely to be older, less educated, unemployed, single, and smokers compared to healthy controls. Among patients with schizophrenia, analyses controlling for age showed that gender was significantly associated with both age of onset and duration of illness, with significant gender-by-age interactions. Marital status was significantly related to age at onset and demonstrated a significant interaction with age in relation to illness duration. Education level was associated with age at onset but not with illness duration. No significant differences in illness onset were found across employment groups.</p><p><strong>Conclusion: </strong>Sociodemographic characteristics are closely associated with key clinical features of schizophrenia, including age at onset and illness duration. These findings highlight the importance of considering gender, marital status, and educational background when interpreting illness trajectories. The results further underscore the need for early intervention strategies, psychoeducation, and integrated social and healthcare support aimed at improving functional outcomes and quality of life for individuals with schizophrenia and their caregivers.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"10-20"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Appendiceal Neuroendocrine Tumors in Children and Adolescents.","authors":"Jelena Roganovic, Luisa Santoro, Calogero Virgone","doi":"10.5644/ama2006-124.496","DOIUrl":"10.5644/ama2006-124.496","url":null,"abstract":"<p><strong>Objective: </strong>To synthesize current evidence on the diagnosis, histopathological evaluation, clinical features, management, and follow-up of appendiceal neuroendocrine tumors (aNETs) in children and adolescents, and to outline key differences from their adult counterparts.</p><p><strong>Background: </strong>Pediatric aNETs are rare gastrointestinal neoplasms that typically exhibit an indolent clinical course with minimal risk of recurrence or metastasis. Their biological and prognostic features differ from those in adults, limiting the applicability of adult-derived guidelines in children.</p><p><strong>Methods: </strong>A mini review of the current literature was conducted, focusing on epidemiology, clinical presentation, diagnostic workup, key pathological features, surgical management, and follow- up strategies for pediatric aNETs.</p><p><strong>Discussion: </strong>Contemporary evidence supports a de-escalated, risk-adapted approach to management, with simple appendectomy being curative in most cases. Multidisciplinary Team (MDT) discussion remains critical for atypical or borderline cases requiring individualized decision-making. Differences from adult aNETs highlight the need for pediatric-specific clinical decision-making.</p><p><strong>Conclusion: </strong>Early recognition, accurate histopathologic evaluation, and tailored surgical management are essential to optimize outcomes for children and adolescents with aNETs.</p>","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"72-76"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}