Journal of Pharmaceutical Technology, Research and Management最新文献

{"title":"Quality by Design (QbD) in Product Development Life Cycle: Retrospect and Prospects","authors":"Bhupinder Singh Bhoop","doi":"10.15415/jptrm.2022.102009","DOIUrl":"https://doi.org/10.15415/jptrm.2022.102009","url":null,"abstract":"","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131434753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Induced Rodent Model of Autism Spectrum Disorders","authors":"Kavita Chauhan, Veerta Sharma, H. Khan, A. Kaur, T. G. Singh","doi":"10.15415/jptrm.2022.102003","DOIUrl":"https://doi.org/10.15415/jptrm.2022.102003","url":null,"abstract":"The term Autism spectrum disorder (ASD) refers to a neuro-developmental disorder that include repetitive behaviours, extremely constrained interests and deficits in social communication. In the last ten years, the numerous epidemiological papers discussing connection between autism and environmental chemical exposures has significantly increased. These findings are crucial because they focus on modifiable risk factors that may open up new possibilities for the primary prevention of the autism-related disability, which is now recognised to be more strongly related to environmental factors than was previously thought. A variety of environmental factors have been known as significant factors relevant to aetiology of ASD, such as lead and mercury (heavy metals), PCB(organic contaminant) and phthalates and BPA. The most accurate animal model of autism among all other models is valproic acid-induced autism, which can reproduce almost all of the molecular and cellular changes seen in humans with ASD. This review provide insight into various diagnostic available for autism, pathophysiology of autism and animal model of autism to develop a pharmacological therapeutic intervention for the treatment of disease.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126603672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Silver and Gold Nanoparticles in the Management of Diabetes: Current Trends and Perspectives","authors":"Mohammad Amir, Manisha Vohra, A. Sharma, Sheetu Wadhwa","doi":"10.15415/jptrm.2022.102006","DOIUrl":"https://doi.org/10.15415/jptrm.2022.102006","url":null,"abstract":"Background: Diabetes mellitus is a severe metabolic disease in which a person’s body cannot control the glucose level in the blood; it results from a defect in insulin secretion, insulin action, or both. Nanotechnology is a rising area in pharmaceutical sciences as nanoparticles are reported to enhance drug efficacy obtained from plant sources through green synthesis. Purpose: The purpose of this review is to focus on the antidiabetic potential of various metallic nanoparticles like silver, gold, copper, and selenium by using their secondary metabolites like tannins, alkaloids, saponins, and steroids. The advantages of green nanoparticle synthesis are that they are eco-friendly, high temperature is not required, can be used on large-scale synthesis, and are cost-effective. Methods: A preliminary search was conducted in PubMed, OVID Medline, Embase, ScienceDirect, Web of Science, and Google Scholar databases using keywords such as “Diabetes, nanoparticles, metallic nanoparticles, gold nanoparticles, silver nanoparticles.” Results: This review includes various marketed formulations of silver and gold nanoparticles particles obtained from various biological sources like allium cepa, argyreia nervosa, callophyllumtomentosum, punica granatum, cassia auriculate, saracaasoka, gymnemasylvestre, etc. along with their research findings for reducing the antidiabetic activity. Conclusion:This review contains details about the silver and gold nanoparticles obtained from various biological sources used to treat diabetes.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122716934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-Crystallization: Approaches, Characterization and Applications in Drug Delivery","authors":"Sayali T. Patil, Monika Mane, Kshitija S. Desai, Satyajeet R. Jagdale, P. A. Jadhav, Harshada A. Patil","doi":"10.15415/jptrm.2022.102004","DOIUrl":"https://doi.org/10.15415/jptrm.2022.102004","url":null,"abstract":"Co-crystals play a significant role in the pharmaceutical sector. Medicinal co crystals are multicomponent systems with at least one active therapeutic ingredient and the rest of the constituents being pharmaceutically acceptable. Co crystallization of a medicinal material with a coformer is a potential and growing method for improving pharmaceutical performance in areas such as solubility, dissolution profile, pharmacokinetics, and stability.. A key barrier to developing novel API compounds is poor bio availability and water solubility, which can limit the effectiveness of new drugs or prevent their approval for the market. In terms of the significant enhancement in solubility profiles compared to the single- active pharmaceutical ingredients, co-crystals provide a distinct and competitive edge over other traditional approaches.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121379284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Regulatory Framework in Current Advancements of Medical Devices","authors":"Hirishita Dhawan, Priyanka Gupta, Anjoo Kamboj","doi":"10.15415/jptrm.2022.102005","DOIUrl":"https://doi.org/10.15415/jptrm.2022.102005","url":null,"abstract":"Background: A medical device is any tool, implant, or IVD that is intended to manage, ameliorate, avert, or identify a human disease. Simple thermometers, bandages, implants, and so on are examples. A medical device’s primary intended use is not accomplished chemically on or within the skin, nor does it require metabolization to accomplish that primary intended use. Medical devices are classified differently by different regulatory bodies. The FDA divides medical devices into three categories, whereas India and Europe divide them into four categories based on risk. Each regulated country has its own set of medical device regulations and guidelines. Purpose: The medical device sector is expected to showcase a remarkable journey of growth by 2029, achieving a 718.92-billion-dollar market with a CAGR of 5.5% over the expansion period of 2022–2029, making it the fastest-growing global market. The earlier medical device has simple inspection and testing but Post Covid19 due to an increase in imports, takeover from foreign manufacturers, and fostering innovation medical devices took off, becoming ever more sophisticated and widely available therefore the need for manufacturing and product standards was recognized, the new regulation was framed and regulatory specialists were recruited. Thereby led to the emergence of a whole new regulatory system and a post-marketing surveillance strategy. Methods: The analysis of current market size, share, and trends on medical devices for USA, Europe, and India was performed and current regulatory standards were observed which are continuously becoming stringent for all the countries with the advancement of technology. Conclusions: The Medical devices sector is the leading growing market. With the advancement in the medical device sector such as cybersecurity, digitalization, data privacy, and innovation, new entrants and new manufacturers the doors for entrepreneurship will open thus, it becomes highly important and necessary to introduce comprehensive regulatory guidelines for safety, effectiveness and customer protection, and satisfaction. The regulated medical devices sector will reach new heights with stringent vigilance and transparency benefitting society.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125377784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Pathological Events in Liver Diseases of Pregnancy","authors":"R. Behera, Amit Kumar, S. Chauhan, A. Grewal, Thakur Gurjeet Singh","doi":"10.15415/jptrm.2022.102002","DOIUrl":"https://doi.org/10.15415/jptrm.2022.102002","url":null,"abstract":"Hepatic dysfunction in a gestational woman can arises from pregnancy-related factors, illnesses that occur concurrently with gestation, or previously existing hepatic disorders which is aggravated by pregnancy. Abnormal liver test findings occur in 3% to 5% of pregnancies due to a variety of probable causes, with clinical effects ranging from self-limiting to swiftly deadly. Abnormal liver tests in pregnant individuals are caused by four major conditions: (i) Physiological changes in pregnancy, (ii) Newly acquired Liver disease, (iii) Pre-existing Liver disease, and (iv) Pregnancy- related Liver disease. Physiologic changes in pregnant women lead to abnormal liver function tests. Hepatic disorders may result in severe illness and death in both mothers as well as fetuses. Quick identification of the disease is crucial, as in critical situations immediate delivery is vital for the mother and developing infant survival. This review focuses on liver problems that are specific to pregnancy. Hyperemesis gravidarum (HG), which appears within the first 12 weeks of pregnancy, is connected to liver damage. Intrahepatic Cholestasis of Pregnancy (ICP) is the most prominent all across the middle and the end term of pregnancy. After birth, pruritus and the related biochemical indications of cholestasis resolve. Both pre-eclampsia and HELLP (elevated liver enzymes, hemolysis, and low platelets) are severe conditions that arise in the last term of pregnancy. Acute fatty liver during pregnancy (AFLP) is a potentially dangerous, uncommon condition that can affect pregnancy’s third trimester. This review summarizes the etiologies, pathogenesis, identification, and treatment of hepatic disorders during pregnancy.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124471175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antianxiety Activity Evaluation of Hibiscus Sabdariffa Linn. Calyces","authors":"Anupam Sharma","doi":"10.15415/jptrm.2022.102001","DOIUrl":"https://doi.org/10.15415/jptrm.2022.102001","url":null,"abstract":"Background: Anxiety is one of the most commonly prevailing psychiatric and behavioural disorders. Evolutionarily, it is regarded as a healthy emotion or behavioural repertoire, which is the outcome of a stressful situation, thereby, helping an individual to cope with a possible risk or a novel situation by increasing awareness and responsiveness. Benzodiazepines, barbiturates, SRIs etc., are used as first line drugs for the management of anxiety, but due to myriad of adverse effects associated with these conventional drugs, inclination of patients towards complementary and alternative medicines (CAMs) has tremendously risen. CAM interventions mainly include herbal remedies.Different parts of Hibiscus sabdariffa have been used traditionally for treating several ailments including mental disorders. Purpose: Keeping in mind the traditional use of H. sabdariffacalyces,the present study was designed to evaluate their antianxiety potential. Methods: Petroleum ether (60-80°C), chloroform, ethanol, and water extracts were prepared using successive Soxhlet extraction and evaluated using elevated plus-maze model. Results: Among all the extracts, ethanol extract showed significant antianxiety activity at a dose of 400 mg/kg. Conclusion: Thus, the study establishes antianxiety activity of H. sabdariffa calyces and also validates their traditional use.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"157 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115991183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Microcrystalline Cellulose Powders Obtained from Gossypiumherbaceum As Dry Binder in the Formulation of Diazepam Tablets","authors":"N. Nwachukwu, S. Ofoefule","doi":"10.15415/jptrm.2022.101007","DOIUrl":"https://doi.org/10.15415/jptrm.2022.101007","url":null,"abstract":"Background: Microcrystalline cellulose (MCC) is a popular dry binder in tablet formulation. Differences in its processing methods can significantly affect its tableting properties. Aim: Assessment of the tableting and in-vitro release properties of diazepam tablets formulated with Gossypiumherbaceum (GH) derived MCC that was dried by two different methods. Methods: G.herbaceum bolls were de-lignified in sodium hydroxide solutions to obtain α-cellulose which was hydrolyzed with 2.0 N hydrochloric acid to obtain MCC. The neutralized damp MCC was separated into two portions. One portion was fluid bed dried (MCC-GossF) while the other portion was lyophilized (MCC-GossL). Diazepam tablets were prepared with 20, 30 and 40%w/w of MCC-GossF and MCC-GossL..Avicel PH 102 (AVH-102) served as comparing standard. The formulations were evaluated using standard methods. Results: The powders flowed well and the tablets met with British Pharmacopoiea specifications. Diazepam tablets containing MCC-GossL (DGL) were stronger than those of MCC-GossF (DCF) (p<0.05). The disintegration times were < 2 min and friability ≤ 1%. The strength of tablets containing AVH-102 (DAV) compared well with those of DGL tablets. More than 80% of diazepam was released from the tablets. Conclusion: The GH MCCs served as good dry binders in the formulation of diazepam tablets.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129556214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moorva – a Drug of Controversial Identity: Review","authors":"G. Panesar, Anupam Sharma","doi":"10.15415/jptrm.2022.101002","DOIUrl":"https://doi.org/10.15415/jptrm.2022.101002","url":null,"abstract":"Introduction: Over the past few years, there has been a huge surge of interest towards Ayurvedic system of medicine, and it has become a subject of intensive research for various aspects. However, variation in the languages and prevalence of folklore medicines has led to confusion in the true identity of different plants having similar name. Moreover, the description of a plant in the ancient literature is found in verses, having ample use of synonyms. These synonyms have caused controversy in the identification of plants and, hence, the correct source of the plant could be misleading. Background: Since herbal products are generally prepared using extracts of plants known for particular activity, the controversial source sometimes may lead to preparation of inefficacious medicines. Review Results: Substantial efforts are being made to standardize the Ayurvedic crude drugs as well as finished Ayurvedic medicines. However, these initiatives imperatively need establishing correct identity of the plant drug. Moorva is an important controversial drug in Ayurveda. Its roots are used for thetreatment of various disorders. Five different plants are considered as Moorva throughout India. Only preliminary pharmacognostic reports are available on these five species. Conclusion: The present review aims at differentiating these five sources of Moorva roots, i.e., C. fragrans, H. isora, M. arenaria, S. roxburghiana and Marsdeniatenacissima","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133456749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico ADMET and Docking Study of Selected Drug Used in Therapy of COVID-19","authors":"Sagar A. Jadhav, Payal Chavan, Supriya Suresh Shete, Dipti Shantisagar Patil, Saroj Dyandev Kolekar, Godfrey Rudolph Mathews, Dipak Babaso Bhingardev, P. Pawar","doi":"10.15415/jptrm.2022.101006","DOIUrl":"https://doi.org/10.15415/jptrm.2022.101006","url":null,"abstract":"Docking is one of the most widely utilized technique used method in structure -based drug design because of its capability to predict the binding conformation of ligands to appropriate target. Ability of binding/ affinity towards the target i.e., bioactive peptides or specific receptor provides strong evidence of binding conformation pattern and affinity for further investigation. Aim- The present study was conducted for evaluation of current API’s potential used in COVID-19. Methods: In-silico molecular docking was performed using softwares such as SWISS ADME, MOLSOFT, MOLINSPIRATION, PYMOL, AUTO-DOCK VINA AND BIOVIA DS VISUALIZER. Results: The current research comprehend the drug likeliness character of selected API’s and their binding affinity with various targets selected by SWISS TARGET PREDICTION. Conclusion: The present investigation suggests that all the targets follow Lipinski rule of five except Remdesivir and Anakinra besides which it possesses enhanced binding affinity toward targets, the binding energy of the protein ligand interaction additionally confirms that the ligand fits into the dynamite pockets which proves to be evident for further in- vivo and in-vitro evaluations.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131287556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}