Guilherme Guedes de Oliveira , Rebeca Milka Lemos Magalhães Liberato , Amaxsell Thiago Barros de Souza , Ayane Cristine Alves Sarmento , Edilmar de Moura Santos , Kleyton Santos de Medeiros , Irami Araújo Filho
{"title":"Evidence on vaping e-cigarettes as a risk factor for cancer: A systematic review","authors":"Guilherme Guedes de Oliveira , Rebeca Milka Lemos Magalhães Liberato , Amaxsell Thiago Barros de Souza , Ayane Cristine Alves Sarmento , Edilmar de Moura Santos , Kleyton Santos de Medeiros , Irami Araújo Filho","doi":"10.1016/j.jcpo.2025.100615","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This review aims to evaluate the association between e-cigarette use and cancer risk.</div></div><div><h3>Study design</h3><div>A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.</div></div><div><h3>Methods</h3><div>Studies were sourced from PubMed/MEDLINE, LILACS, Embase, Web of Science, and Scopus up to September 2024. Observational studies evaluating the association between e-cigarette use and cancer risk were included. Data selection and extraction were performed independently and in pairs. The risk of bias was assessed using the Newcastle-Ottawa Scale (NOS) for cohort and case-control studies and the Joanna Briggs Institute (JBI) critical appraisal tool for cross-sectional studies.</div></div><div><h3>Results</h3><div>Ten studies were included in the final analysis, a total of 143,975 patients. Skin cancer represented 7 % (n = 635) of cases, followed by breast cancer at 4 % (n = 370), prostate cancer at 2 % (n = 234), melanoma at 1.4 % (n = 118), and colon cancer 1.2 % (n = 106). A single study identified associations between e-cigarette use and various types of cancer, along with links to lung disease, depression, and physical inactivity. Another study suggested a potential association between e-cigarette use and lung cancer, as well as a later-stage diagnosis for breast and colorectal cancers. However, three studies found no significant link between e-cigarette use and non–muscle-invasive bladder cancer.</div></div><div><h3>Conclusion</h3><div>E-cigarette use may be associated with an increased risk of certain cancers, including cervical and breast cancer. However, the evidence remains inconclusive, and more rigorous longitudinal studies are needed to provide clearer conclusions.</div></div>","PeriodicalId":38212,"journal":{"name":"Journal of Cancer Policy","volume":"45 ","pages":"Article 100615"},"PeriodicalIF":2.0000,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cancer Policy","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213538325000591","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HEALTH POLICY & SERVICES","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
This review aims to evaluate the association between e-cigarette use and cancer risk.
Study design
A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
Methods
Studies were sourced from PubMed/MEDLINE, LILACS, Embase, Web of Science, and Scopus up to September 2024. Observational studies evaluating the association between e-cigarette use and cancer risk were included. Data selection and extraction were performed independently and in pairs. The risk of bias was assessed using the Newcastle-Ottawa Scale (NOS) for cohort and case-control studies and the Joanna Briggs Institute (JBI) critical appraisal tool for cross-sectional studies.
Results
Ten studies were included in the final analysis, a total of 143,975 patients. Skin cancer represented 7 % (n = 635) of cases, followed by breast cancer at 4 % (n = 370), prostate cancer at 2 % (n = 234), melanoma at 1.4 % (n = 118), and colon cancer 1.2 % (n = 106). A single study identified associations between e-cigarette use and various types of cancer, along with links to lung disease, depression, and physical inactivity. Another study suggested a potential association between e-cigarette use and lung cancer, as well as a later-stage diagnosis for breast and colorectal cancers. However, three studies found no significant link between e-cigarette use and non–muscle-invasive bladder cancer.
Conclusion
E-cigarette use may be associated with an increased risk of certain cancers, including cervical and breast cancer. However, the evidence remains inconclusive, and more rigorous longitudinal studies are needed to provide clearer conclusions.