Journal of Cancer Policy最新文献

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The productivity cost of mortality due to lung cancer, breast cancer and melanoma in Europe across 2010, 2015 and 2019. 2010 年、2015 年和 2019 年欧洲因肺癌、乳腺癌和黑色素瘤导致死亡的生产成本。
IF 2
Journal of Cancer Policy Pub Date : 2024-08-13 DOI: 10.1016/j.jcpo.2024.100499
Agnes Brandtmüller, Anne Meiwald, Edward Oliver, Robert Hughes, Pedro Miguel Gonzalez Capote, Georgie Weston, Goran Bencina
{"title":"The productivity cost of mortality due to lung cancer, breast cancer and melanoma in Europe across 2010, 2015 and 2019.","authors":"Agnes Brandtmüller, Anne Meiwald, Edward Oliver, Robert Hughes, Pedro Miguel Gonzalez Capote, Georgie Weston, Goran Bencina","doi":"10.1016/j.jcpo.2024.100499","DOIUrl":"10.1016/j.jcpo.2024.100499","url":null,"abstract":"<p><strong>Background: </strong>Cancer caused an estimated 2.2 million deaths across Europe in 2020. This analysis estimated the cost of lost productivity due to premature deaths associated with lung, breast and melanoma cancer and investigated the temporal trends across European regions across 2010, 2015 and 2019.</p><p><strong>Method: </strong>The human capital approach was used to estimate the indirect costs from lung, melanoma, and breast cancers (ICD-10 code: C33-34, C43, and C50, respectively) in Northern, Eastern, Southern, and Western Europe. Age-specific mortality, and country-specific wages and employment rates were used to calculate years of productive life lost (YPLL), YPLL/death and present value of future lost productivity (PVFLP). Data were sourced from the World Health Organization, Eurostat, and the World Bank.</p><p><strong>Results: </strong>The number of cancer deaths remained relatively stable from 2010 to 2019. YPLL/death decreased across all European regions and for all cancers between 2010 and 2019 (reported ranges across European regions; lung cancer: 25-42 %; breast cancer: 18-21 %; melanoma: 31-37 %). In Europe, the decrease in PVFLP in 2019 compared to 2010 was €2995M for lung cancer, €295M for melanoma, and €466M for breast cancer, with an overall reduction of productivity cost of €3756M in these cancer types.</p><p><strong>Conclusion: </strong>The results from this study illustrate a decreased trend in productivity costs from 2010 to 2019 which could be driven by deaths occurring at an older age, suggesting that advances in cancer prevention and the treatment landscape have extended the life of cancer patients, yielding less productivity losses.</p><p><strong>Policy summary: </strong>The indirect economic costs modelled show the impact of past effective health policies and new treatments. Continued efforts to improve public health policies in supporting public awareness of risk factors and value of early diagnosis could lead to further reduction in these losses. Prevention, early diagnosis, and activation of early treatment pathways could serve to reduce loss of life and improve productivity.</p>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scenario analysis and multi-criteria decision analysis to explore alternative reimbursement pathways for whole genome sequencing for blood cancer patients 通过情景分析和多标准决策分析,探索血癌患者全基因组测序的替代报销途径。
IF 2
Journal of Cancer Policy Pub Date : 2024-08-12 DOI: 10.1016/j.jcpo.2024.100501
{"title":"Scenario analysis and multi-criteria decision analysis to explore alternative reimbursement pathways for whole genome sequencing for blood cancer patients","authors":"","doi":"10.1016/j.jcpo.2024.100501","DOIUrl":"10.1016/j.jcpo.2024.100501","url":null,"abstract":"<div><h3>Background</h3><p>Whole genome sequencing (WGS) has transformative potential for blood cancer management, but reimbursement is hindered by uncertain benefits relative to added costs. This study employed scenario planning and multi-criteria decision analysis (MCDA) to evaluate stakeholders’ preferences for alternative reimbursement pathways, informing future health technology assessment (HTA) submission of WGS in blood cancer.</p></div><div><h3>Methods</h3><p>Key factors influencing WGS reimbursement in blood cancers were identified through a literature search. Hypothetical scenarios describing various evidential characteristics of WGS for HTA were developed using the morphological approach. An online survey, incorporating MCDA weights, was designed to gather stakeholder preferences (consumers/patients, clinicians/health professionals, industry representatives, health economists, and HTA committee members) for these scenarios. The survey assessed participants' approval of WGS reimbursement for each scenario, and scenario preferences were determined using the geometric mean method, applying an algorithm to improve reliability and precision by addressing inconsistent responses.</p></div><div><h3>Results</h3><p>Nineteen participants provided complete survey responses, primarily clinicians or health professionals (n = 6; 32 %), consumers/patients and industry representatives (both at n = 5; 26 %). “Clinical impact of WGS results on patient care\" was the most critical criterion (criteria weight of 0.25), followed by \"diagnostic accuracy of WGS\" (0.21), \"cost-effectiveness of WGS\" (0.19), \"availability of reimbursed treatment after WGS\" (0.16), and \"eligibility criteria for reimbursed treatment based on actionable WGS results\" and \"cost comparison of WGS\" (both at 0.09). Participants preferred a scenario with substantial clinical evidence, high access to reimbursed targeted treatment, cost-effectiveness below $50,000 per quality-adjusted life year (QALY) gained, and affordability relative to standard molecular tests. Reimbursement was initially opposed until criteria such as equal cost to standard tests and better treatment accessibility were met.</p></div><div><h3>Conclusion</h3><p>Payers commonly emphasize acceptable cost-effectiveness, but strong clinical evidence for many variants and comparable costs to standard tests are likely to drive positive reimbursement decisions for WGS.</p></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213538324000353/pdfft?md5=36b95bafbf28ed46ab943234879423c0&pid=1-s2.0-S2213538324000353-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Globalization of clinical research in oncology: Status, challenges, and future directions 肿瘤学临床研究的全球化:现状、挑战和未来方向。
IF 2
Journal of Cancer Policy Pub Date : 2024-08-10 DOI: 10.1016/j.jcpo.2024.100500
{"title":"Globalization of clinical research in oncology: Status, challenges, and future directions","authors":"","doi":"10.1016/j.jcpo.2024.100500","DOIUrl":"10.1016/j.jcpo.2024.100500","url":null,"abstract":"<div><h3>Purpose</h3><p>Cancer is the second-leading cause of death worldwide, and its burden is increasing around the world, particularly in low- and middle-income countries (LMICs). Yet, cancer research has historically been conducted primarily in high-income countries (HICs).</p></div><div><h3>Methods</h3><p>In this review, we describe the results of our literature search into the current state of international cancer trials, including the benefits, challenges, limitations, and ethical concerns regarding the international conduct of HIC-led trials. We also propose some possible means of addressing these challenges and overcoming these barriers to extend the benefits of cancer research to people around the world.</p></div><div><h3>Results</h3><p>Over the last several decades, there has been a shift toward inclusion of investigators and participants from LMICs in pivotal cancer clinical trials.</p></div><div><h3>Conclusions</h3><p>While inclusion of LMIC countries has benefits, including increased diversity of participant populations, investment in research infrastructure in LMICs, and potential expansion of cancer treatment options around the world, the continued leadership of most trials by HICs presents ethical concerns, including potential exploitation of researchers and participants from LMICs, lack of focus on cancer types prevalent in all participating regions, and disparities in access to approved therapies once the trial is complete.</p></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Smoking and alcohol habits in head and neck cancers: How many patients stop after diagnosis? 头颈部癌症患者的吸烟和饮酒习惯:有多少患者在确诊后戒烟?
IF 2
Journal of Cancer Policy Pub Date : 2024-07-25 DOI: 10.1016/j.jcpo.2024.100498
{"title":"Smoking and alcohol habits in head and neck cancers: How many patients stop after diagnosis?","authors":"","doi":"10.1016/j.jcpo.2024.100498","DOIUrl":"10.1016/j.jcpo.2024.100498","url":null,"abstract":"<div><h3>Background</h3><p>Smoking and alcohol are the main risk factors for head and neck cancer. Despite the significant psychological impact, many patients continue to smoke and drink alcohol after diagnosis of cancer. This study aims to analyze the patients’ behavior post diagnosis and treatment of head and neck cancer.</p></div><div><h3>Methods</h3><p>An observational retrospective study was conducted on patients suffering from head and neck cancer. Their smoking and alcohol habits before and after diagnosis of cancer were studied.</p></div><div><h3>Results</h3><p>A total of 85 patients were recruited: 80 % males, mean age 61.77±9.30 years. Among smokers, 35.80 % continued smoking post-diagnosis. A statistically significant correlation was found between smoking habit after diagnosis of cancer and type of treatment and tracheostomy. Among drinkers, 65.52 % continued to consume alcohol after diagnosis of cancer. A statistically significant correlation was found between alcohol consumption post-diagnosis and sex.</p></div><div><h3>Conclusions</h3><p>Patients undergoing more invasive treatments are more likely to quit smoking and/or drinking alcohol, suggesting the strong psychological impact of cancer and its therapy. Many patients continue smoking and consuming alcohol due to unawareness, depression, or addiction. However, most patients reduced cigarette smoking and alcohol consumption. Comprehensive care, including psychological support, is essential for these patients.</p></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A cross-sector approach to explore socio-ecological associations with treatment engagement behaviours in Northern Ghana 在加纳北部采用跨部门方法探索与参与治疗行为相关的社会生态因素。
IF 2
Journal of Cancer Policy Pub Date : 2024-07-25 DOI: 10.1016/j.jcpo.2024.100497
{"title":"A cross-sector approach to explore socio-ecological associations with treatment engagement behaviours in Northern Ghana","authors":"","doi":"10.1016/j.jcpo.2024.100497","DOIUrl":"10.1016/j.jcpo.2024.100497","url":null,"abstract":"<div><h3>Background</h3><p>Cancer presents a growing global burden, not least in African countries such as Ghana where high cancer treatment dropouts has been identified due to numerous social, cultural and financial reasons. There is little understanding regarding patterns of treatment access behaviour, especially in Northern Ghana, which this study was designed to explore.</p></div><div><h3>Methods</h3><p>Through cross-sector collaboration, we extracted and clinically validated cancer patient records available in the Tamale Teaching Hospital. These were analysed descriptively and through multi-variate logistic regression. A treatment mapping process was also applied to highlight challenges in data collection. Multiple imputation with chained equations was conducted for high levels of missing data. Sensitivity analysis was applied to assess the impact of missing data.</p></div><div><h3>Results</h3><p>Treatment drop-out was high even when uncertainty due to missing data was accounted for, and only 27 % of patients completely engaged with treatment. High drop-out was found for all cancers including those covered by the Ghana National Health Insurance scheme. Multi-variate logistic regression revealed that social, health condition and systemic factors influence treatment engagement until completion. High missing data was observed for liver, ovarian, colorectal, gastric, bladder, oesophageal and head and neck and skin cancers, and soft tissue sarcomas, which limited model fitting.</p></div><div><h3>Conclusion</h3><p>Treatment drop-out is a critical issue in Northern Ghana. There was high missing data due to the dynamic, complex and decentralised treatment pathway. Future studies are needed to understand the complex challenges in data recording.</p></div><div><h3>Policy summary</h3><p>Treatment drop out is a pertinent issue that policy makers should look to address. Further discussion with stakeholders involved in cancer treatment and data collection is required to better understand challenges to routine data collection in the local setting. This will allow policy to be designed to cater for the impact of multiple intersecting health and social factors on treatment completion.</p></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213538324000316/pdfft?md5=9aa42e3388642df1e933f8bb0d6d5c5a&pid=1-s2.0-S2213538324000316-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inclusivity of patients in early phase breast cancer clinical trials 早期乳腺癌临床试验的患者包容性
IF 2
Journal of Cancer Policy Pub Date : 2024-07-20 DOI: 10.1016/j.jcpo.2024.100494
{"title":"Inclusivity of patients in early phase breast cancer clinical trials","authors":"","doi":"10.1016/j.jcpo.2024.100494","DOIUrl":"10.1016/j.jcpo.2024.100494","url":null,"abstract":"<div><h3>Introduction</h3><p>Studies have shown that certain groups of patients are underrepresented in clinical trials including non-Caucasian ethnicity, poor fluency in English, low socioeconomic status, older age, neurodivergence, and large Body Mass Index (BMI). There is a need to ensure adequate representation of these groups so that the results of any trial accurately reflect the population.</p><p>The aim of this study was to review the pathway of patients recruited into two early phase breast cancer clinical and determine the inclusivity of patients from the aforementioned sub-groups.</p></div><div><h3>Methods</h3><p>The Breast Cancer Research Database was reviewed, and the characteristics of all patients who were screened for eligibility in two early phase clinical trials was examined. The English Indices of Deprivation was used to populate the Index of Multiple Deprivation (IMD) for each patient using their postcode.</p></div><div><h3>Results</h3><p>In total, 392 patients were eligible to participate, between September 2020 to May 2023. Of these, 144 (36.7 %) were recruited to these two trials. In all, 100 % of patients eligible for these trials were approached and screened for participation. Eligible patients had a mean age of 53.5 years. Recruited patients were younger on average than those not recruited (49.1 years vs 56.0 years, p&lt;0.0001). Only one recruited patient required an interpreter, compared with 24 (9.7 %%) of those who were not recruited (p&lt;0.001).</p><p>There was no difference in the IMD (p=0.38), BMI (p=0.34) and neurodiversity (p=0.10) between patients recruited into clinical trials and those who were not.</p></div><div><h3>Conclusion</h3><p>Older age and poor fluency in the English language remain barriers to participation in early-phase clinical trials despite implementing a clear pathway to trial recruitment. There is a pressing need to address these barriers by raising awareness, improve appropriate training and providing comprehensive trial information to patients in the language of their choice.</p></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-world cost-effectiveness of panel-based genomic testing to inform therapeutic decisions for metastatic colorectal cancer 为转移性结直肠癌治疗决策提供信息的基于面板的基因组测试的实际成本效益
IF 2
Journal of Cancer Policy Pub Date : 2024-07-18 DOI: 10.1016/j.jcpo.2024.100496
{"title":"Real-world cost-effectiveness of panel-based genomic testing to inform therapeutic decisions for metastatic colorectal cancer","authors":"","doi":"10.1016/j.jcpo.2024.100496","DOIUrl":"10.1016/j.jcpo.2024.100496","url":null,"abstract":"<div><h3>Background</h3><p>Mutations in <em>KRAS</em> and <em>NRAS</em> are associated with a lack of response to cetuximab and panitumumab, two biologics used for third-line therapy of metastatic colorectal cancer (mCRC). In British Columbia, Canada, eligibility for cetuximab or panitumumab was first based on single-gene <em>KRAS</em> testing. OncoPanel, a multi-gene next-generation sequencing panel with both <em>KRAS</em> and <em>NRAS</em>, was introduced in 2016. Our objective was to estimate the real-world cost-effectiveness of OncoPanel versus to single-gene <em>KRAS</em> testing to inform eligibility for cetuximab or panitumumab in mCRC.</p></div><div><h3>Methods</h3><p>Using population-based administrative health data, we identified a cohort of mCRC patients who had received a <em>KRAS</em> or OncoPanel test, and completed prior chemotherapy in 2010–2019. We matched <em>KRAS</em>- and OncoPanel-tested patients (1:1) using genetic matching to balance baseline covariates. Mean and incremental 3-year costs, survival, and quality-adjusted survival were estimated using inverse-probability-of-censoring weighting and bootstrapping. We conducted scenario-based sensitivity analysis for key costs and assumptions.</p></div><div><h3>Findings</h3><p>All OncoPanel-tested cases (n=371) were matched to a <em>KRAS</em>-tested comparator. In the <em>KRAS</em> and OncoPanel groups, respectively, 55·8 % and 41·2 % of patients were potentially eligible for cetuximab or panitumumab based on mutation status. Incremental cost and effectiveness of OncoPanel were $72 (95 % CI: −6387, 6107), −0·004 life-years (95 % CI: −0·119, 0·113), and −0·011 quality-adjusted life-years (95 % CI: −0·094, 0·075). Reductions in systemic therapy costs were offset by increased costs in other resources. Results were moderately sensitive to time horizon and changes in testing or treatment cost.</p></div><div><h3>Interpretation</h3><p>The use of OncoPanel resulted in more precise targeting of cetuximab and panitumumab, but there was no change in incremental cost or quality-adjusted survival. Understanding the balance of costs achieved in practice can provide insight into the effect of future changes in testing policy, test cost, treatment eligibility, or drug prices in this setting.</p></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213538324000304/pdfft?md5=54132aeba8d8f707a75493f9b1a6b33f&pid=1-s2.0-S2213538324000304-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging cancer prevention efforts: Georgia's alignment with European code against cancer 癌症预防工作的桥梁:格鲁吉亚与《欧洲抗癌法典》接轨。
IF 2
Journal of Cancer Policy Pub Date : 2024-07-14 DOI: 10.1016/j.jcpo.2024.100495
{"title":"Bridging cancer prevention efforts: Georgia's alignment with European code against cancer","authors":"","doi":"10.1016/j.jcpo.2024.100495","DOIUrl":"10.1016/j.jcpo.2024.100495","url":null,"abstract":"<div><p>This report provides a concise overview of how Georgia has integrated the principles of the European Code Against Cancer (ECAC) into its national cancer strategies. Through a structured exploration, we highlight Georgia's commitment to cancer prevention, while addressing the challenges and opportunities encountered.</p></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Whole genome sequencing as a ticket to cancer treatment in the Netherlands: Are inequalities in access to molecular diagnostics unfair? 在荷兰,全基因组测序是癌症治疗的入场券:分子诊断机会的不平等是否不公平?
IF 2
Journal of Cancer Policy Pub Date : 2024-06-20 DOI: 10.1016/j.jcpo.2024.100492
Jilles Smids , Charlotte Bomhof , Maarten IJzerman , Eline Bunnik
{"title":"Whole genome sequencing as a ticket to cancer treatment in the Netherlands: Are inequalities in access to molecular diagnostics unfair?","authors":"Jilles Smids ,&nbsp;Charlotte Bomhof ,&nbsp;Maarten IJzerman ,&nbsp;Eline Bunnik","doi":"10.1016/j.jcpo.2024.100492","DOIUrl":"10.1016/j.jcpo.2024.100492","url":null,"abstract":"<div><p>Whole genome sequencing (WGS) of a tumour may sometimes reveal additional potential targets for medical treatment. Practice variation in the use of WGS is therefore a source of unequal access to targeted therapies and, as a consequence, of disparities in health outcomes. Moreover, this may even be more significant if patients seek access to WGS by paying a relatively limited amount of money out of pocket, and sometimes effectively buy themselves a ticket to (very) expensive publicly funded treatments. Should resulting unequal access to WGS be considered unfair? Drawing from current practice in the Dutch healthcare system, known as egalitarian, we argue that differences in employment of WGS between hospitals are the consequence of the fact that medical innovation and its subsequent uptake inevitably takes time. Consequently, temporal inequalities in access can be deemed acceptable, or at least tolerated, because and insofar as, ultimately, all patients benefit. However, we argue <em>against</em> allowing a practice of out-of-pocket payments for WGS in publicly funded healthcare systems, for four reasons: because allowing private spending favours patients with higher socio-economic status significantly more than practice variation between hospitals does, may lead to displacement of publicly funded health care, does not help to ultimately benefit all, and may undermine the solidaristic ethos essential for egalitarian healthcare systems.</p></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmaceutical company funding of cancer patient advocacy organizations in the Netherlands 荷兰制药公司对癌症患者权益保护组织的资助》(Pharmaceutical Company Funding of Cancer Patient Advocacy Organizations in the Netherlands)。
IF 1.3
Journal of Cancer Policy Pub Date : 2024-06-12 DOI: 10.1016/j.jcpo.2024.100493
Anne M.J. Somers , Ashley J. Duits , Michael J. Samson , John-John B. Schnog
{"title":"Pharmaceutical company funding of cancer patient advocacy organizations in the Netherlands","authors":"Anne M.J. Somers ,&nbsp;Ashley J. Duits ,&nbsp;Michael J. Samson ,&nbsp;John-John B. Schnog","doi":"10.1016/j.jcpo.2024.100493","DOIUrl":"10.1016/j.jcpo.2024.100493","url":null,"abstract":"<div><h3>Background</h3><p>Financial conflicts of interest (FCOI) of medical professionals and associated organizations with pharmaceutical companies (pharma) might contribute to the use of low value oncological treatments. Value criteria for oncological drug approvals in the Netherlands have recently become more stringent leading to objections by cancer patient advocacy organizations (cPAOs). Considering the importance of cPAOs input in cancer patient care we analyzed whether pharma funding of cPAOs occurs in the Netherlands.</p></div><div><h3>Methods</h3><p>The cPAO websites and available annual reports were evaluated for disclosure of pharma funding for the years 2021 and 2022. Also, data from the Dutch Healthcare Transparency Registry (DHTR) were extracted.</p></div><div><h3>Results</h3><p>Twenty-one of 34 (61.8 %) cPAOs received pharma funding (with 20 registered in the DHTR), and for 13 (29.4 %) cPAOs no reporting of pharma funding could be found. Three of the cPAOs disclosed pharma funding directly on their main website. Online educational material was available from 22 cPAOs on their websites with pharma funding disclosed on the educational material in 5. The total registered amount of pharmaceutical funding was €667,232.00 in 2021 and €536,098.00 in 2022. The median (and interquartile ranges) DHTR registered amount of support per cPAO that received funding in the studied period was €23,799.50 (14,823.75–84,663.30). The most common funding category as defined in the DHTR was project sponsorship.</p></div><div><h3>Conclusions</h3><p>Financial support by the pharmaceutical industry is common for Dutch cPAOs. Given the importance of cPAOs and their objective input in the societal debate on the availability of cancer drugs, the potential influence of pharma sponsoring should be critically evaluated.</p></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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