Rupali Gupta, R. Vishwakarma, Yashwant Giri, Varinder Singh
{"title":"总形合花全植物甲醇提取物对实验性胃溃疡大鼠的胃保护作用","authors":"Rupali Gupta, R. Vishwakarma, Yashwant Giri, Varinder Singh","doi":"10.15415/jptrm.2019.72007","DOIUrl":null,"url":null,"abstract":"Peptic ulcer is a condition which results from an imbalance between offensive and defensive factors of gastrointestinal system. The investigation was designed to evaluate the antiulcer activity of Symplocos racemosa whole plant methanol extract (MESR) in rat model of indomethacininduced gastric ulceration. The total acidity, gastric volume, pH and free acidity were measured to determine the anti-ulcer activity of MESR. Pretreatment with MESR (125-500 mg/kg) markedly reduced the indomethacin-induced increase in gastric ulcer index and score. These results revealed that antisecretory effects MESR were responsible for antiulcer activity of MESR.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"21 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat\",\"authors\":\"Rupali Gupta, R. Vishwakarma, Yashwant Giri, Varinder Singh\",\"doi\":\"10.15415/jptrm.2019.72007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Peptic ulcer is a condition which results from an imbalance between offensive and defensive factors of gastrointestinal system. The investigation was designed to evaluate the antiulcer activity of Symplocos racemosa whole plant methanol extract (MESR) in rat model of indomethacininduced gastric ulceration. The total acidity, gastric volume, pH and free acidity were measured to determine the anti-ulcer activity of MESR. Pretreatment with MESR (125-500 mg/kg) markedly reduced the indomethacin-induced increase in gastric ulcer index and score. These results revealed that antisecretory effects MESR were responsible for antiulcer activity of MESR.\",\"PeriodicalId\":382729,\"journal\":{\"name\":\"Journal of Pharmaceutical Technology, Research and Management\",\"volume\":\"21 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmaceutical Technology, Research and Management\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15415/jptrm.2019.72007\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Technology, Research and Management","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15415/jptrm.2019.72007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat
Peptic ulcer is a condition which results from an imbalance between offensive and defensive factors of gastrointestinal system. The investigation was designed to evaluate the antiulcer activity of Symplocos racemosa whole plant methanol extract (MESR) in rat model of indomethacininduced gastric ulceration. The total acidity, gastric volume, pH and free acidity were measured to determine the anti-ulcer activity of MESR. Pretreatment with MESR (125-500 mg/kg) markedly reduced the indomethacin-induced increase in gastric ulcer index and score. These results revealed that antisecretory effects MESR were responsible for antiulcer activity of MESR.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
