Acta medica academica最新文献_第6页

Influence of Minimal Residual Disease at Day 15 of Induction Therapy on Survival of Children with Acute Lymphoblastic Leukemia 诱导治疗第 15 天时的最小残留病灶对急性淋巴细胞白血病患儿存活率的影响

Acta medica academica Pub Date : 2024-02-01 DOI: 10.5644/ama2006-124.427

Jelica Samardžić-Predojević, Biljana Đurđević-Banjac, Dragana Malcic-Zanic

{"title":"Influence of Minimal Residual Disease at Day 15 of Induction Therapy on Survival of Children with Acute Lymphoblastic Leukemia","authors":"Jelica Samardžić-Predojević, Biljana Đurđević-Banjac, Dragana Malcic-Zanic","doi":"10.5644/ama2006-124.427","DOIUrl":"https://doi.org/10.5644/ama2006-124.427","url":null,"abstract":"Objective. The aim of the study was to evaluate the impact of minimal residual disease (MRD) on day 15 of induction therapy (d15) on the treatment outcome in children with acute lymphoblastic leukemia (ALL). \u0000Materials and Methods. The study included 74 patients (1-18 years) with ALL, who were treated at the Pediatric Clinic of the University Clinical Center Banja Luka from January 2011 to May 2021. All patients were treated according to ALL IC-BFM 2009 protocol. MRD on bone mar- row was assessed d15, using the multiparameter flow cytometry method (FCM). \u0000Results. Of all, 59.46% of patients had MRD d15 0.1−10%, MRD<0.1% had 18.92% of patients, and 21.62% had MRD >10%. Patients with the lowest MRD had the highest 5-year overall survival (OS) and event-free survival (89.5% and 91% respectively) and the lowest cumulative risk for relapse or death (9.7% and 8.1%), in contrast to patients with MRD>10% in whom OS was 80.0%, and the risk of recurrence is 20%. Predicted MRD d15 was significantly associated with prednisone response assessed in the peripheral blood on day 8 (P<0.001) and statistically significantly positive correlation (r=0.498; P<0.001) was found. \u0000Conclusion. MRD measurement d15 has a great prognostic significance for patients in the standard and high risk groups, but not for patients in the intermediate risk group. The introduction of additional testing is necessary for better identification of patients with an increased risk of disease recurrence.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"2017 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139879095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Minimal Residual Disease at Day 15 of Induction Therapy on Survival of Children with Acute Lymphoblastic Leukemia 诱导治疗第 15 天时的最小残留病灶对急性淋巴细胞白血病患儿存活率的影响

Acta medica academica Pub Date : 2024-02-01 DOI: 10.5644/ama2006-124.427

Jelica Samardžić-Predojević, Biljana Đurđević-Banjac, Dragana Malcic-Zanic

{"title":"Influence of Minimal Residual Disease at Day 15 of Induction Therapy on Survival of Children with Acute Lymphoblastic Leukemia","authors":"Jelica Samardžić-Predojević, Biljana Đurđević-Banjac, Dragana Malcic-Zanic","doi":"10.5644/ama2006-124.427","DOIUrl":"https://doi.org/10.5644/ama2006-124.427","url":null,"abstract":"Objective. The aim of the study was to evaluate the impact of minimal residual disease (MRD) on day 15 of induction therapy (d15) on the treatment outcome in children with acute lymphoblastic leukemia (ALL). \u0000Materials and Methods. The study included 74 patients (1-18 years) with ALL, who were treated at the Pediatric Clinic of the University Clinical Center Banja Luka from January 2011 to May 2021. All patients were treated according to ALL IC-BFM 2009 protocol. MRD on bone mar- row was assessed d15, using the multiparameter flow cytometry method (FCM). \u0000Results. Of all, 59.46% of patients had MRD d15 0.1−10%, MRD<0.1% had 18.92% of patients, and 21.62% had MRD >10%. Patients with the lowest MRD had the highest 5-year overall survival (OS) and event-free survival (89.5% and 91% respectively) and the lowest cumulative risk for relapse or death (9.7% and 8.1%), in contrast to patients with MRD>10% in whom OS was 80.0%, and the risk of recurrence is 20%. Predicted MRD d15 was significantly associated with prednisone response assessed in the peripheral blood on day 8 (P<0.001) and statistically significantly positive correlation (r=0.498; P<0.001) was found. \u0000Conclusion. MRD measurement d15 has a great prognostic significance for patients in the standard and high risk groups, but not for patients in the intermediate risk group. The introduction of additional testing is necessary for better identification of patients with an increased risk of disease recurrence.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"156 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139819336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Animal Model of Cisplatin-Induced Oral Mucositis: Dose Optimization 顺铂诱发口腔黏膜炎的动物模型：剂量优化

Acta medica academica Pub Date : 2024-01-19 DOI: 10.5644/ama2006-124.422

Oke Kadarullah, D. Tamtomo, Brian Wasita, Made Setiamika

{"title":"Animal Model of Cisplatin-Induced Oral Mucositis: Dose Optimization","authors":"Oke Kadarullah, D. Tamtomo, Brian Wasita, Made Setiamika","doi":"10.5644/ama2006-124.422","DOIUrl":"https://doi.org/10.5644/ama2006-124.422","url":null,"abstract":"Objective. The present study aimed to develop and validate an animal model of chemotherapy-induced oral mucositis due to cisplatin administration. \u0000Materials and Methods. Oral mucositis was induced in Wistar rats by cisplatin. Twenty healthy male Wistar rats were divided into four groups: a control group, and cisplatin 3 mg/kgBW (D1), cisplatin 5 mg/kgBW (D2), and cis- platin 6 mg/kgBW groups (D3). The D1, D2, and D3 groups received the cisplatin intraperitoneally on days 1, 3, and 5, whereas the control group did not receive anything. On day 7 and day 14 the entire experiment was terminated in all groups and the changes in body weight, oral mucositis grades, and histopathological scores were evaluated. \u0000Results. Cisplatin administration created a strong oral mucositis effect on groups D2 and D3. All the cisplatin doses decreased the rats’ body weight by day 14. The worst oral mucositis grades and histopathological scores resulted from the administration of cisplatin at a dose of 5 mg/kgBW. \u0000Conclusions. In conclusion the cisplatin 5 mg/kgBW administered on days 1, 3, and 5 by intraperitoneal administration was the optimum dose to induce oral mucositis.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"49 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139611910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Correlation between Resistance to Diazepam and Expression of Inflammatory Markers in The Peripheral Blood of Patients with Status of Epilepticus 地西泮抗药性与癫痫状态患者外周血中炎症标志物表达的相关性研究

Acta medica academica Pub Date : 2024-01-17 DOI: 10.5644/ama2006-124.423

C. N. Mahama, M. Louisa, F. Octaviana, D. Suryandari, A. Budikayanti, Heri Wibowo

{"title":"Investigation of Correlation between Resistance to Diazepam and Expression of Inflammatory Markers in The Peripheral Blood of Patients with Status of Epilepticus","authors":"C. N. Mahama, M. Louisa, F. Octaviana, D. Suryandari, A. Budikayanti, Heri Wibowo","doi":"10.5644/ama2006-124.423","DOIUrl":"https://doi.org/10.5644/ama2006-124.423","url":null,"abstract":"Objective. This study investigated several inflammatory markers’ gene and protein expression in status epilepticus (SE) and their correlation with diazepam resistance. \u0000Materials and Methods. Peripheral blood samples were collected from 18 adult patients with SE in Cipto Mangunkusumo Central Hospital, consisting of 12 diazepam-responsive and six diazepam-resistant samples, within 72 hours of the onset of the seizure. We collected baseline demographic and clinical data from each subject. Peripheral blood mononuclear cells (PBMCs) were isolated, cultured, stimulated with lipopolysaccharide (LPS) 1 mg/ml, and harvested for RNA isolation. The RNA was used to determine the expression of Human Mobility Group Box 1 (HMGB1), Inter- leukin-6 (IL-6), IL-10, Toll-like Receptor 4 (TLR4), and Glial fibrillary acidic protein (GFAP). In addition, we performed serum protein assay of HMGB1, IL-6, IL-10, TLR4, and GFAP to compare with gene expression. \u0000Results. We found a significant differ- ence between the responsive and resistant groups for serum HMGB1 and IL-6 concentration. The mRNA expression of HMGB1 and IL-6 was significantly higher in LPS-stimulated samples in the responsive but not in the resistant groups. The ratio of IL-6 to IL-10 showed a significant difference between LPS and control in the responsive group. Diazepam response was significantly correlated with seizure duration and serum protein concentration of HMGB1. \u0000Conclusion. HMGB1 was highly expressed in the resistant group and strongly correlated with diazepam response, and there was a significant increase in HMGB1 mRNA expres- sion in response to LPS stimulation. These findings suggest that targeting HMGB1 may be a promising therapeutic strategy and that HMGB1 levels could be a valuable biomarker for predicting diazepam resistance in SE.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"115 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139616229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relative Role of Family Affluence and Social Support on Depression and Selfesteem among Adolescents in Nigeria: a Cross-sectional Study 家庭富裕程度和社会支持对尼日利亚青少年抑郁和自尊的相对作用：一项横断面研究

Acta medica academica Pub Date : 2024-01-15 DOI: 10.5644/ama2006-124.421

B. Edet, Emmanuel Essien, F. Eleazu, Roger Abang, Emmanuel Ochijele, Faithful Daniel

{"title":"The Relative Role of Family Affluence and Social Support on Depression and Selfesteem among Adolescents in Nigeria: a Cross-sectional Study","authors":"B. Edet, Emmanuel Essien, F. Eleazu, Roger Abang, Emmanuel Ochijele, Faithful Daniel","doi":"10.5644/ama2006-124.421","DOIUrl":"https://doi.org/10.5644/ama2006-124.421","url":null,"abstract":"Objectives. To assess the relative importance of social support and family affluence in depression and self-esteem among ado- lescents in Calabar, Nigeria. \u0000Methods. This cross-sectional study was conducted among adolescent students in Calabar, Nigeria. Using stratified random sampling, 332 students were selected for participation. The Family Affluence Scale (FAS), Oslo Social Support Scale (OSS), Becks Depression Inventory (BDI) and Rosenberg Self-Esteem Inventory (RSES) were administered. To facilitate comparisons, the sample was divided into four groups: those with low OSS and low FAS scores, those with low OSS and high FAS scores, those with high OSS and low FAS scores, and those with high scores in both OSS and FAS. Groups were com- pared using the Kruskal-Wallis Test. Linear regression analysis was conducted to determine the predictors of depression and self-esteem. All analyses were performed using IBM SPSS version 21. \u0000Results. Respondents with low levels of social support, irrespective of family affluence, had significantly higher depression scores and significantly lower self-esteem scores (P< 0.05). In linear regression analyses, social support (95%CI [-1.35,-0.58]) and female gender (95%CI [1.49,5.29]) emerged as predic- tors of depression, while social support (95%CI [0.25,0.64]) and age (95%CI [-0.79,-0.11]) emerged as predictors of self-esteem. Affluence did not predict depression or self-esteem. \u0000Conclusions. Social support is of greater relative importance in depression and self-esteem in our study. In developing nations with lean resources, enhanced social support might buffer against the effect of low socio-economic status on mental health.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139622011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Hyoid Bone - the Anatomy of a Small Bone of the Neck in Hellenic and GrecoRoman Medical Literature 舌骨--希腊和古希腊罗马医学文献中的颈部小骨解剖学

Acta medica academica Pub Date : 2023-12-27 DOI: 10.5644/ama2006-124.419

Maria Rachi, George Dagres, Panagiotis Georgakopoulos, Evaggelos Mavrommatis

引用次数: 0

The Effects of Helichrysum italicum Extract on the Extracellular Matrix of the Skin. 腊菊提取物对皮肤细胞外基质的影响

Acta medica academica Pub Date : 2023-12-01 DOI: 10.5644/ama2006-124.425

Erkin Pekmezci, Murat Türkoğlu

{"title":"The Effects of Helichrysum italicum Extract on the Extracellular Matrix of the Skin.","authors":"Erkin Pekmezci, Murat Türkoğlu","doi":"10.5644/ama2006-124.425","DOIUrl":"10.5644/ama2006-124.425","url":null,"abstract":"Objective: An in-vitro study was performed to investigate the molecular basis of the wound healing and skin protective features of Helichrysum italicum (HI), a medicinal plant from the Mediterranean basin.Materials and methods: A dermal fibroblast cell line culture was treated with HI hydro-alcoholic extract to detect the gene expression levels of three selected primers: FGF-2, HAS-2 and MMP-9. Cell proliferation assay was performed using a XTT reagent. RNA isolations were carried out from both the extract treated study cell group and the control cell group using a TRI reagent. GAPDH was used as the reference gene. Gene expressions were determined by real time RT-qPCR. The results were represented as 'Target/GAPDH Fold Change'. Statistical evaluation was performed by Student's t test.Results: HI extract caused statistically significant upregulation of FGF-2 (P=0.0473) and HAS-2 (P=0.0335) gene expressions compared to the untreated control cells. The treatment ended with 1.74 and 3.10 fold changes for FGF-2 and HAS-2, respectively.Conclusion: In general, it may be considered that HI has certain anabolic effects on the extracellular matrix of the skin because of the significant increases it causes in FGF-2 and HAS-2. Therefore, it may have a promising future in anti-aging studies and cosmetic dermatology. The results obtained in this study may also partially explain the molecular basis of the health benefits of HI on skin, including improvement in wound healing, and protection against the detrimental effects of ultraviolet exposure.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 3","pages":"182-187"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparison of Cathelicidin Levels in the Skin of Leprosy Patients and Their Household Contacts. 麻风病人及其家庭接触者皮肤中猫嗜血杆菌素水平的比较。

Acta medica academica Pub Date : 2023-12-01 DOI: 10.5644/ama2006-124.424

Fifa Argentina, Oki Suwarsa, Hendra Gunawan, Afiat Berbudi

引用次数: 0

Toxic Cardiomyopathy in a Young Patient Treated for Her2-Positive Early Breast Cancer: Case Report and Literature Review. 一名接受 Her2 阳性早期乳腺癌治疗的年轻患者的中毒性心肌病：病例报告和文献综述。

Acta medica academica Pub Date : 2023-12-01 DOI: 10.5644/ama2006-124.417

Amina Hadžibeganović, Dijana Koprić

{"title":"Toxic Cardiomyopathy in a Young Patient Treated for Her2-Positive Early Breast Cancer: Case Report and Literature Review.","authors":"Amina Hadžibeganović, Dijana Koprić","doi":"10.5644/ama2006-124.417","DOIUrl":"10.5644/ama2006-124.417","url":null,"abstract":"Objective: We present the case of toxic cardiomyopathy in a healthy thirty-eight-year-old female patient treated for Her2-positive early breast cancer.Case report: During the neoadjuvant treatment, the patient received four cycles of AC regimen and four cycles of docetaxel in combination with trastuzumab biosimilar. Two days after she received the ninth dose of trastuzumab biosimilar, she reported feebleness, palpitation, and dyspnoea. A heart ultrasound was performed and was normal without changes in the ejection fraction (EF) compared to previous checks. Three days later she reports worsening of her symptoms that were highly suggestive of heart failure. A cardiologist was consulted who insisted that the patient's symptoms were the consequence of the disease progression. A CT scan showed signs of heart failure. A heart ultrasound was done and the EF dropped to 30%. Drainage of the right pleural cavity was performed and pharmacotherapy for heart failure was started. The treatment led to clinical improvement, but eighteen months later EF is still not back to normal.Conclusion: This is a rare case of toxic cardiomyopathy in a young, previously healthy, patient who received anthracyclines followed by trastuzumab biosimilar in combination with taxanes. All the medications this patient received are potentially cardiotoxic. However, the overall presentation is not typical for any of these medications since the patient presented with symptoms and signs of heart failure with significant dilatation of the right atrium, which persists eighteen months after its onset, with only a small increase in the EF. There is also a possibility that the antineoplastic therapy the patient received only facilitated dilatative cardiomyopathy, while the main causative factor was intrinsic or extrinsic.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"225-230"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138795620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience. 遗传性血栓性疾病与癌症患儿血栓形成的风险：单中心经验。

Acta medica academica Pub Date : 2023-12-01 DOI: 10.5644/ama2006-124.430

Ana Đordević, Blaženka Grahovac, Silvije Šegulja, Lidija Bilić Zulle, Jelena Roganović

{"title":"Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience.","authors":"Ana Đordević, Blaženka Grahovac, Silvije Šegulja, Lidija Bilić Zulle, Jelena Roganović","doi":"10.5644/ama2006-124.430","DOIUrl":"10.5644/ama2006-124.430","url":null,"abstract":"Objectives: Thrombosis is an increasingly recognized complication of childhood malignancy and its treatment. The incidence and etiology of pediatric cancer-related thrombosis is still not well understood. The aim of this study was to evaluate the prevalence of common prothrombotic genetic conditions in children with cancer, the frequency of thrombosis, and the role of inherited thrombophilia in the development of thrombosis in a pediatric oncology population.Patients and methods: Forty-seven children (36 treated for hematological malignancies and 11 for solid tumors) with a median age of 8.8. years (range 0.4 - 19.3 years) were included in the study. Genetic polymorphisms of Factor V Leiden (G1691A), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T were determined by real-time polymerase chain reaction-based DNA analysis.Results: Four (8.5%) patients were heterozygous for Factor V Leiden, 3 (6.4%) were heterozygous for prothrombin G20210A mutation, and 3 (6.4%) were homozygous for MTHFR C677T mutation. All patients had implanted central venous catheters. Four (8.5%) children had documented thrombosis, three of which were in the upper venous system. Two of the four patients with thrombosis had Factor V Leiden heterozygosity.Conclusions: Thrombosis is an important complication of childhood cancer. The risk of thrombosis may be increased in patients with Factor V Leiden. In the absence of consensus guidelines, our results support the recommendation for thrombophilia screening in children with cancer.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 3","pages":"161-168"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0