New Microbes and New Infections最新文献

{"title":"Web-based real-time risk assessment of coronavirus disease 2019 infection in schools and social dining settings","authors":"Yuta Okada,&nbsp;Minami Ueda,&nbsp;Hiroshi Nishiura","doi":"10.1016/j.nmni.2025.101600","DOIUrl":"10.1016/j.nmni.2025.101600","url":null,"abstract":"<div><h3>Background</h3><div>Schools and dining situations are associated with a high risk of indoor transmission of coronavirus disease 2019 (COVID-19). Performing risk assessment in real time could enable organizers to adjust the duration and size of indoor activities depending on the epidemic situation.</div></div><div><h3>Methods</h3><div>The per-hour transmission rates of COVID-19 from a single infector in school and social dining settings were estimated from COVID-19 surveillance data in Japan from January to February 2022 using a mathematical model. We then developed a web application that calculates the risk of COVID-19 infection in those settings, accounting for place of residence, vaccination history, duration of indoor activity, and the number of participants.</div></div><div><h3>Results</h3><div>The estimated per-hour transmission rates were 0.01934 (95 %CrI: 0.01939–0.01947) in social dining settings and 0.00324 (95 %CrI: 0.00323–0.00325) in school settings. Accounting for the epidemiological risk of having infected persons in indoor settings, a web application was devised to compute the risk of a single participant contracting COVID-19 at the event. Web application users can vary input variables including the duration and the number of participants, thereby benefiting the real time risk reduction.</div></div><div><h3>Conclusions</h3><div>The per-hour transmission rate was higher in social dining settings compared with that in school settings, but the greater number of participants that is typical of gatherings at schools might offset this gap in per-hour per-infector transmission risk. The proposed web application can act as an important tool for promoting risk awareness regarding COVID-19 in high-risk settings.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101600"},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory impact of COVID-19 in young adults: A propensity score-weighted cohort study","authors":"Thibault Lovey ,&nbsp;Nejla Gültekin ,&nbsp;Zeno Stanga ,&nbsp;Andreas Stettbacher ,&nbsp;Jeremy Werner Deuel ,&nbsp;Patricia Schlagenhauf","doi":"10.1016/j.nmni.2025.101598","DOIUrl":"10.1016/j.nmni.2025.101598","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic has raised concerns regarding persisting cardiorespiratory effects in young adults. This study aimed to assess the impact of COVID-19 on cardiopulmonary function in this population.</div></div><div><h3>Methods</h3><div>This investigation, using data from the LoCoMo study, evaluated young recruits from the Swiss Armed Forces, aged 18–30 years. Participants were categorized based on their SARS-CoV-2 infection status and underwent cardiopulmonary exercise testing (CPET), spirometry, and diffusion capacity tests (DLCO). Propensity score weighting adjusted for confounding factors compared key outcomes between the control and COVID-19 groups.</div></div><div><h3>Finding</h3><div>We evaluated 242 participants in the control group and 240 in the COVID-19 group. The propensity score-weighted analysis showed no significant differences in most CPET and pulmonary outcomes. The COVID-19 group exhibited a significant reduction in systolic blood pressure (SBP) at peak exercise by 7.68 mmHg (p = 0.001), more pronounced in recent cases (&lt;6 months, 14.60 mmHg, p = 0.002) and persisting after infection in non-recent cases (&gt;6 months, 9.07 mmHg, p = &lt;0.001). There was an increase in V'Epeak [% predicted MVV] by 2.92 % in the COVID-19 group, notably in the “non-recent” subgroup who had been infected more than 6 months previously (p = 0.003).</div></div><div><h3>Interpretation</h3><div>Young adults can exhibit persisting cardiopulmonary effects post-COVID-19, including reduced systolic blood pressure at peak exercise and increased ventilatory response, likely due to deconditioning and muscle weakness. These findings underscore the importance of maintaining physical activity during recovery to mitigate these effects.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101598"},"PeriodicalIF":2.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emergence of oropouche fever: A potential new threat?","authors":"Shriyansh Srivastava ,&nbsp;Ranjit Sah ,&nbsp;Molakpogu Ravindra Babu ,&nbsp;Deepika Sharma ,&nbsp;Dheeraj Sharma ,&nbsp;Sachin Kumar ,&nbsp;Sathvik Belagodu Sridhar ,&nbsp;Tarun Wadhwa ,&nbsp;Javedh Shareef ,&nbsp;G.S.N. Koteswara Rao ,&nbsp;Jack Feehan ,&nbsp;Vasso Apostolopoulos ,&nbsp;Sanjit Sah ,&nbsp;Rachana Mehta ,&nbsp;Vini Mehta ,&nbsp;Aroop Mohanty ,&nbsp;Lysien Zambrano ,&nbsp;D. Katterine Bonilla-Aldana ,&nbsp;Camila Luna ,&nbsp;Tania do Socorro Souza Chaves ,&nbsp;Alfonso J. Rodriguez-Morales","doi":"10.1016/j.nmni.2025.101596","DOIUrl":"10.1016/j.nmni.2025.101596","url":null,"abstract":"<div><div>Oropouche fever, caused by the <em>Oropouche virus</em> (OROV), has become a significant public health concern. Recent outbreaks highlight its increasing global spread, driven by environmental, social, and ecological factors. The disease presents clinical similarities to other arboviral infections, making accurate diagnosis essential for effective management and prevention. This article examines the epidemiological patterns of Oropouche fever, including its geographic distribution and outbreak drivers. It explores the clinical manifestations of the disease, focusing on common symptoms, complications such as fatal cases and fetal abnormalities, and the necessity of differential diagnosis. The pathophysiology of OROV infection is analyzed, detailing viral entry mechanisms, immune responses, and the role of vectors in transmission. Additionally, we assess diagnostic challenges, comparing serological and molecular methods while identifying their limitations. Therapeutic strategies are also reviewed, including symptomatic treatments and potential antiviral candidates. Findings indicate that OROV infections mimic other arboviral diseases, complicating clinical diagnosis. Current diagnostic tools have limitations in accuracy and accessibility, particularly in resource-limited settings. Symptomatic treatment remains the primary approach, as no specific antiviral therapies or vaccines exist. The study identifies gaps in diagnostic development, vaccine research, and public health surveillance. Oropouche fever threatens global health, necessitating improved surveillance, diagnostic tools, and targeted research efforts. Enhancing epidemiological studies and developing effective vaccines will mitigate its impact. Strengthening public health strategies can help control the spread of OROV and reduce its burden on affected populations.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101596"},"PeriodicalIF":2.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of tick-borne infections in blood donors in Europe: a systematic review","authors":"Sophie Mathys ,&nbsp;Nejla Gültekin ,&nbsp;Zeno Stanga ,&nbsp;Ismail Ülgür ,&nbsp;Patricia Schlagenhauf","doi":"10.1016/j.nmni.2025.101597","DOIUrl":"10.1016/j.nmni.2025.101597","url":null,"abstract":"<div><h3>Background</h3><div>Tick-borne infections (TBIs) pose an increasing threat to public health and recent research shows a wide range of infections transmitted to humans by tick bite. This situation may have an impact on blood safety in the context of transfusion-transmitted TBIs. We aimed to assess the seroprevalence of TBIs in blood donors in Europe in the period 2000 to 2024.</div></div><div><h3>Methods</h3><div>This systematic review followed PRISMA guidelines. We searched PubMed, Embase, MEDLINE, Scopus, CINAHL, and national reporting systems up to April 2024 using keywords related to TBIs, Europe and epidemiology. Two reviewers independently screened and selected studies, focusing on seroprevalence of TBIs in European blood donors from 2000 to 2024. Data extraction and risk of bias assessment were performed.</div></div><div><h3>Results</h3><div>The search yielded 5304 articles, of which 56 met the inclusion criteria. We added one article after citation search. The included studies encompassed 19 European countries and 11 different TBIs. The most studied pathogen was <em>Borrelia</em> spp. The majority of studies used antibody detection as a diagnostic technique. The highest seroprevalence rates were observed for <em>Tick-Borne Encephalitis Virus</em> (<em>TBEV</em>), <em>Bartonella</em> spp., <em>Rickettsia</em> spp. and <em>Borrelia</em> spp. with pathogen seropositivity rates, in some studies, of over 20 % depending on the pathogen and the vaccination status of included individuals.</div></div><div><h3>Conclusions</h3><div>This study highlights the need to focus on a wider range of tick-borne pathogens to better understand the epidemiological landscape of TBIs. Additionally, incorporating Nucleic Acid Amplification Testing of donated blood will improve the ability to differentiate between past exposure and potential infectivity, to allow for an improved assessment of TBI transmission risk in transfusion medicine.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101597"},"PeriodicalIF":2.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myanmar earthquake: a One Health approach to address potential infectious threats","authors":"AbdulRahman A. Saied","doi":"10.1016/j.nmni.2025.101595","DOIUrl":"10.1016/j.nmni.2025.101595","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101595"},"PeriodicalIF":2.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and genotyping of human papillomavirus DNA in peripheral blood mononuclear cells from blood donors in Iran","authors":"Shahab Falahi ,&nbsp;Katayoun Arvaneh ,&nbsp;Hassan Nourmohammadi ,&nbsp;Amir Abdoli ,&nbsp;Arezoo Bozorgomid ,&nbsp;Azra Kenarkoohi","doi":"10.1016/j.nmni.2025.101593","DOIUrl":"10.1016/j.nmni.2025.101593","url":null,"abstract":"<div><h3>Introduction</h3><div>Human papillomavirus (HPV) is one of the most common sexually transmitted infections. In addition to sexual transmission, papillomavirus can also be transmitted through surfaces, autoinoculation and vertical transmission. Limited studies have also indicated the presence of HPV DNA in the blood of healthy individuals. The aim of this study was to investigate the prevalence of DNA in peripheral blood mononuclear cells (PBMCs) of blood donors of Ilam city-Iran.</div></div><div><h3>Material and methods</h3><div>We explored the prevalence of HPVs in 108 (58 males and 50 females) blood donors. DNA was extracted from the buffy coat, and genotyping was performed by sequencing after generic nested-PCR detection procedure using MY09/11 and GP5+/6+ primers targeting L1 region in HPV genome.</div></div><div><h3>Results</h3><div>HPV DNA was detected in 11 out of 108 samples (10.18 %). Genotype 16 was identified in 3 cases, followed by genotype 6 in 2 cases and genotypes 11, 31, 35, 51, 53, 59 each in one case. The positive cases included 4 men and 7 women, and their ages ranged from 25 to 37 years.</div></div><div><h3>Conclusion</h3><div>HPV DNA was detected in PBMCs of asymptomatic blood donors. These results support the concern about blood transfusion as a potential source of HPV transmission and need for future studies.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101593"},"PeriodicalIF":2.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic resistance patterns of community-acquired urinary tract infections caused by Enterobacterales in Albania","authors":"Silvi Bozo ,&nbsp;Irida Ikonomi Hoxha ,&nbsp;Silva Tafaj ,&nbsp;Teuta Xhindi","doi":"10.1016/j.nmni.2025.101592","DOIUrl":"10.1016/j.nmni.2025.101592","url":null,"abstract":"<div><h3>Background</h3><div>The escalating rates of antibiotic resistance, especially through Extended-Spectrum Beta-Lactamase (ESBL) production within Enterobacterales represents a critical challenge in the effective management and treatment of urinary tract infections (UTIs). This study aims to examine the distribution of pathogens, assess the prevalence of ESBL production, and analyze the resistance patterns of Enterobacterales isolated from outpatient urocultures in Albania.</div></div><div><h3>Methods</h3><div>Midstream urine specimens from 406 patients were cultured on MacConkey agar and analyzed using the VITEK 2 automated system (bioMérieux, France). Samples with a bacterial count of ≥100,000 CFU/ml were considered positive for UTIs. Statistical analyses were conducted using SPSS software, version 27.0.</div></div><div><h3>Results</h3><div>Among the analyzed samples, 271 (66.7 %) tested positive for UTIs. Gram-negative bacteria, particularly Enterobacterales (88.5 %) were the most common while <em>E. coli</em> was the predominant microorganism (87.0 %). The demographic analysis revealed that females (74.5 %) and young adults (18–34 years) (54.0 %) were the most affected groups. High resistance rates were observed for tetracycline (55.0 %), piperacillin (43.0 %), and trimethoprim (38.5 %), while resistance to meropenem was very low (1.0 %). A total of 25 isolates (12.5 %) were positive for ESBL production. Among the <em>E. coli</em> isolates, 12.1 % (21/174) tested positive. Statistical analysis indicated a significant association between female gender and increased antibiotic resistance.</div></div><div><h3>Conclusions</h3><div>Our findings highlight the significant issue of antibiotic resistance in community-acquired UTIs in Albania, particularly involving Enterobacterales. Ongoing surveillance and tailored treatment strategies, alongside antibiotic stewardship programs, are crucial to address this growing public health concern.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101592"},"PeriodicalIF":2.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of Anopheles stephensi as a malaria vector in Sudan","authors":"Ibrahim Nagmeldin Hassan","doi":"10.1016/j.nmni.2025.101594","DOIUrl":"10.1016/j.nmni.2025.101594","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101594"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measles outbreaks in the United States in 2025: Practice, policy, and the canary in the coalmine","authors":"Georgia-Leigh Hewitt ,&nbsp;Amir Obeid ,&nbsp;Philip R. Fischer","doi":"10.1016/j.nmni.2025.101591","DOIUrl":"10.1016/j.nmni.2025.101591","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101591"},"PeriodicalIF":2.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted next-generation sequencing enhances precision and rapid detection in healthcare-associated infection Surveillance: Unveiling multidrug-resistant colonization in ICUs","authors":"Tangchun Liu ,&nbsp;Shuyan Deng ,&nbsp;Wandi Liu,&nbsp;Jinzhao Zhang,&nbsp;Pengfei Wang ,&nbsp;Zhengfei Yang","doi":"10.1016/j.nmni.2025.101589","DOIUrl":"10.1016/j.nmni.2025.101589","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to evaluate the potential advantages of targeted next-generation sequencing (tNGS) over conventional bacterial culture methods for pathogen detection in hospital-associated infections (HAIs).</div></div><div><h3>Methods</h3><div>All EICU medical staff and all medical staff from the Physical Examination Centre completed a questionnaire. Nasopharyngeal specimens were collected from medical staff who met all of the inclusion criteria and none of the exclusion criteria. EICU medical staff provided 2 samples each, while Physical Examination Centre staff provided 1 sample each. For EICU medical staff, one of their two nasopharyngeal swabs was subjected to tNGS testing, and the other to bacterial culture testing. For the PEC staff, their nasopharyngeal swabs were subjected to tNGS testing. Additionally, six pairs of spectacles and six keyboards used by EICU medical staff were randomly selected, and the surfaces were swabbed with sterile swabs for tNGS testing.</div></div><div><h3>Results</h3><div>In 23 nasal swab samples from EICU group, tNGS detected 14 species of microorganism in 29 instances within 19 h. Bacterial culture detected 2 species of microorganism in 4 instances, 2 positive samples within 19 h and confirmed another 2 positive samples within 69 h. A total of 42 samples with 14 different microorganism species were collected from the nasopharyngeal swabs of 23 EICU members and 15 PEC members. Among them, 29 cases (69 %) of 14 different microorganisms were detected in EICU staff, with an average of 1.3 microorganism species detected per person, while 13 cases (28 %) of 6 different microorganisms were detected in PEC staff, with an average of 0.9 microorganism species detected per person. The most common colonizing bacteria included <em>Staphylococcus aureus</em>, <em>Acinetobacter baumannii</em>, and <em>Klebsiella</em> spp. Compared to bacterial culture, tNGS offers advantages in monitoring HAIs, including a broad range of detectable microorganisms, high sensitivity of results, and shorter reporting time for positive results. Bacteria colonizing the EICU carry more antibiotic resistance genes.</div></div><div><h3>Conclusions</h3><div>tNGS outperforms conventional culture in healthcare-associated infection surveillance, with higher sensitivity and accelerated pathogen identification. Simultaneously, tNGS revealed extensive colonization of multidrug-resistant (MDR) pathogens (e.g., <em>Acinetobacter baumannii</em>, MRSA) in EICU environments, highlighting its utility in monitoring complex antimicrobial resistance patterns.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101589"},"PeriodicalIF":2.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}