European Journal of Radiology Open最新文献

{"title":"Minimal dose CT for left ventricular ejection fraction and combination with chest-abdomen-pelvis CT","authors":"Martin Weber Kusk ,&nbsp;Søren Hess ,&nbsp;Oke Gerke ,&nbsp;Lone Deibjerg Kristensen ,&nbsp;Christina Stolzenburg Oxlund ,&nbsp;Tina Elisabeth Ormstrup ,&nbsp;Janus Mølgaard Christiansen ,&nbsp;Shane J. Foley","doi":"10.1016/j.ejro.2024.100583","DOIUrl":"https://doi.org/10.1016/j.ejro.2024.100583","url":null,"abstract":"<div><h3>Objectives</h3><p>This prospective study tested the diagnostic accuracy, and absolute agreement with MRI of a low-dose CT protocol for left ventricular ejection fraction (LVEF) measurement. Furthermore we assessed its potential for combining it with Chest-Abdomen-Pelvis CT (CAP-CT) for a one-stop examination.</p></div><div><h3>Materials &amp; methods</h3><p>Eighty-two patients underwent helical low-dose CT. Cardiac magnetic resonance imaging (MRI) was the reference standard. In fifty patients, CAP-CT was performed concurrently, using a modified injection protocol. In these, LVEF was measured with radioisotope cardiography (MUGA). Patients &gt;18 years, without contrast media or MRI contraindications, were included. Bias was measured with Bland-Altman analysis, classification accuracy with Receiver Operating Characteristics, and inter-reader agreement with Intra-Class Correlation Coefficient (ICC). Correlation was examined using Pearson's correlation coefficients. CAP image quality was compared to previous scans with visual grading characteristics.</p></div><div><h3>Results</h3><p>The mean CT dose-length-product (DLP) was 51.8 mGycm, for an estimated effective dose of 1.4 mSv, compared to 5.7 mSv for MUGA. CT LVEF bias was between 2 % and 10 %, overestimating end-diastolic volume. When corrected for bias, sensitivity and specificity of 100 and 98.5 % for classifying reduced LVEF (50 % MRI value) was achieved. ICC for MUGA was significantly lower than MRI and CT. Distinction of renal medulla and cortex was reduced in the CAP scan, but proportion of diagnostic scans was not significantly different from standard protocol.</p></div><div><h3>Conclusion</h3><p>When corrected for inter-modality bias, CT classifies patients with reduced LVEF with high accuracy at a quarter of MUGA dose and can be combined with CAP-CT without loss of diagnostic quality.</p></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"13 ","pages":"Article 100583"},"PeriodicalIF":1.8,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352047724000388/pdfft?md5=d3624d446dfd93a7467c41937a54a97b&pid=1-s2.0-S2352047724000388-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced dose helical CT scout imaging on next generation wide volume CT system decreases scan length and overall radiation exposure","authors":"Alexa E. Golbus ,&nbsp;John L. Schuzer ,&nbsp;Chloe Steveson ,&nbsp;Shirley F. Rollison ,&nbsp;James Matthews ,&nbsp;Joseph Henry-Ellis ,&nbsp;Marco Razeto ,&nbsp;Marcus Y. Chen","doi":"10.1016/j.ejro.2024.100578","DOIUrl":"https://doi.org/10.1016/j.ejro.2024.100578","url":null,"abstract":"<div><h3>Purpose</h3><p>Traditional CT acquisition planning is based on scout projection images from planar anterior-posterior and lateral projections where the radiographer estimates organ locations. Alternatively, a new scout method utilizing ultra-low dose helical CT (3D Landmark Scan) offers cross-sectional imaging to identify anatomic structures in conjunction with artificial intelligence based Anatomic Landmark Detection (ALD) for automatic CT acquisition planning. The purpose of this study is to quantify changes in scan length and radiation dose of CT examinations planned using 3D Landmark Scan and ALD and performed on next generation wide volume CT versus examinations planned using traditional scout methods. We additionally aim to quantify changes in radiation dose reduction of scans planned with 3D Landmark Scan and performed on next generation wide volume CT.</p></div><div><h3>Methods</h3><p>Single-center retrospective analysis of consecutive patients with prior CT scan of the same organ who underwent clinical CT using 3D Landmark Scan and automatic scan planning. Acquisition length and dose-length-product (DLP) were collected. Data was analyzed by paired t-tests.</p></div><div><h3>Results</h3><p>104 total CT examinations (48.1 % chest, 15.4 % abdomen, 36.5 % chest/abdomen/pelvis) on 61 individual consecutive patients at a single center were retrospectively analyzed. 79.8 % of scans using 3D Landmark Scan had reduction in acquisition length compared to the respective prior acquisition. Median acquisition length using 3D Landmark Scan was 26.7 mm shorter than that using traditional scout methods (p &lt; 0.001) with a 23.3 % median total radiation dose reduction (245.6 (IQR 150.0–400.8) mGy cm vs 320.3 (IQR 184.1–547.9) mGy cm). CT dose index similarly was overall decreased for scans planned with 3D Landmark and ALD and performed on next generation CT versus traditional methods (4.85 (IQR 3.8–7) mGy vs. 6.70 (IQR 4.43–9.18) mGy, respectively, p &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>Scout imaging using reduced dose 3D Landmark Scan images and Anatomic Landmark Detection reduces acquisition range in chest, abdomen, and chest/abdomen/pelvis CT scans. This technology, in combination with next generation wide volume CT reduces total radiation dose.</p></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"13 ","pages":"Article 100578"},"PeriodicalIF":2.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352047724000339/pdfft?md5=e5ed7f7f3246ee284cee1840d28083d1&pid=1-s2.0-S2352047724000339-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical-radiomics nomogram based on automated segmentation of chest CT to discriminate PRISm and COPD patients","authors":"TaoHu Zhou ,&nbsp;Yu Guan ,&nbsp;XiaoQing Lin ,&nbsp;XiuXiu Zhou ,&nbsp;Liang Mao ,&nbsp;YanQing Ma ,&nbsp;Bing Fan ,&nbsp;Jie Li ,&nbsp;WenTing Tu ,&nbsp;ShiYuan Liu ,&nbsp;Li Fan","doi":"10.1016/j.ejro.2024.100580","DOIUrl":"https://doi.org/10.1016/j.ejro.2024.100580","url":null,"abstract":"<div><h3>Purpose</h3><p>It is vital to develop noninvasive approaches with high accuracy to discriminate the preserved ratio impaired spirometry (PRISm) group from the chronic obstructive pulmonary disease (COPD) groups. Radiomics has emerged as an image analysis technique. This study aims to develop and confirm the new radiomics-based noninvasive approach to discriminate these two groups.</p></div><div><h3>Methods</h3><p>Totally 1066 subjects from 4 centers were included in this retrospective research, and classified into training, internal validation or external validation sets. The chest computed tomography (CT) images were segmented by the fully automated deep learning segmentation algorithm (Unet231) for radiomics feature extraction. We established the radiomics signature (Rad-score) using the least absolute shrinkage and selection operator algorithm, then conducted ten-fold cross-validation using the training set. Last, we constructed a radiomics signature by incorporating independent risk factors using the multivariate logistic regression model. Model performance was evaluated by receiver operating characteristic (ROC) curve, calibration curve, and decision curve analyses (DCA).</p></div><div><h3>Results</h3><p>The Rad-score, including 15 radiomic features in whole-lung region, which was suitable for diffuse lung diseases, was demonstrated to be effective for discriminating between PRISm and COPD. Its diagnostic accuracy was improved through integrating Rad-score with a clinical model, and the area under the ROC (AUC) were 0.82(95 %CI 0.79–0.86), 0.77(95 %CI 0.72–0.83) and 0.841(95 %CI 0.78–0.91) for training, internal validation and external validation sets, respectively. As revealed by analysis, radiomics nomogram showed good fit and superior clinical utility.</p></div><div><h3>Conclusions</h3><p>The present work constructed the new radiomics-based nomogram and verified its reliability for discriminating between PRISm and COPD.</p></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"13 ","pages":"Article 100580"},"PeriodicalIF":2.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352047724000352/pdfft?md5=4350c77666fa3e691e8c4b13e144787a&pid=1-s2.0-S2352047724000352-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141323985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional sectional measurement approach for serial volume changes in shoulder muscles after arthroscopic rotator cuff repair","authors":"Keita Nagawa ,&nbsp;Yuki Hara ,&nbsp;Hirokazu Shimizu ,&nbsp;Koichiro Matsuura ,&nbsp;Kaiji Inoue ,&nbsp;Eito Kozawa ,&nbsp;Katsunobu Sakaguchi ,&nbsp;Mamoru Niitsu","doi":"10.1016/j.ejro.2024.100577","DOIUrl":"https://doi.org/10.1016/j.ejro.2024.100577","url":null,"abstract":"<div><h3>Purpose</h3><p>This study assessed the serial volume changes in multiple shoulder muscles simultaneously following arthroscopic rotator cuff repair (ARCR) by a three-dimensional (3D) modeling-based sectional measurement. These volume changes were correlated with background preoperative factors.</p></div><div><h3>Methods</h3><p>Four consecutive magnetic resonance imaging scans (preoperatively and postoperatively at 3, 6, and 12 months) of 33 shoulders from 31 patients who underwent arthroscopic rotator cuff repair were examined. We focused on the sectional volume differences of the supraspinatus, infraspinatus, teres minor, and subscapularis between preoperatively and 3 months postoperatively (Dif.pre.3mo) and between 3 and 12 months postoperatively (Dif.3.12mo). The correlation between volume differences and clinical/demographic parameters was determined by a multivariate analysis.</p></div><div><h3>Results</h3><p>No statistically significant differences were observed for most serial changes in the shoulder muscle volumes. The tear-site muscles (supraspinatus and infraspinatus) showed similar tendencies for volume changes, whereas the non-tear-site muscles (teres minor and subscapularis) differed. A negative correlation was observed between Dif.pre.3mo and Dif.3.12mo for the supraspinatus, infraspinatus, and teres minor. These perioperative volume differences might correlate with tear size and symptom duration in the supraspinatus, as well as with a history of steroid injections and work and sports activity levels in the infraspinatus and teres minor.</p></div><div><h3>Conclusion</h3><p>The serial volume changes in multiple shoulder muscles after ARCR measured using our 3D sectional approach exhibited different tendencies and clinical implications depending on the primary and non-primary site of tears. Our method may serve as a potential indicator to facilitate muscle recovery and prevent the progression of postoperative muscle atrophy.</p></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"13 ","pages":"Article 100577"},"PeriodicalIF":2.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352047724000327/pdfft?md5=9255e03712724df64d87828167e8caa1&pid=1-s2.0-S2352047724000327-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141314334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of spectral dual-layer CT, D-dimer concentration, and COVID-19 pneumonia in diagnosis of pulmonary embolism","authors":"Tomáš Jůza ,&nbsp;Vlastimil Válek ,&nbsp;Daniel Vlk ,&nbsp;Marek Dostál ,&nbsp;Tomáš Andrašina","doi":"10.1016/j.ejro.2024.100575","DOIUrl":"https://doi.org/10.1016/j.ejro.2024.100575","url":null,"abstract":"<div><h3>Purpose</h3><p>To demonstrate advantages of spectral dual-layer computed tomography (CT) in diagnosing pulmonary embolism (PE). To compare D-dimer values in patients with PE and concomitant COVID-19 pneumonia to those in patients without PE and COVID-19 pneumonia. To compare D-dimer values in cases of minor versus extensive PE.</p></div><div><h3>Methods</h3><p>A monocentric retrospective study of 1500 CT pulmonary angiographies (CTPAs). Three groups of 500 consecutive examinations: 1) using conventional multidetector CT (CTC), 2) using spectral dual-layer CT (CTS), and 3) of COVID-19 pneumonia patients using spectral dual-layer CT (COV). Only patients with known D-dimer levels were enrolled in the study.</p></div><div><h3>Results</h3><p>Prevalence of inconclusive PE findings differed significantly between CTS and CTC (0.8 % vs. 5.4 %, <em>p</em> &lt; 0.001). In all groups, D-dimer levels were significantly higher in PE positive patients than in patients without PE (CTC, 8.04 vs. 3.05 mg/L; CTS, 6.92 vs. 2.57 mg/L; COV, 10.26 vs. 2.72 mg/L, <em>p</em> &lt; 0.001). There were also statistically significant differences in D-dimer values between minor and extensive PE in the groups negative for COVID-19 (CTC, 5.16 vs. 8.98 mg/L; CTS 3.52 vs. 9.27 mg/L, <em>p</em> &lt; 0.001). The lowest recorded D-dimer value for proven PE in patients with COVID-19 pneumonia was 1.19 mg/L.</p></div><div><h3>Conclusion</h3><p>CTPAs using spectral dual-layer CT reduce the number of inconclusive PE findings. Plasma D-dimer concentration increases with extent of PE. Cut-off value of D-dimer with 100 % sensitivity for patients with COVID-19 pneumonia could be doubled to 1.0 mg/L. This threshold would have saved 110 (22 %) examinations in our cohort.</p></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"12 ","pages":"Article 100575"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352047724000303/pdfft?md5=62989ee72eca53a148c6fa9194a9f0ea&pid=1-s2.0-S2352047724000303-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141243645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in radiology","authors":"Lorenzo Faggioni ,&nbsp;Francesca Coppola","doi":"10.1016/j.ejro.2024.100547","DOIUrl":"10.1016/j.ejro.2024.100547","url":null,"abstract":"","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"12 ","pages":"Article 100547"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352047724000029/pdfft?md5=e1c8ae1c7f600bc217b442a7c272412e&pid=1-s2.0-S2352047724000029-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139393056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Surveillance one year post focal cryotherapy for clinically significant prostate cancer using mpMRI and PIRADS v2.1: An initial experience from a prospective phase II mandatory biopsy study” [Eur. J. Radiol. Open 11 (2023) 100529]","authors":"Jyothirmayi Velaga ,&nbsp;Kae Jack Tay ,&nbsp;Guanqi Hang ,&nbsp;Yu Guang Tan ,&nbsp;John S.P. Yuen ,&nbsp;Melvin L.K. Chua ,&nbsp;Rajan T. Gupta ,&nbsp;Thomas J. Polascik ,&nbsp;Nye Thane Ngo ,&nbsp;Yan Mee Law","doi":"10.1016/j.ejro.2024.100556","DOIUrl":"10.1016/j.ejro.2024.100556","url":null,"abstract":"","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"12 ","pages":"Article 100556"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S235204772400011X/pdfft?md5=ffefe6c3f6c9850c7c28201f64596ab8&pid=1-s2.0-S235204772400011X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140466260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T1 and T2-mapping in pancreatic MRI: Current evidence and future perspectives","authors":"Alessandro Beleù ,&nbsp;Davide Canonico ,&nbsp;Giovanni Morana","doi":"10.1016/j.ejro.2024.100572","DOIUrl":"10.1016/j.ejro.2024.100572","url":null,"abstract":"<div><p>Conventional T1- and T2-weighted magnetic resonance imaging (MRI) of the pancreas can vary significantly due to factors such as scanner differences and pulse sequence variations. This review explores T1 and T2 mapping techniques, modern MRI methods providing quantitative information about tissue relaxation times. Various T1 and T2 mapping pulse sequences are currently under investigation. Clinical and research applications of T1 and T2 mapping in the pancreas include their correlation with fibrosis, inflammation, and neoplasms. In chronic pancreatitis, T1 mapping and extracellular volume (ECV) quantification demonstrate potential as biomarkers, aiding in early diagnosis and classification. T1 mapping also shows promise in evaluating pancreatic exocrine function and detecting glucose metabolism disorders. T2* mapping is valuable in quantifying pancreatic iron, offering insights into conditions like thalassemia major. However, challenges persist, such as the lack of consensus on optimal sequences and normal values for healthy pancreas relaxometry. Large-scale studies are needed for validation, and improvements in mapping sequences are essential for widespread clinical integration. The future holds potential for mixed qualitative and quantitative models, extending the applications of relaxometry techniques to various pancreatic lesions and enhancing routine MRI protocols for pancreatic pathology diagnosis and prognosis.</p></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"12 ","pages":"Article 100572"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352047724000273/pdfft?md5=cdcf766f3285fee6aab6fc4786bd7908&pid=1-s2.0-S2352047724000273-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141235141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging differentiation of solid pseudopapillary neoplasms and neuroendocrine neoplasms of the pancreas","authors":"Ekaterina Khristenko ,&nbsp;Matthias M. Gaida ,&nbsp;Christine Tjaden ,&nbsp;Verena Steinle ,&nbsp;Martin Loos ,&nbsp;Korbinian Krieger ,&nbsp;Tim F. Weber ,&nbsp;Hans-Ulrich Kauczor ,&nbsp;Miriam Klauß ,&nbsp;Philipp Mayer","doi":"10.1016/j.ejro.2024.100576","DOIUrl":"10.1016/j.ejro.2024.100576","url":null,"abstract":"<div><h3>Purpose</h3><p>The present study aimed to compare the computed tomography (CT) and magnetic resonance imaging (MRI) features of solid pseudopapillary neoplasms (SPNs) and pancreatic neuroendocrine neoplasms (pNENs).</p></div><div><h3>Method</h3><p>Lesion imaging features of 39 patients with SPNs and 127 patients with pNENs were retrospectively extracted from 104 CT and 91 MRI scans.</p></div><div><h3>Results</h3><p>Compared to pNEN patients, SPN patients were significantly younger (mean age 51.8 yrs versus 32.7 yrs) and more often female (female: male ratio, 5.50:1 versus 1.19:1). Most SPNs and pNENs presented as well-defined lesions with an expansive growth pattern. SPNs more often appeared as round or ovoid lesions, compared to pNENs which showed a lobulated or irregular shape in more than half of cases (p&lt;0.01). A surrounding capsule was detected in the majority of SPNs, but only in a minority of pNENs (&lt;0.01). Hemorrhage occurred non-significantly more often in SPNs (p=0.09). Signal inhomogeneity in T1-fat-saturated (p&lt;0.01) and T2-weighted imaging (p=0.046) as well as cystic degeneration (p&lt;0.01) were more often observed in SPNs. Hyperenhancement in the arterial and portal-venous phase was more common in pNENs (p&lt;0.01). Enlargement of locoregional lymph nodes (p&lt;0.01) and liver metastases (p=0.03) were observed in some pNEN patients, but not in SPN patients. Multivariate logistic regression identified the presence of a capsule (p&lt;0.01), absence of arterial hyperenhancement (p&lt;0.01), and low patient age (p&lt;0.01), as independent predictors for SPN.</p></div><div><h3>Conclusions</h3><p>The present study provides three key features for differentiating SPNs from pNENs extracted from a large patient cohort: presence of a capsule, absence of arterial hyperenhancement, and low patient age.</p></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"12 ","pages":"Article 100576"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352047724000315/pdfft?md5=0fc285091bff630d36381fc08d26f2f0&pid=1-s2.0-S2352047724000315-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141230279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing the rate of datasets amenable to CTFFR and quantitative plaque analysis: Value of software for reducing stair-step artifacts demonstrated in photon-counting detector CT","authors":"Costanza Lisi ,&nbsp;Lukas J. Moser ,&nbsp;Victor Mergen ,&nbsp;Thomas Flohr ,&nbsp;Matthias Eberhard ,&nbsp;Hatem Alkadhi","doi":"10.1016/j.ejro.2024.100574","DOIUrl":"https://doi.org/10.1016/j.ejro.2024.100574","url":null,"abstract":"<div><h3>Purpose</h3><p>To determine the value of an algorithm for reducing stair-step artifacts for advanced coronary analyses in sequential mode coronary CT angiography (CCTA).</p></div><div><h3>Methods</h3><p>Forty patients undergoing sequential mode photon-counting detector CCTA with at least one stair-step artifact were included. Twenty patients (14 males; mean age 57±17years) with 45 segments showing stair-step artifacts and without atherosclerosis were included for CT_FFR analysis. Twenty patients (20 males; mean age 74±13years) with 22 segments showing stair-step artifacts crossing an atherosclerotic plaque were included for quantitative plaque analysis. Artifacts were graded, and CT_FFR and quantitative coronary plaque analyses were performed in standard reconstructions and in those reconstructed with a software (entitled <em>ZeeFree</em>) for artifact reduction.</p></div><div><h3>Results</h3><p>Stair-step artifacts were significantly reduced in <em>ZeeFree</em> compared to standard reconstructions (p&lt;0.05). In standard reconstructions, CT_FFR was not feasible in 3/45 (7 %) segments but was feasible in all <em>ZeeFree</em> reconstructions. In 9/45 (20 %) segments without atherosclerosis, the <em>ZeeFree</em> algorithm led to a change of CT_FFR values from pathologic in standard to physiologic values in <em>ZeeFree</em> reconstructions. In one segment (1/22, 5 %), quantitative plaque analysis was not feasible in standard but only in <em>ZeeFree</em> reconstruction. The mean overall plaque volume (111±60 mm³), the calcific (77±47 mm³), fibrotic (31±28 mm³), and lipidic (4±3 mm³) plaque components were higher in standard than in <em>ZeeFree</em> reconstructions (overall 75±50 mm³, p&lt;0.001; calcific 51±42 mm³, p&lt;0.001; fibrotic 22±19 mm³, p&lt;0.05; lipidic 3±3 mm³, p=0.055).</p></div><div><h3>Conclusion</h3><p>Despite the lack of reference standard modalities for CT_FFR and coronary plaque analysis, initial evidence indicates that an algorithm for reducing stair-step artifacts in sequential mode CCTA increases the rate and quality of datasets amenable to advanced coronary artery analysis, hereby potentially improving patient management.</p></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"12 ","pages":"Article 100574"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352047724000297/pdfft?md5=4ded2bc69dd5866771bdaa0616fd7d89&pid=1-s2.0-S2352047724000297-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141244911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}