New Microbes and New Infections最新文献

{"title":"Fatal and rare Chandipura virus cases in India: Etiopathogenesis, complications and prevention","authors":"Aminath Waafira, Kannan Subbaram, Razana Faiz, Zeba Un Naher, Punya Laxmi Manandhar, Sheeza Ali","doi":"10.1016/j.nmni.2024.101492","DOIUrl":"10.1016/j.nmni.2024.101492","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101492"},"PeriodicalIF":2.9,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of human Herpes Virus-8 infection in Iranian cirrhotic patients on the waiting list for liver transplantation: A cross-sectional analysis","authors":"Javad Moayedi,&nbsp;Ava Hashempour,&nbsp;Zahra Musavi,&nbsp;Farzaneh Ghasabi,&nbsp;Nastaran Khodadad,&nbsp;Mohamad Ali Davarpanah,&nbsp;Ali Hasanshahi","doi":"10.1016/j.nmni.2024.101496","DOIUrl":"10.1016/j.nmni.2024.101496","url":null,"abstract":"<div><h3>Background</h3><div><em>Human Herpes Virus 8</em> (<em>HHV-8</em>) is involved in autoimmunity. However, its association with advanced liver disease has not been fully explained. Herein, the prevalence of <em>HHV-8</em> viremia was assessed in Iranian liver transplant candidates with a confirmed diagnosis of cirrhosis.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted on 230 patients with cryptogenic cirrhosis, virus-related cirrhosis, and autoimmune hepatitis, as well as 140 healthy blood donors from April 2022 to September 2023. The <em>HHV-8</em> IgG antibody concentration and viral load were evaluated <em>via</em> ELISA and RT‒PCR, respectively.</div></div><div><h3>Results</h3><div>Anti-<em>HHV-8</em> IgG antibodies were detected in 25 cirrhotic patients (10.8 %) and four healthy individuals (2.6 %) (p = 0.022). The majority of the seropositive patients had cryptogenic cirrhosis (20.4 %), followed by autoimmune hepatitis (13.1 %) and virus-related cirrhosis (4.7 %). The seropositivity of <em>HHV-8</em> IgG antibody was significantly different among the etiologies of liver cirrhosis (p = 0.011). However, <em>HHV-8</em> genomic DNA was not detected in the sera of the patients or healthy blood donors.</div></div><div><h3>Conclusion</h3><div>The role of <em>HHV-8</em> infection in the development of posttransplant diseases, together with the higher seroprevalence of <em>HHV-8</em> antibodies in cirrhotic patients than in healthy individuals, highlights the importance of both primary and latent infections in liver transplantation. Therefore, serological and molecular screening of <em>HHV-8</em> is highly suggested for liver transplant candidates and organ donors. The possibility of antibody-mediated epitope mimicry in cryptogenic and autoimmune groups with moderate <em>HHV-8</em> antibody positivity and negative viral loads may account for the development of advanced liver diseases.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101496"},"PeriodicalIF":2.9,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cases of brain eating amoeba in India: Primary amoebic meningoencephalitis clinical features and pathogenesis","authors":"Mariyam Niusha Naseer,&nbsp;Kannan Subbaram,&nbsp;Razana Faiz,&nbsp;Zeba Un Naher,&nbsp;Punya Laxmi Manandhar,&nbsp;Sheeza Ali","doi":"10.1016/j.nmni.2024.101491","DOIUrl":"10.1016/j.nmni.2024.101491","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101491"},"PeriodicalIF":2.9,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-emergence of vaccine-derived polio in the demographic Republic of Congo: Causes and consequences","authors":"Malik Olatunde Oduoye ,&nbsp;Samuel Chinonso Ubechu ,&nbsp;Marina Ramzy Mourid ,&nbsp;Ahmad Ibrahim Ahmad ,&nbsp;Abdullahi Adeyemi Adegoke ,&nbsp;Umulkhairah Onyioiza Arama ,&nbsp;Muhammad Furqan ,&nbsp;Saiyad Ali ,&nbsp;Bashiru Muhammad Auwal ,&nbsp;F.N.U. Fariha ,&nbsp;Ankini Mukherjee ,&nbsp;Aymar Akilimali","doi":"10.1016/j.nmni.2024.101489","DOIUrl":"10.1016/j.nmni.2024.101489","url":null,"abstract":"<div><div>Poliovirus is a deadly disease that needs to be eradicated in the world. Recently, issues with circulating vaccine-derived polioviruses (cVDPVs) in the Democratic Republic of the Congo (DRC) have been raised in the country. This article aims to determine the increase in Type 1 cVDPV1 and Type 2 cVDPV2 in the DRC. Relevant articles on PubMed, Google Scholar, ResearchGate, and Web of Science were searched from 2010 to 2023. Our findings indicate that the Democratic Republic of Congo has struggled with polio outbreaks, with the virus primarily linked to cVDPVs produced from vaccines rather than wild poliovirus. These cVDPVs have the potential to revert to their paralyzing capabilities by evolving from the weakened virus seen in the oral polio vaccination (OPV). Several regions in DRC have reported cVDPV outbreaks of cVDPVs. Numerous cVDPV2 outbreaks were documented in various provinces during the 2017–2018 period. Addressing the cVDPV outbreak in the DRC requires a concerted global effort, involving collaboration among governments, international health organizations, and donor agencies. There should be global support and collaboration among governments, international health organizations, and donor agencies to address the cVDPV outbreak in the DRC.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101489"},"PeriodicalIF":2.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The resurgence of monkeypox: Epidemiology, clinical features, and public health implications in the post-smallpox eradication era","authors":"Parminder Singh ,&nbsp;Sathvik Belagodu Sridhar ,&nbsp;Javedh Shareef ,&nbsp;Sirajunisa Talath ,&nbsp;Priyanka Mohapatra ,&nbsp;Mahalaqua Nazli Khatib ,&nbsp;Suhas Ballal ,&nbsp;Mandeep Kaur ,&nbsp;Deepak Nathiya ,&nbsp;Shilpa Sharma ,&nbsp;G.V. Siva Prasad ,&nbsp;Aashna Sinha ,&nbsp;Amit Varma ,&nbsp;Ganesh Bushi ,&nbsp;Abhay M. Gaidhane ,&nbsp;Prakasini Satapathy ,&nbsp;Muhammed Shabil ,&nbsp;Renu Sah ,&nbsp;Jaffar A. Al-Tawfiq ,&nbsp;Ranjit Sah ,&nbsp;Alfonso J. Rodriguez-Morales","doi":"10.1016/j.nmni.2024.101487","DOIUrl":"10.1016/j.nmni.2024.101487","url":null,"abstract":"<div><div>The recent global resurgence of Mpox (formerly monkeypox), primarily transmitted via close contact and respiratory droplets, highlights a significant shift in its epidemiology, particularly among men who have sex with men (MSM). This resurgence underscores the need for robust public health responses and improved surveillance. This comprehensive review of current literature focuses on recent outbreaks, virology, and available treatments. Epidemiological data were gathered from various international health reports and analysed to understand transmission dynamics and outbreak patterns. Mpox, characterised by symptoms like fever and rash, has shown variable clinical presentations, particularly among immunocompromised individuals. Recent outbreaks have prompted the development of new diagnostic methods and treatments, including antivirals like Tecovirimat and vaccines such as MVA-BN. Studies have demonstrated the effectiveness of these vaccines in preventing infection, which is crucial for outbreak containment. The global response to the Mpox resurgence requires integrated strategies combining vaccination, antiviral treatments, and public health policies tailored to high-risk populations. Future efforts should focus on vaccine distribution equity and enhancing diagnostic capabilities to effectively manage and mitigate the impact of Mpox.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101487"},"PeriodicalIF":2.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the first case of Mpox in Jordan 2024: A Look at the national preparedness and response measures","authors":"Dalia Zayed,&nbsp;Salam Momani,&nbsp;Mus'ab Banat,&nbsp;Ala'a B. Al-Tammemi","doi":"10.1016/j.nmni.2024.101488","DOIUrl":"10.1016/j.nmni.2024.101488","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101488"},"PeriodicalIF":2.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polio eradication: A perspective from the UK","authors":"Hilary Simons,&nbsp;Dipti Patel","doi":"10.1016/j.nmni.2024.101490","DOIUrl":"10.1016/j.nmni.2024.101490","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101490"},"PeriodicalIF":2.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole genome-based characterization of extended-spectrum β-lactamase-producing Enterobacter cloacae from orthopedic patients and environment of a tertiary referral hospital in Tanzania","authors":"Benson R. Kidenya ,&nbsp;Gerald Mboowa ,&nbsp;Ivan Sserwadda ,&nbsp;Stephen Kanyerezi ,&nbsp;Esther Nakafu ,&nbsp;Inyasi Lawrence Akaro ,&nbsp;Baraka Mkinze ,&nbsp;Moses L. Joloba ,&nbsp;Jeremiah Seni","doi":"10.1016/j.nmni.2024.101486","DOIUrl":"10.1016/j.nmni.2024.101486","url":null,"abstract":"<div><h3>Objectives</h3><div>We investigated the genomic epidemiology of extended-spectrum <em>β</em>-lactamase-producing <em>Enterobacter cloacae</em> (ESBL-Ec) isolates from patients and hospital environment to better understand their distribution to help devising effective strategies for infection prevention and control.</div></div><div><h3>Methods</h3><div>We screened ESBL-Ec at Bugando Medical Center (BMC) in Mwanza, Tanzania. Rectal swabs from orthopedic patients on admission and swabs from the neighboring inanimate environment were collected. Following microbial culture, DNA was extracted from pure ESBL-Ec, and whole-genome sequencing was done. Sequence typing (ST), plasmid replicons, drug resistance, and virulence genes were deciphered using the Rapid Microbial Analysis Pipeline (rMAP).</div></div><div><h3>Results</h3><div>We obtained 209 ESBL isolates, of which 15 (7.2 %) were ESBL-Ec [8 (53.3 %) from patients and 7 (46.7 %) from the environment]. Seven isolates were novel and eight were diverse, each with a unique ST. All isolates harbored two to five <em>β</em>-lactamase genes, with the predominance of <em>bla</em>_{<em>CTX-M-15</em>} (15/15<em>), bla</em>_{<em>OXA-1</em>} (14/15)<em>, bla</em>_<em>TEM</em> (14/15) and <em>bla</em>_<em>ACT</em> (12/15). The most common non β-lactam drug resistance genes were <em>aac(3)-IIa</em> (14/15<em>), aac(6′)-Ib-cr</em> (14/15)<em>, fosA</em> (14/15<em>),</em> and <em>qnrB1</em> (12/15<em>), aph(3″)-Ib</em> (10/15) and <em>aph(6)-Id</em> (10/15)<em>.</em> Eleven different types of plasmid replicons were identified in 14/15 of the isolates, harboring one to five plasmids, with the most common plasmids being <em>IncFII</em> (11/15) and <em>IncFIB</em> (10/15). All isolates harbored the outer membrane protein (<em>omp</em>A), and curli protein <em>(csg</em>) was in 14/15 isolates.</div></div><div><h3>Conclusion</h3><div>Admitted orthopedic patients and the hospital environment act as a reservoir of ESBL-Ec with diverse STs and endowed with drug resistance and arsenals of virulence genes, calling for their routine screening on admission for mitigation of potential subsequent infections.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101486"},"PeriodicalIF":2.9,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002701/pdfft?md5=69e1e0576ba5035ddcdd853f9e1a34a4&pid=1-s2.0-S2052297524002701-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating multidisciplinary expertise and technological innovations in tracking infectious diseases","authors":"Alberto Rizzo","doi":"10.1016/j.nmni.2024.101485","DOIUrl":"10.1016/j.nmni.2024.101485","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101485"},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002695/pdfft?md5=aea3695046fded5511082793efa5c008&pid=1-s2.0-S2052297524002695-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and characterisation of colistin-resistant Acinetobacter colistiniresistens co-producing IMP-1 and OXA-58 carbapenemases","authors":"Satoshi Nishida ,&nbsp;Yasuo Ono","doi":"10.1016/j.nmni.2024.101484","DOIUrl":"10.1016/j.nmni.2024.101484","url":null,"abstract":"<div><h3>Background</h3><div>Carbapenem-resistant <em>Acinetobacter</em> is of increasing global concern because infections are challenging to treat with standard antibiotics. Here, we identified a previously uncharacterised <em>Acinetobacter</em> sp. clinical isolate as <em>Acinetobacter colistiniresistens</em> co-producing IMP-1 and OXA-58. We also examined expression of genes related to antibiotic susceptibility and drug resistance, including <em>bla</em>_IMP.</div></div><div><h3>Methods</h3><div>The isolate was deposited at the National Institute of Technology and Evaluation (NITE) as <em>Acinetobacter</em> sp. NBRC 110496. Susceptibility was defined according to the Clinical and Laboratory Standards Institute (CLSI) breakpoints. Genomic and clonal analyses were performed to identify species and resistance genes.</div></div><div><h3>Results</h3><div>The isolate was resistant to β-lactams, including broad-spectrum cephalosporins and carbapenems, polymyxins, and trimethoprim/sulfamethoxazole. Genomic analysis identified the isolate as <em>A. colistiniresistens</em> harbouring <em>bla</em>_IMP-1, <em>bla</em>_OXA-58, <em>bla</em>_OXA-670, <em>aac(6′)-Ib</em>, <em>aac(6′)-Ij</em>, <em>ant(3”)-I</em><em>I</em>, <em>aph(3’)-VI</em>, <em>msrE</em>, <em>mphE</em>, and <em>sul1</em>. Colistin resistance was associated with the <em>eptA</em>-like gene, which encodes a lipid A-modifying enzyme. SNP-based phylogenetic analysis revealed that the strain clustered with other strains isolated in Japan. The IMP-1/OXA-58-producing strain described in this study has a novel integron structure surrounding <em>bla</em>_IMP-1, <em>aacA</em> and <em>sul1</em>.</div></div><div><h3>Conclusions</h3><div>Colistin-resistant IMP-1/OXA-58-co-producing <em>A. colistiniresistens</em> was identified in a patient. This isolate could serve as a reservoir for carbapenemase-producing organisms. This study suggests that screening for colistin-resistant isolates is crucial to preserve colistin as a therapeutic agent for multidrug-resistant bacteria. Identification of this MDR isolate in Asia, and the danger of it spreading worldwide, should raise serious concerns.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101484"},"PeriodicalIF":2.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}