Dominique Hange , Amanda von Below , Valter Sundh , Lauren Lissner , Cecilia Björkelund
{"title":"瑞典女性队列五十年中的癌症：哥德堡妇女人口研究（1968-2019）的结果。","authors":"Dominique Hange , Amanda von Below , Valter Sundh , Lauren Lissner , Cecilia Björkelund","doi":"10.1016/j.jcpo.2025.100622","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Cancer remains a leading cause of global mortality, with increasing prevalence posing ongoing public health challenges. Despite medical advances, women are often underrepresented in clinical research. In Sweden, high cancer rates among women underscore the importance of long-term studies. The Population Study of Women in Gothenburg (PSWG), initiated in 1968, provides a unique opportunity to explore cancer trends across five decades in a representative cohort of Swedish women.</div></div><div><h3>Methods</h3><div>This population-based cohort study included 2165 women initially examined in 1968–69, with additional cohorts recruited in 1980, 1992, and 2004. Participants were followed longitudinally until the end of 2019. Cancer incidence and cause-specific mortality data were obtained from medical records and national registries. Associations between demographic and lifestyle factors (including smoking and socioeconomic status) and cancer outcomes were assessed using descriptive and inferential statistical methods.</div></div><div><h3>Results</h3><div>Out of 2165 participants, 634 (29 %) were diagnosed with cancer during the follow-up period. The most common cancer types were breast (n = 150, 6.9 %) and skin cancer (n = 130, 6.0 %). Smoking and higher socioeconomic status were significantly associated with increased cancer incidence. Among 1154 women aged 60–90 at follow-up, 761 deaths occurred, with 181 (24 %) attributed to cancer—most frequently liver, breast, and gastrointestinal cancers. Smoking was also linked to elevated cancer-related mortality.</div></div><div><h3>Conclusion</h3><div>This study demonstrates the value of long-term cohort data in tracking cancer trends among women. Cancer incidence increased over time, with smoking linked to both higher incidence and mortality. While established associations were confirmed, no new links were found between lower socioeconomic status and cancer, although higher socioeconomic status was associated with increased incidence.</div></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"45 ","pages":"Article 100622"},"PeriodicalIF":2.0000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cancer across five decades in a Swedish female cohort: Findings from the Population Study of Women in Gothenburg (1968–2019)\",\"authors\":\"Dominique Hange , Amanda von Below , Valter Sundh , Lauren Lissner , Cecilia Björkelund\",\"doi\":\"10.1016/j.jcpo.2025.100622\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Cancer remains a leading cause of global mortality, with increasing prevalence posing ongoing public health challenges. Despite medical advances, women are often underrepresented in clinical research. In Sweden, high cancer rates among women underscore the importance of long-term studies. The Population Study of Women in Gothenburg (PSWG), initiated in 1968, provides a unique opportunity to explore cancer trends across five decades in a representative cohort of Swedish women.</div></div><div><h3>Methods</h3><div>This population-based cohort study included 2165 women initially examined in 1968–69, with additional cohorts recruited in 1980, 1992, and 2004. Participants were followed longitudinally until the end of 2019. Cancer incidence and cause-specific mortality data were obtained from medical records and national registries. Associations between demographic and lifestyle factors (including smoking and socioeconomic status) and cancer outcomes were assessed using descriptive and inferential statistical methods.</div></div><div><h3>Results</h3><div>Out of 2165 participants, 634 (29 %) were diagnosed with cancer during the follow-up period. The most common cancer types were breast (n = 150, 6.9 %) and skin cancer (n = 130, 6.0 %). Smoking and higher socioeconomic status were significantly associated with increased cancer incidence. Among 1154 women aged 60–90 at follow-up, 761 deaths occurred, with 181 (24 %) attributed to cancer—most frequently liver, breast, and gastrointestinal cancers. Smoking was also linked to elevated cancer-related mortality.</div></div><div><h3>Conclusion</h3><div>This study demonstrates the value of long-term cohort data in tracking cancer trends among women. Cancer incidence increased over time, with smoking linked to both higher incidence and mortality. While established associations were confirmed, no new links were found between lower socioeconomic status and cancer, although higher socioeconomic status was associated with increased incidence.</div></div>\",\"PeriodicalId\":38212,\"journal\":{\"name\":\"Journal of Cancer Policy\",\"volume\":\"45 \",\"pages\":\"Article 100622\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cancer Policy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213538325000669\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"HEALTH POLICY & SERVICES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cancer Policy","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213538325000669","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HEALTH POLICY & SERVICES","Score":null,"Total":0}
Cancer across five decades in a Swedish female cohort: Findings from the Population Study of Women in Gothenburg (1968–2019)
Background
Cancer remains a leading cause of global mortality, with increasing prevalence posing ongoing public health challenges. Despite medical advances, women are often underrepresented in clinical research. In Sweden, high cancer rates among women underscore the importance of long-term studies. The Population Study of Women in Gothenburg (PSWG), initiated in 1968, provides a unique opportunity to explore cancer trends across five decades in a representative cohort of Swedish women.
Methods
This population-based cohort study included 2165 women initially examined in 1968–69, with additional cohorts recruited in 1980, 1992, and 2004. Participants were followed longitudinally until the end of 2019. Cancer incidence and cause-specific mortality data were obtained from medical records and national registries. Associations between demographic and lifestyle factors (including smoking and socioeconomic status) and cancer outcomes were assessed using descriptive and inferential statistical methods.
Results
Out of 2165 participants, 634 (29 %) were diagnosed with cancer during the follow-up period. The most common cancer types were breast (n = 150, 6.9 %) and skin cancer (n = 130, 6.0 %). Smoking and higher socioeconomic status were significantly associated with increased cancer incidence. Among 1154 women aged 60–90 at follow-up, 761 deaths occurred, with 181 (24 %) attributed to cancer—most frequently liver, breast, and gastrointestinal cancers. Smoking was also linked to elevated cancer-related mortality.
Conclusion
This study demonstrates the value of long-term cohort data in tracking cancer trends among women. Cancer incidence increased over time, with smoking linked to both higher incidence and mortality. While established associations were confirmed, no new links were found between lower socioeconomic status and cancer, although higher socioeconomic status was associated with increased incidence.
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