Acta medica academica最新文献_第5页

Influence of Minimal Residual Disease at Day 15 of Induction Therapy on Survival of Children with Acute Lymphoblastic Leukemia 诱导治疗第 15 天时的最小残留病灶对急性淋巴细胞白血病患儿存活率的影响

Acta medica academica Pub Date : 2024-02-01 DOI: 10.5644/ama2006-124.427

Jelica Samardžić-Predojević, Biljana Đurđević-Banjac, Dragana Malcic-Zanic

{"title":"Influence of Minimal Residual Disease at Day 15 of Induction Therapy on Survival of Children with Acute Lymphoblastic Leukemia","authors":"Jelica Samardžić-Predojević, Biljana Đurđević-Banjac, Dragana Malcic-Zanic","doi":"10.5644/ama2006-124.427","DOIUrl":"https://doi.org/10.5644/ama2006-124.427","url":null,"abstract":"Objective. The aim of the study was to evaluate the impact of minimal residual disease (MRD) on day 15 of induction therapy (d15) on the treatment outcome in children with acute lymphoblastic leukemia (ALL). \u0000Materials and Methods. The study included 74 patients (1-18 years) with ALL, who were treated at the Pediatric Clinic of the University Clinical Center Banja Luka from January 2011 to May 2021. All patients were treated according to ALL IC-BFM 2009 protocol. MRD on bone mar- row was assessed d15, using the multiparameter flow cytometry method (FCM). \u0000Results. Of all, 59.46% of patients had MRD d15 0.1−10%, MRD<0.1% had 18.92% of patients, and 21.62% had MRD >10%. Patients with the lowest MRD had the highest 5-year overall survival (OS) and event-free survival (89.5% and 91% respectively) and the lowest cumulative risk for relapse or death (9.7% and 8.1%), in contrast to patients with MRD>10% in whom OS was 80.0%, and the risk of recurrence is 20%. Predicted MRD d15 was significantly associated with prednisone response assessed in the peripheral blood on day 8 (P<0.001) and statistically significantly positive correlation (r=0.498; P<0.001) was found. \u0000Conclusion. MRD measurement d15 has a great prognostic significance for patients in the standard and high risk groups, but not for patients in the intermediate risk group. The introduction of additional testing is necessary for better identification of patients with an increased risk of disease recurrence.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"2017 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139879095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Minimal Residual Disease at Day 15 of Induction Therapy on Survival of Children with Acute Lymphoblastic Leukemia 诱导治疗第 15 天时的最小残留病灶对急性淋巴细胞白血病患儿存活率的影响

Acta medica academica Pub Date : 2024-02-01 DOI: 10.5644/ama2006-124.427

Jelica Samardžić-Predojević, Biljana Đurđević-Banjac, Dragana Malcic-Zanic

{"title":"Influence of Minimal Residual Disease at Day 15 of Induction Therapy on Survival of Children with Acute Lymphoblastic Leukemia","authors":"Jelica Samardžić-Predojević, Biljana Đurđević-Banjac, Dragana Malcic-Zanic","doi":"10.5644/ama2006-124.427","DOIUrl":"https://doi.org/10.5644/ama2006-124.427","url":null,"abstract":"Objective. The aim of the study was to evaluate the impact of minimal residual disease (MRD) on day 15 of induction therapy (d15) on the treatment outcome in children with acute lymphoblastic leukemia (ALL). \u0000Materials and Methods. The study included 74 patients (1-18 years) with ALL, who were treated at the Pediatric Clinic of the University Clinical Center Banja Luka from January 2011 to May 2021. All patients were treated according to ALL IC-BFM 2009 protocol. MRD on bone mar- row was assessed d15, using the multiparameter flow cytometry method (FCM). \u0000Results. Of all, 59.46% of patients had MRD d15 0.1−10%, MRD<0.1% had 18.92% of patients, and 21.62% had MRD >10%. Patients with the lowest MRD had the highest 5-year overall survival (OS) and event-free survival (89.5% and 91% respectively) and the lowest cumulative risk for relapse or death (9.7% and 8.1%), in contrast to patients with MRD>10% in whom OS was 80.0%, and the risk of recurrence is 20%. Predicted MRD d15 was significantly associated with prednisone response assessed in the peripheral blood on day 8 (P<0.001) and statistically significantly positive correlation (r=0.498; P<0.001) was found. \u0000Conclusion. MRD measurement d15 has a great prognostic significance for patients in the standard and high risk groups, but not for patients in the intermediate risk group. The introduction of additional testing is necessary for better identification of patients with an increased risk of disease recurrence.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"156 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139819336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Animal Model of Cisplatin-Induced Oral Mucositis: Dose Optimization 顺铂诱发口腔黏膜炎的动物模型：剂量优化

Acta medica academica Pub Date : 2024-01-19 DOI: 10.5644/ama2006-124.422

Oke Kadarullah, D. Tamtomo, Brian Wasita, Made Setiamika

{"title":"Animal Model of Cisplatin-Induced Oral Mucositis: Dose Optimization","authors":"Oke Kadarullah, D. Tamtomo, Brian Wasita, Made Setiamika","doi":"10.5644/ama2006-124.422","DOIUrl":"https://doi.org/10.5644/ama2006-124.422","url":null,"abstract":"Objective. The present study aimed to develop and validate an animal model of chemotherapy-induced oral mucositis due to cisplatin administration. \u0000Materials and Methods. Oral mucositis was induced in Wistar rats by cisplatin. Twenty healthy male Wistar rats were divided into four groups: a control group, and cisplatin 3 mg/kgBW (D1), cisplatin 5 mg/kgBW (D2), and cis- platin 6 mg/kgBW groups (D3). The D1, D2, and D3 groups received the cisplatin intraperitoneally on days 1, 3, and 5, whereas the control group did not receive anything. On day 7 and day 14 the entire experiment was terminated in all groups and the changes in body weight, oral mucositis grades, and histopathological scores were evaluated. \u0000Results. Cisplatin administration created a strong oral mucositis effect on groups D2 and D3. All the cisplatin doses decreased the rats’ body weight by day 14. The worst oral mucositis grades and histopathological scores resulted from the administration of cisplatin at a dose of 5 mg/kgBW. \u0000Conclusions. In conclusion the cisplatin 5 mg/kgBW administered on days 1, 3, and 5 by intraperitoneal administration was the optimum dose to induce oral mucositis.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"49 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139611910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relative Role of Family Affluence and Social Support on Depression and Selfesteem among Adolescents in Nigeria: a Cross-sectional Study 家庭富裕程度和社会支持对尼日利亚青少年抑郁和自尊的相对作用：一项横断面研究

Acta medica academica Pub Date : 2024-01-15 DOI: 10.5644/ama2006-124.421

B. Edet, Emmanuel Essien, F. Eleazu, Roger Abang, Emmanuel Ochijele, Faithful Daniel

{"title":"The Relative Role of Family Affluence and Social Support on Depression and Selfesteem among Adolescents in Nigeria: a Cross-sectional Study","authors":"B. Edet, Emmanuel Essien, F. Eleazu, Roger Abang, Emmanuel Ochijele, Faithful Daniel","doi":"10.5644/ama2006-124.421","DOIUrl":"https://doi.org/10.5644/ama2006-124.421","url":null,"abstract":"Objectives. To assess the relative importance of social support and family affluence in depression and self-esteem among ado- lescents in Calabar, Nigeria. \u0000Methods. This cross-sectional study was conducted among adolescent students in Calabar, Nigeria. Using stratified random sampling, 332 students were selected for participation. The Family Affluence Scale (FAS), Oslo Social Support Scale (OSS), Becks Depression Inventory (BDI) and Rosenberg Self-Esteem Inventory (RSES) were administered. To facilitate comparisons, the sample was divided into four groups: those with low OSS and low FAS scores, those with low OSS and high FAS scores, those with high OSS and low FAS scores, and those with high scores in both OSS and FAS. Groups were com- pared using the Kruskal-Wallis Test. Linear regression analysis was conducted to determine the predictors of depression and self-esteem. All analyses were performed using IBM SPSS version 21. \u0000Results. Respondents with low levels of social support, irrespective of family affluence, had significantly higher depression scores and significantly lower self-esteem scores (P< 0.05). In linear regression analyses, social support (95%CI [-1.35,-0.58]) and female gender (95%CI [1.49,5.29]) emerged as predic- tors of depression, while social support (95%CI [0.25,0.64]) and age (95%CI [-0.79,-0.11]) emerged as predictors of self-esteem. Affluence did not predict depression or self-esteem. \u0000Conclusions. Social support is of greater relative importance in depression and self-esteem in our study. In developing nations with lean resources, enhanced social support might buffer against the effect of low socio-economic status on mental health.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139622011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic Cardiomyopathy in a Young Patient Treated for Her2-Positive Early Breast Cancer: Case Report and Literature Review. 一名接受 Her2 阳性早期乳腺癌治疗的年轻患者的中毒性心肌病：病例报告和文献综述。

Acta medica academica Pub Date : 2023-12-01 DOI: 10.5644/ama2006-124.417

Amina Hadžibeganović, Dijana Koprić

{"title":"Toxic Cardiomyopathy in a Young Patient Treated for Her2-Positive Early Breast Cancer: Case Report and Literature Review.","authors":"Amina Hadžibeganović, Dijana Koprić","doi":"10.5644/ama2006-124.417","DOIUrl":"10.5644/ama2006-124.417","url":null,"abstract":"Objective: We present the case of toxic cardiomyopathy in a healthy thirty-eight-year-old female patient treated for Her2-positive early breast cancer.Case report: During the neoadjuvant treatment, the patient received four cycles of AC regimen and four cycles of docetaxel in combination with trastuzumab biosimilar. Two days after she received the ninth dose of trastuzumab biosimilar, she reported feebleness, palpitation, and dyspnoea. A heart ultrasound was performed and was normal without changes in the ejection fraction (EF) compared to previous checks. Three days later she reports worsening of her symptoms that were highly suggestive of heart failure. A cardiologist was consulted who insisted that the patient's symptoms were the consequence of the disease progression. A CT scan showed signs of heart failure. A heart ultrasound was done and the EF dropped to 30%. Drainage of the right pleural cavity was performed and pharmacotherapy for heart failure was started. The treatment led to clinical improvement, but eighteen months later EF is still not back to normal.Conclusion: This is a rare case of toxic cardiomyopathy in a young, previously healthy, patient who received anthracyclines followed by trastuzumab biosimilar in combination with taxanes. All the medications this patient received are potentially cardiotoxic. However, the overall presentation is not typical for any of these medications since the patient presented with symptoms and signs of heart failure with significant dilatation of the right atrium, which persists eighteen months after its onset, with only a small increase in the EF. There is also a possibility that the antineoplastic therapy the patient received only facilitated dilatative cardiomyopathy, while the main causative factor was intrinsic or extrinsic.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":" ","pages":"225-230"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138795620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience. 遗传性血栓性疾病与癌症患儿血栓形成的风险：单中心经验。

Acta medica academica Pub Date : 2023-12-01 DOI: 10.5644/ama2006-124.430

Ana Đordević, Blaženka Grahovac, Silvije Šegulja, Lidija Bilić Zulle, Jelena Roganović

{"title":"Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience.","authors":"Ana Đordević, Blaženka Grahovac, Silvije Šegulja, Lidija Bilić Zulle, Jelena Roganović","doi":"10.5644/ama2006-124.430","DOIUrl":"10.5644/ama2006-124.430","url":null,"abstract":"Objectives: Thrombosis is an increasingly recognized complication of childhood malignancy and its treatment. The incidence and etiology of pediatric cancer-related thrombosis is still not well understood. The aim of this study was to evaluate the prevalence of common prothrombotic genetic conditions in children with cancer, the frequency of thrombosis, and the role of inherited thrombophilia in the development of thrombosis in a pediatric oncology population.Patients and methods: Forty-seven children (36 treated for hematological malignancies and 11 for solid tumors) with a median age of 8.8. years (range 0.4 - 19.3 years) were included in the study. Genetic polymorphisms of Factor V Leiden (G1691A), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T were determined by real-time polymerase chain reaction-based DNA analysis.Results: Four (8.5%) patients were heterozygous for Factor V Leiden, 3 (6.4%) were heterozygous for prothrombin G20210A mutation, and 3 (6.4%) were homozygous for MTHFR C677T mutation. All patients had implanted central venous catheters. Four (8.5%) children had documented thrombosis, three of which were in the upper venous system. Two of the four patients with thrombosis had Factor V Leiden heterozygosity.Conclusions: Thrombosis is an important complication of childhood cancer. The risk of thrombosis may be increased in patients with Factor V Leiden. In the absence of consensus guidelines, our results support the recommendation for thrombophilia screening in children with cancer.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 3","pages":"161-168"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coccygeal Disc Disease as a Possible Cause of Coccygodynia. 可能导致尾骨痛的尾椎间盘疾病

Acta medica academica Pub Date : 2023-12-01 DOI: 10.5644/ama2006-124.418

Spyridon P Galanakos, Nikolaos D Karakousis, George Bablekos, Sophia Fontara

引用次数: 0

Comparing Endoscopic Measurements of the Anterior and Posterior Ethmoidal Arteries with CT Measurements: A Cadaveric Study. 筛窦前动脉和后动脉的内镜测量与CT测量的比较：尸体解剖研究。

Acta medica academica Pub Date : 2023-08-01 DOI: 10.5644/ama2006-124.410

Rukiye Ozcelik Erdem, Mehmet Akif Dundar, Muzaffer Seker, Hamdi Arbag

{"title":"Comparing Endoscopic Measurements of the Anterior and Posterior Ethmoidal Arteries with CT Measurements: A Cadaveric Study.","authors":"Rukiye Ozcelik Erdem, Mehmet Akif Dundar, Muzaffer Seker, Hamdi Arbag","doi":"10.5644/ama2006-124.410","DOIUrl":"10.5644/ama2006-124.410","url":null,"abstract":"Objective: To reveal the reliability of radiological measurements of the ethmoid arteries.Method: Five fresh frozen cadaveric heads underwent computed tomography and endoscopic sinus surgery. The lateromedial length of the anterior ethmoidal artery (AEA) and its distance to the axilla of the middle turbinate (MTA), the sphenoethmoidal recess (SR) and the posterior ethmoidal artery were measured. The posterior ethmoidal artery (PEA) was referenced to the SR. These anatomical parameters were measured both radiologically and endoscopically, and the compatibility of the two was examined.Results: Ten nasal cavities were dissected. We found that the distance of MTA to the AEA was 16±8 mm in dissection, 21±4 mm radiologically in the sagittal section, the distance of SR to the AEA was 14±3 mm in dissection, 19±4 mm radiologically in the sagittal section, and the distance of the AEA to the PEA was 10±3 mm in dissection, 12±3 mm radiologically in the axial section. The distance of the PEA to SR was 6±3 mm in dissection, 8±2 mm radiologically in the sagittal section.Conclusions: The distance of the AEA to the MTA, the distance of the AEA to the PEA and the distance of the PEA to the SR were compatible with each other in the dissection and in the radiologically evaluation, whereas the distance of the AEA to the SR was not compatible.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 2","pages":"105-111"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71486980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress Response Assessment between First and Second Elective Caesarean Sections by Comparing Cortisol Levels. 通过比较皮质醇水平评估第一次和第二次选择性剖腹产的应激反应。

Acta medica academica Pub Date : 2023-08-01 DOI: 10.5644/ama2006-124.411

Dionysios Galatis, Christos Benekos, Panagiotis-Konstantinos Karachalios, Antonios Strongylos, Foteini Anifantaki, Ioannis Dalivigkas, Argyrios Monastiriotis, Nikolaos Kiriakopoulos

{"title":"Stress Response Assessment between First and Second Elective Caesarean Sections by Comparing Cortisol Levels.","authors":"Dionysios Galatis, Christos Benekos, Panagiotis-Konstantinos Karachalios, Antonios Strongylos, Foteini Anifantaki, Ioannis Dalivigkas, Argyrios Monastiriotis, Nikolaos Kiriakopoulos","doi":"10.5644/ama2006-124.411","DOIUrl":"10.5644/ama2006-124.411","url":null,"abstract":"Objectives. The aim of this study was to compare the stress response produced during elective CS for the first and second time. For that goal, cortisol blood levels before, during and after childbirth were measured. Materials and Methods. We performed this prospective observational study during the period of September 2020 to September 2021. Blood samples were taken from all participants at three different stages. A statistical analysis was performed to compare the CS1 (first elective Caesarean) and CS2 (second elective Caesarean) groups. Results. At every stage, the levels of cortisol were statistically higher in the CS1 group than in the CS2 group. Therefore, CS2 generates a significantly less stressful response than CS1. Between stages, in CS2 cortisol was lowered at a faster rate than in CS1, meaning the stress response initiated was present for a longer time period in the CS1 group. Conclusion. A second elective caesarean section is a safe procedure that does not place an unnecessary burden upon the mother. This is an important fact that practitioners can rely upon while designing the ideal management of a pregnant woman for the stressful environment of birth.","PeriodicalId":38313,"journal":{"name":"Acta medica academica","volume":"52 2","pages":"112-118"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71486984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Erlenmeyer Flask Deformity on Computed Tomography. 计算机断层扫描中的锥形烧瓶变形。

Acta medica academica Pub Date : 2023-08-01 DOI: 10.5644/ama2006-124.415

Chrysovalantis Stylianou, Savas Deftereos

引用次数: 0