New Microbes and New Infections最新文献

{"title":"Lymphotropic polyomavirus and Merkel cell polyomavirus in patients infected with HIV or hepatitis B or C virus","authors":"Bahman Abedi Kiasari ,&nbsp;Amir Hossein Alipour ,&nbsp;Negar Hemmati ,&nbsp;Mohammad Gholamnezhad ,&nbsp;Fatemeh Hoda Fallah","doi":"10.1016/j.nmni.2024.101471","DOIUrl":"10.1016/j.nmni.2024.101471","url":null,"abstract":"<div><h3>Background</h3><p>LPV and MCV emerge as recent additions to the Polyomaviridae family, capable of inducing important infections. Studies have suggested the presence of LPV in human populations, with potential involvement in central nervous system (CNS) diseases. Additionally, MCV, closely related to LPV, has been implicated in Merkel cell carcinoma (MCC). This study aimed to explore the prevalence of LPV and MCV in individuals with compromised immunity due to chronic viral infections.</p></div><div><h3>Methods</h3><p>340 specimens, including HIV PCR-positive, HBV PCR-positive, HCV PCR-positive, and HIV/HBV/HCV negative sera, underwent screening via PCR technique to identify LPV and MCV genomes. Subsequently, sequencing was employed to validate the viral identity.</p></div><div><h3>Results</h3><p>Out of all specimens, MCV DNA was detected in 8.52 % of participants, with a significantly higher prevalence in HIV-positive individuals (26.4 %). LPV was detected in only one HIV-positive patient. No co-detection of MCV and LPV was observed. Phylogenetic analysis confirmed the genetic similarity of the detected MCV strains to known references, while the LPV sequence showed 99 % identity to the published sequences of LPV-K38.</p></div><div><h3>Conclusion</h3><p>This research provides insights into the prevalence of LPV and MCV in individuals with chronic viral infections. The study highlights the potential association between MCV and immunocompromised states, emphasizing the need for comprehensive investigations to understand the epidemiology, transmission routes, and clinical implications of these polyomaviruses in human populations.</p></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101471"},"PeriodicalIF":2.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002555/pdfft?md5=1fc181c2e36d0b8abfa9c32ed7c3c9c4&pid=1-s2.0-S2052297524002555-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse pregnancy outcomes in maternal malarial infection: A systematic review and meta-analysis","authors":"Prakasini Satapathy ,&nbsp;Mahalaqua Nazli Khatib ,&nbsp;Shilpa Gaidhane ,&nbsp;Quazi Syed Zahiruddin ,&nbsp;Rakesh Kumar Sharma ,&nbsp;Sarvesh Rustagi ,&nbsp;Jumana M. Al-Jishi ,&nbsp;Hawra Albayat ,&nbsp;Mona A. Al Fares ,&nbsp;Mohammed Garout ,&nbsp;Hayam A. Alrasheed ,&nbsp;Maha F. Al-Subaie ,&nbsp;Ali A. Rabaan ,&nbsp;Ranjit Sah","doi":"10.1016/j.nmni.2024.101474","DOIUrl":"10.1016/j.nmni.2024.101474","url":null,"abstract":"<div><h3>Background</h3><p>Malaria in pregnancy is a critical public health issue that can lead to severe adverse outcomes for both mother and fetus. This systematic review and meta-analysis evaluated the prevalence of adverse birth outcomes in malaria-infected pregnancies and examines their association with the condition.</p></div><div><h3>Method</h3><p>We searched databases up to January 30, 2024, for observational studies on pregnant women with malaria. Data were analyzed using a random-effects model to calculate pooled prevalence rates and risk ratios (RRs) for adverse outcomes, with statistical support from R software version 4.3.</p></div><div><h3>Results</h3><p>Thirty-one studies were included, showing high prevalence of low birth weight (LBW; 17.4 %), preterm birth (17.9 %), and small for gestational age (SGA; 16.1 %) in malaria-affected pregnancies. Infected mothers were significantly more likely to have LBW infants (RR = 1.755), preterm births (RR = 1.484), and SGA infants (RR = 1.554). The risk of stillbirth was not significantly increased (RR = 1.238).</p></div><div><h3>Conclusion</h3><p>Malaria in pregnancy significantly elevates the risk of LBW, preterm birth, and SGA, underscoring the need for effective malaria prevention and treatment strategies in endemic regions. Future research should aim to refine and implement these strategies to enhance maternal and neonatal health outcomes.</p></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101474"},"PeriodicalIF":2.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002580/pdfft?md5=36ff30e2b55722e8a9d74ecd3478eece&pid=1-s2.0-S2052297524002580-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142130036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of impregnated mosquito nets and the case of Papua New Guinea","authors":"Olalekan John Okesanya,&nbsp;Don Eliseo Lucero-Prisno III,&nbsp;Jerico Bautista Ogaya,&nbsp;Emery Manirambona,&nbsp;Bonaventure Michael Ukoaka,&nbsp;Safayet Jamil","doi":"10.1016/j.nmni.2024.101475","DOIUrl":"10.1016/j.nmni.2024.101475","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101475"},"PeriodicalIF":2.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002592/pdfft?md5=5b8537901cea669c39e0941aca97814a&pid=1-s2.0-S2052297524002592-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated data collection tool for real-world cohort studies of chronic hepatitis B: Leveraging OCR and NLP technologies for improved efficiency","authors":"Xiaomei Zhou ,&nbsp;Tao Zeng ,&nbsp;Yibo Zhang ,&nbsp;Yingying Liao ,&nbsp;Jaime Smith ,&nbsp;Lin Zhang ,&nbsp;Chao Wang ,&nbsp;Qinghai Li ,&nbsp;Dongbo Wu ,&nbsp;Yutian Chong ,&nbsp;Xinhua Li","doi":"10.1016/j.nmni.2024.101469","DOIUrl":"10.1016/j.nmni.2024.101469","url":null,"abstract":"<div><h3>Background</h3><p>Collecting and standardizing clinical research data is a very tedious task. This study is to develop an intelligent data collection tool, named CHB-EDC, for real-world cohort studies of chronic hepatitis B (CHB), which can assist in standardized and efficient data collection.</p></div><div><h3>Methods</h3><p>CHB_EDC is capable of automatically processing various formats of data, including raw data in image format, using internationally recognized data standards, OCR, and NLP models. It can automatically populate the data into eCRFs designed in the REDCap system, supporting the integration of patient data from electronic medical record systems through commonly used web application interfaces. This tool enables intelligent extraction and aggregation of data, as well as secure and anonymous data sharing.</p></div><div><h3>Results</h3><p>For non-electronic data collection, the average accuracy of manual collection was 98.65 %, with an average time of 63.64 min to collect information for one patient. The average accuracy CHB-EDC was 98.66 %, with an average time of 3.57 min to collect information for one patient. In the same data collection task, CHB-EDC achieved a comparable average accuracy to manual collection. However, in terms of time, CHB-EDC significantly outperformed manual collection (p &lt; 0.05). Our research has significantly reduced the required collection time and lowered the cost of data collection while ensuring accuracy.</p></div><div><h3>Conclusion</h3><p>The tool has significantly improved the efficiency of data collection while ensuring accuracy, enabling standardized collection of real-world data.</p></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101469"},"PeriodicalIF":2.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002531/pdfft?md5=d192ae7ffffc801b31fe3c79f37b552b&pid=1-s2.0-S2052297524002531-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and characterisation of carbapenem-resistant Streptococcus nidrosiense sp. nov. isolated from blood culture","authors":"Torunn Gresdal Rønning ,&nbsp;Camilla Olaisen ,&nbsp;Christina Gabrielsen Ås ,&nbsp;Jan Egil Afset ,&nbsp;Maria Schei Haugan","doi":"10.1016/j.nmni.2024.101473","DOIUrl":"10.1016/j.nmni.2024.101473","url":null,"abstract":"<div><h3>Background</h3><p>This study aimed to investigate a highly resistant strain of <em>Streptococcus</em> sp. isolated from a patient with bloodstream infection and determine its taxonomic classification.</p></div><div><h3>Methods</h3><p>The strain was isolated from blood culture from a 65-year-old male patient admitted to St. Olavs University hospital, Trondheim, Norway, in 2023. Antimicrobial susceptibility testing as well as phenotypic and biochemical characterization were performed. Whole genome sequencing was conducted and genomic comparison to <em>Streptococcus</em> type strains was carried out.</p></div><div><h3>Results</h3><p>The strain was initially identified as <em>Streptococcus mitis</em>/<em>oralis</em> but showed significant genetic differences, suggesting that it belonged to an undescribed species within the <em>Streptococcus</em> genus. Phenotypic and biochemical characterization identified the strain as a non-motile, facultative anaerobic bacterium with α-hemolysis. Antimicrobial susceptibility testing showed resistance to all beta-lactams tested. Genomic analyses confirmed the classification of the strain as a novel species, which was designated <em>Streptococcus nidrosiense</em>.</p></div><div><h3>Conclusion</h3><p>This study combines conventional phenotypic tests with whole genome sequencing for accurate taxonomic classification of a bacterial strain isolated from blood culture. The identification of a novel species within the <em>Streptococcus</em> genus contributes to the understanding of microbial diversity and antibiotic resistance of the <em>Streptococcus</em> genus in clinical settings.</p></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101473"},"PeriodicalIF":2.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002579/pdfft?md5=2438980f6adbb4c40a1e86893aa4c2e9&pid=1-s2.0-S2052297524002579-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of SEN virus prevalence in hemophilia patients","authors":"Davod Javanmard ,&nbsp;Motahareh Mahi-Birjand ,&nbsp;Effat Alemzadeh ,&nbsp;Mahdie Mohammadi ,&nbsp;Masood Ziaee","doi":"10.1016/j.nmni.2024.101470","DOIUrl":"10.1016/j.nmni.2024.101470","url":null,"abstract":"<div><h3>Background</h3><p>Hemophilia and transfusion-dependent patients are at high risk of a wide range of blood-borne agents. Among these, SEN virus (SENV) stands out as a significant concern due to its association with transfusion-induced non-A to non-E hepatitis. This study, therefore, aimed to investigate the prevalence of this virus in hemophilia patients, focusing on potential complications and risk factors.</p></div><div><h3>Method</h3><p>This was a cross-sectional study conducted in a hemophilia center in the east of Iran. Blood samples were taken from patients and healthy people, and demographic and clinical information was collected. The sera samples were then subjected to DNA extraction. PCR-based methods detected SENV and its genotype, and then phylogenetic analysis was performed. The collected data were analyzed and interpreted by SPSS22 software.</p></div><div><h3>Results</h3><p>The mean age of patients and the healthy group was 26.18 ± 14.97 and 41.69 ± 14.05, respectively. Among the patient and healthy groups, 94.5 % and 36.4 % were male, and the rest were female, respectively. Most of the participants in the patient group had hemophilia type A (85.5 %), then type B (7.3 %), VWD type (3.6 %), and F and plt type (1.8 %) were in the next categories. SENV-DNA was detected in 58.2 % of patients and 20 % of healthy groups (P-value: 0.00). Among these, H and D genotypes were found in 35 % and 23.7 % of patients and 12.7 % and 7.3 % of healthy groups, respectively. The prevalence of the virus was significantly related to minor elevation of AST and was higher in hemophilia type A (63.8 %) and severe type of disease (63.2 %).</p></div><div><h3>Conclusion</h3><p>This study underscore the significant prevalence of the SENV virus in hemophilia patients, a particularly noteworthy finding compared to the healthy population. With the limited information available about this virus, our findings highlight the importance of continuous monitoring and follow-up of high-risk groups in relation to blood-borne pathogens, providing reassurance about the ongoing efforts in the field.</p></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101470"},"PeriodicalIF":2.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002543/pdfft?md5=3b058549663a1c772b26551c98dbe950&pid=1-s2.0-S2052297524002543-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staphylococcus nepalensis infecting a companion animal: Genomic insights from an emerging multidrug-resistant pathogen","authors":"Luciana Sartori,&nbsp;Andrey G. Sacramento,&nbsp;Fábio P. Sellera,&nbsp;João Pedro Rueda Furlan,&nbsp;Fernanda B. Barbosa,&nbsp;Fernanda Esposito,&nbsp;Nilton Lincopan,&nbsp;Terezinha Knöbl","doi":"10.1016/j.nmni.2024.101472","DOIUrl":"10.1016/j.nmni.2024.101472","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101472"},"PeriodicalIF":2.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002567/pdfft?md5=4ce1526838e425cc4902481d03df1da7&pid=1-s2.0-S2052297524002567-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 infection of domestic animals and their role in evolution and emergence of variants of concern","authors":"Olajumoke Olufunmilayo Joseph ,&nbsp;Samuel Olatunde Dahunsi ,&nbsp;Anthony Okoh","doi":"10.1016/j.nmni.2024.101468","DOIUrl":"10.1016/j.nmni.2024.101468","url":null,"abstract":"<div><h3>Background</h3><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is responsible for COVID-19 pandemic, is a zoonotic RNA virus that has been reported in animals, including domestic animals. Due to the growing concern of health threat that could arise from active transmission of SARS-CoV-2 between pet owners and their pets, there is need to monitoring the emergence of a highly pathogenic strain of SARS-CoV-2 that is capable of transboundary infection, or a serious outbreak among human populations.</p></div><div><h3>Methods</h3><p>We carried out a search in English, on PubMed and NCBI (National Center for Biotechnology Information) SARS-CoV-2 resources for relevant journals and nucleotide sequence data, that were published between 2019 and 2023. The CoVsurver mutations application on GISAID webpage was used to analyse mutation, nucleotide sequence alignment was carried out using MAFFT (Multiple Alignment using Fast Fourier Transform) version 7 and maximum likelihood tree was constructed by bootstrapping with 1000 replicates on MEGA 11 software.</p></div><div><h3>Results</h3><p>A total of 47 mutations at the Spike gene region were identified, and mutation D614 was the most observed mutation. Nucleotide sequences of isolates from domestic animals had high sequence identity with Wuhan-Hu-1 reference sequence and the representative sequences of previously circulating VOCs from humans.</p></div><div><h3>Conclusion</h3><p>This reveals that there is spill over of previously circulating variants of concern (VOC) to household pets from their infected owners. Hence, there is an urgent need for more intense surveillance to be carried out globally to monitor evolution of SARS-CoV-2 coronaviruses as a result of human – pet association.</p></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101468"},"PeriodicalIF":2.9,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S205229752400252X/pdfft?md5=54c29551151bf1776ba6e27dbe20c824&pid=1-s2.0-S205229752400252X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142058317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Mpox outbreak: Are we prepared for emerging strains?","authors":"Ranjit Sah ,&nbsp;Shriyansh Srivastava ,&nbsp;Rachana Mehta,&nbsp;Sachin Kumar,&nbsp;Sanjit Sah,&nbsp;Aroop Mohanty,&nbsp;Jack Feehan,&nbsp;Jaffar A. Al-Tawfiq ,&nbsp;Vasso Apostolopoulos","doi":"10.1016/j.nmni.2024.101466","DOIUrl":"10.1016/j.nmni.2024.101466","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101466"},"PeriodicalIF":2.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002506/pdfft?md5=06a31866f737fba0d2e7ba45e7186b26&pid=1-s2.0-S2052297524002506-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oropouche fever rears its head in Cuba: What lies beneath the surface?","authors":"Angel A. Escobedo,&nbsp;Alfonso J. Rodríguez-Morales","doi":"10.1016/j.nmni.2024.101460","DOIUrl":"10.1016/j.nmni.2024.101460","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101460"},"PeriodicalIF":2.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002440/pdfft?md5=8ee0239e07f5d613d22fb7e4bd4083d4&pid=1-s2.0-S2052297524002440-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142058318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}