Regulatory and Pathological Roles of CaSR and TRPC in Podocytes

Background: Podocytes, or glomerular visceral epithelial cells, are highly special-ised epithelial cells that cover the glomerular basement membrane’s outer surface. Recent research suggests that podocytes play a signifi-cant role in the physiology and pathology of the glomerulus. The cal- cium-sensing receptor (CaSR) has a variety of roles in maintaining systemic calcium homeostasis, and it is expressed by a variety of cell types, each with its own set of regulatory activities. CaSR activation in podocytes provides prosurvival effects and protects the cell against puromycin aminonucleoside damage, according to new research by Oh and associates. Purpose: Given that CaSR activation has mostly context-dependent cellular implications, further research is needed to determine its specific involvement in podocyte physiology and pathology. Glomerular kidney disease is a significant healthcare burden, and it is thought to be a collection of illnesses for which there is no precise and effective treatment. Conclusion: Excellent scientific and genetic research have identified processes that go wrong in podocytes, the glomerular filter’s regulating cells. Now the challenge is how to des-ignate targets for new, better medicines.