Journal of the Mechanical Behavior of Biomedical Materials最新文献

{"title":"A microstructural material model for adipose tissue under blunt impact considering different types of loading","authors":"Felicitas Lanzl ,&nbsp;Steffen Peldschus ,&nbsp;Gerhard A. Holzapfel ,&nbsp;Fabian Duddeck ,&nbsp;Gerhard Sommer","doi":"10.1016/j.jmbbm.2025.107042","DOIUrl":"10.1016/j.jmbbm.2025.107042","url":null,"abstract":"<div><div>Modeling of subcutaneous adipose tissue (SAT) plays an important role in forensic biomechanics as blunt force trauma represents one of the most common types of injury. To better understand the involved injury mechanisms, a material model is needed that can (i) represent realistic behavior for combined loading scenarios and (ii) consider the microstructure of the SAT. Therefore, a SAT model was developed that consists of two parts for the strain–energy function – a neo-Hookean part representing the adipocytes and a part representing the surrounding reinforced basement membrane, which is modeled via three circular fiber families oriented in the three main planes, resulting in isotropic model behavior. To verify the performance of the model, the analytical and numerical model solution were compared with experimental data under biaxial tension at different stretch ratios (<span><math><mrow><mn>1</mn><mo>:</mo><mn>1</mn></mrow></math></span>, <span><math><mrow><mn>1</mn><mo>:</mo><mn>0</mn><mo>.</mo><mn>5</mn></mrow></math></span>, <span><math><mrow><mn>0</mn><mo>.</mo><mn>5</mn><mo>:</mo><mn>1</mn></mrow></math></span>) and under simple shear using an objective evaluation method. The material parameters were evaluated by fitting to the data under equibiaxial tension. For the numerical analysis, the model was implemented as a user-defined material in LS-DYNA to simulate the respective experimental setups. The analytical fitting of the model was robust. Using the resulting material parameters, both the analytical and numerical simulation results were able to represent the experimental data under biaxial tension as well as under simple shear quite well. Since the fitting was only performed with data under equibiaxial tension, these findings suggest that the model assumptions are reasonable. Therefore, the model could help to further investigate the injury mechanisms in blunt impacts.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"169 ","pages":"Article 107042"},"PeriodicalIF":3.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a subject-specific finite element analysis workflow to assess local biomechanics during segmental bone defect healing","authors":"Farhan Muhib ,&nbsp;Kylie E. Williams ,&nbsp;Steven A. LaBelle ,&nbsp;Angela S.P. Lin ,&nbsp;Robert E. Guldberg ,&nbsp;Jeffrey A. Weiss","doi":"10.1016/j.jmbbm.2025.107065","DOIUrl":"10.1016/j.jmbbm.2025.107065","url":null,"abstract":"<div><div>Longitudinal estimation of local strain distributions within the regenerative niche of segmental femoral fractures is important for understanding mechanobiology principles for bone healing to design more effective rehabilitation regimens and mitigate nonunion complications. Finite element (FE) modeling is the standard for investigating these biomechanical parameters, yet most existing models lack clinical relevance due to their use of generic data and computational inefficiency. This study developed a subject-specific FE workflow aimed at accurate biomechanical predictions based on subject-specific data while addressing the limitations of previous approaches. For the experimental study, near-critical-sized segmental bone defects were created in the femurs of Wistar rats and stabilized with internal fixators before rehabilitation. Subject-specific geometries of the defect were generated from <em>in vivo</em> micro-CT scans, which were also used to assign material coefficients. Generalized geometries of the cortical and trabecular bone and fixator were integrated to increase computational efficiency. In addition, axial strain data from strain gauges on the fixators were used to define subject-specific boundary conditions, enabling a longitudinal study of the healing process. Sensitivity analyses revealed that incorporating subject-specific boundary conditions significantly enhanced model accuracy, a factor often overlooked in conventional approaches. The workflow was used to build six defect models to approximate compressive strains within the defect and the joint contact force. Strain distributions correlated with experimentally observed mineralization and better predicted functional bone bridging (union) compared to bone volume metrics. This efficient workflow facilitates the assessment of local biomechanics during bone healing and highlights their influence on adaptive regeneration. Further, the findings support the potential application of the subject-specific modeling workflow to guide clinical decision-making and improve therapeutic outcomes for treating bone fractures.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"169 ","pages":"Article 107065"},"PeriodicalIF":3.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a μ-volume sample holder for non-destructive and contactless assessment of the mechanical properties in soft biomaterials","authors":"Maria Elena Lombardo ,&nbsp;Maud Viallon ,&nbsp;Dimitria B. Camasão ,&nbsp;Pascale Chevallier ,&nbsp;Francesco Copes ,&nbsp;Roberto López-Munoz ,&nbsp;David Gendron ,&nbsp;Cédric Schmitt ,&nbsp;Anis H. Henni ,&nbsp;Diego Mantovani","doi":"10.1016/j.jmbbm.2025.107066","DOIUrl":"10.1016/j.jmbbm.2025.107066","url":null,"abstract":"<div><div>The mechanical characterization of soft biomaterials, like hydrogels, plays a key role for the successful development of new biomimetic constructs for numerous bioengineering and biomedical fields. Conventionally, mechanical properties are assessed using destructive approaches, including rheometer, which are weakly adapted to biomedical samples, mainly due to the lack of possibility to carry out in situ tests to follow gelation process. Recently, a non-destructive and contactless approach, named viscoelastic testing of bilayered materials (VeTBiM), was reported to measure the viscoelastic properties of soft hydrogels using low amplitude vibration. However, the high volumes required to obtain reliable results is considered a drawback for those applications in regenerative medicine demanding rare, highly purified and high-cost biomolecules. In this work, a new μ-volume sample holder is presented as cost-effective and time-efficient tool for the assessment of the mechanical properties of biomolecules-rich gels involving complex and time-consuming preparation. The new sample holder has been validated by comparing the data obtained on various gelatin and Pluronic F-127 hydrogels with the data from the conventional rotational rheometer. The results show the potential of the new sample holder in the characterization of viscoelastic materials through a contactless approach. Furthermore, this study contributes to confirm the versatility of VeTBiM for the future development of soft hydrogels for tissue engineering and regenerative medicine applications.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"169 ","pages":"Article 107066"},"PeriodicalIF":3.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printable bioactive glass-based polymer-infiltrated ceramic for biomimetic tooth root applications","authors":"Ryo Mori ,&nbsp;Misaki Matsuo ,&nbsp;Kanna Saimoto ,&nbsp;Yuki Nagamatsu ,&nbsp;Ayako Washio ,&nbsp;Kentaro Ono ,&nbsp;Chiaki Kitamura ,&nbsp;Hiroshi Ikeda","doi":"10.1016/j.jmbbm.2025.107060","DOIUrl":"10.1016/j.jmbbm.2025.107060","url":null,"abstract":"<div><div>Titanium implants are widely utilized for tooth root reconstruction due to their excellent mechanical and biological properties. However, their mechanical properties differ from those of dentin. This study aims to develop a 3D-printable polymer-infiltrated ceramic network (PICN) as a tooth root restoration material that mimics the natural root shape, mechanical properties, and biocompatibility. A bioactive glass (BG)-based photocurable slurry was prepared for vat photopolymerization, printed, sintered, and subsequently polymer-infiltrated to form 3D-printable PICN (3D-PICN). For comparison, 3D-printable BG (3D-BG), a dense ceramic without resin infiltration, was fabricated using the same printing and sintering process. The photocurable slurry was characterized for its rheological and photopolymerization behaviors, including viscosity, cure depth, degree of conversion, overgrowth, and printing accuracy. The results confirmed its suitability for vat photopolymerization, enabling the precise fabrication of tooth root-shaped structures. Mechanical properties, including work of fracture, flexural strength, flexural modulus, and Vickers hardness, were evaluated for both 3D-PICN and 3D-BG. The results revealed that the mechanical properties of 3D-PICN closely match those of dentin, whereas 3D-BG exhibits properties similar to enamel. Biocompatibility was assessed through <em>in vitro</em> simulated body fluid immersion tests and <em>in vivo</em> implantation in a ten-week-old rat tibia model, followed by histological analysis. The findings confirmed good biocompatibility of 3D-PICN with bone tissue. The 3D-PICN demonstrated excellent printability, mechanical compatibility with dentin, and favorable biocompatibility, suggesting its potential as a promising material for tooth root reconstruction applications.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"169 ","pages":"Article 107060"},"PeriodicalIF":3.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of thermal aging on a urethane acrylate-based 3D printing resin incorporated with antibacterial quaternary ammonium methacrylate","authors":"Gan Jin ,&nbsp;Yunqi Liu ,&nbsp;Zhihao Zhang ,&nbsp;Yeonwoo Yim ,&nbsp;Dae Gyun Lee ,&nbsp;Min Suk Shim ,&nbsp;Reuben Kim ,&nbsp;Jong-Eun Kim","doi":"10.1016/j.jmbbm.2025.107063","DOIUrl":"10.1016/j.jmbbm.2025.107063","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to determine the impacts of thermal aging on the mechanical properties, biocompatibility, and antibacterial effectiveness of a urethane acrylate-based (UA) 3D printing resin containing dimethylaminohexadecyl methacrylate (DMAHDM).</div></div><div><h3>Methods</h3><div>DMAHDM was synthesized and incorporated into UA resin at 0.25 wt%, 0.5 wt%, 0.75 wt%, and 1 wt%. Specimens were 3D printed, washed, post-cured, and thermal cycled at 5 °C and 55 °C for 833, 2500, and 5000 cycles. The group without DMAHDM or aging was considered as the control group. Degree of conversion (DC), color differences, antibacterial effectiveness, cell viability, and mechanical properties were evaluated. Two-way analysis of variance was performed with a significance cutoff of α = 0.05.</div></div><div><h3>Results</h3><div>DC increased with the DMAHDM concentration, with the highest DC being observed at 1 wt% (53.68 ± 0.35 %) (mean ± standard deviation). The color of the specimens showed significant changes after 2500 and 5000 cycles. Antibacterial effectiveness was improved with 0.75 wt% and 1 wt% DMAHDM. Cytotoxicity was observed with prolonged thermal aging cycles. Flexural strength decreased with increasing DMAHDM concentrations and aging, with the lowest values at 1 wt% (93.02 ± 17.96 MPa) after 5000 cycles. However, Vickers hardness significantly increased with both DMAHDM and aging, reaching a peak at 5000 cycles (24.49 ± 0.96 HV).</div></div><div><h3>Conclusions</h3><div>DMAHDM concentration and thermal aging significantly influenced UA-based 3D printing resins properties. Higher DMAHDM concentration enhanced antibacterial effectiveness and Vickers hardness yet reduced flexural strength after 0.75 wt%. Thermal aging decreased flexural strength while improving DC and hardness. Prolonged aging also led to color changes and increased cytotoxicity.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"169 ","pages":"Article 107063"},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forced reeling from Bombyx mori reveals the mechanically toughest silk fiber at the natural spinning speed","authors":"Kenjiro Yazawa ,&nbsp;Yuka Tatebayashi","doi":"10.1016/j.jmbbm.2025.107062","DOIUrl":"10.1016/j.jmbbm.2025.107062","url":null,"abstract":"<div><div>Domesticated silkworms produce silk fibers in a mild condition, where humidity and temperature are controlled at a constant level. The natural silk spinning mechanisms of silkworms have not yet been elucidated. Previous studies have demonstrated that wild silkworms have evolved to spin mechanically and structurally robust silk fibers irrespective of reeling speeds. Here, we examined the influence of spinning speeds on the physical properties of silk fibers that are forcibly reeled from the domesticated silkworm, <em>Bombyx mori</em> (<em>B. mori</em>). We found that the <em>B. mori</em> maintained physical properties of the spun fibers in a narrower range of reeling speeds compared with wild silkworms. When the reeling speed was higher than the threshold of 60 mm/s, the molecular alignment of the silk fibers increased, while the ductility decreased. The toughness of silk fibers was highest when the reeling speed was close to the natural spinning speed of 10 mm/s. The <em>B. mori</em> silkworms might have less resistance to changes of the reeling speeds than wild silkworms that live in the wild. This study is not only useful for clarifying the biological system underlying the silk spinning of silkworms but can also contribute to considering spinning conditions aimed for producing synthetic silk.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"169 ","pages":"Article 107062"},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probability of fatigue failure and minimum sample size requirements for cyclically loaded bone","authors":"Andrew Koshyk ,&nbsp;Andrew J. Pohl ,&nbsp;Colin R. Firminger ,&nbsp;W. Brent Edwards","doi":"10.1016/j.jmbbm.2025.107061","DOIUrl":"10.1016/j.jmbbm.2025.107061","url":null,"abstract":"<div><div>Fatigue-life measurements of bone exhibit a significant amount of scatter, which may be characterized probabilistically using a Weibull analysis. Despite an abundance of fatigue testing literature, a standard recommendation for the number of samples required to adequately characterize the probability of fatigue failure in bone does not exist. The primary objective of this work was to determine the minimum sample size required to fit a Weibull distribution to fatigue-life measurements of cyclically loaded bone. Two existing experimental datasets comprising cortical and subchondral bone samples were used in this work. Weibull parameters were estimated using both the maximum likelihood and rank regression methods. A Monte Carlo simulation was used to estimate Weibull parameters for different sample sizes and a convergence analysis was used to determine the minimum required sample size. A simulated dataset with known population parameters was also used to assess the accuracy of the estimated Weibull parameters and to compare the two estimation methods. Our findings suggest that as many as <em>n</em> = 11 samples may be required to adequately quantify Weibull parameters from fatigue tests of bone. At the converged sample size, Weibull parameters differed from true population-level parameters by 3 %–25 %, depending on the estimation method. The maximum likelihood method provided the most accurate and precise estimates of Weibull parameters. These findings provide a framework for future studies aimed at reliably quantifying the probability of fatigue failure in bone.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"169 ","pages":"Article 107061"},"PeriodicalIF":3.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial relationship between histological staining intensity and corneal stiffness variations: Insights from AFM indentation in infant African green monkeys","authors":"Yingnan Zhai ,&nbsp;Jianing Wang ,&nbsp;Valentina O. Mendoza ,&nbsp;Ming Ye ,&nbsp;Kourosh Shahraki ,&nbsp;Donny W. Suh ,&nbsp;Donald S. Minckler ,&nbsp;Tatiana Karpova ,&nbsp;Kenia Nunes ,&nbsp;Pengfei Dong ,&nbsp;Linxia Gu","doi":"10.1016/j.jmbbm.2025.107047","DOIUrl":"10.1016/j.jmbbm.2025.107047","url":null,"abstract":"<div><div>This study investigated the spatial variations of mechanical properties and microstructure in the cornea using atomic force microscopy (AFM) indentation tests and histological analysis. Corneal samples were collected from three infant African green monkeys, approximately 6 months old. Hematoxylin and eosin (H&amp;E) staining was performed on corneal cross-sections to examine microstructure and quantify staining intensity. AFM indentations were conducted to quantify stiffness variations through pathline scanning and 16 × 16 stiffness mappings. Results showed that the corneal microstructure transitions from thinner, denser lamellae in the anterior layer to thicker, looser lamellae in the posterior layer. Stiffness variations along pathlines in the central, paracentral, peripheral, and limbus regions correlate positively with the corresponding staining intensities. The average stiffness across all samples was highest at the central anterior cornea (392.6 ± 118.4 kPa) and anterior limbus (645.4 ± 158.1 kPa). Additionally, both the anterior and posterior layers showed higher stiffness than the middle layer, except in the central region. AFM stiffness maps further revealed the layered structure of the lamellae. The stiffness variations between layers may result from different orientations of collagen fibrils in each lamellae. These observations were expected to provide valuable insights into corneal microstructure and mechanical properties variations during the progression of corneal diseases, aiding in the design of optimal artificial corneas. While this study focuses on infant monkey eyes, further testing across different age and sex groups is needed to refine these observations.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"169 ","pages":"Article 107047"},"PeriodicalIF":3.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical behavior of torsional honeycomb implants during mastication","authors":"Qiwen Ding ,&nbsp;Jinghu Yu ,&nbsp;Yumin Yang ,&nbsp;Shanhua Qian ,&nbsp;Fangyong Zhu ,&nbsp;Haifeng Xu","doi":"10.1016/j.jmbbm.2025.107046","DOIUrl":"10.1016/j.jmbbm.2025.107046","url":null,"abstract":"<div><div>Dental implant technology addresses masticatory dysfunction caused by tooth loss, with honeycomb structures emerging as promising candidates due to their exceptional energy absorption properties. This study systematically investigates the mechanical performance of titanium alloy honeycomb implants featuring variable twisted angles (0°–180°), aiming to optimize implant design for improved stress distribution in peri-implant bone tissue. Combined with finite element (FE) simulation and an in-vitro experimental platform based on a masticatory robot, the mechanical response of the implant under static compression and chewing different textures of food were analyzed. The results demonstrated an inverse relationship between torsional angle and both relative density and energy absorption capacity. Low-torsion configurations (≤60°) exhibited superior performance, reducing stress concentrations at thread roots and tails by 1.3–5.3 % compared to conventional designs under single axial load, while reducing by 1.5–7.2 % under combined load. The maximum strain at implant-bone interface was reduced by 1.6–3.4 % under single load and 8.9–14 % under combined load through the geometric torsion of the internal honeycomb structure, respectively. In-vitro test results showed that the low-torsion structure (&lt;90°) was more advantageous in reducing mechanical stimulation of bone tissue during chewing hard and brittle food. These findings highlight torsional honeycomb designs as a dual-functional solution combining biomechanical compatibility with structural resilience, providing actionable insights for next generation dental implant optimization.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"169 ","pages":"Article 107046"},"PeriodicalIF":3.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the influence of sol-gel bioactive glass 92S6 P123 on 3D-Printed scaffold fabrication","authors":"Théodore Berthelot ,&nbsp;Ronan Lebullenger ,&nbsp;Damien Brézulier ,&nbsp;Sylvie Tricot ,&nbsp;Sandrine Cammas-Marion ,&nbsp;Bertrand Lefeuvre ,&nbsp;Anita Lucas","doi":"10.1016/j.jmbbm.2025.107041","DOIUrl":"10.1016/j.jmbbm.2025.107041","url":null,"abstract":"<div><div>Additive manufacturing techniques for scaffold fabrication have shown remarkable potential in tissue engineering and regenerative medicine. In this study, a novel approach involving a composite material consisting of an association of sol-gel bioactive glass, 92S6 P123, with polylactic acid (PLA) was explored to create intricate three-dimensional (3D) scaffolds. The main objective was to analyze the impact of incorporating bioactive glass 92S6 P123 on the properties of 3D-printed scaffolds, subsequently optimizing the architectural design (grid versus gyroid), pore size, and porosity to obtain the best compromise between mechanical properties and porosity. The selected scaffold architecture, the gyroid, exhibits morphological features reminiscent of cancellous bone; this structure was carefully tailored to promote mechanical support and facilitate cell proliferation.</div><div>This study sheds light on the significance of incorporating bioactive glass 92S6 P123 into 3D-printed scaffolds. Moreover, the tailored scaffold architecture exhibited promising results in terms of the mechanical stability and cellular invasion. This study contributes to the evolving field of scaffold design for tissue engineering applications, offering insights into the interplay between scaffold composition, architecture, and <em>in vivo</em> performance. The knowledge gained from this study holds implications for the development of advanced regenerative therapies and implantable constructs in orthopaedic and tissue engineering disciplines.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"168 ","pages":"Article 107041"},"PeriodicalIF":3.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}