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Regulatory and Pathological Roles of CaSR and TRPC in Podocytes CaSR和TRPC在足细胞中的调控和病理作用
Journal of Pharmaceutical Technology, Research and Management Pub Date : 2021-05-07 DOI: 10.15415/jptrm.2021.91002
Gaaminepreet Singh, T. G. Singh
{"title":"Regulatory and Pathological Roles of CaSR and TRPC in Podocytes","authors":"Gaaminepreet Singh, T. G. Singh","doi":"10.15415/jptrm.2021.91002","DOIUrl":"https://doi.org/10.15415/jptrm.2021.91002","url":null,"abstract":"Background: Podocytes, or glomerular visceral epithelial cells, are highly special-ised epithelial cells that cover the glomerular basement membrane’s outer surface. Recent research suggests that podocytes play a signifi-cant role in the physiology and pathology of the glomerulus. The cal- cium-sensing receptor (CaSR) has a variety of roles in maintaining systemic calcium homeostasis, and it is expressed by a variety of cell types, each with its own set of regulatory activities. CaSR activation in podocytes provides prosurvival effects and protects the cell against puromycin aminonucleoside damage, according to new research by Oh and associates. Purpose: Given that CaSR activation has mostly context-dependent cellular implications, further research is needed to determine its specific involvement in podocyte physiology and pathology. Glomerular kidney disease is a significant healthcare burden, and it is thought to be a collection of illnesses for which there is no precise and effective treatment. Conclusion: Excellent scientific and genetic research have identified processes that go wrong in podocytes, the glomerular filter’s regulating cells. Now the challenge is how to des-ignate targets for new, better medicines.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128067218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stiff Person Syndrome Misdiagnosed as Oxaliplatin Induced Neurotoxicity 误诊为奥沙利铂所致神经毒性
Journal of Pharmaceutical Technology, Research and Management Pub Date : 2021-05-07 DOI: 10.15415/jptrm.2021.91001
Shaima K A, M. D., Rooha K, Sarita J
{"title":"Stiff Person Syndrome Misdiagnosed as Oxaliplatin Induced Neurotoxicity","authors":"Shaima K A, M. D., Rooha K, Sarita J","doi":"10.15415/jptrm.2021.91001","DOIUrl":"https://doi.org/10.15415/jptrm.2021.91001","url":null,"abstract":"Introduction: Stiff person syndrome is characterized by muscle rigidity that waxes and wanes along with concurrent spasms. The symptoms of the stiff-person syndrome were identical to those of oxaliplatin side effects. Methods: This was a case report of a 65-year-old man who was diagnosed with stiff-person syndrome. He experienced pain with bleeding from the rectum. Screening tests were used to check foramphiphysin antibodies and electromyography. FNAC was done from the government hospital which was conclusive of metastasis. He was initiated on Capecitabine and Oxaliplatin protocol. Results: During the hospital stay, he was treated with 1gm Methylprednisolone for 5 days and sequentially with immunoglobulin 2gm per day for 5 days, concomitantly Benzodiazepam was given 10mg three times a day for 3 days but later withdrawn as the patient started experiencing dizziness. He achieved no clinical benefit in neurological status. Eventually developed aspiration pneumonia and succumbed to death after one month of diagnosis of SPS. Conclusion: Further studies should carry out to develop an evidence-based approach to diagnosing and treating SPS patients.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128909828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review on the Role of Coconut Oil in Dermatitis Diseases 椰子油在皮炎疾病中的作用研究进展
Journal of Pharmaceutical Technology, Research and Management Pub Date : 2020-11-17 DOI: 10.15415/jptrm.2020.82010
Pavas Sharma, D. Chauhan, S. Bose, Rakesh Kumar, Rajesh Kumar, A. Mittal
{"title":"A Review on the Role of Coconut Oil in Dermatitis Diseases","authors":"Pavas Sharma, D. Chauhan, S. Bose, Rakesh Kumar, Rajesh Kumar, A. Mittal","doi":"10.15415/jptrm.2020.82010","DOIUrl":"https://doi.org/10.15415/jptrm.2020.82010","url":null,"abstract":"Background: Coconut oil, or copra oil is obtained from the nut/kernel of matured coconuts garnered from the Cocosnucifera. Coconut oil is an edible oil derived from the kernels of harvested mature coconuts harvested from the coconut palm. In recent decades, this oil has risen to the status of a health food superstar in the health food industry. Celebrities are welcoming its use, nutritionists are promoting it, and patients are praising it for its many benefits. Purpose: This oil has been linked to a range of health advantages. These include improvements in skin care, hair care, stress management, losing weight & cholesterol level management, immune modulatory effects, cardiovascular applications, and, most recently, Alzheimer’s disease. However, for several years, coconut oil was demonised, and consumers were led to believe that it was harmful to their health because it would clog arteries and cause heart disease. The tide has shifted, and in recent years, increased awareness of the favourable health advantages of coconut oil has emerged. Conclusion: The usage of coconut oil, particularly crude coconut oil, is increasingly popular; however some individuals are still doubtful. This present review makes an attempt to provide a scientific assessment of the medicinal qualities of this oil.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121576001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetic Studies of Curcumin Based Pyrazoline MAO Inhibitors
Journal of Pharmaceutical Technology, Research and Management Pub Date : 2020-11-17 DOI: 10.15415/jptrm.2020.82012
V. N. Badavath, Venkatesan Jayaprakash, S. Mondal, S. Arora, O. Acevedo, A. Thakur, Rajasekhara Reddy Iska
{"title":"Pharmacokinetic Studies of Curcumin Based Pyrazoline MAO Inhibitors","authors":"V. N. Badavath, Venkatesan Jayaprakash, S. Mondal, S. Arora, O. Acevedo, A. Thakur, Rajasekhara Reddy Iska","doi":"10.15415/jptrm.2020.82012","DOIUrl":"https://doi.org/10.15415/jptrm.2020.82012","url":null,"abstract":"Background: Curcumin is a natural phenolic compound obtained from Curcuma longa, with proven human monoamine oxidase (MAO) inhibitory activity, but due to its poor oral bioavailability, blood-brain barrier permeability and extensive metabolism in the liver, it has never been recognized as a drug candidate. Purpose: In this study, the structure-based-drug design (SBDD) was adopted to incorporate the structural features of Curcumin with an aim to improve drug permeability and metabolic stability. Method: A series of ferulic amides (half portion of curcumin) (1-3) and curcumin based pyrazolinescompounds (4-6) were designed and Curcumintested for their membrane permeability and liver microsomal metabolic stability in a various animal in an in-vitro assay system. Conclusion: All the designed compounds showed a significant enhancement in permeability and metabolic stability is achieved through chemical modification.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125136458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein Kinase Structure, Function, and its Binding Sites for Understanding the Role in Anticancer Therapy 蛋白激酶结构、功能及其结合位点在抗癌治疗中的作用
Journal of Pharmaceutical Technology, Research and Management Pub Date : 2020-11-17 DOI: 10.15415/jptrm.2020.82011
Adarsh Sahu
{"title":"Protein Kinase Structure, Function, and its Binding Sites for Understanding the Role in Anticancer Therapy","authors":"Adarsh Sahu","doi":"10.15415/jptrm.2020.82011","DOIUrl":"https://doi.org/10.15415/jptrm.2020.82011","url":null,"abstract":"Background: Protein kinases are involved in regulating different aspects of metabolism including cell growth, differentiation and regulation of cell cycle. Deregulated protein kinases are thought to affect various forms of tumor growth. The advent of protein kinase inhibitors has caused a great shift in the way we treat cancer. Purpose: There were several inhibitors of protein kinases that had been approved by the FDA in the last few decades. Therefore the need of the hour is to know the structure of the protein kinase to design the effective therapy for cancer treatment. Interaction of the drug with the protein is successful if the drug binds to the cavity of the receptor or protein and brings conformational changes, therefore the binding site in the protein should be well understood. Conclusion: Thus in this mini review we have systematically discussed the structure of protein kinase and their binding sites so the future designing of the potential molecules should have better efficacy.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129099517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial Activity of Juglans regia Root Bark Extracts 核桃根皮提取物的抗菌活性研究
Journal of Pharmaceutical Technology, Research and Management Pub Date : 2020-11-17 DOI: 10.15415/jptrm.2020.82007
Aadil Wani, M. Nireekshan Kumar
{"title":"Antimicrobial Activity of Juglans regia Root Bark Extracts","authors":"Aadil Wani, M. Nireekshan Kumar","doi":"10.15415/jptrm.2020.82007","DOIUrl":"https://doi.org/10.15415/jptrm.2020.82007","url":null,"abstract":"Background: Juglans regia tree is widely found in several parts of India, Europe and Central Asia. Different parts of J. regia are rich sources of alkaloids, flavonoids, glycosides, saponins, amino acids, and terpenoids. J. regiais has antiasthmatic, anti-atherosclerotic, antihypertensive, antioxidant, antidiabetic, antimicrobial, cardioprotective, hepatoprotective, hypolipidemic, osteoblastic, and wound healing activities. The bark and roots are used against tooth decay and ringworm infection. Purpose: In the present study we evaluated antibacterial and antifungal activities of J. regia root bark. Methods: Extracts of root bark of J. regia were prepared using methanol, water, and petroleum ether. Methanolic and aqueous extracts in concentrations 50, 100 and 200 mg/ml were tested against three Gram negative bacterial strains (S. typhi, P. vulgaris, and E. coli), one Gram positive strain (S. aureus) and fungi (S. cerevisiae, P. chrysogenum, and A. fumigatus). Results: The extracts effectively inhibited growth of cultured microorganisms. Methanolic extracts showed maximum zone of inhibition (ZOI) for all the microorganisms ranging from 12.8 – 17.0 mm. Aqueous extract disclosed maximum effectiveness against S. typhi. Conclusions: Quantification of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) revealed potent antibacterial activities of methanolic extracts (200 mg/ml) of J. regia root bark.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132441057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Docking Approach to Identify Potential AntiCandidal Potential of Curcumin 分子对接方法鉴定姜黄素潜在的抗药力
Journal of Pharmaceutical Technology, Research and Management Pub Date : 2020-11-17 DOI: 10.15415/jptrm.2020.82008
N. Rani, Prerna Sharma, Prof Vikas Kumar, Praveen Kumar
{"title":"Molecular Docking Approach to Identify Potential AntiCandidal Potential of Curcumin","authors":"N. Rani, Prerna Sharma, Prof Vikas Kumar, Praveen Kumar","doi":"10.15415/jptrm.2020.82008","DOIUrl":"https://doi.org/10.15415/jptrm.2020.82008","url":null,"abstract":"Background: Candida albicans is a kind of fungus that can lead to mortality. In the presence of the enzyme Lanosterol-demethylase, Ergosterol, the major sterol in the fungal cell membrane, is the resulting product of Lanosterol (Cytochrome P450DM). Purpose: Azole antifungal drugs target this enzyme as a target enzyme. The work included selecting and modelling the target enzyme. Cucumin’s inhibitory effect on Cytochrome P450 was tested utilising molecular docking experiments. Methods: Chem sketch was used to create compound structures, and Molergo Virtual Docker was used to do molecular docking. Results: All of the curcumin and conventional medicines, such as Ketoconazole, Clotrimazole, and Miconazole, have interaction with 14-demethylase amino acid residues, Haem and water molecules in the target site, as per the docking research.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131181269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Protein Kinase C in Diabetic Complications 蛋白激酶C在糖尿病并发症中的作用
Journal of Pharmaceutical Technology, Research and Management Pub Date : 2019-11-05 DOI: 10.15415/jptrm.2019.72011
Simran, A. Grewal, S. Arora, T. G. Singh
{"title":"Role of Protein Kinase C in Diabetic Complications","authors":"Simran, A. Grewal, S. Arora, T. G. Singh","doi":"10.15415/jptrm.2019.72011","DOIUrl":"https://doi.org/10.15415/jptrm.2019.72011","url":null,"abstract":"Diabetes is the most common and systemic disorder associated with hyperglycemia which is the significant factor in the development of micro- and macrovascular changes. Many mechanistic approaches i.e. activation of Protein kinase C, glycation end products production, hexosamine pathway and polyol pathway induce cellular damage and lead to the development of diabetic complications like nephropathy, neuropathy, retinopathy, and myopathy. One of the adverse effects of long-lasting hyperglycemia is activation of PKC (intracellular signaling enzyme) and has become a field of great research interest. Hence, in this review special emphasis is placed on microvascular complications which are due to activation of PKC. Clinical trials have also been conducted using selective PKC inhibitors and have shown positive results against hyperglycemia.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122994944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Insights of Breast Cancer & Barriers to its Therapy 乳腺癌的见解及其治疗障碍
Journal of Pharmaceutical Technology, Research and Management Pub Date : 2019-11-05 DOI: 10.15415/jptrm.2019.72010
Nidhi Garg, Suman Baishnab, R. Das, K. Kaur, Saurabh Gupta, S. Arora
{"title":"Insights of Breast Cancer & Barriers to its Therapy","authors":"Nidhi Garg, Suman Baishnab, R. Das, K. Kaur, Saurabh Gupta, S. Arora","doi":"10.15415/jptrm.2019.72010","DOIUrl":"https://doi.org/10.15415/jptrm.2019.72010","url":null,"abstract":"Breast cancer is the most common cancer across the globe occurring commonly in women population, and it is one of the main causes of mortality in women. In 2018, 1,62,468 new cases and 87,090 death cases of breast cancer were registered in India. In these recent years, lots of studies were conducted in breast cancer related to treatment and management, but in spite of getting so much advancement in the treatment of breast cancer still, the mortality rate of women is increasing day by day. Numerous factors are acting as barriers or challenges in breast cancer preventive therapy. It includes lack of knowledge regarding the treatment of cancer and patient getting insecure about treatment, fear of having side effects, cost of treatment and the efficacy of the drugs being prescribed. The study intended to determine the perceived insights and barriers to treatment of breast cancer.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126475614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat 总形合花全植物甲醇提取物对实验性胃溃疡大鼠的胃保护作用
Journal of Pharmaceutical Technology, Research and Management Pub Date : 2019-11-05 DOI: 10.15415/jptrm.2019.72007
Rupali Gupta, R. Vishwakarma, Yashwant Giri, Varinder Singh
{"title":"Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat","authors":"Rupali Gupta, R. Vishwakarma, Yashwant Giri, Varinder Singh","doi":"10.15415/jptrm.2019.72007","DOIUrl":"https://doi.org/10.15415/jptrm.2019.72007","url":null,"abstract":"Peptic ulcer is a condition which results from an imbalance between offensive and defensive factors of gastrointestinal system. The investigation was designed to evaluate the antiulcer activity of Symplocos racemosa whole plant methanol extract (MESR) in rat model of indomethacininduced gastric ulceration. The total acidity, gastric volume, pH and free acidity were measured to determine the anti-ulcer activity of MESR. Pretreatment with MESR (125-500 mg/kg) markedly reduced the indomethacin-induced increase in gastric ulcer index and score. These results revealed that antisecretory effects MESR were responsible for antiulcer activity of MESR.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125397744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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