European Journal of Radiology Open最新文献

{"title":"Deep learning for Three‐Class Classification of ground-glass nodules on non-enhanced chest CT: A multicenter comparative study of CNN architectures","authors":"Meihua Shao ,&nbsp;Jian Wang ,&nbsp;Lin Zhu ,&nbsp;Jianfei Tu ,&nbsp;Guohua Cheng ,&nbsp;Linyang He ,&nbsp;Hengfeng Shi ,&nbsp;Cui Zhang ,&nbsp;Hong Yu","doi":"10.1016/j.ejro.2025.100690","DOIUrl":"10.1016/j.ejro.2025.100690","url":null,"abstract":"<div><h3>Objective</h3><div>To develop, validate, and compare four three-dimensional (3D) convolutional neural network (CNN) models for differentiating ground-glass nodules (GGNs) on non-contrast chest computed tomography (CT) scans, specifically classifying them as adenomatous hyperplasia (AAH)/adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), or invasive adenocarcinoma (IA).</div></div><div><h3>Materials and methods</h3><div>This multi-center study retrospectively enrolled 4284 consecutive patients with surgically resected and pathologically confirmed AAH/AIS, MIA, or IA from four hospitals between January 2015 and December 2023. GGNs were randomly partitioned into a training set (n = 3083, 72 %) and a validation set (n = 1277, 28 %). Four 3D deep learning models (Res2Net 3D, DenseNet3D, ResNet50 3D, Vision Transformer 3D) were implemented for GGN segmentation and three-class classification. Additionally, variants of the Res2Net 3D model were developed by incorporating clinical and CT features: Res2Net 3D_w2 (sex, age), Res2Net 3D_w6 (adding lesion size, location, and smoking history), and Res2Net 3D_w10 (sex, age, location, the mean, maximum, and standard deviation of CT attenuation, nodule volume, volume ratio, volume ratio within the left/right lung, and the maximum CT value of the entire lung). Model performance was evaluated using accuracy, recall, precision, F1-score, and area under the receiver operating characteristic curve (AUC).</div></div><div><h3>Results</h3><div>Res2Net 3D outperformed others, achieving AUCs of 0.91 (AAH/AIS), 0.88 (MIA), and 0.92 (IA). Its F1-scores were 0.416, 0.500, and 0.929, respectively. All Res2Net variants achieved accuracies between 0.83–0.84.</div></div><div><h3>Conclusion</h3><div>The Res2Net 3D model accurately differentiates GGN subtypes using non-contrast CT, showing high performance, especially for invasive adenocarcinoma.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100690"},"PeriodicalIF":2.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145264884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight-bearing MRI of the cervical spine: A scoping review of clinical utility and emerging applications","authors":"Jonathan Verderame ,&nbsp;Muhammad Shakib Arslan ,&nbsp;Farhan Mukhtar ,&nbsp;Zaheer Abbas","doi":"10.1016/j.ejro.2025.100694","DOIUrl":"10.1016/j.ejro.2025.100694","url":null,"abstract":"<div><h3>Objective</h3><div>Weight-bearing magnetic resonance imaging enables assessment of the cervical spine and craniocervical junction under physiological load, potentially revealing pathology that is occult on conventional supine imaging. This scoping review synthesizes current evidence, maps clinical and emerging applications, and identifies key gaps requiring further investigation.</div></div><div><h3>Methods</h3><div>A structured search was conducted in PubMed, Scopus, Web of Science, Google Scholar, and Semantic Scholar (July 2025). Eligible studies were reviewed for diagnostic utility, technical considerations, clinical indications, and outcomes. Methodological quality was appraised descriptively in line with Joanna Briggs Institute guidance.</div></div><div><h3>Results</h3><div>Nine studies, published between 2008 and 2025, met inclusion criteria. Upright and dynamic MRI detected posture-dependent changes including spinal canal narrowing, cord compression, foraminal stenosis, ligamentous buckling, cerebellar tonsillar descent, altered sagittal alignment, and CSF flow differences. Findings were more pronounced in flexion extension and upright postures compared with supine imaging. Normative studies established reference metrics for CCJ motion and prevertebral soft tissue width. Preliminary evidence also highlights applications in connective tissue disorders, Chiari malformation, and upper cervical chiropractic practice, although most studies were feasibility reports with small sample sizes and heterogeneous protocols.</div></div><div><h3>Conclusion</h3><div>Emerging evidence suggests that WBMRI provides added diagnostic value in selected cervical spine and CCJ conditions by revealing dynamic or load-sensitive pathology not captured on standard supine imaging. While current evidence remains preliminary, standardized protocols, higher-field technologies, and large multicenter outcome-based studies are essential to validate diagnostic thresholds, improve reproducibility, and define the role of WBMRI in routine clinical care.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100694"},"PeriodicalIF":2.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145264883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glymphatic dysfunction as an imaging biomarker for cognitive impairment in patients with β-thalassemia major: A multimodal MRI study","authors":"Xingye Yang ,&nbsp;Meiru Bu ,&nbsp;Xi Deng ,&nbsp;Haifeng Zheng ,&nbsp;Chengli Wu ,&nbsp;Wei Cui ,&nbsp;Muliang Jiang ,&nbsp;Bihong T. Chen","doi":"10.1016/j.ejro.2025.100692","DOIUrl":"10.1016/j.ejro.2025.100692","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Cerebral lymphatic abnormalities have been associated with neurodegenerative processes. However, brain glymphatic system and its role in cognitive impairment in β-thalassemia major (β-TM) remain unknown. This study assessed brain glymphatic alterations in β-TM using advanced neuroimaging and their correlation with cognitive deficits.</div></div><div><h3>Method</h3><div>Thirty-five β-TM patients and forty matched healthy controls (HC) underwent standardized cognitive assessment and diffusion tensor imaging (DTI). Automated segmentation derived glymphatic parameters: Analysis Along the Perivascular Space index (DTI-ALPS index), choroid plexus volume fraction (CPVF), perivascular space volume fraction (PVSVF), and fractional volume of free water in white matter (FW-WM) and were compared between groups. Correlations with cognitive scores were analyzed.</div></div><div><h3>Result</h3><div>Compared with the HC, β-TM patients showed significantly lower DTI-ALPS index values in the left hemisphere (1.4527vs1.5275,P = 0.003), the right hemisphere (1.3648vs1.4492,P = 0.004) and bilateral hemispheres (1.4087vs1.4884,P = 0.001), alongside higher CPVF values in the left hemisphere (0.5426vs0.4655,P = 0.034), the right hemisphere (0.5296vs0.4439,P = 0.018) and bilateral hemispheres (1.0731vs0.9095,P = 0.01). The patient group also had higher PVSVF values in the white matter (0.2848vs0.2488,P = 0.841), the subcortical regions (0.1718vs0.1470,P = 0.349) and whole brain (0.4566vs0.3958,P = 0.678), and had higher FW-WM value (0.1580vs0.1557,P = 0.384). Lower DTI-ALPS index and higher FW-WM value was associated with poorer cognitive performance in the β-TM patients (P &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The DTI-ALPS index is a potential neuroimaging biomarker for glymphatic dysfunction and cognitive impairment in β-TM. Increased CP volume implicated underlying glymphatic alterations, supporting integration of glymphatic MRI metrics into clinical cognitive assessment for this population.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100692"},"PeriodicalIF":2.9,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145264885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise-related changes in knee articular structures detected using magnetic resonance imaging T1ρ and T2 mapping","authors":"Keita Nagawa ,&nbsp;Hirokazu Shimizu ,&nbsp;Saki Tsuchihashi ,&nbsp;Kaiji Inoue ,&nbsp;Shinji Kakemoto ,&nbsp;Taira Shiratori ,&nbsp;Akane Kaizu ,&nbsp;Masahiro Koyama ,&nbsp;Yuya Yamamoto ,&nbsp;Masami Yoneyama ,&nbsp;Naoki Sugita ,&nbsp;Eito Kozawa","doi":"10.1016/j.ejro.2025.100693","DOIUrl":"10.1016/j.ejro.2025.100693","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the changes in various knee joint structures before and after physical activities using magnetic resonance imaging (MRI) T1ρ and T2 mapping.</div></div><div><h3>Methods</h3><div>MRI of the right knee was performed for 12 healthy volunteers before and after jumping rope, flexion and extension, and at rest. Different parts of articular cartilage, anterior and posterior cruciate ligaments, medial and lateral meniscus, gastrocnemius muscle and Hoffa’s fat pad were quantitatively assessed based on T1ρ and T2 values. A paired t-test was performed to determine whether the effects of various activities on different parts of the knee articular structures were statistically different.</div></div><div><h3>Results</h3><div>The T1ρ values for the lateral meniscus decreased, while both T1ρ and T2 values for the gastrocnemius muscle increased after jumping rope. No statistically significant differences were observed in the other parts of the meniscus, cruciate ligaments, and Hoffa’s fat pad. The T1ρ and T2 values for the weight-bearing cartilages of the femur and tibia were both reduced after jumping rope. However, no statistically significant differences were observed in the cartilage after flexion and extension or at rest.</div></div><div><h3>Conclusions</h3><div>MRI T1ρ and T2 mapping can be used to evaluate the changes in various joint structures before and after physical activities. These changes in knee tissue were hypothesized to reflect variations in tissue fluid, collagen fibers, and proteoglycan content. Further studies are required to investigate the influence of exercise on articular structures using MRI mapping techniques.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100693"},"PeriodicalIF":2.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High performance of low/ultralow-dose photon-counting CT for pulmonary metastasis in young musculoskeletal malignancy patients","authors":"Shanshui Zhou ,&nbsp;Qiyuan Bao ,&nbsp;Haipeng Dong ,&nbsp;Jiqiang Li ,&nbsp;Zhihan Xu ,&nbsp;Lianjun Du ,&nbsp;Wenjie Yang ,&nbsp;Yong Lu ,&nbsp;Weibin Zhang ,&nbsp;Fuhua Yan ,&nbsp;Le Qin","doi":"10.1016/j.ejro.2025.100689","DOIUrl":"10.1016/j.ejro.2025.100689","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the performance of chest photon-counting CT (PCCT) at low-dose (LD) and ultralow-dose (ULD) in young musculoskeletal malignancy patients with pulmonary metastasis and compare with prior standard-dose energy-integrating CT (EICT).</div></div><div><h3>Materials and methods</h3><div>From August to November 2023, this prospective study recruited consecutive participants with prior EICT images and grouped them into LD and ULD groups to receive PCCT examination. Two observers independently and blindly evaluated the image quality using a five-point Likert scale. Intraindividual differences between PCCT and EICT were compared using the Wilcoxon signed-rank test or paired samples <em>t</em>-test.</div></div><div><h3>Results</h3><div>The LD and ULD groups included 50 (19 [16; 21] years; 33 males) and 50 participants (19 [14; 21] years; 30 males), respectively. The interval between EICT and PCCT examinations was 116 (88.5; 194) days. Compared with EICT, PCCT obtained median effective dose reduction rates of 87.62 % (3.78 [3.15; 5.18] vs. 0.43 [0.39; 0.58] mSv; <em>p</em> &lt; 0.001) and 92.58 % (3.92 [2.96; 4.95] vs. 0.27 [0.22; 0.34] mSv; <em>p</em> &lt; 0.001) in the LD and ULD groups, respectively. For subjective assessments, PCCT has superior overall image quality (5 [5; 5] vs. 5 [4; 5]) and lung nodule visualization (5 [5; 5] vs. 5 [4; 5]) to EICT (all <em>p</em>-values &lt;0.001).</div></div><div><h3>Conclusion</h3><div>PCCT provided higher image quality and lung nodule visualization with significant dose reduction compared to EICT in these young musculoskeletal malignancy patients.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100689"},"PeriodicalIF":2.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectral computer-tomography and the ability to detect occult femoral neck and scaphoid fractures – A systematic review and exploratory meta-analysis","authors":"Camilla Thøgersen Buxbom ,&nbsp;Amalie Braithwaite ,&nbsp;Søren Hess ,&nbsp;Lars Lykke Hermansen ,&nbsp;Martin Weber Kusk","doi":"10.1016/j.ejro.2025.100686","DOIUrl":"10.1016/j.ejro.2025.100686","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review aims to describe the ability of spectral computed tomography (SCT) to identify bone marrow oedema (BME) in the scaphoid bone and the femoral neck compared to magnetic resonance images (MRI).</div></div><div><h3>Materials and methods</h3><div>PubMed, Embase and Cochrane Library were searched from the 1st of October 2024; eligible studies had patients over 15 years of age, underwent SCT and had MRI as a gold standard. Sensitivities, specificities, negative predictive values (NPV) and positive predictive values (PPV) were noted or calculated from available information. Bias and applicability were assessed using QUADAS-2 tools. A random-effects model was used in the meta-analysis, and heterogeneity was assessed using I² statistics.</div></div><div><h3>Results</h3><div>1061 studies were identified and screened by title/abstract. Twenty-two studies underwent full-text assessment. A total of four were included, of which three were suitable for meta-analysis regarding the scaphoid bone. Pooled sensitivity was 93 %, specificity was 98 %, PPV was 92 % and NPV was 98 %. A single study concerning the femoral neck was located, with sensitivity, specificity, PPV and NPV of 87 %, 94 %, 93 % and 89 % respectively.</div></div><div><h3>Conclusions</h3><div>Data regarding the ability of SCT to detect BME in the femoral neck and scaphoid bone are promising, but limited, with only small studies available. There is a need for larger prospective studies, regarding both the detection of occult fractures in the femoral neck and the scaphoid bone.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100686"},"PeriodicalIF":2.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic measurement of Caton index on knee X-ray images using a key point detection model","authors":"Ting Li ,&nbsp;Nadeer M. Gharaibeh ,&nbsp;Gang Wu","doi":"10.1016/j.ejro.2025.100687","DOIUrl":"10.1016/j.ejro.2025.100687","url":null,"abstract":"<div><h3>Purpose</h3><div>To explore the feasibility of the You Only Look Once (YOLO) algorithm in the measurement of Carton index.</div></div><div><h3>Methods</h3><div>1156 knee X-ray images were collected from two centers (960 and 196). Five key points at patella and tibia on knee X-ray were labeled using the software of Labelme. YOLO11 pose models (including YOLO11n, YOLO11m and YOLO11x) were refined by labeled images from center A, and was then used to detect keypoints on images from center B. A line was the line between anterior edge of the tibial plateau and the lower pole of patellar articular surface, and B line was patellar articular surface. Carton index (A/B ratio) of 196 cases was obtained by senior radiologist, junior radiologist and YOLO respectively. The Bland Altman plot, Pearson Correlation test, Mean Absolute Error (MAE) and Intra-class correlation coefficient (ICC) were used to evaluate the agreement in measurement.</div></div><div><h3>Results</h3><div>Carton index of 196 images were automatically obtained with YOLO11n-pose, YOLO11m-pose and YOLO11x-pose. The ICC between senior and junior radiologists was 0.89. Pearson correlation coefficients were 0.23, 0.43 and 0.73 respectively for YOLO11n, YOLO11m and YOLO11x. ICC were 0.23, 0.42 and 0.72 respectively for YOLO11n, YOLO11m and YOLO11x. MAE were 0.20, 0.17 and 0.10 respectively for YOLO11n, YOLO11m and YOLO11x.</div></div><div><h3>Conclusions</h3><div>YOLO11x-pose model shows promise in the automatic measurement of Carton index on the knee X-ray image.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100687"},"PeriodicalIF":2.9,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quantitative CT perfusion-derived online dynamic nomogram for predicting hemorrhagic transformation after intravenous thrombolysis in acute ischemic stroke","authors":"Yanping Zheng ,&nbsp;Peirong Jiang ,&nbsp;Xiuzhu Xu ,&nbsp;Liwei Xue ,&nbsp;Jialin Chen ,&nbsp;Yunjing Xue","doi":"10.1016/j.ejro.2025.100685","DOIUrl":"10.1016/j.ejro.2025.100685","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the diagnostic value of cerebral perfusion and its predictive ability of hemorrhagic transformation (HT) in acute ischemic stroke (AIS) after intravenous thrombolysis (IVT) using CT perfusion (CTP).</div></div><div><h3>Methods</h3><div>Retrospective cohort of 55 AIS patients who underwent CTP before IVT was included. Clinical information, such as the National Institutes of Health Stroke Scale (NIHSS) score and history of atrial fibrillation (AF), were collected. CTP parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), permeability surface area product (PS), time-to-maximum (Tmax), time to peak (TTP), were measured in pathological hemispheres. Relative values (rCBV, rCBF, rMTT, rPS, rTmax, rTTP) were calculated as pathological-to-asymptomatic hemisphere ROI ratios. Comparisons between HT and non-HT groups were conducted using Student’s t-Test and Mann-Whitney U test. ROC curve and Logistic regression analysis were used to evaluate model predictive values. Delong's test compared AUC differences among parameters. Dynamic nomogram model was constructed with R-shiny and evaluated.</div></div><div><h3>Results</h3><div>NIHSS score at admission, NIHSS score before IVT, NIHSS score after IVT, NIHSS score at discharge, AF, PS and rPS were significantly higher than those in the non-HT group (<em>p</em> &lt; 0.005). ROC curve and logistic regression analyses revealed that the combined model including NIHSS score before IVT, AF, and rPS displayed the highest AUC of 0.899 (95 % CI:0.814,0.984; <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Dynamic nomogram model combined NIHSS score before IVT, AF and rPS may act as a real-time visualization tool in the prediction of HT risk after IVT in patients with AIS.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100685"},"PeriodicalIF":2.9,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of dynamic contrast-enhanced MRI in the diagnosis of acute radiation-induced rectal injury in patients with rectal cancer: A comparison with endoscopy","authors":"Wen-jie Fan ,&nbsp;Yu-ru Ma ,&nbsp;Quan-meng Liu ,&nbsp;Ning Zhang ,&nbsp;Yi-yan Liu ,&nbsp;Zi-qiang Wen ,&nbsp;Bao-lan Lu ,&nbsp;Jian-peng Yuan ,&nbsp;Shen-ping Yu ,&nbsp;Yan Chen","doi":"10.1016/j.ejro.2025.100684","DOIUrl":"10.1016/j.ejro.2025.100684","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) quantitative parameters in acute radiation-induced rectal injury (RRI) among patients with rectal cancer.</div></div><div><h3>Methods</h3><div>This retrospective study included patients confirmed to rectal cancer who underwent rectal MRI (including a DCE-MRI sequence) and endoscopy after neoadjuvant chemoradiotherapy from November 2014 to July 2022. The enrolled patients were divided into an acute RRI group and a non-acute RRI group based on Vienna rectoscopy score. Two radiologists independently measured DCE-MRI quantitative parameters (including the forward volume transfer constant [<em>K</em>^trans], rate constant [<em>k</em>_ep], and fractional extravascular extracellular space volume [<em>v</em>_e]) and thickness of rectal wall. Receiver operating characteristic curve analysis was performed to analyze statistically significant parameters.</div></div><div><h3>Results</h3><div>Forty-nine patients (median age, 58 years; interquartile range, 14 years; 34 men) were enrolled, 28 of whom were in the acute RRI group. <em>K</em>^trans in patients with acute RRI was significantly lower compared to those without acute RRI (0.049 min⁻¹ vs 0.107 min⁻¹; <em>P</em> &lt; 0.001). The area under the receiver operating characteristic curve of <em>K</em>^trans was 0.80. With a <em>K</em>^trans cutoff value of 0.079 min⁻¹, the sensitivity and specificity were 93 % and 67 %, respectively.</div></div><div><h3>Conclusion</h3><div><em>K</em>^trans demonstrated moderate performance in diagnosing acute RRI, providing a non-invasive and objective basis for managing and treating rectal cancer patients with acute RRI.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100684"},"PeriodicalIF":2.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive diagnostic value of pericoronary fat attenuation index for identifying culprit lesions in acute coronary syndrome","authors":"Fengfeng Yang ,&nbsp;Zhengyang Li ,&nbsp;Haoran Cai,&nbsp;Jing Zhu,&nbsp;Huijia Liu,&nbsp;Yang Zhao","doi":"10.1016/j.ejro.2025.100682","DOIUrl":"10.1016/j.ejro.2025.100682","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to determine the efficacy of fat attenuation index (FAI) as a non-invasive diagnostic tool in the precise identification of culprit lesions in individuals diagnosed with acute coronary syndrome (ACS).</div></div><div><h3>Methods</h3><div>A retrospective analysis of 230 patients with non-ST-segment elevation ACS. PCAT attenuation (FAI_standard) was measured in the proximal 40-mm segment of each major coronary artery. Furthermore, the average PCAT attenuation of the identified lesions was designated as FAI_lesion. The average PCAT attenuation across the complete length of coronary artery, referred to as FAI_average, was computed. Plaque characteristics (volume, composition) were analyzed via coronary computed tomography angiography. Multivariable logistic regression identified predictors of culprit lesions, and diagnostic performance was assessed using area under the curve (AUC) and decision curve analysis.</div></div><div><h3>Results</h3><div>Culprit lesions exhibited significantly elevated levels of PCAT attenuation across the parameters of FAI_standard, FAI_average, and FAI_lesion. FAI_lesion demonstrated superior diagnostic accuracy versus FAI_standard and FAI_average, and also emerged as the strongest independent predictor (Odds ratio = 2.598, P &lt; 0.001). In training and test sets, a composite model integrating FAI_lesion with additional indices demonstrated enhanced diagnostic efficacy for the detection of culprit lesions in patients with ACS (AUC = 0.960, 0.803). Low-attenuation plaque volume (&lt;30 HU) was independently associated with culprit lesions (OR = 3.12, P = 0.002).</div></div><div><h3>Conclusion</h3><div>FAI_lesion, a superior non-invasive biomarker for high-risk ACS lesions compared to traditional FAI, enables earlier precise risk stratification through clinical integration.</div></div>","PeriodicalId":38076,"journal":{"name":"European Journal of Radiology Open","volume":"15 ","pages":"Article 100682"},"PeriodicalIF":2.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}