New Microbes and New Infections最新文献

{"title":"Platelet dynamics and thrombocytopenia in dengue fever: A prospective cohort study from Shenzhen, China","authors":"Liping Guo ,&nbsp;Yuchen Gu ,&nbsp;Ying Zhang ,&nbsp;Haimei Zhang ,&nbsp;Weizhen Weng ,&nbsp;Shuai Wu ,&nbsp;Jing Yuan","doi":"10.1016/j.nmni.2025.101624","DOIUrl":"10.1016/j.nmni.2025.101624","url":null,"abstract":"<div><h3>Introduction</h3><div>Dengue fever, the most prevalent arthropod-borne viral disease, causes ∼400 million infections annually. Although thrombocytopenia is commonly associated with dengue, how it evolves in relation to viral load and immune responses remains poorly understood. This study aimed to elucidate platelet-virus-immune interactions in acute dengue by systematically tracking of viral load, platelet parameters, and leukocyte dynamics.</div></div><div><h3>Methods</h3><div>A prospective cohort study was conducted at Third People's Hospital in 2024, involving 135 confirmed dengue cases, supported by retrospective data from 2014 to 2023. Platelet counts, hematocrit (HCT), and cellular immunity markers (lymphocyte/neutrophil percentages) were longitudinally tracked. Viral load was quantified via NS5 gene Ct values. Statistical analyses involved LOESS regression and Pearson/Spearman correlations.</div></div><div><h3>Results</h3><div>Platelet counts exhibited a biphasic decline, reaching nadir levels (mean: 97.65 × 10⁹/L) at 6 days post-onset, with recovery by day 9. Thrombocytopenia severity was stratified as intermediate-low (50–99 × 10⁹/L; 50 %, 64/128) and very low (&lt;50 × 10⁹/L; 14.8 %, 19/128). Platelet decline correlated with elevated lymphocyte percentages (40 % vs. 17.8 % pre-decline; p &lt; 0.001) and suppressed neutrophils (46.6 % vs. 68.3 %; p &lt; 0.001). Critically, platelet counts inversely correlated with viral load (Ct values: R = 0.25, p = 0.028), HCT (R = −0.25), and platelet activation markers (MPV: R = −0.55; P-LCR: R = −0.57), while positively associating with platelet hematocrit (PCT: R = 0.97). No cases progressed to severe dengue despite extreme thrombocytopenia.</div></div><div><h3>Conclusions</h3><div>This study identifies distinct dengue thrombocytopenia kinetics driven by viral load. Predominant moderate thrombocytopenia (50–99 × 10⁹/L) challenges conventional risk stratification, advocating integrated monitoring of platelet indices and viral replication. These data advance both risk prediction and mechanistic knowledge of platelet-virus interactions.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101624"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of armed conflict in eastern Democratic Republic of Congo on the risk of malaria outbreaks in children under five years old","authors":"Hermann Yokolo,&nbsp;Christian Tague,&nbsp;Joshua Ekouo,&nbsp;Dujardin Makeda,&nbsp;Aymar Akilimali","doi":"10.1016/j.nmni.2025.101636","DOIUrl":"10.1016/j.nmni.2025.101636","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101636"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, and Babesia microti coinfections in human populations from 1946 to 2024: a systematic review and meta-analysis","authors":"Fukai Bao ,&nbsp;Jiaru Yang ,&nbsp;Zhenhua Ji ,&nbsp;Caijun Zha ,&nbsp;Aihua Liu","doi":"10.1016/j.nmni.2025.101621","DOIUrl":"10.1016/j.nmni.2025.101621","url":null,"abstract":"<div><h3>Background</h3><div><em>Borrelia burgdorferi</em> (Bb), <em>Anaplasma phagocytophilum</em> (Ap), and <em>Babesia microti</em> (Bm) could coinfect humans since they are transmitted via the same vectors. The prevalence of coinfections is more frequent than expected, threatening global health. However, the data on global prevalence are unclear. Obtaining comprehensive prevalence data is critical for evaluating the coinfection threat.</div></div><div><h3>Methods</h3><div>This meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. We searched studies from the Web of Science, Scopus, Ovid, PubMed, and EBSCO from inception to March 15, 2024. Data were pooled by a random effects model. This study has been registered on PROSPERO (CRDCRD42022380305).</div></div><div><h3>Results</h3><div>We searched 18064 articles and included 34 articles, involving 23851 people. Bb + Ap global coinfection prevalence was 2.9 % (95 % CI 1.8 to 4.3), Bb + Bm was 3.9 % (95 % CI 1.7 to 8.8), Ap + Bm was 0.5 % (95 % CI 0.2 to 1.4), and Bb + Ap + Bm was 2.1 % (95 % CI 0.7 to 5.9). Amongst Bb + Ap group, prevalence of China (1.3 %, 95 %CI 0.9 to 1.7) was lower than that of Europe (3.2 %, 95 % CI 1.9 to 5.2) and USA (2.7 %, 95 % CI 1.0 to 5.3).</div></div><div><h3>Conclusions</h3><div><em>Borrelia burgdorferi</em>, <em>Anaplasma phagocytophilum</em>, and <em>Babesia microti</em> coinfection in the human population is prevalent in the Northern Hemisphere. Bb + Ap and Bb + Bm are more commonplace than Ap + Bm and Bb + Ap + Bm; meanwhile, Bb + Ap + Bm has the lowest prevalence. Coinfections are most prevalent in Europe and the USA. Bb + AP coinfection occurs more frequently in Europe than in the USA.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101621"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yellow fever in children and adolescents amid the South American outbreak, 2024/2025","authors":"Alfonso J. Rodriguez-Morales ,&nbsp;Daniela Torres-Hernández ,&nbsp;Maria Eugenia Guevara ,&nbsp;Alicia Chang-Cojulun ,&nbsp;Jose Brea-Del Castillo ,&nbsp;Romina Rios-Blanco ,&nbsp;Manuela Isbeth Mérida-Barrios ,&nbsp;Melissa Palmieri ,&nbsp;Maria L. Avila-Agüero","doi":"10.1016/j.nmni.2025.101635","DOIUrl":"10.1016/j.nmni.2025.101635","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101635"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burden of dengue fever in travellers: a systematic literature review","authors":"Martin P. Grobusch ,&nbsp;Marta Díaz-Menéndez ,&nbsp;Eduardo Bittencourt de Gomensoro ,&nbsp;Caroline Mächler ,&nbsp;Bojana Milovanović","doi":"10.1016/j.nmni.2025.101631","DOIUrl":"10.1016/j.nmni.2025.101631","url":null,"abstract":"<div><h3>Background</h3><div>Dengue is a mosquito-borne viral infection with growing global impact, including international travellers travelling to and from endemic regions. This systematic literature review aimed to assess the clinical and economic burden of dengue in travellers from non-endemic countries.</div></div><div><h3>Methods</h3><div>This systematic review was conducted following the PRISMA guidelines to assess the incidence, prevalence, mortality, healthcare resource use, and costs of dengue fever in travellers between non-endemic and endemic regions. We systematically searched MEDLINE, Embase, Google Scholar, PubMed, and Epistemonikos. Due to heterogeneity, data were synthesised descriptively without quantitative analysis.</div></div><div><h3>Results</h3><div>Seventy unique studies were included. Heterogeneity in design, inconsistent reporting, and lack of denominator data limited the ability to calculate incidence rates or compare risks across regions. Two prospective studies provided incidence rates, reaching 58.7 cases per 1000 person-months of travel. No studies reported prevalence data. With three cases, reported mortality was rare. No cost data were identified, but limited data on healthcare resource use were identified from seven publications.</div></div><div><h3>Conclusions</h3><div>Findings highlight the challenges in quantifying individual risk and the need for improved surveillance, prospective data collection, and targeted prevention strategies. These results support improved travel health guidance and may inform vaccination strategies for travellers to endemic regions.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101631"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A large-scale chikungunya outbreak in China: Implications for global health in the era of climate change","authors":"Ala'a B. Al-Tammemi ,&nbsp;Ruba A. Al-Smadi ,&nbsp;Tareq L. Mukattash","doi":"10.1016/j.nmni.2025.101632","DOIUrl":"10.1016/j.nmni.2025.101632","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101632"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The discontinuation of the Fleming fund: Implications for global mitigation of antimicrobial resistance","authors":"Patrick Ashinze ,&nbsp;Oluwadamilare Olatunbosun ,&nbsp;Jasmine Kaur ,&nbsp;Maryam Olabisi Atofarati ,&nbsp;Abba Owoicho ,&nbsp;Toniloba Akingbola ,&nbsp;Daniel Olumuyiwa Ogunruku ,&nbsp;Folayemi Abiodun Iwaloye","doi":"10.1016/j.nmni.2025.101625","DOIUrl":"10.1016/j.nmni.2025.101625","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101625"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An open-label phase II trial of sotrovimab (VIR-7831) prophylaxis against COVID-19 infection in immunocompromised individuals with impaired SARS-CoV-2 humoral immunity","authors":"Isabel H. Gonzalez-Bocco ,&nbsp;Rayven Frierson ,&nbsp;Alyssa Cho ,&nbsp;Fabiola A. Reyes Curcio ,&nbsp;Andres E. Franceschi ,&nbsp;Chloe Lahoud ,&nbsp;Dimitrios G. Moshovitis ,&nbsp;Katherine Beluch ,&nbsp;Manu Balusu ,&nbsp;C. Elizabeth Keleher ,&nbsp;Keri M. Sullivan ,&nbsp;Michael Dougan ,&nbsp;Qianwen Wang ,&nbsp;Jennifer H. Han ,&nbsp;Ahmed Nader ,&nbsp;Alicia Aylott ,&nbsp;Wei Wang ,&nbsp;Brian T. Chan ,&nbsp;Sarah P. Hammond ,&nbsp;Jennifer Manne-Goehler ,&nbsp;Sophia Koo","doi":"10.1016/j.nmni.2025.101620","DOIUrl":"10.1016/j.nmni.2025.101620","url":null,"abstract":"<div><h3>Background</h3><div>Immunocompromised individuals have a limited humoral immune response to SARS-CoV-2 vaccination and are at higher risk of severe COVID-19. Sotrovimab is a monoclonal antibody (mAb) targeting a conserved SARS-CoV-2 spike protein epitope.</div></div><div><h3>Methods</h3><div>This phase II open-label study evaluated the safety and tolerability of sotrovimab pre-exposure prophylaxis in immunocompromised adults with impaired vaccine response. Between February and June 2022 in the northeastern region of the USA, participants received sotrovimab 500 mg IV on Treatment Day (TD) 1 and 2000 mg IV on TD2 due to the spread of the Omicron BA.2 subvariant. Follow-up lasted 36 weeks (∼5 half-lives), assessing safety and tolerability, PK, COVID-19 incidence and severity, and quality of life.</div></div><div><h3>Results</h3><div>Ninety-three subjects received 500 mg on TD1, of whom 81 received 2000 mg on TD2. Three patients reported five drug-related adverse events, four grade 2 infusion-related reactions and one grade 2 headache, all resolving quickly. Among 35 SARS-CoV-2 cases, 94 % had no activity limitations or hospitalizations per the National Institute of Allergy and Infectious Diseases Ordinal Scale. Sotrovimab exhibited dose-dependent increases in exposures at doses of 500 mg and 2000 mg.</div></div><div><h3>Conclusion</h3><div>Sotrovimab pre-exposure prophylaxis had a favorable safety profile and was well tolerated at both doses, with low immunogenicity. These findings support mAbs’ safety as COVID-19 pre-exposure prophylaxis in this population.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101620"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144867134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling of knowledge and attitudes as key determinants of Mpox prevention practices among university students in Ghana: a cross-sectional analysis","authors":"Napoleon Bellua Sam ,&nbsp;Nuhu Abdul-Aziz Yembedara ,&nbsp;Adams Dramani","doi":"10.1016/j.nmni.2025.101615","DOIUrl":"10.1016/j.nmni.2025.101615","url":null,"abstract":"<div><h3>Introduction</h3><div>Mpox has surfaced as a primary health problem since the global outbreak in 2022. This study sought to evaluate and also use structural equation modelling (SEM) to predict the knowledge, attitudes, and preventive practices concerning Mpox among students.</div></div><div><h3>Methods</h3><div>A descriptive cross-sectional survey was conducted with 469 students at the University for Development Studies. Data were collected using a structured questionnaire with SEM and cumulative percentage employed to analyze and predict both knowledge and attitudes on preventive practices among university students.</div></div><div><h3>Results</h3><div>A significant majority (84.2 %) correctly identified Mpox as an infectious disease caused by the Mpox virus, though 55.0 % incorrectly believed it to be the same as smallpox. The overall knowledge of Mpox among university students was poor (59.1 %), with 40.9 % demonstrating either acceptable (32.4 %) or excellent (8.5 %) levels of knowledge. Despite this, 77 % of students had a favorable attitude towards the disease. Preventive practices were predominantly excellent, with 78.7 % of students exhibiting excellent practices, while only 3.8 % demonstrated poor practices. SEM revealed a positive, statistically significant association between knowledge (β = 0.23, P &lt; 0.001), attitude (β = 0.38, P &lt; 0.001), and preventive practices. Additionally, a strong positive effect was found between knowledge and attitudes towards Mpox (β = 0.50, P &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The study emphasizes that although students have limited knowledge about Mpox, their positive attitudes greatly aid in the implementation of successful preventive measures. Improving knowledge may result in even better preventive actions, highlighting the necessity of focused educational programmes to raise students' knowledge of Mpox.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101615"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic characterization and pathogenic mechanisms of Bacillus cereus WGPSB-2 isolated from the Himalayas","authors":"A.R.N.S. Subanna ,&nbsp;Ashish Kumar Singh ,&nbsp;Amit U. Paschapur ,&nbsp;Nutan Karki ,&nbsp;Sunaullah Bhat ,&nbsp;Stanley J ,&nbsp;K.K. Mishra ,&nbsp;Lakshmi Kant","doi":"10.1016/j.nmni.2025.101616","DOIUrl":"10.1016/j.nmni.2025.101616","url":null,"abstract":"<div><div>The utilization of microbial agents for the management of white grub has been a long-standing practice in biocontrol. In a previous study, we isolated entomopathogenic bacteria <em>Bacillus cereus</em> WGPSB-2 from the Himalayan region. To gain insights into the genetic characteristics and potential mechanisms underlying the pathogenicity of <em>B. cereus</em> WGPSB-2, we performed genomic analysis of <em>B. cereus</em> WGPSB-2. The genome has 9 contigs with a total length of 4.98 megabases, GC content of 35 %, 4506 protein-coding genes, 55 tRNA, and 30 rRNA. In the genome of <em>B. cereus</em>, a total of 37 genes predicted to encode peptide synthetases. Among these, five core biosynthetic gene clusters including <em>bpsA</em>, <em>bpsB</em>, <em>bpsC</em>, <em>bpsD</em>, and <em>dpgA</em> have been predicted. The results revealed that the WGPSB-2 strain possesses several genetic attributes associated with insect pathogenicity, including the presence of toxin-encoding genes and genes involved in entomopathogenicity. Comparative analysis with other entomopathogenic bacterial strain revealed high degree of genetic similarity, suggesting that the WGPSB-2 is closely related to other insect pathogenic strains. The findings may inform the development of novel strategies for pest management and provide a foundation for future studies on the genetic diversity and evolution of insect pathogenicity in <em>B. cereus</em>.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101616"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}