Journal of the Mechanical Behavior of Biomedical Materials最新文献

{"title":"Plating after tumor curettage in human femora does not efficiently improve torsional stability ex vivo","authors":"Annika vom Scheidt , Felix Pirrung , Petr Henyš , Birgit Oppelt , Andreas Leithner , Niels Hammer , Marko Bergovec","doi":"10.1016/j.jmbbm.2024.106798","DOIUrl":"10.1016/j.jmbbm.2024.106798","url":null,"abstract":"<div><h3>Background</h3><div>Surgical treatments of benign primary bone tumors of the femur face the challenge of limiting tissue damage and contamination while providing sufficient stabilization to avoid fracture. While no clear treatment guidelines exist, surgical treatment commonly consists of femoral fenestration and curettage with optional filling and plating of the defect. Mono- or bicortical plating of distal femoral defects aim to reduce fracture risk and have been shown to increase axial stability. However, it remains unclear whether plating increases torsional stability of the affected femur.</div></div><div><h3>Questions/purposes</h3><div>This biomechanical study aimed to determine how much additional stability can be achieved by mono- or bicortical plating of femoral defects after fenestration. The following hypotheses were investigated: 1. Preventive plating of distal femur bone defects enhances torsional stability when compared to femoral fenestration alone. 2. A condition close to the intact (nonpathological) bone can be achieved by bone plating. 3. Defect shape influences torsional stability.</div></div><div><h3>Patients and methods</h3><div>Thiel embalmed human femora (n = 24) were left intact or subjected to the following surgical treatments (A) defect creation via fenestration, (B) defect with short monocortical plating, (C) defect with long bicortical plating. All femora were torsion tested in midstance position using pre-cycling and testing until failure. Quantitative computed tomography pre and post testing allowed bone mineral density calculation and crack path analysis. Finite element analysis provided insight into defect shape variations.</div></div><div><h3>Results</h3><div>Torsion experiments showed no relevant enhancement of torsional stability due to mono- or bicortical plating. There were no significant differences in maximum torque between unplated and plated femora with defect (defect: 35.38 ± 7.53 Nm, monocortical plating: 37.77 ± 9.82 Nm, bicortical plating: 50.27 ± 9.72 Nm, p > 0.05). Maximum torque for all treatment groups was significantly lower compared to intact femora (155–200 Nm, p < 0.001). Cracks originated predominantly from the proximal posterior corner of the defect and intersected with screw holes in plated femora. The influence of variations of the defect corner shapes had no significant influence on maximum torque and angle.</div></div><div><h3>Conclusion</h3><div>This biomechanical study shows that mono- or bicortical plating is not an effective preventive treatment against torsional failure of femora with distal defects as the resulting maximum torque was drastically reduced compared to intact femora. Thus, the initial hypotheses have to be rejected. As habitual loading of the femur includes a combination of axial and torsional loading, the observed lack of prevention against torsional failure might help to explain the occurrence of fractures despite plating. Future research towards amelior","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"161 ","pages":"Article 106798"},"PeriodicalIF":3.3,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shore hardness of bulk polyurethane affects the properties of nanofibrous materials differently","authors":"Iwona Łopianiak ,&nbsp;Beata Butruk-Raszeja ,&nbsp;Michał Wojasiński","doi":"10.1016/j.jmbbm.2024.106793","DOIUrl":"10.1016/j.jmbbm.2024.106793","url":null,"abstract":"<div><div>The present study shows the effect of the hardness of bulk polyurethane on the properties of nanofibrous materials produced in the solution blow spinning process. This study focuses on nanofibrous materials made from medical-grade polyurethanes with different hardness values on the Shore scale, from 75A to 75D. We aimed to determine the effect of the intrinsic properties of polyurethane used to produce nanofibers on the tensile properties of the resulting nanofibrous materials and <em>in vitro</em> platelet adhesiveness. This study used a solution blow spinning process to produce nanofibrous materials from polyurethane solutions. It evaluates their properties using scanning electron microscopy, followed by porosity determination, tensile testing, and platelet adhesion assays. Generally, the bulk polymer's Shore hardness affects nanofibrous products' porosity and tensile properties. In the tested Shore hardness range, the most visible differences in material properties were observed for the fibers produced from the hardest (75D) and softest (75A) polyurethanes. The nanofibrous material produced using 75D polyurethane exhibited the highest porosity, up to approximately 0.87, owing to the low packing density of the stiff nanofibers. It also remained the stiffest, with the highest Young's modulus. On the other hand, the softest 75A polyurethane produced a less porous nanofibrous mat with the highest tensile strength among the tested polyurethanes. All tested nanofibrous materials retained their platelet adhesion resistance upon processing into nanofibers, with a mean platelet coverage below 1 % of the nanofibrous mat surface. The study results provide insights into the relationship between the hardness of bulk polyurethane and the properties of nanofibrous materials, which can be useful in various biomedical applications, particularly in producing tissue-engineered vascular grafts.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"161 ","pages":"Article 106793"},"PeriodicalIF":3.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micromechanical characteristics of titanium alloy (Ti-6Al-4V) made by laser powder bed fusion using an in-situ SEM micropillar compression technique","authors":"Md Bengir Ahmed Shuvho ,&nbsp;Afifah Z. Juri ,&nbsp;Animesh K. Basak ,&nbsp;Andrei Kotousov ,&nbsp;Ling Yin","doi":"10.1016/j.jmbbm.2024.106794","DOIUrl":"10.1016/j.jmbbm.2024.106794","url":null,"abstract":"<div><div>While titanium alloy (Ti-6Al-4V) made by laser powder bed fusion (L–PBF) exhibits complex deformation behaviors, its important micromechanical properties in relation to loading directions are not fully understood. This research aims to investigate the micromechanical behaviors of printed L–PBF Ti-6Al-4V alloys under vertical (i.e., the loading direction perpendicular to printed layers) and horizontal (i.e., the loading direction parallel to printed layers) compressions using <em>in-situ</em> scanning electron microscopy (SEM) micropillar techniques. Ti-6Al-4V alloys were L-PBF-printed using a 45° rotate scanning strategy with vertical and horizontal build directions. The microstructures of the two alloys were analyzed using the SEM with energy-dispersive X-ray spectroscopy (EDS). The titanium alloy micropillars were produced using focused ion beam (FIB) milling in the SEM. <em>In-situ</em> SEM micropillar compressions were conducted using a flat diamond indenter. Vertical alloy had smaller cross-patterned finer α′ martensite than horizontal one. While both vertical and horizontal micropillars showed elastic-plastic behaviors, the former had significantly higher yield, fracture, and compression strength values, as well as resilience and toughness, than the latter, leading to the formation of favorable shear bands. Both micropillars exhibited ductile fractures but had distinct failure mechanisms. The ductile fracture in the vertical micropillars was due to strain hardening, large plastic deformation, and shear band formation, while the ductile fracture in the horizontal ones was attributed to compression-induced bending and plastic buckling. The micromechanical characteristics of L–PBF Ti-6Al-4V materials provides an important insight into the small-scale deformation and failure mechanisms of the alloys influenced by loading directions.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"161 ","pages":"Article 106794"},"PeriodicalIF":3.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142587475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural optimization and in vitro corrosion analysis of biodegradable Mg-Nd-Zn-Zr alloy clip","authors":"Lin Mao ,&nbsp;Yujie Zhou ,&nbsp;Xin Zheng ,&nbsp;Xue Cai ,&nbsp;Yilong Chen ,&nbsp;Wanwen Yang ,&nbsp;Jvxiao Wang ,&nbsp;Jian Zhang ,&nbsp;Chengli Song","doi":"10.1016/j.jmbbm.2024.106790","DOIUrl":"10.1016/j.jmbbm.2024.106790","url":null,"abstract":"<div><div>Magnesium (Mg) alloy which benefits from biodegradability and mechanical characteristics offers great potential for the development of degradable hemostatic clips. However, the deformation process induces stress concentration, which in turn accelerates the corrosion rate of Mg hemostatic clips. In this study, two types of R-shape clips based on Mg-Nd-Zn-Zr alloy were designed with structural features of no teeth and staggered teeth and simulated using finite element analysis (FEA), and the corrosion behaviors of the Mg clips were investigated by immersion test and electrochemical measurement. Furthermore, the clamping properties of the Mg clips were evaluated by burst pressure test. The simulation results showed that the R-shape clip with staggered teeth caused the minimum stress (1.237 MPa) to blood vessels. After the clamping deformation process, the closed clips remained intact without any signs of cracking. <em>In vitro</em> degradation analysis indicated that the corrosion rate of the closed clip was slightly faster than that of the open clip, and the Mg clip maintained its efficacy in achieving vascular closure even after a 4-week period of immersion, indicating a commendable performance in secure ligation closure. In addition, the burst pressure test results showed that the staggered teeth clip exhibited a higher burst pressure (88.73 ± 2.58 kPa) with less mechanical damage occurring to the ligated vessels compared with the toothless clip, meeting the requirements for clinical application. Therefore, the newly developed R-shape Mg alloy clip, featuring staggered teeth, has demonstrated excellent mechanical stability and shows great promise in the application of biodegradable tissue clips.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"161 ","pages":"Article 106790"},"PeriodicalIF":3.3,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142587473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-inspired space-filling fractal metamaterial","authors":"Tiantian Li,&nbsp;Yaning Li","doi":"10.1016/j.jmbbm.2024.106791","DOIUrl":"10.1016/j.jmbbm.2024.106791","url":null,"abstract":"<div><div>Inspired by mammal cranial sutures with spatiotemporal morphological variation, two-phase space-filling fractal metamaterial was designed. Designs with different levels of complexity are fabricated via multi-material polymer jetting. Mechanical tests and systematic finite element (FE) simulations are conducted to evaluate the mechanical performance of the designs. It is found that the hierarchical number <em>N</em> of two-phase space-filling fractal metamaterial played an important role in their mechanical behaviors. The experimental results show that with increasing the hierarchical number <em>N</em>, these metamaterials show enhanced stiffness, strength, and toughness under tensile tests. From the simulation results, we found by decoupling the strain energy density in two phases, with increasing <em>N</em>, the soft phase has contributed almost the same energy level, however, the hard phase has contributed increasing energy level. Moreover, we found the volume fraction and the stiffness ratio of the hard phase dominate the overall mechanical properties of these two-phase space-filling fractal metamaterial. The bio-inspired mechanical metamaterials have broad applications in engineering materials for dissipating energy dissipation, mitigating impact, and retarding damages.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106791"},"PeriodicalIF":3.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of tendon attachment to 3D printed Ti6Al4V implant versus Trevira® implant: A paired experimental animal study","authors":"Sarah S. Freund ,&nbsp;Anna B. Borgognoni ,&nbsp;Michael M. Bendtsen ,&nbsp;Jørgen Baas ,&nbsp;Jeppe S. Byskov ,&nbsp;Bahram Ranjkesh ,&nbsp;Steen Bærentzen ,&nbsp;Jens R. Nyengaard ,&nbsp;Thomas Baad-Hansen","doi":"10.1016/j.jmbbm.2024.106789","DOIUrl":"10.1016/j.jmbbm.2024.106789","url":null,"abstract":"<div><h3>Background</h3><div>Soft-tissue attachment is crucial for the success of megaprosthesis surgery and improvement in current treatment is needed. The aim of this study was to compare the biomechanical and histomorphometric properties of soft-tissue attachment between 3D printed Ti6Al4V implants featuring a 630 μm microporous structure and commercially available Trevira® implants with a 200 μm porous structure in a non-loadbearing ovine model.</div></div><div><h3>Methods</h3><div>Ten skeletally mature ewes underwent surgical implantation with both implants. After 4-weeks, mechanical pull-out testing assessed the attachment strength, while histomorphometric analysis evaluated fibroblast cell profile density, multinucleated giant cell profile density, microvessel length and volume density.</div></div><div><h3>Results</h3><div>3D printed Ti6Al4V implants demonstrated a 129% greater attachment strength compared to Trevira® implants (p = 0.003). In the Trevira® group, a 35% increase in fibroblast profile density (p &lt; 0.001) and a 98% increase in multinucleated giant cell profile density (p &lt; 0.001) were observed, with no significant difference in microvessel length density between the groups. However, the Ti6Al4V group exhibited a 50% higher microvessel volume density (p &lt; 0.001) compared to the Trevira® group.</div></div><div><h3>Conclusion</h3><div>3D printed Ti6Al4V implants with a 630 μm microporous structure demonstrated superior attachment strength, enhanced neovascularization, and reduced foreign body reaction compared to the Trevira® implants. These findings suggest that 3D printed Ti6Al4V implants may enhance soft-tissue attachment in megaprosthesis surgeries.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106789"},"PeriodicalIF":3.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical property, corrosion behavior and cytocompatibility of CoCrMo for dental application: A comparative study of cast and laser powder bed fusion","authors":"L.Y. Ma,&nbsp;F.Y. Sun,&nbsp;Y. Li,&nbsp;H. Yu","doi":"10.1016/j.jmbbm.2024.106788","DOIUrl":"10.1016/j.jmbbm.2024.106788","url":null,"abstract":"<div><div>In this work, by employing powders sourced directly from the original ingot for additive manufacturing, we enabled a comparative overview of the performance between CoCrMo manufactured via laser powder bed fusion (LPBF) and those in their original cast condition. Microstructural analysis revealed that the cast (CT) alloy predominantly consisted of coarse grains with distribution of sigma phase, while the LPBF process resulted in a refined grain structure devoid of the sigma phase. The tensile strength tests demonstrated that the LPBF-derived CoCrMo alloy had substantially greater tensile strength, and ductility compared to CT alloy. Corrosion tests indicated superior corrosion resistance in the LPBF alloy, albeit with a lower metal ion release. In vitro assays confirmed that LPBF CoCrMo alloys displayed favorable cytocompatibility. Consequently, it is concluded that the CoCrMo alloy processed through laser powder bed fusion exhibited enhanced mechanical performance and corrosion resistance. These improvements are primarily attributed to the transformation of the original coarse columnar grain structure through the LPBF technique.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106788"},"PeriodicalIF":3.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of surface morphology and chemical composition on friction properties of Xenopeltis hainanensis scales","authors":"Ge Shi ,&nbsp;Long Zheng ,&nbsp;Jinhao Wang ,&nbsp;Yuehua Dong ,&nbsp;Luquan Ren","doi":"10.1016/j.jmbbm.2024.106786","DOIUrl":"10.1016/j.jmbbm.2024.106786","url":null,"abstract":"<div><div>The scales of <em>Xenopeltis hainanensis</em>, a snake that can crawl in fields, valleys, and other places, can serve as inspiration for the design of scale-like bionic materials. We present a systematic morphological, microstructural, chemical, and mechanical analysis, including elastic modulus, hardness, and wear morphology of the scales to understand the friction basis for achieving the reptile requirements. At the surface level, a comb-like arrangement of microstructures on the ventral scales provides more surface area and reduces pressure. The separation of microstructures, along with the bending and delamination of collagen fibrils could contribute to energy dissipation, which helps prevent catastrophic failure at deeper structural levels. At the cross-sectional level, a greater thickness provides more distribution of stresses over a larger volume, reducing local deformation and increasing the resistance to damage. At the material level, the ventral scales show higher modulus (E = 384.65 ± 19.03 MPa, H = 58.67 ± 6.15 MPa) than other regions of snake scales, which is attributed to the increased thickness of the scales and the higher concentration of sulfur (S). The experimental results, combined with Energy-dispersive X-ray spectroscopy and SEM characterization, provide a complete picture of the fiction properties influenced by surface morphology and chemical composition during scratch extension of the <em>Xenopeltis hainanensis</em> scales.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106786"},"PeriodicalIF":3.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Force and energy transmission at the brain-skull interface of the minipig in vivo and post-mortem","authors":"Shuaihu Wang ,&nbsp;Kevin N. Eckstein ,&nbsp;Ruth J. Okamoto ,&nbsp;Matthew D.J. McGarry ,&nbsp;Curtis L. Johnson ,&nbsp;Philip V. Bayly","doi":"10.1016/j.jmbbm.2024.106775","DOIUrl":"10.1016/j.jmbbm.2024.106775","url":null,"abstract":"<div><div>The brain-skull interface plays an important role in the mechano-pathology of traumatic brain injury (TBI). A comprehensive understanding of the mechanical behavior of the brain-skull interface <em>in vivo</em> is significant for understanding the mechanisms of TBI and creating accurate computational models. Here we investigate the force and energy transmission at the minipig brain-skull interface by non-invasive methods in the live (<em>in vivo</em>) and dead animal (<em>in situ</em>). Displacement fields in the brain and skull were measured in four female minipigs by magnetic resonance elastography (MRE), and the relative displacements between the brain and skull were estimated. Surface maps of deviatoric stress, the apparent mechanical properties of the brain-skull interface, and the net energy flux were generated for each animal when alive and at specific times post-mortem. After death, these maps reveal increases in relative motion between brain and skull, brain surface stress, stiffness of brain-skull interface, and net energy flux from skull to brain. These results illustrate the ability to study both skull and brain mechanics by MRE; the observed post-mortem decrease in the protective capability of the brain-skull interface emphasizes the importance of measuring its behavior <em>in vivo</em>.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"161 ","pages":"Article 106775"},"PeriodicalIF":3.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding mechanotransduction in the distal colon and rectum via multiscale and multimodal computational modeling","authors":"Amirhossein Shokrani ,&nbsp;Ashkan Almasi ,&nbsp;Bin Feng ,&nbsp;David M. Pierce","doi":"10.1016/j.jmbbm.2024.106771","DOIUrl":"10.1016/j.jmbbm.2024.106771","url":null,"abstract":"<div><div>Visceral pain in the large bowel is a defining symptom of irritable bowel syndrome (IBS) and the primary reason that patients visit gastroenterologists. This pain is reliably triggered by mechanical distension of the distal colon and rectum (colorectum). Consequently, the process of mechanotransduction by sensory afferents, responsible for translating mechanical colorectal stimuli into neural action potentials, plays a central role in IBS-related bowel pain. In this study, we aim to enhance our understanding of colorectal mechanotransduction by combining experimental findings in colorectal biomechanics and afferent neural encoding within a comprehensive computational simulation framework. To achieve this, we implemented a three-layered, fiber-reinforced finite element model that accurately replicates the nonlinear, heterogeneous, and anisotropic mechanical characteristics of the mouse colorectum. This model facilitates the computation of local mechanical stresses and strains around individual afferent endings, which have diameters on the micron-scale. We then integrated a neural membrane model to simulate the encoding of action potentials by afferent nerves in response to microscopic stresses and strains along the afferent endings. Our multiscale simulation framework enables the assessment of three hypotheses regarding the mechanical gating of action potential generation: (1) axial stress dominates mechanical gating of mechanosensitive channels, (2) both axial and circumferential stresses contribute, and (3) membrane shear stress dominates. Additionally, we explore how the orientation of afferent endings impacts neural encoding properties. This computational framework not only allows for the virtual investigation of colorectal mechanotransduction in the context of prolonged visceral hypersensitivity but can also guide the development of new experimental studies aimed at uncovering the neural and biomechanical mechanisms underlying IBS-related bowel pain.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"160 ","pages":"Article 106771"},"PeriodicalIF":3.3,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}