New Microbes and New Infections最新文献

{"title":"Whole genome-based characterization of extended-spectrum β-lactamase-producing Enterobacter cloacae from orthopedic patients and environment of a tertiary referral hospital in Tanzania","authors":"Benson R. Kidenya ,&nbsp;Gerald Mboowa ,&nbsp;Ivan Sserwadda ,&nbsp;Stephen Kanyerezi ,&nbsp;Esther Nakafu ,&nbsp;Inyasi Lawrence Akaro ,&nbsp;Baraka Mkinze ,&nbsp;Moses L. Joloba ,&nbsp;Jeremiah Seni","doi":"10.1016/j.nmni.2024.101486","DOIUrl":"10.1016/j.nmni.2024.101486","url":null,"abstract":"<div><h3>Objectives</h3><div>We investigated the genomic epidemiology of extended-spectrum <em>β</em>-lactamase-producing <em>Enterobacter cloacae</em> (ESBL-Ec) isolates from patients and hospital environment to better understand their distribution to help devising effective strategies for infection prevention and control.</div></div><div><h3>Methods</h3><div>We screened ESBL-Ec at Bugando Medical Center (BMC) in Mwanza, Tanzania. Rectal swabs from orthopedic patients on admission and swabs from the neighboring inanimate environment were collected. Following microbial culture, DNA was extracted from pure ESBL-Ec, and whole-genome sequencing was done. Sequence typing (ST), plasmid replicons, drug resistance, and virulence genes were deciphered using the Rapid Microbial Analysis Pipeline (rMAP).</div></div><div><h3>Results</h3><div>We obtained 209 ESBL isolates, of which 15 (7.2 %) were ESBL-Ec [8 (53.3 %) from patients and 7 (46.7 %) from the environment]. Seven isolates were novel and eight were diverse, each with a unique ST. All isolates harbored two to five <em>β</em>-lactamase genes, with the predominance of <em>bla</em>_{<em>CTX-M-15</em>} (15/15<em>), bla</em>_{<em>OXA-1</em>} (14/15)<em>, bla</em>_<em>TEM</em> (14/15) and <em>bla</em>_<em>ACT</em> (12/15). The most common non β-lactam drug resistance genes were <em>aac(3)-IIa</em> (14/15<em>), aac(6′)-Ib-cr</em> (14/15)<em>, fosA</em> (14/15<em>),</em> and <em>qnrB1</em> (12/15<em>), aph(3″)-Ib</em> (10/15) and <em>aph(6)-Id</em> (10/15)<em>.</em> Eleven different types of plasmid replicons were identified in 14/15 of the isolates, harboring one to five plasmids, with the most common plasmids being <em>IncFII</em> (11/15) and <em>IncFIB</em> (10/15). All isolates harbored the outer membrane protein (<em>omp</em>A), and curli protein <em>(csg</em>) was in 14/15 isolates.</div></div><div><h3>Conclusion</h3><div>Admitted orthopedic patients and the hospital environment act as a reservoir of ESBL-Ec with diverse STs and endowed with drug resistance and arsenals of virulence genes, calling for their routine screening on admission for mitigation of potential subsequent infections.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101486"},"PeriodicalIF":2.9,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002701/pdfft?md5=69e1e0576ba5035ddcdd853f9e1a34a4&pid=1-s2.0-S2052297524002701-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating multidisciplinary expertise and technological innovations in tracking infectious diseases","authors":"Alberto Rizzo","doi":"10.1016/j.nmni.2024.101485","DOIUrl":"10.1016/j.nmni.2024.101485","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101485"},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002695/pdfft?md5=aea3695046fded5511082793efa5c008&pid=1-s2.0-S2052297524002695-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and characterisation of colistin-resistant Acinetobacter colistiniresistens co-producing IMP-1 and OXA-58 carbapenemases","authors":"Satoshi Nishida ,&nbsp;Yasuo Ono","doi":"10.1016/j.nmni.2024.101484","DOIUrl":"10.1016/j.nmni.2024.101484","url":null,"abstract":"<div><h3>Background</h3><div>Carbapenem-resistant <em>Acinetobacter</em> is of increasing global concern because infections are challenging to treat with standard antibiotics. Here, we identified a previously uncharacterised <em>Acinetobacter</em> sp. clinical isolate as <em>Acinetobacter colistiniresistens</em> co-producing IMP-1 and OXA-58. We also examined expression of genes related to antibiotic susceptibility and drug resistance, including <em>bla</em>_IMP.</div></div><div><h3>Methods</h3><div>The isolate was deposited at the National Institute of Technology and Evaluation (NITE) as <em>Acinetobacter</em> sp. NBRC 110496. Susceptibility was defined according to the Clinical and Laboratory Standards Institute (CLSI) breakpoints. Genomic and clonal analyses were performed to identify species and resistance genes.</div></div><div><h3>Results</h3><div>The isolate was resistant to β-lactams, including broad-spectrum cephalosporins and carbapenems, polymyxins, and trimethoprim/sulfamethoxazole. Genomic analysis identified the isolate as <em>A. colistiniresistens</em> harbouring <em>bla</em>_IMP-1, <em>bla</em>_OXA-58, <em>bla</em>_OXA-670, <em>aac(6′)-Ib</em>, <em>aac(6′)-Ij</em>, <em>ant(3”)-I</em><em>I</em>, <em>aph(3’)-VI</em>, <em>msrE</em>, <em>mphE</em>, and <em>sul1</em>. Colistin resistance was associated with the <em>eptA</em>-like gene, which encodes a lipid A-modifying enzyme. SNP-based phylogenetic analysis revealed that the strain clustered with other strains isolated in Japan. The IMP-1/OXA-58-producing strain described in this study has a novel integron structure surrounding <em>bla</em>_IMP-1, <em>aacA</em> and <em>sul1</em>.</div></div><div><h3>Conclusions</h3><div>Colistin-resistant IMP-1/OXA-58-co-producing <em>A. colistiniresistens</em> was identified in a patient. This isolate could serve as a reservoir for carbapenemase-producing organisms. This study suggests that screening for colistin-resistant isolates is crucial to preserve colistin as a therapeutic agent for multidrug-resistant bacteria. Identification of this MDR isolate in Asia, and the danger of it spreading worldwide, should raise serious concerns.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101484"},"PeriodicalIF":2.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious diseases within a war-torn health system: The re-emergence of polio in Gaza","authors":"Dalia Zayed,&nbsp;Mus'ab Banat,&nbsp;Ala'a B. Al-Tammemi","doi":"10.1016/j.nmni.2024.101483","DOIUrl":"10.1016/j.nmni.2024.101483","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101483"},"PeriodicalIF":2.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002671/pdfft?md5=5471af375968804b90d6d256b3ba9668&pid=1-s2.0-S2052297524002671-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naegleria Fowleri: The prevalence of a brain-eating amoeba in freshwater bodies in India","authors":"Vardhini Ganesh Iyer,&nbsp;Novonil Deb,&nbsp;Dattatreya Mukherjee,&nbsp;Sanjit Sah,&nbsp;Aroop Mohanty,&nbsp;Vikash Jaiswal ,&nbsp;Ranjit Sah","doi":"10.1016/j.nmni.2024.101482","DOIUrl":"10.1016/j.nmni.2024.101482","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101482"},"PeriodicalIF":2.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S205229752400266X/pdfft?md5=2596d0c84fdbca3e2e1d9bea607f000c&pid=1-s2.0-S205229752400266X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Household animals and the risk of hepatitis E for pregnant women","authors":"Milad Zandi,&nbsp;Fatemeh Sadat Mousavi,&nbsp;Hashem Khanbabaei","doi":"10.1016/j.nmni.2024.101481","DOIUrl":"10.1016/j.nmni.2024.101481","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101481"},"PeriodicalIF":2.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002658/pdfft?md5=c28d9c87b65c167ea07f70993a80cb9d&pid=1-s2.0-S2052297524002658-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the surge in Crimean-Congo hemorrhagic fever incidence in Iraq: A call for action","authors":"Dana Khdr Sabir,&nbsp;Paywast Jamal Jalal,&nbsp;Fro Rzgar Khdir","doi":"10.1016/j.nmni.2024.101479","DOIUrl":"10.1016/j.nmni.2024.101479","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101479"},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002634/pdfft?md5=dc912d8df87e0a5ece5d671d5fadaef9&pid=1-s2.0-S2052297524002634-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Encounter: The first documented human infection of avian influenza A(H5N2)","authors":"Prakriti Pokhrel,&nbsp;Amogh Verma,&nbsp;Kumud Pant,&nbsp;Mahalaqua Nazli Khatib,&nbsp;Mahendra Pratap Singh,&nbsp;Quazi Syed Zahiruddin,&nbsp;Sarvesh Rustagi,&nbsp;Sanjit Sah","doi":"10.1016/j.nmni.2024.101478","DOIUrl":"10.1016/j.nmni.2024.101478","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101478"},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002622/pdfft?md5=3d0a5118d67b2ffdcf8a24419eff83e9&pid=1-s2.0-S2052297524002622-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox crisis: A national public health concern in Democratic Republic of the Congo","authors":"Lucien Baraka,&nbsp;Elie Kihanduka,&nbsp;Mayar Moustafa Budair,&nbsp;Francois Rhugendabanga,&nbsp;Styves Banga,&nbsp;Jones Onesime,&nbsp;Hardy Elembwe,&nbsp;Samson Hangi,&nbsp;Excellent Rugendabanga,&nbsp;Aymar Akilimali","doi":"10.1016/j.nmni.2024.101480","DOIUrl":"10.1016/j.nmni.2024.101480","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101480"},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002646/pdfft?md5=59c41621e2c853457cfe7982b79bb5f7&pid=1-s2.0-S2052297524002646-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of and risk factors for infectious disease syndromic symptoms among pilgrimage to Arba'een mass gathering religious in 2023","authors":"Hosein Azizi ,&nbsp;Behrouz Naghili ,&nbsp;Fariba Abbasi ,&nbsp;Lotfali Haghiri ,&nbsp;Elham Davtalab Esmaeili","doi":"10.1016/j.nmni.2024.101477","DOIUrl":"10.1016/j.nmni.2024.101477","url":null,"abstract":"<div><h3>Background</h3><p>There is a growing participation of Shia Muslims, in the Arba'een pilgrimage every year. It is imperative to conduct a comprehensive study on the transmission of diseases among Arba'een pilgrims in order to identify and promptly respond to potential epidemics effectively. We aimed to assess the syndromic symptoms associated with infectious diseases and the prevalence of mask usage among patients visiting outpatient clinics during the Arba'een pilgrimage in Ira, in 2023.</p></div><div><h3>Methods</h3><p>In this descriptive-analytical study, 300 outpatients who sought medical care at outpatient clinics during the Arba'een pilgrimage were randomly selected. The study data and infectious disease syndromic symptoms were assessed using trained healthcare professionals. A multiple logistic regression analysis was carried out to estimate the crude and Adjusted odds ratios (AORs) of symptoms and risk factors associated with respiratory syndrome and flu-like symptoms with 95 % confidence intervals.</p></div><div><h3>Results</h3><p>The mean age of the participants was 39 years and 61 % of those were male. Out of 72 (24 %) of mask users, 41.6 % had changed masks in less than 8 h. The most common syndromic symptoms was Flu-like illness (53 %). In the final analysis, not wearing a mask AOR = 1.40 (1.1–9.8) and smoking AOR = 3.25 (1.1–9.5) both elevated the risk of the flu-like syndrome and severe respiratory disease symptoms.</p></div><div><h3>Conclusions</h3><p>Pilgrims are especially vulnerable to the flu and other respiratory illnesses. Therefore, performing a differential diagnosis in these people, including flu and COVID-19, is essential to prevent an outbreak during the Arba'een pilgrimage.</p></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101477"},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002610/pdfft?md5=94a0242ec2c93b6d066293f982981259&pid=1-s2.0-S2052297524002610-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}