Journal of the Mechanical Behavior of Biomedical Materials最新文献_第2页

Poro-viscoelastic mechanical characterization of healthy and osteoarthritic human articular cartilage 健康和患骨关节炎的人关节软骨的孔粘弹性力学特性。

IF 3.5 2区医学

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-10-10 DOI: 10.1016/j.jmbbm.2025.107226

Jessica Faber , Alexander Greiner , Paula Büttner , Chiara Schoppe , Lars Bräuer , Friedrich Paulsen , Torsten Blunk , Mario Perl , Marcel Betsch , Silvia Budday

{"title":"Poro-viscoelastic mechanical characterization of healthy and osteoarthritic human articular cartilage","authors":"Jessica Faber , Alexander Greiner , Paula Büttner , Chiara Schoppe , Lars Bräuer , Friedrich Paulsen , Torsten Blunk , Mario Perl , Marcel Betsch , Silvia Budday","doi":"10.1016/j.jmbbm.2025.107226","DOIUrl":"10.1016/j.jmbbm.2025.107226","url":null,"abstract":"<div><div>Articular cartilage serves an important mechanical function in the human body. For the design of implants for cartilage repair after injury or disease, it is key to thoroughly understand the unique mechanical properties of the native tissue. Here, we use multimodal mechanical testing combined with poro-viscoelastic modeling, finite element simulations, and histology to characterize the region-specific macroscopic large-strain mechanical properties of healthy and osteoarthritic human articular cartilage as well as their relation to the underlying microanatomy. We individually characterize tissue from medial and lateral sides, respectively, of the human femoral condyle and tibial plateau. Our results show that there are no significant differences between the medial and lateral sides, but tissue from the tibial plateau is slightly softer than tissue from the femoral condyle. Osteoarthritis leads to a significantly softened mechanical response, which correlates with corresponding microstructural changes. Through the presented combination of experiments and poro-viscoelastic material parameter identification for healthy and osteoarthritic cartilage, we confirm a reduction in stiffness and an increase in permeability due to the disease. The parameters can be valuable for future finite element simulations of the knee joint The presented results will help guide the design of implants that are able to restore cartilage structure and function, bridging biomechanics and regenerative medicine for osteoarthritis treatment.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"173 ","pages":"Article 107226"},"PeriodicalIF":3.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical characterization of the equine linea alba and finite element modeling of suture patterns effects on its closure 马白线的力学特性及对缝合模式影响的有限元建模。

IF 3.5 2区医学

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-10-10 DOI: 10.1016/j.jmbbm.2025.107228

Jellis Bollens , Lise Gheysen , Maria Verkade , Janne Stael , Ann Martens , Patrick Segers

{"title":"Mechanical characterization of the equine linea alba and finite element modeling of suture patterns effects on its closure","authors":"Jellis Bollens , Lise Gheysen , Maria Verkade , Janne Stael , Ann Martens , Patrick Segers","doi":"10.1016/j.jmbbm.2025.107228","DOIUrl":"10.1016/j.jmbbm.2025.107228","url":null,"abstract":"<div><div>Postoperative incisional complications are common in horses following abdominal surgery, which typically involves an incision through the abdominal wall along the linea alba. The linea alba is a fibrous band running in the craniocaudal direction along the ventral abdomen. This incision is closed with sutures, where the choice of suture pattern and surgical technique has shown to influence the rate of complications.</div><div>Therefore, this study investigated how different suture patterns and variations influence the stresses in the tissue by combining experimental and computational biomechanics. The mechanical properties of the equine linea alba were first characterized using uniaxial tensile tests. The samples were loaded in either the longitudinal, craniocaudal, or the transversal, laterolateral, direction. Based on the resulting stress-strain data, the Gasser-Ogden-Holzapfel material model was calibrated. This material model was then applied to develop a finite element model of the sutured linea alba, using an interrupted suture pattern. By changing the bite size, the distance from the incision to the suture entry point in the tissue, and the step size, the distance between stitches, their effect on the maximum principal stresses was analyzed. Additionally, a continuous suture pattern was modeled for comparison with the interrupted pattern.</div><div>The tensile tests revealed stiffer behavior of the linea alba in the longitudinal direction compared to the transversal direction. An increase in bite and step size led to a rise in the maximum principal stresses, with bite size having the largest effect. Switching from an interrupted to a continuous pattern only slightly increased stresses.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"173 ","pages":"Article 107228"},"PeriodicalIF":3.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shear-induced rotation mechanism of VWF A2 domain plays important role in mediating platelet adhesion VWF A2结构域的剪切诱导旋转机制在介导血小板粘附中起重要作用

IF 3.5 2区医学

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-10-10 DOI: 10.1016/j.jmbbm.2025.107224

Kuan-Yu Pan , Shu-Wei Chang

{"title":"Shear-induced rotation mechanism of VWF A2 domain plays important role in mediating platelet adhesion","authors":"Kuan-Yu Pan , Shu-Wei Chang","doi":"10.1016/j.jmbbm.2025.107224","DOIUrl":"10.1016/j.jmbbm.2025.107224","url":null,"abstract":"<div><div>von Willebrand Factor (VWF) is a blood glycoprotein which plays an important role in mediating platelet adhesion to damaged blood vessel during hemostasis. It is known that the shear stress in blood stretches the A2 structural domain and regulates the platelet adhesion behavior through the cleavage by the metalloprotease ADAMTS13. The mechanical forces mediating the cleavage rate and the unfolding mechanism of A2 domain where the cleavage site (Tyr1605–Met1606 in <em>β</em><sub>4</sub>) resides is highly related to proper regulation of VWF proteolysis for maintaining normal hemostasis. Past studies have addressed the unfolding mechanism by conducting AFM experiments or SMD simulations. However, the local interaction of VWF with the surrounding fluid under shear flow were not considered, which might influence the unfolding pathway and the force required to facilitate the exposure of the cleavage site. Therefore, it's intriguing to study the unfolding pathway under shear flow at the molecular level to identify the conformational intermediates and force responses. In this study, we perform a molecular dynamics simulation with imposed shear flow on the VWF A2 domain to reveal how shear flow alters its molecular structure. Our results reveal that the loading condition strongly affects the molecular unfolding of VWF on its capability of rotation, which is crucial for stabilizing the βsheet and reducing the unfolding force under physiological condition. These findings provide fundamental knowledge for the development of future treatments of related diseases.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"173 ","pages":"Article 107224"},"PeriodicalIF":3.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanical evaluation of shape-optimized CAD/CAM magnesium plates for mandibular reconstruction 形状优化CAD/CAM镁板下颌骨重建的生物力学评价

IF 3.5 2区医学

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-10-06 DOI: 10.1016/j.jmbbm.2025.107222

Philipp Ruf , Kilian Richthofer , Vincenzo Orassi , Claudius Steffen , Georg N. Duda , Max Heiland , Sara Checa , Carsten Rendenbach

{"title":"Biomechanical evaluation of shape-optimized CAD/CAM magnesium plates for mandibular reconstruction","authors":"Philipp Ruf , Kilian Richthofer , Vincenzo Orassi , Claudius Steffen , Georg N. Duda , Max Heiland , Sara Checa , Carsten Rendenbach","doi":"10.1016/j.jmbbm.2025.107222","DOIUrl":"10.1016/j.jmbbm.2025.107222","url":null,"abstract":"<div><div>Magnesium CAD/CAM miniplates are a promising alternative to titanium plates for mandibular reconstruction. However, gas formation is an inherent part of the magnesium degradation process, and thus, the quantity of magnesium used in fixation scenarios should be limited. Previous studies described several strategies to limit material volume, such as plate thickness reduction and shape-optimization. In particular, shape-optimization has been described as a strategy to limit material volume while maintaining mechanical integrity.</div><div>In consequence, the present study compared a shape-optimized CAD/CAM magnesium miniplate with standard CAD/CAM magnesium miniplates of varying thicknesses using a biomechanical finite element model. A single-segment mandibular reconstruction was chosen as the investigative scenario, evaluated under different biting tasks to assess the different plate shapes.</div><div>The shape-optimized magnesium plate demonstrated similar primary fixation stability compared to standard CAD/CAM magnesium miniplates, despite having reduced plate material and surface area. Shape optimization could help minimize magnesium volume and surface area to mitigate the issue of gas formation during the degradation process <em>in vivo</em> while maintaining biomechanical performance comparable to common CAD/CAM miniplates.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"173 ","pages":"Article 107222"},"PeriodicalIF":3.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of strategies for improving the mechanical properties of 3D bioprinted skin grafts 改善生物3D打印皮肤移植物机械性能的策略综述。

IF 3.5 2区医学

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-10-06 DOI: 10.1016/j.jmbbm.2025.107223

Zhongxuan Shi , Hao Lv , Yu Wang , Danyang Zhao , Dong Han

{"title":"A review of strategies for improving the mechanical properties of 3D bioprinted skin grafts","authors":"Zhongxuan Shi , Hao Lv , Yu Wang , Danyang Zhao , Dong Han","doi":"10.1016/j.jmbbm.2025.107223","DOIUrl":"10.1016/j.jmbbm.2025.107223","url":null,"abstract":"<div><div>As the largest organ of the human body, the skin serves as a crucial protective barrier against external damage. While traditional approaches to skin injury treatment increasingly struggle to meet clinical demands, three-dimensional (3D) bioprinting has emerged as an innovative approach for tissue-engineered skin regeneration. Nevertheless, challenges persist regarding the mechanical integrity of bioprinted constructs, particularly post-printing graft shrinkage. This review systematically examines three key strategies for enhancing the mechanical properties of 3D bioprinted skin grafts: (i) Biomaterial innovation through novel material development and composite systems that substantially improve structural stability; (ii) Advanced structural design incorporating bioinspired architectures, topological optimization, and gradient configurations to achieve biomimetic mechanical performance; (iii) Post-fabrication processing techniques involving novel crosslinking methods and parameter modulation to reinforce mechanical strength. By critically analyzing these synergistic enhancement strategies, this work establishes a conceptual framework to guide future research in developing clinically viable 3D bioprinted skin substitutes with optimal biomechanical functionality.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"173 ","pages":"Article 107223"},"PeriodicalIF":3.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increasing the fatigue strength of laser-powder bed fusion manufactured Ti6Al4V hip stems by means of appropriate post-treatments 通过适当的后处理提高激光粉末床熔合Ti6Al4V髋骨的疲劳强度。

IF 3.5 2区医学

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-10-06 DOI: 10.1016/j.jmbbm.2025.107221

Stefan Schroeder , Jens Gibmeier , Phuong Thao Mai , Maximilian C.M. Fischer , Moritz M. Innmann , Tobias Renkawitz , J. Philippe Kretzer

{"title":"Increasing the fatigue strength of laser-powder bed fusion manufactured Ti6Al4V hip stems by means of appropriate post-treatments","authors":"Stefan Schroeder , Jens Gibmeier , Phuong Thao Mai , Maximilian C.M. Fischer , Moritz M. Innmann , Tobias Renkawitz , J. Philippe Kretzer","doi":"10.1016/j.jmbbm.2025.107221","DOIUrl":"10.1016/j.jmbbm.2025.107221","url":null,"abstract":"<div><div>Due to the lower fatigue resistance of LPBF manufactured Ti6Al4V alloy compared to wrought material, hip stems are still manufactured conventionally, despite the advantages of patient-specific joint replacements. Therefore, the aim of the study was the investigation of appropriate post-treatments to increase the fatigue resistance of LPBF manufactured Ti6Al4V alloy using a four-point bending setup and a Locati-test. The results showed that only a combination of a hot isostatic pressing process and a sufficient surface treatment can lead to similar fatigue results as wrought material. Thereby, machining, deep rolling and shot peening turned out to be suitable surface treatments. For complex geometries like hip stems, shot peening is the most sufficient surface treatment. A combined surface treatment of shot peening and polishing led to similar fatigue results as the shot peening process alone. It can be followed that a combination of shot peening with a previous hot isostatic pressing process leads to satisfying fatigue results comparable to the wrought material and can be applied on complex geometries like hip stems. In addition, shoulder and neck area of a hip stem can be polished after the HIP process and the shot peening procedure without any reduction in fatigue strength.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"173 ","pages":"Article 107221"},"PeriodicalIF":3.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shaping the mechanical properties of a gelatin hydrogel interface via amination 通过胺化形成明胶水凝胶界面的机械性能

IF 3.5 2区医学

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-10-01 DOI: 10.1016/j.jmbbm.2025.107219

Génesis Ríos Adorno , Kyle B. Timmer , Raul A. Sun Han Chang , Jiachun Shi , Simon A. Rogers , Brendan A.C. Harley

{"title":"Shaping the mechanical properties of a gelatin hydrogel interface via amination","authors":"Génesis Ríos Adorno , Kyle B. Timmer , Raul A. Sun Han Chang , Jiachun Shi , Simon A. Rogers , Brendan A.C. Harley","doi":"10.1016/j.jmbbm.2025.107219","DOIUrl":"10.1016/j.jmbbm.2025.107219","url":null,"abstract":"<div><div>Injuries to musculoskeletal interfaces, such as the tendon-to-bone insertion of the rotator cuff, present significant physiological and clinical challenges for repair due to complex gradients of structure, composition, and cellularity. Advances in interface tissue engineering require stratified biomaterials able to both provide local instructive signals to support multiple tissue phenotypes while also reducing the risk of strain concentrations and failure at the transition between dissimilar materials. Here, we describe adaptation of a thiolated gelatin (Gel-SH) hydrogel via selective amination of carboxylic acid subunits on the gelatin backbone. The magnitude and kinetics of HRP-mediated primary crosslinking and carbodiimide-mediated secondary crosslinking reactions can be tuned through amination and thiolation of carboxylic acid subunits on the gelatin backbone. We also show that a stratified biomaterial comprised of mineralized (bone-mimetic) and non-mineralized (tendon-mimetic) collagen scaffold compartments linked by an aminated Gel-SH hydrogel demonstrate improved mechanical performance and reduced strain concentrations. Together, these results highlight significant mechanical advantages that can be derived from modifying the gelatin macromer via controlled amination and thiolation and suggest an avenue for tuning the mechanical performance of hydrogel interfaces within stratified biomaterials.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"173 ","pages":"Article 107219"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulated oral environment affects zirconia aging and mechanical strength 模拟口腔环境影响氧化锆老化和机械强度

IF 3.5 2区医学

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-10-01 DOI: 10.1016/j.jmbbm.2025.107217

Danyal A. Siddiqui , Smriti G. Natarajan , Bhuvana Lakkasetter Chandrashekar , Danieli C. Rodrigues

{"title":"Simulated oral environment affects zirconia aging and mechanical strength","authors":"Danyal A. Siddiqui , Smriti G. Natarajan , Bhuvana Lakkasetter Chandrashekar , Danieli C. Rodrigues","doi":"10.1016/j.jmbbm.2025.107217","DOIUrl":"10.1016/j.jmbbm.2025.107217","url":null,"abstract":"<div><h3>Background</h3><div>Zirconia is an emerging alternative to titanium for dental implant systems. However, zirconia surfaces can deteriorate under aqueous conditions, thereby compromising mechanical performance. The goal of this study was to assess the impact of biological exposure or aging simulating the oral cavity on the surface integrity and mechanical strength of surface-treated zirconia.</div></div><div><h3>Methods</h3><div>Partially yttria- or magnesia-stabilized zirconia specimens were polished, acid-etched, or sandblasted. Zirconia disks were exposed to mammalian cells or bacteria. Surface degradation via tetragonal-to-monoclinic phase transformation was assessed by Raman microscopy. Zirconia bars were subjected to accelerated aging by exposure to autoclave steam. Surface morphology was examined by scanning electron microscopy, and mechanical strength was measured using four-point bend test loading until failure.</div></div><div><h3>Results</h3><div>Early-colonizing oral bacteria significantly increased monoclinic content ∼5-fold on acid-etched yttria-stabilized zirconia versus control (p < 0.05). Surface monoclinic content on acid-etched zirconia increased rapidly (54.6 ± 9.3 %) after 4 h of aging before plateauing (77.0 ± 5.7 %) after 20 h. In contrast, polished or sandblasted zirconia exhibited minimal monoclinic content (∼4 %) after 4 h that gradually increased to ∼40 % by 20 h. Acid-etching treatment significantly reduced the flexural strength of zirconia (585 ± 34 MPa) while sandblasting variants were statistically similar (922 ± 52 MPa) to machined control (921 ± 74 MPa). Aging reduced the flexural strength of machined or sandblasted zirconia, which was significant (p < 0.05) for machined zirconia (782 ± 178 MPa).</div></div><div><h3>Conclusions</h3><div>Acid-etching and/or exposure to acidic environment increase zirconia susceptibility to surface degradation, impacting its surface and mechanical properties.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"173 ","pages":"Article 107217"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of the fatigue threshold behavior of UHMWPE 超高分子量聚乙烯的疲劳阈值行为表征。

IF 3.5 2区医学

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-10-01 DOI: 10.1016/j.jmbbm.2025.107220

Bethany B. Smith , Anurag Roy , Robert O. Ritchie , Lisa A. Pruitt

{"title":"Characterization of the fatigue threshold behavior of UHMWPE","authors":"Bethany B. Smith , Anurag Roy , Robert O. Ritchie , Lisa A. Pruitt","doi":"10.1016/j.jmbbm.2025.107220","DOIUrl":"10.1016/j.jmbbm.2025.107220","url":null,"abstract":"<div><div>Ultra-high-molecular-weight-polyethylene (UHMWPE) has been the material of choice for bearings in total joint replacements (TJRs) for decades as a result of its excellent wear resistance, chemical inertness, energetic toughness, low friction, and biocompatibility. Utilization of this polymer in orthopedic devices requires oxidation, wear, and fatigue resistance. Balancing these important properties by tailoring processing techniques and modulating microstructural features has been an ongoing endeavor in the field. Research into the clinical applications of UHMWPE has primarily focused on the challenges of wear and oxidation while studies into the realm of fatigue have been more limited. Literature gaps exist in fully understanding the fatigue crack initiation near notches or propagation of small existing flaws in UHMWPE used in TJRs. In particular, the characterization of the fatigue thresholds and near-threshold fatigue behavior of orthopedic grade UHMWPE has yet to be thoroughly explored. In this work, we characterized the fatigue crack arrest threshold of clinically-relevant UHMWPE formulations. Correlations between the fatigue thresholds and bulk mechanical properties as well as microstructural properties were examined across these medical resins. The important role played by crosslinking in influencing the fatigue performance of UHMWPE is highlighted in this study. In addition, it is established that J-integral fracture toughness is the best predictor of fatigue thresholds and could possibly be used as a stand-in metric for fatigue performance if thresholds cannot be directly ascertained. Finally, this study corroborates that the true constitutive parameters best describe the mechanical behavior of UHMWPE.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"173 ","pages":"Article 107220"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and characterization of lithium disilicate glass-ceramics derived from sol-gel route with varied agitation speeds 溶胶-凝胶法制备不同搅拌速度的二硅酸锂微晶玻璃

IF 3.5 2区医学

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-09-30 DOI: 10.1016/j.jmbbm.2025.107218

Yaming Zhang , Xinyi Bai , Ding Li , Xi Liu , Xigeng Lyu , Fu Wang

{"title":"Preparation and characterization of lithium disilicate glass-ceramics derived from sol-gel route with varied agitation speeds","authors":"Yaming Zhang , Xinyi Bai , Ding Li , Xi Liu , Xigeng Lyu , Fu Wang","doi":"10.1016/j.jmbbm.2025.107218","DOIUrl":"10.1016/j.jmbbm.2025.107218","url":null,"abstract":"<div><div>Lithium disilicate (LD) glass-ceramics were fabricated through conventional sol-gel and pressureless sintering methods, with the influence of stirring speeds (200, 400, 600 and 1000 rpm) on their microstructural evolution, phase formation, and mechanical properties being systematically investigated. The variation in agitation speed significantly affected the agglomerated sizes and morphological characteristics of the gel-derived LD powers, which in true induced noticeable differences in phase compositions and crystallinities of both the precursor powers and the final glass-ceramics. These morphological variations directly correlated with the archived relative densities of the sintered LD glass-ceramics, and the mechanical property variations were also linked with the differing aspect ratios of the precipitated LD crystals within the microstructures. Optimal performance was obtained at the stirring speed of 400 rpm, yielding glass-ceramics with exceptional properties: highest relative density (94.01 ± 0.16 %), flexural strength (182.72 ± 1.5 MPa), hardness (3.84 ± 0.20 GPa), and fracture toughness (3.07 ± 0.17 MPa·m<sup>1/2</sup>). These finding demonstrated that mechanical stirring parameters profoundly influenced the characteristics of gel-derived LD powders and resultant glass-ceramics, suggesting potential applicability of this process control strategy to other gel-derived lithium silicate materials, including Li<sub>2</sub>SiO<sub>3</sub> and Li<sub>4</sub>SiO<sub>4</sub>.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"173 ","pages":"Article 107218"},"PeriodicalIF":3.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0