European Journal of Radiology Open最新文献

{"title":"Value of dynamic contrast-enhanced MRI in the diagnosis of acute radiation-induced rectal injury in patients with rectal cancer: A comparison with endoscopy","authors":"Wen-jie Fan ,&nbsp;Yu-ru Ma ,&nbsp;Quan-meng Liu ,&nbsp;Ning Zhang ,&nbsp;Yi-yan Liu ,&nbsp;Zi-qiang Wen ,&nbsp;Bao-lan Lu ,&nbsp;Jian-peng Yuan ,&nbsp;Shen-ping Yu ,&nbsp;Yan Chen","doi":"10.1016/j.ejro.2025.100684","DOIUrl":"10.1016/j.ejro.2025.100684","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) quantitative parameters in acute radiation-induced rectal injury (RRI) among patients with rectal cancer.</div></div><div><h3>Methods</h3><div>This retrospective study included patients confirmed to rectal cancer who underwent rectal MRI (including a DCE-MRI sequence) and endoscopy after neoadjuvant chemoradiotherapy from November 2014 to July 2022. The enrolled patients were divided into an acute RRI group and a non-acute RRI group based on Vienna rectoscopy score. Two radiologists independently measured DCE-MRI quantitative parameters (including the forward volume transfer constant [<em>K</em>^trans], rate constant [<em>k</em>_ep], and fractional extravascular extracellular space volume [<em>v</em>_e]) and thickness of rectal wall. Receiver operating characteristic curve analysis was performed to analyze statistically significant parameters.</div></div><div><h3>Results</h3><div>Forty-nine patients (median age, 58 years; interquartile range, 14 years; 34 men) were enrolled, 28 of whom were in the acute RRI group. <em>K</em>^trans in patients with acute RRI was significantly lower compared to those without acute RRI (0.049 min⁻¹ vs 0.107 min⁻¹; <em>P</em> &lt; 0.001). The area under the receiver operating characteristic curve of <em>K</em>^trans was 0.80. With a <em>K</em>^trans cutoff value of 0.079 min⁻¹, the sensitivity and specificity were 93 % and 67 %, respectively.</div></div><div><h3>Conclusion</h3><div><em>K</em>^trans demonstrated moderate performance in diagnosing acute RRI, providing a non-invasive and objective basis for managing and treating rectal cancer patients with acute RRI.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100684"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac MRI-derived ventricular-pulmonary arterial coupling predicts outcomes in connective tissue disease-associated pulmonary arterial hypertension patients","authors":"Yidan Zhu ,&nbsp;Ke Xu ,&nbsp;Han Jia ,&nbsp;Wangyan Liu ,&nbsp;Xiaoxuan Sun ,&nbsp;Qiang Wang ,&nbsp;Yi Xu ,&nbsp;Yinsu Zhu","doi":"10.1016/j.ejro.2025.100700","DOIUrl":"10.1016/j.ejro.2025.100700","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the prognostic value of cardiovascular magnetic resonance (CMR) parameters in patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH).</div></div><div><h3>Materials and methods</h3><div>This retrospective cohort study involved 135 patients with documented CTD-PAH. Cardiac functional parameters including right ventricle end-diastolic volume index (RVEDVI), end-systolic volume index (RVESVI), stroke volume index (RVSVI), ejection fraction (RVEF), and SV/ESV; the volumetric parameter; T1 mapping and late gadolinium enhancement (LGE) parameters; strain parameters like RV global longitudinal strain(GLS); and hemodynamics parameters like mean velocity at the pulmonary artery (mvPA) and PA relative area change (PA RAC) were calculated from CMR images. Survival analysis was conducted using Kaplan–Meier and Cox regression. The endpoint was the occurrence of clinical deterioration events.</div></div><div><h3>Results</h3><div>The median follow-up time was 22.27 months (interquartile range: 11.5–31.9 months).RVIP ECV, RVGLS, RVEDVI, RVESVI, RVMI, and RAA, as well as mvPA, SV/ESV, RVEF, and PA RAC, were associated with adverse outcomes. SV/ESV ≤ 0.55, RV GLS &gt; -12.1 %, and PA RAC≤ 16.1 % were significant independent predictors of prognosis. The combined parameters provided incremental prognostic value over COMPERA 2.0 (area under the curve (AUC) from 0.771 to 0.899; P = 0.001).And time-dependent ROC curve confirmed the predictive efficiency of the combined parameters in year 3, with the AUC reaching 0.821(95 % CI: 0.698–0.945).</div></div><div><h3>Conclusion</h3><div>Multiparametric CMR provides a non-invasive, efficient method to assess prognosis in CTD-PAH patients. Key parameters including SV/ESV, RV GLS, and PA RAC significantly predicted survival and confer incremental prognostic utility over COMPERA 2.0, offering reliable prognostic markers for clinical interventions.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100700"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of MRI radiomics in predicting lymph node metastasis in prostate cancer: A systematic review","authors":"Alireza Teymouri ,&nbsp;Mohammad Saeid Khonji ,&nbsp;Parisa Alaghi ,&nbsp;Sina Azadnajafabad ,&nbsp;Ava Teymouri ,&nbsp;Sina Delazar","doi":"10.1016/j.ejro.2025.100673","DOIUrl":"10.1016/j.ejro.2025.100673","url":null,"abstract":"<div><h3>Purpose</h3><div>Prostate cancer (PCa) is frequently associated with pelvic lymph node metastasis (PLNM), which may be missed by conventional imaging, particularly in micrometastatic disease. MRI-based radiomics offers potential to improve detection. This review evaluates recent advancements and diagnostic accuracy of MRI radiomics for predicting PLNM in PCa patients.</div></div><div><h3>Methods</h3><div>PubMed, Embase, and Web of Science were systematically searched through January 1, 2025, using terms like “prostate cancer,” “radiomics,” and “pelvic lymph node metastasis.” Eligible studies were assessed using the Radiomics Quality Score (RQS). Study characteristics and performance metrics were narratively synthesized. Pooled area under the receiver operating characteristic curve (AUC) was calculated for PLNM prediction in studies using prostate as regions of interest (ROI), reported with 95 % confidence intervals (CI); p-value &lt; 0.05 was considered significant.</div></div><div><h3>Results</h3><div>Nine studies (2021–2024) involving 2344 PCa patients were included. Radiomics models using prostate as ROI achieved a pooled AUC of 0.78 (95 %CI: 0.72–0.84) with mild heterogeneity (I² = 19.81 %, p &lt; 0.38). Models with lymph nodes as ROI showed AUCs of 0.93–0.95. Integrating imaging reports and clinical data often improved diagnostic accuracy. Radiomics outperformed clinical nomograms in five studies, although the difference was insignificant in one study (p &gt; 0.05). Median RQS was 16/36; studies lacked prospective design and cost-effectiveness analysis.</div></div><div><h3>Conclusion</h3><div>MRI radiomics predicts PLNM with moderate accuracy, particularly when using pelvic lymph nodes as ROI. Standardized protocols, feature extraction, and clinical data integration are crucial for consistency. Prospective studies with larger cohorts are needed to validate these findings.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100673"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis of imaging characteristics and upgrade rates in noninvasive lobular neoplasia of the breast","authors":"Fatemeh Shakki Katouli ,&nbsp;Negin Salehi ,&nbsp;Faezeh Soveyzi ,&nbsp;Mina Abedi ,&nbsp;Parya Valizadeh ,&nbsp;Hamed Ghorani ,&nbsp;Seyedeh Melika Hashemi ,&nbsp;Jayran Zebardast ,&nbsp;Madjid Shakiba ,&nbsp;Sadaf Alipour","doi":"10.1016/j.ejro.2025.100691","DOIUrl":"10.1016/j.ejro.2025.100691","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Non-invasive lobular neoplasia (NLN) encompasses a range of lobular breast lesions that may precede invasive breast cancer. Microcalcifications detected through mammography play a crucial role in evaluating breast lesions and are often associated with NLN. This study focuses on the prevalence and significance of microcalcifications in NLN, noting that they can be the sole radiographic finding in many cases. While mammography is highly sensitive for detecting microcalcifications, it has limitations in diagnosing NLN, as some lesions may not show up on scans. Advanced imaging techniques like magnetic resonance imaging (MRI) offer improved diagnostic accuracy, particularly in dense breast tissue, but more research is needed for their routine use. Additionally, the risk of NLN progressing to malignant lesions highlights the importance of vigilant monitoring and management. This study aims to analyze the relationship between microcalcifications and NLN, addressing progression risks and implications for clinical practice.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Method&lt;/h3&gt;&lt;div&gt;This systematic review and meta-analysis (CRD42022346891) involved a comprehensive search of databases such as PubMed and Scopus from 2000 to 2023, using keywords related to lobular carcinoma and mammography. Eligible English-language studies included those reporting mammographic findings of pure NLN lesions confirmed by histopathologic evaluation and surgical excision. Exclusion criteria involved studies without surgical results or definitive imaging findings. Two independent reviewers assessed titles and abstracts, resolving discrepancies as needed. Data were systematically extracted using a standardized form, with the selection process depicted in a PRISMA flow diagram.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Result&lt;/h3&gt;&lt;div&gt;Meta-analysis of included studies revealed that the pooled proportion of any mammographic microcalcification among all NLN lesions was 0.70 (95 % CI: 0.63–0.76). Pure microcalcification (without an associated mass or distortion) was the most common presentation, with a pooled proportion of 0.67 (95 % CI: 0.60–0.74) among all lesions and 0.99 (95 % CI: 0.96–1.00) among lesions presenting with any microcalcification. The overall pooled upgrade rate to malignancy was 0.18 (95 % CI: 0.11–0.25), with a significantly higher rate for lobular carcinoma in situ (LCIS) at 0.22 (95 % CI: 0.15–0.30) compared to atypical lobular hyperplasia (ALH) at 0.06 (95 % CI: 0.01–0.14). Microcalcifications were present in the majority of upgraded lesions (pooled proportion: 0.78, 95 % CI: 0.69–0.87). A small but significant proportion of lesions (0.08, 95 % CI: 0.03–0.17) had no mammographic findings. All pooled estimates showed high heterogeneity. Sensitivity analysis confirmed the robustness of the results, while Egger's test indicated potential publication bias.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;In conclusion this study highlights the significant prevalence of microcalcifications i","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100691"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of machine learning models for predicting high-grade subtypes of lung adenocarcinoma based on delta radiomics: A multicenter cohort study","authors":"Feiyang Zhong ,&nbsp;Ting Li ,&nbsp;Wenping Li ,&nbsp;Lijun Wu ,&nbsp;Pengju Zhang ,&nbsp;Pengxin Yu ,&nbsp;Yuan Fang ,&nbsp;Meiyan Liao ,&nbsp;Shaohong Zhao","doi":"10.1016/j.ejro.2025.100699","DOIUrl":"10.1016/j.ejro.2025.100699","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the effectiveness of delta radiomics in predicting high-grade components in lung adenocarcinoma and to develop a robust machine learning model for clinical application.</div></div><div><h3>Methods</h3><div>This retrospective multi-center cohort study included lung cancer patients from three hospitals who had pre-surgery CT follow-up scans. Training (n = 491) and validation (n = 210) were performed using cases from Center 1, and testing was conducted using cases from Centers 2 and 3 (n = 92). Radiomic features were extracted from baseline and follow-up CT images, and delta radiomic features were calculated. The LASSO algorithm was used for radiomic feature selection, and rad-score and delta rad-score were constructed. Significant clinical and radiomic features were combined to build the final machine learning model. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC), DeLong test, decision curve analysis (DCA), and integrated discrimination improvement (IDI) analysis.</div></div><div><h3>Results</h3><div>In the external test cohort, the integrated machine learning model constructed based on clinical features (CTR, smoking status, maximum diameter of the solid component), rad-score, and delta rad-score showed that the random forest model performed the best, with an AUC of 0.91. The random forest model outperformed the clinical model (AUC = 0.80), rad-score (AUC = 0.79), and delta rad-score (AUC = 0.81). DCA and IDI indicated that the random forest model provides superior clinical benefit and improvement.</div></div><div><h3>Conclusion</h3><div>Delta radiomics significantly aids in identifying high-grade subtypes of lung adenocarcinoma. The integrated machine learning model offers an effective approach for prediction of high-grade components, with potential clinical implications.</div></div><div><h3>Clinical Relevance Statement</h3><div>This study presents a novel application of delta radiomics to predict high-grade lung adenocarcinoma, which may influence surgical management and improve patient outcomes.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100699"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quantitative CT perfusion-derived online dynamic nomogram for predicting hemorrhagic transformation after intravenous thrombolysis in acute ischemic stroke","authors":"Yanping Zheng ,&nbsp;Peirong Jiang ,&nbsp;Xiuzhu Xu ,&nbsp;Liwei Xue ,&nbsp;Jialin Chen ,&nbsp;Yunjing Xue","doi":"10.1016/j.ejro.2025.100685","DOIUrl":"10.1016/j.ejro.2025.100685","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the diagnostic value of cerebral perfusion and its predictive ability of hemorrhagic transformation (HT) in acute ischemic stroke (AIS) after intravenous thrombolysis (IVT) using CT perfusion (CTP).</div></div><div><h3>Methods</h3><div>Retrospective cohort of 55 AIS patients who underwent CTP before IVT was included. Clinical information, such as the National Institutes of Health Stroke Scale (NIHSS) score and history of atrial fibrillation (AF), were collected. CTP parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), permeability surface area product (PS), time-to-maximum (Tmax), time to peak (TTP), were measured in pathological hemispheres. Relative values (rCBV, rCBF, rMTT, rPS, rTmax, rTTP) were calculated as pathological-to-asymptomatic hemisphere ROI ratios. Comparisons between HT and non-HT groups were conducted using Student’s t-Test and Mann-Whitney U test. ROC curve and Logistic regression analysis were used to evaluate model predictive values. Delong's test compared AUC differences among parameters. Dynamic nomogram model was constructed with R-shiny and evaluated.</div></div><div><h3>Results</h3><div>NIHSS score at admission, NIHSS score before IVT, NIHSS score after IVT, NIHSS score at discharge, AF, PS and rPS were significantly higher than those in the non-HT group (<em>p</em> &lt; 0.005). ROC curve and logistic regression analyses revealed that the combined model including NIHSS score before IVT, AF, and rPS displayed the highest AUC of 0.899 (95 % CI:0.814,0.984; <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Dynamic nomogram model combined NIHSS score before IVT, AF and rPS may act as a real-time visualization tool in the prediction of HT risk after IVT in patients with AIS.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100685"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight-bearing MRI of the cervical spine: A scoping review of clinical utility and emerging applications","authors":"Jonathan Verderame ,&nbsp;Muhammad Shakib Arslan ,&nbsp;Farhan Mukhtar ,&nbsp;Zaheer Abbas","doi":"10.1016/j.ejro.2025.100694","DOIUrl":"10.1016/j.ejro.2025.100694","url":null,"abstract":"<div><h3>Objective</h3><div>Weight-bearing magnetic resonance imaging enables assessment of the cervical spine and craniocervical junction under physiological load, potentially revealing pathology that is occult on conventional supine imaging. This scoping review synthesizes current evidence, maps clinical and emerging applications, and identifies key gaps requiring further investigation.</div></div><div><h3>Methods</h3><div>A structured search was conducted in PubMed, Scopus, Web of Science, Google Scholar, and Semantic Scholar (July 2025). Eligible studies were reviewed for diagnostic utility, technical considerations, clinical indications, and outcomes. Methodological quality was appraised descriptively in line with Joanna Briggs Institute guidance.</div></div><div><h3>Results</h3><div>Nine studies, published between 2008 and 2025, met inclusion criteria. Upright and dynamic MRI detected posture-dependent changes including spinal canal narrowing, cord compression, foraminal stenosis, ligamentous buckling, cerebellar tonsillar descent, altered sagittal alignment, and CSF flow differences. Findings were more pronounced in flexion extension and upright postures compared with supine imaging. Normative studies established reference metrics for CCJ motion and prevertebral soft tissue width. Preliminary evidence also highlights applications in connective tissue disorders, Chiari malformation, and upper cervical chiropractic practice, although most studies were feasibility reports with small sample sizes and heterogeneous protocols.</div></div><div><h3>Conclusion</h3><div>Emerging evidence suggests that WBMRI provides added diagnostic value in selected cervical spine and CCJ conditions by revealing dynamic or load-sensitive pathology not captured on standard supine imaging. While current evidence remains preliminary, standardized protocols, higher-field technologies, and large multicenter outcome-based studies are essential to validate diagnostic thresholds, improve reproducibility, and define the role of WBMRI in routine clinical care.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100694"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145264883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmentation of visceral and subcutaneous adipose tissue in abdominal CT-datasets with and without contrast medium: Influence of iterative reconstruction on 2D- and 3D-segmentation","authors":"Robin F. Gohmann ,&nbsp;Fyn Kaiser ,&nbsp;Batuhan Temiz ,&nbsp;Sebastian Gottschling ,&nbsp;Christian Krieghoff ,&nbsp;Christian Lücke ,&nbsp;Matthias Horn ,&nbsp;Matthias Gutberlet","doi":"10.1016/j.ejro.2025.100707","DOIUrl":"10.1016/j.ejro.2025.100707","url":null,"abstract":"<div><h3>Purpose</h3><div>Segmentation of visceral and subcutaneous adipose tissue in computed tomography (CT) datasets has shown much promise in research and for medical applications, e.g. for risk stratification and guiding therapies. This study evaluates the influence of iterative reconstruction (IR) and filtered back projection (FBP) techniques on 2D- and 3D-segmentation of adipose tissue in CT images with and without contrast medium.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 31 patients to compare adipose tissue density and quantity between IR and FBP across different compartments and contrast phases. Segmentation was performed using a fixed threshold (-190 to -30 HU).</div></div><div><h3>Results</h3><div>Significant differences were observed in 2D-segmentation, particularly for visceral adipose tissue in non-enhanced scans (-0.54 ± 1.4 HU; <em>p</em> = 0.04) and subcutaneous adipose tissue in venous scans (-0.48 ± 1.2 HU; <em>p</em> = 0.03). In 3D-segmentation, subcutaneous adipose tissue density in venous scans was also lower with IR compared to FBP (-0.67 ± 1.2 HU; <em>p</em> = 0.004).</div></div><div><h3>Conclusion</h3><div>Adipose tissue segmentation between IR and FBP revealed minimal and only occasionally yields statistically significant differences in density and quantity across adipose tissue compartments and contrast phases. The observed differences were very small, casting doubt on their clinical relevance at the level of individual patients. However, even subtle systematic variations may warrant consideration in population-based studies or longitudinal research where methodological consistency is critical.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100707"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) for ablation of osteoid osteoma: Long-term results from 10 years of experience","authors":"Francesco Arrigoni ,&nbsp;Federico Bruno ,&nbsp;Pierpaolo Palumbo ,&nbsp;Luigi Rinvenuto ,&nbsp;Mario Muselli ,&nbsp;Roberto Calbi ,&nbsp;Carmine Zoccali ,&nbsp;Luigi Zugaro ,&nbsp;Alessandra Splendiani ,&nbsp;Antonio Barile ,&nbsp;Ernesto Di Cesare","doi":"10.1016/j.ejro.2025.100708","DOIUrl":"10.1016/j.ejro.2025.100708","url":null,"abstract":"<div><div>Osteoid Osteoma (OO) is a benign but extremely painful bone lesion, mostly treated using Radiofrequency Ablation with needle (RFA). Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is an alternative technique able to ablate without using needles or skin incisions. Given the scarcity of literature in this field, the purpose of this paper is to retrospectively analyze long-term results of MRgFUS treatments of OO and to investigate technical limits. This is a retrospective analysis of all the MRgFUS procedures performed in our institution to treat OOs. Demographic, clinical data, and morphological features were analyzed, looking for correlation between the clinical results and the morphological features. Sixty-seven procedures were analyzed. The success rate – intended as complete pain relief - was 91 %. Almost all the patients (60 out of 67) were followed up to 4 years. A thick bone cortex above the nidus (p.014) and a short distance between the nidus and the ultrasound source (p.002) were statistically linked to failure. No complications were recorded. This is the largest series of OO treated using MRgFUS even reported. The main strength of this study lies in its large sample size and the extended follow-up period for nearly all patients (4 years for 90 % of patients) which allow us to clearly confirm the safety and efficacy of this ablative technique. Moreover, exclusion criteria for this treatment modality are proposed, based on two causes of treatment failure identified during our procedures.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100708"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and MRI variables associated with close or positive margins during breast-conserving surgery using MRI projection mapping in breast carcinoma with nonmass enhancement","authors":"Maki Amano ,&nbsp;Jun Ozeki ,&nbsp;Yumi Koyama ,&nbsp;Xiaoyan Tang ,&nbsp;Fumi Nozaki ,&nbsp;Mayumi Tani ,&nbsp;Yasuo Amano","doi":"10.1016/j.ejro.2025.100681","DOIUrl":"10.1016/j.ejro.2025.100681","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the utility of a magnetic resonance imaging (MRI) projection mapping system (PMS) for determining the resection lines during breast-conserving surgery (BCS) in patients with breast cancer presenting with nonmass enhancement (NME) and identify the clinical or MRI variables associated with close or positive margins.</div></div><div><h3>Materials and methods</h3><div>Forty-one patients with breast cancer exhibiting NME were enrolled. In the operating room, a maximum intensity projection image generated from supine MRI was projected onto the breast using a PMS, which employed a structured light method to measure the surface of the breast. Cancer contours delineated on the MRI-PMS, with an additional safety margin, served as the resection lines for cylindrical BCS. Margins were pathologically categorized as negative (&gt; 2 mm), close (≤ 2 mm), or positive. The association between margin status and clinical or MRI variables was analyzed.</div></div><div><h3>Results</h3><div>Surgical margins were negative in 24 patients (58.5 %), close in 15 (36.6 %), and positive in 2 (4.9 %). There were significant differences in the maximum diameter of nonmass components (NMCs) shown by pathology, that of NME on MRI, and the discrepancy between the two diameters between patients with negative margin and those with close or positive margin (&lt; 0.05 for all). Receiver operating characteristics revealed that threshold of 40 mm for NMEs provided high specificity of 91.7 %.</div></div><div><h3>Conclusion</h3><div>The MRI-PMS led to a low rate of positive margins during BCS in patients with breast cancer with NMEs. Large NMCs and NMEs are associated with positive or close margin.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100681"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}