Journal of Cancer Policy最新文献

{"title":"Comparing the time spent in clinic by patients receiving, subcutaneous and intravenous formulations of cancer drugs: A pilot study","authors":"Sana Kagalwalla ,&nbsp;Alexander K. Tsai ,&nbsp;Michelle Tregear ,&nbsp;Andrea Maranda ,&nbsp;Damé Idossa ,&nbsp;Anne H. Blaes ,&nbsp;Helen M. Parsons ,&nbsp;Rachel I. Vogel ,&nbsp;Arjun Gupta","doi":"10.1016/j.jcpo.2025.100625","DOIUrl":"10.1016/j.jcpo.2025.100625","url":null,"abstract":"<div><h3>Background</h3><div>Subcutaneous (SC) formulations of cancer-directed and supportive care drugs are associated with time savings relative to their intravenous (IV) formulations in clinical trials, but it is unclear if these time savings apply in routine practice.</div></div><div><h3>Methods</h3><div>We performed a retrospective study of adults with breast cancer treated at a single U.S. academic clinic site in 2024. We matched patients who received (1) SC trastuzumab/pertuzumab, or (2) SC denosumab, 1:1 to patients who received comparator IV formulations (IV trastuzumab/pertuzumab, or IV zoledronic acid, respectively) and had the same number and type of appointment(s) that day. We used Real-time location system (RTLS) badge data to calculate total time spent in the clinic and in the infusion area, and compared these between groups.</div></div><div><h3>Results</h3><div>Among 14 patient-days with SC trastuzumab/pertuzumab and 15 patient-days with SC denosumab matched 1:1 with their IV comparators, most days included other ambulatory services performed (10/14 for SC trastuzumab/pertuzumab, 14/15 for SC denosumab). For trastuzumab/ pertuzumab, the median infusion area time was 65 min for SC vs. 110 min for IV (median difference, 48 min, p &lt; 0.003). The median total clinic time was 166 min for SC vs. 198 min for IV (median difference, 44 min, p = 0.206). For SC denosumab vs IV zoledronic acid, the median total clinic time was 99 min for SC vs. 110 min for IV (median difference, 19 min, p = 0.049).</div></div><div><h3>Conclusion</h3><div>Despite impressive time savings in clinical trials, SC trastuzumab/pertuzumab and SC denosumab offered only modest time savings compared with their IV counterparts when delivered in clinic.</div></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"45 ","pages":"Article 100625"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence on vaping e-cigarettes as a risk factor for cancer: A systematic review","authors":"Guilherme Guedes de Oliveira ,&nbsp;Rebeca Milka Lemos Magalhães Liberato ,&nbsp;Amaxsell Thiago Barros de Souza ,&nbsp;Ayane Cristine Alves Sarmento ,&nbsp;Edilmar de Moura Santos ,&nbsp;Kleyton Santos de Medeiros ,&nbsp;Irami Araújo Filho","doi":"10.1016/j.jcpo.2025.100615","DOIUrl":"10.1016/j.jcpo.2025.100615","url":null,"abstract":"<div><h3>Objective</h3><div>This review aims to evaluate the association between e-cigarette use and cancer risk.</div></div><div><h3>Study design</h3><div>A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.</div></div><div><h3>Methods</h3><div>Studies were sourced from PubMed/MEDLINE, LILACS, Embase, Web of Science, and Scopus up to September 2024. Observational studies evaluating the association between e-cigarette use and cancer risk were included. Data selection and extraction were performed independently and in pairs. The risk of bias was assessed using the Newcastle-Ottawa Scale (NOS) for cohort and case-control studies and the Joanna Briggs Institute (JBI) critical appraisal tool for cross-sectional studies.</div></div><div><h3>Results</h3><div>Ten studies were included in the final analysis, a total of 143,975 patients. Skin cancer represented 7 % (n = 635) of cases, followed by breast cancer at 4 % (n = 370), prostate cancer at 2 % (n = 234), melanoma at 1.4 % (n = 118), and colon cancer 1.2 % (n = 106). A single study identified associations between e-cigarette use and various types of cancer, along with links to lung disease, depression, and physical inactivity. Another study suggested a potential association between e-cigarette use and lung cancer, as well as a later-stage diagnosis for breast and colorectal cancers. However, three studies found no significant link between e-cigarette use and non–muscle-invasive bladder cancer.</div></div><div><h3>Conclusion</h3><div>E-cigarette use may be associated with an increased risk of certain cancers, including cervical and breast cancer. However, the evidence remains inconclusive, and more rigorous longitudinal studies are needed to provide clearer conclusions.</div></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"45 ","pages":"Article 100615"},"PeriodicalIF":2.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes and barriers to intervention research targeted at improving cervical cancer screening uptake in Sub-Saharan Africa: A survey of researchers’ perspectives","authors":"Phinda G. Khumalo ,&nbsp;Lisa Mackenzie ,&nbsp;Mariko Carey ,&nbsp;Rob Sanson-Fisher","doi":"10.1016/j.jcpo.2025.100624","DOIUrl":"10.1016/j.jcpo.2025.100624","url":null,"abstract":"<div><h3>Background</h3><div>Cervical cancer remains a major public health crisis in Sub-Saharan Africa, partly due to low screening rates. Despite the need for intervention research to inform strategies to increase screening participation, limited research has explored the specific challenges faced by researchers conducting intervention research on cervical cancer screening in this region. This study examined researchers’ attitudes and perceived barriers to conducting intervention research aimed at enhancing cervical cancer screening uptake in the region. The study also identified factors associated with endorsing a higher number of barriers.</div></div><div><h3>Methods</h3><div>An online survey was conducted among researchers who had published studies on cervical cancer screening in Sub-Saharan Africa between 2010 and 2020. Data on attitudes, perceived barriers, sociodemographic and research experience characteristics were collected. Descriptive statistics and linear regression analysis were used to analyse data.</div></div><div><h3>Results</h3><div>One hundred and fifty-seven researchers from 17 sub-Saharan African countries completed the survey (response rate: 26.5 %). Most participants acknowledged the necessity of increasing intervention research to improve screening uptake. Common perceived barriers included insufficient funding (89 %), slow ethical and regulatory approvals (61 %), and challenges in measuring screening uptake (57 %). Less experienced researchers were more likely to endorse a greater number of barriers.</div></div><div><h3>Conclusions</h3><div>Researchers recognised the importance of intervention research to improve cervical cancer screening uptake in Sub-Saharan Africa. However, they faced significant barriers, particularly relating to funding, regulatory processes, and measurement challenges. Researchers with less experience in research perceived more barriers, indicating a need for targeted support.</div></div><div><h3>Policy summary</h3><div>A coordinated response is required to address these barriers. Priorities include investing in context-specific research, streamlining ethics and regulatory processes, enhancing early-career researcher training, and establishing dedicated funding for intervention studies. Future efforts should focus on country-specific research, regional ethics harmonisation, and sustainable capacity-building initiatives.</div></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"45 ","pages":"Article 100624"},"PeriodicalIF":2.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turning Lessons into Action: Building an Inclusive Oncology Care for Transgender and gender-diverse People- Pavia & Milano framework.","authors":"Amelia Barcellini, Chiara Cassani, Anna Maria Mancuso, Giuseppe Antonelli, Claudio Baggini, Laura Beduschi, Elisabetta Bettega, Fabiola Bologna, Daniele Calzavara, Cristina Campiglio, Francesco Celestina, Maria Grazia Colombo, Claudia Roberta Combei, Simone D'Alpaos, Silvia Deandrea, Silvia Desigis, Alessandra Dell'Era, Francesca Dionigi, Cinzia Fasola, Silvia Illari, Bianca Iula, Nicla La Verde, Manuela Nebuloni, Gianmarco Negri, Mara Ravasi, Lorenzo Ruggieri, Raffaela Sartori, Simona Secondino, Maria Silvia Spinelli, Barbara Tagliaferri, Davide Dalu, Laura Deborah Locati","doi":"10.1016/j.jcpo.2025.100621","DOIUrl":"https://doi.org/10.1016/j.jcpo.2025.100621","url":null,"abstract":"<p><p>Italy remains one of the lowest-ranking Western European countries in terms of rights and protections for transgender and gender-diverse (TGD) individuals, with serious consequences for equitable healthcare access. In response to these disparities, and thanks to the initiative and support of the advocacy group Salute Donna Odv Salute Uomo, a multidisciplinary team organised a series of public conferences in Pavia and Milan in 2024. These events brought together healthcare professionals, researchers, LGBTQIA+ organisations, and patient advocates to define practical strategies for more inclusive cancer care. The outcome is a shared framework presented in this manuscript, aimed at enhancing cultural competence and institutional responsiveness in oncology services for TGD patients.</p>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":" ","pages":"100621"},"PeriodicalIF":2.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer across five decades in a Swedish female cohort: Findings from the Population Study of Women in Gothenburg (1968–2019)","authors":"Dominique Hange ,&nbsp;Amanda von Below ,&nbsp;Valter Sundh ,&nbsp;Lauren Lissner ,&nbsp;Cecilia Björkelund","doi":"10.1016/j.jcpo.2025.100622","DOIUrl":"10.1016/j.jcpo.2025.100622","url":null,"abstract":"<div><h3>Background</h3><div>Cancer remains a leading cause of global mortality, with increasing prevalence posing ongoing public health challenges. Despite medical advances, women are often underrepresented in clinical research. In Sweden, high cancer rates among women underscore the importance of long-term studies. The Population Study of Women in Gothenburg (PSWG), initiated in 1968, provides a unique opportunity to explore cancer trends across five decades in a representative cohort of Swedish women.</div></div><div><h3>Methods</h3><div>This population-based cohort study included 2165 women initially examined in 1968–69, with additional cohorts recruited in 1980, 1992, and 2004. Participants were followed longitudinally until the end of 2019. Cancer incidence and cause-specific mortality data were obtained from medical records and national registries. Associations between demographic and lifestyle factors (including smoking and socioeconomic status) and cancer outcomes were assessed using descriptive and inferential statistical methods.</div></div><div><h3>Results</h3><div>Out of 2165 participants, 634 (29 %) were diagnosed with cancer during the follow-up period. The most common cancer types were breast (n = 150, 6.9 %) and skin cancer (n = 130, 6.0 %). Smoking and higher socioeconomic status were significantly associated with increased cancer incidence. Among 1154 women aged 60–90 at follow-up, 761 deaths occurred, with 181 (24 %) attributed to cancer—most frequently liver, breast, and gastrointestinal cancers. Smoking was also linked to elevated cancer-related mortality.</div></div><div><h3>Conclusion</h3><div>This study demonstrates the value of long-term cohort data in tracking cancer trends among women. Cancer incidence increased over time, with smoking linked to both higher incidence and mortality. While established associations were confirmed, no new links were found between lower socioeconomic status and cancer, although higher socioeconomic status was associated with increased incidence.</div></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"45 ","pages":"Article 100622"},"PeriodicalIF":2.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Return-to-work regulations for cancer survivors in Europe — A structured expert-description approach","authors":"Sophie Klara Schellack,&nbsp;Carmen Koko,&nbsp;Johannes Soff,&nbsp;Clara Breidenbach,&nbsp;Christoph Kowalski","doi":"10.1016/j.jcpo.2025.100623","DOIUrl":"10.1016/j.jcpo.2025.100623","url":null,"abstract":"<div><h3>Background</h3><div>Thirty-six percent of new cancer diagnoses in Europe in 2022 affected people of working age, potentially leading to substantial changes in their working lives, such as a withdrawal from work. Successful return to work has been found to be associated with several predictive factors, including health and social-system factors. The present study aimed to identify which policies and practices are in place on the health and social-system level to help cancer survivors return to work in selected European countries.</div></div><div><h3>Methods</h3><div>The present research project followed a qualitative approach. Return-to-work processes were assessed with experts from European countries, using a semistructured guideline. Processes were systematically assessed along the patient pathway using a prestructured grid. Two researchers then examined the grid independently and classified the processes into different approaches.</div></div><div><h3>Results</h3><div>Experts from eight countries were recruited (from Germany, Belgium, the Netherlands, Finland, Ireland, Spain, Cyprus, Luxembourg). The results show “comprehensive” return-to-work approaches in Germany, Belgium, Netherlands, Ireland and Finland, “stepwise” approaches in Luxembourg and Spain, and an “ad-hoc” approach in Cyprus. We identified particular gaps in the provision of care in rural regions and for self-employed cancer survivors or cancer survivors who were already unemployed at the time of diagnosis. Assessment along the patient pathway revealed that return-to-work processes are unstructured, with varying contact persons in most of the European countries represented, making it difficult for cancer survivors to navigate.</div></div><div><h3>Conclusion</h3><div>In summary, the processes involved in cancer survivors’ return to work vary along the patient pathway across European countries. Typically, these processes are not structured in a patient-friendly way, and successful uptake of available services depends on the patient’s own initiative and willingness on the part of care professionals. Return-to-work processes for cancer survivors vary in European countries to an extent that is in conflict with European Union policy aims.</div></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"45 ","pages":"Article 100623"},"PeriodicalIF":2.0,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to enhance palliative care access in rural populations and increase awareness of life-limiting illnesses in India: A scoping review","authors":"Hung Phan Huu ,&nbsp;Ishita Gandhi","doi":"10.1016/j.jcpo.2025.100612","DOIUrl":"10.1016/j.jcpo.2025.100612","url":null,"abstract":"<div><h3>Background</h3><div>As of April 2023, India is reported to be the most populated country in the globe by the United Nations, with estimation of around 1.5 billion citizens. Despite the development in palliative delivery in recent years, access to such services in rural populations remains underutilized and shows many difficulties. As life expectancy increases, those who live in rural areas are faced with higher incidences of non-communicable diseases along with the already burdened prevalence of infectious diseases, leading to an ever-high demand for end-of-life healthcare services that are easy to access and affordable.</div></div><div><h3>Objectives</h3><div>To identify strategies to enhance care quality and ways to raise community awareness of the importance of end-of-life healthcare services by systematically addressing the challenges in palliative care delivery in remote communities in India.</div></div><div><h3>Methods</h3><div>We conducted a scoping review using PubMed, EMBASE, Cochrane Library and Web of Science databases following PRISMA guidelines up to February 2024 focusing on palliative care delivery and quality improvement in rural Indian communities, aligning WHO ICCCF elements.</div></div><div><h3>Results</h3><div>From 366 records, 22 papers met the inclusion criteria and were synthesized. 16 articles discussed care model implementation, 3 focused on awareness and education, and 3 analyzed policy challenges. Barriers identified include geographical, socioeconomic, and workforce challenges, alongside cultural misconceptions. Strategies proposed involve comprehensive training, community engagement, and policy reforms.</div></div><div><h3>Conclusions</h3><div>Addressing palliative care barriers in rural India requires improving infrastructure, expanding the healthcare workforce, and fostering cultural sensitivity. Community involvement and strategic collaboration are vital for enhancing access and quality of care.</div></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"45 ","pages":"Article 100612"},"PeriodicalIF":2.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence on “Evaluation of treatment protocols based on the ESMO-magnitude of clinical benefit scale for gastrointestinal system cancers and their relationship with reimbursement policies in Turkey”","authors":"Hinpetch Daungsupawong ,&nbsp;Viroj Wiwanitkit","doi":"10.1016/j.jcpo.2025.100619","DOIUrl":"10.1016/j.jcpo.2025.100619","url":null,"abstract":"","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"45 ","pages":"Article 100619"},"PeriodicalIF":2.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of treatment protocols based on the ESMO-magnitude of clinical benefit scale for gastrointestinal system cancers and their relationship with reimbursement policies in Turkey","authors":"Orhun Akdogan","doi":"10.1016/j.jcpo.2025.100620","DOIUrl":"10.1016/j.jcpo.2025.100620","url":null,"abstract":"","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"45 ","pages":"Article 100620"},"PeriodicalIF":2.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financial toxicity of surgical cancer treatment in LMICs: Implications for patients and health systems","authors":"Ajagbe Oluwasanmi Adekunle ,&nbsp;Adegbesan Abiodun ,&nbsp;Adewunmi Akingbola ,&nbsp;Samuel Tundealao ,&nbsp;Onyekachi Emmanuel Anyagwa ,&nbsp;Adebayo Adedayo Mobolaji ,&nbsp;Adeolu Badejo ,&nbsp;Onanuga Damilola Daniel ,&nbsp;Olajuwon Oduntan ,&nbsp;Oluwasola Olamide Victor ,&nbsp;Babatunde Ismail Bale ,&nbsp;Obagade Ibukunoluwa Oluwatoyin ,&nbsp;Atunde Folajimi ,&nbsp;Joel Chuku","doi":"10.1016/j.jcpo.2025.100616","DOIUrl":"10.1016/j.jcpo.2025.100616","url":null,"abstract":"<div><div>Financial toxicity, the economic burden experienced by patients due to cancer treatment, has emerged as a critical concern, particularly in low- and middle-income countries (LMICs) where health systems are often under-resourced and out-of-pocket expenditure dominates healthcare financing. This narrative review explores the financial toxicity associated with surgical cancer treatment in LMICs, highlighting its multifaceted impact on patients and health systems. Drawing on current literature, we examined direct medical costs, non-medical expenses, income loss, and coping strategies such as debt and asset depletion. We also assessed how these financial pressures lead to delayed treatment, reduced adherence, poor clinical outcomes, and catastrophic health expenditure. At the health systems level, financial toxicity undermines cancer control efforts, exacerbates health inequities, and limits progress toward universal health coverage. The review further identified structural barriers, such as inadequate health insurance schemes, fragmented surgical services, and a lack of social safety nets, that intensify economic hardship for cancer patients. We concluded by recommending policy reforms, including the integration of financial risk protection mechanisms, investment in surgical oncology infrastructure, and the inclusion of cancer surgery in national cancer control plans. Addressing the financial toxicity of surgical cancer care is vital to improving cancer outcomes and advancing equitable, sustainable health systems in LMICs.</div></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"45 ","pages":"Article 100616"},"PeriodicalIF":2.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}