New Microbes and New Infections最新文献

{"title":"Cross-border prevalence of putative-hypervirulent Klebsiella pneumoniae differs between tertiary hospitals in Austria and Germany","authors":"Bernd Neumann ,&nbsp;Sophie Wilhelm ,&nbsp;Jan Marco Kern ,&nbsp;Joerg Steinmann","doi":"10.1016/j.nmni.2025.101606","DOIUrl":"10.1016/j.nmni.2025.101606","url":null,"abstract":"<div><div>We conducted a prospective testing protocol for surveillance of putative hypervirulent <em>Klebsiella pneumoniae</em> in two tertiary hospitals in Germany and Austria, over a one year study period. In total, 45 (1.02 %) putative hvKp of around 4400 <em>K. pneumoniae</em> were identified. The study revealed a 3.3-times higher prevalence of putative hvKp in the German hospital.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101606"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening global health Equity: The imperative of the WHO pandemic agreement","authors":"Esam Ibraheem Azhar ,&nbsp;Sherif A. El-Kafrawy ,&nbsp;Ziad A. Memish","doi":"10.1016/j.nmni.2025.101607","DOIUrl":"10.1016/j.nmni.2025.101607","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101607"},"PeriodicalIF":2.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First record of methicillin-resistant Staphylococcus aureus (MRSA) isolated from the Meia Ponte River and effluent in Brazil: an analysis of 1198 isolates","authors":"Igor Romeiro dos Santos ,&nbsp;Leandro Fonseca de Lima ,&nbsp;Marcelino Benvindo de Souza ,&nbsp;Isabela Náthaly Machado da Silva ,&nbsp;Adriano Roberto Vieira de Sousa ,&nbsp;Alexandre Melo Bailão ,&nbsp;Cátia Lira do Amaral ,&nbsp;Elisa Flávia Luiz Cardoso Bailão","doi":"10.1016/j.nmni.2025.101603","DOIUrl":"10.1016/j.nmni.2025.101603","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to detect environmental reservoirs of multidrug-resistant <em>Staphylococcus aureus</em> and methicillin-resistant <em>S. aureus</em> (MRSA) in Central Brazil.</div></div><div><h3>Methods</h3><div>Membrane filtration with growth on Baird-Parker agar base was used to recover <em>S. aureus</em> and MRSA from the effluents of a sewage treatment plant (STP) and surface water from an important Cerrado river. Effluent samples were collected at two points in the STP (pre- and post-treatment). Surface water was collected at six points along the Meia Ponte River, from its source to the mouth. Air samples were collected at all these collection points in 2022, totaling four campaigns between the dry and rainy seasons.</div></div><div><h3>Results</h3><div><em>S. aureus</em> was isolated at all collection points in all campaigns, totaling 87715 isolates. Of the 1198 selected isolates, 83 were cefoxitin (FOX)-resistant, indicating a methicillin-resistance phenotype. The antimicrobial profiles of the 83 FOX-resistant isolates were investigated, and 88 % could be considered multidrug-resistant <em>S. aureus</em>. Of the 83 FOX-resistant isolates, more than 70 % were resistant to clindamycin, erythromycin, and rifampicin. The presence of the <em>mecA</em> gene was confirmed in 18 isolates collected along the Meia Ponte River and inside the STP, with 15 exhibiting multidrug-resistant phenotypes. The results of the principal component analysis (PCA) revealed an association between <em>S. aureus</em> isolates and the urbanized environment/STP, as well as the presence of antimicrobials.</div></div><div><h3>Conclusion</h3><div>This study is a pioneer in identifying the presence of MRSA in Brazilian water bodies, highlighting the urgent need for monitoring antimicrobial resistance in urban rivers.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101603"},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global resurgence of tularemia: Challenges and strategic public health imperatives","authors":"Ashutosh Pareek ,&nbsp;Pooja Malani ,&nbsp;Aaushi Pareek ,&nbsp;Runjhun Singhal ,&nbsp;Lance R. McMahon ,&nbsp;Vasso Apostolopoulos ,&nbsp;Anil Chuturgoon","doi":"10.1016/j.nmni.2025.101605","DOIUrl":"10.1016/j.nmni.2025.101605","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101605"},"PeriodicalIF":2.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro susceptibility of Burkholderia cepacia to ceftazidime-avibactam: A systematic review","authors":"Abolfazl Rafati Zomorodi ,&nbsp;Leila Ghanbari_Afra ,&nbsp;Hossein Faridafshar ,&nbsp;Seyed Nooreddin Faraji ,&nbsp;Fatemeh Zarepour ,&nbsp;Maryamosadat Mavaei ,&nbsp;Mohammad Rahmanian","doi":"10.1016/j.nmni.2025.101601","DOIUrl":"10.1016/j.nmni.2025.101601","url":null,"abstract":"<div><h3>Background</h3><div><em>Burkholderia cepacia</em> complex (BCC) is a group of multi-drug resistant (MDR) pathogens that are challenging to treat, especially in cystic fibrosis (CF) patients. Ceftazidime-avibactam is a promising antibiotic combination for treating BCC infections, but its efficacy requires further in vitro evaluation.</div></div><div><h3>Methods</h3><div>This systematic review was conducted following the PRISMA guidelines to assess the in vitro susceptibility of BCC strains to ceftazidime-avibactam. We systematically searched PubMed, Web of Science, Scopus, and Embase databases. Inclusion criteria required original articles reporting on BCC susceptibility to ceftazidime-avibactam using standard antimicrobial susceptibility testing methods.</div></div><div><h3>Results</h3><div>A total of 9 studies met the inclusion criteria. These studies were conducted between 2010 and 2024, with data from the USA, France, Germany, Belgium, and other countries. The studies used various methods, including agar dilution, broth microdilution, and disc diffusion. The minimum inhibitory concentration (MIC) range for ceftazidime-avibactam was found to vary, with the combination showing significantly improved susceptibility compared to ceftazidime alone.</div></div><div><h3>Conclusion</h3><div>This systematic review demonstrates that ceftazidime-avibactam significantly enhances the susceptibility of BCC strains, supporting its potential as an effective therapeutic option for BCC infections in CF patients. Further clinical studies are needed to confirm these findings and guide treatment strategies.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101601"},"PeriodicalIF":2.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thelaziasis in humans: A systematic review of reported cases","authors":"D. Katterine Bonilla-Aldana ,&nbsp;Jorge Luis Bonilla-Aldana ,&nbsp;Jaime David Acosta-España ,&nbsp;Ranjit Sah ,&nbsp;Alfonso J. Rodriguez-Morales","doi":"10.1016/j.nmni.2025.101599","DOIUrl":"10.1016/j.nmni.2025.101599","url":null,"abstract":"<div><h3>Background</h3><div>Thelaziasis is an emerging vector-borne zoonotic disease caused by <em>Thelazia</em> spp., which primarily affects animals but is increasingly recognised in humans, where it causes ocular infections. Human thelaziasis remains underreported and poorly understood in many regions despite its growing relevance.</div></div><div><h3>Methods</h3><div>This systematic review analyzed epidemiological, clinical, diagnostic, and therapeutic data from 134 documented human cases of thelaziasis reported across 18 countries. Data sources included peer-reviewed publications and case reports, focusing on identifying trends in geographic distribution, clinical presentation, diagnostic techniques, and treatment approaches.</div></div><div><h3>Results</h3><div>Most cases (82.8%) were reported in Asia, particularly in South Korea, China, India, and Japan. The most common symptoms were foreign body sensation (53%), conjunctival hyperemia (39.6%), and epiphora (33.6%). Infestation was unilateral in 90.3% of cases. Diagnosis was primarily made through direct visual identification of the parasite, while molecular confirmation was used in a limited number of cases. <em>Thelazia callipaeda</em> was the predominant species identified (88.8%). Manual extraction was the mainstay of treatment (88.8%), with antiparasitic agents used in selected instances. Reinfection occurred in 6% of cases.</div></div><div><h3>Conclusion</h3><div>This review underscores the growing recognition of human thelaziasis, particularly in Asia, and highlights the potential underdiagnosis in non-endemic regions. Environmental changes, globalization, and increasing human-animal interactions may facilitate the spread of the disease. Strengthening awareness, surveillance, and control measures is essential. Adopting a One Health approach, integrating human, animal, and environmental health perspectives, is critical for effective prevention and mitigation strategies.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101599"},"PeriodicalIF":2.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Web-based real-time risk assessment of coronavirus disease 2019 infection in schools and social dining settings","authors":"Yuta Okada,&nbsp;Minami Ueda,&nbsp;Hiroshi Nishiura","doi":"10.1016/j.nmni.2025.101600","DOIUrl":"10.1016/j.nmni.2025.101600","url":null,"abstract":"<div><h3>Background</h3><div>Schools and dining situations are associated with a high risk of indoor transmission of coronavirus disease 2019 (COVID-19). Performing risk assessment in real time could enable organizers to adjust the duration and size of indoor activities depending on the epidemic situation.</div></div><div><h3>Methods</h3><div>The per-hour transmission rates of COVID-19 from a single infector in school and social dining settings were estimated from COVID-19 surveillance data in Japan from January to February 2022 using a mathematical model. We then developed a web application that calculates the risk of COVID-19 infection in those settings, accounting for place of residence, vaccination history, duration of indoor activity, and the number of participants.</div></div><div><h3>Results</h3><div>The estimated per-hour transmission rates were 0.01934 (95 %CrI: 0.01939–0.01947) in social dining settings and 0.00324 (95 %CrI: 0.00323–0.00325) in school settings. Accounting for the epidemiological risk of having infected persons in indoor settings, a web application was devised to compute the risk of a single participant contracting COVID-19 at the event. Web application users can vary input variables including the duration and the number of participants, thereby benefiting the real time risk reduction.</div></div><div><h3>Conclusions</h3><div>The per-hour transmission rate was higher in social dining settings compared with that in school settings, but the greater number of participants that is typical of gatherings at schools might offset this gap in per-hour per-infector transmission risk. The proposed web application can act as an important tool for promoting risk awareness regarding COVID-19 in high-risk settings.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101600"},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory impact of COVID-19 in young adults: A propensity score-weighted cohort study","authors":"Thibault Lovey ,&nbsp;Nejla Gültekin ,&nbsp;Zeno Stanga ,&nbsp;Andreas Stettbacher ,&nbsp;Jeremy Werner Deuel ,&nbsp;Patricia Schlagenhauf","doi":"10.1016/j.nmni.2025.101598","DOIUrl":"10.1016/j.nmni.2025.101598","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic has raised concerns regarding persisting cardiorespiratory effects in young adults. This study aimed to assess the impact of COVID-19 on cardiopulmonary function in this population.</div></div><div><h3>Methods</h3><div>This investigation, using data from the LoCoMo study, evaluated young recruits from the Swiss Armed Forces, aged 18–30 years. Participants were categorized based on their SARS-CoV-2 infection status and underwent cardiopulmonary exercise testing (CPET), spirometry, and diffusion capacity tests (DLCO). Propensity score weighting adjusted for confounding factors compared key outcomes between the control and COVID-19 groups.</div></div><div><h3>Finding</h3><div>We evaluated 242 participants in the control group and 240 in the COVID-19 group. The propensity score-weighted analysis showed no significant differences in most CPET and pulmonary outcomes. The COVID-19 group exhibited a significant reduction in systolic blood pressure (SBP) at peak exercise by 7.68 mmHg (p = 0.001), more pronounced in recent cases (&lt;6 months, 14.60 mmHg, p = 0.002) and persisting after infection in non-recent cases (&gt;6 months, 9.07 mmHg, p = &lt;0.001). There was an increase in V'Epeak [% predicted MVV] by 2.92 % in the COVID-19 group, notably in the “non-recent” subgroup who had been infected more than 6 months previously (p = 0.003).</div></div><div><h3>Interpretation</h3><div>Young adults can exhibit persisting cardiopulmonary effects post-COVID-19, including reduced systolic blood pressure at peak exercise and increased ventilatory response, likely due to deconditioning and muscle weakness. These findings underscore the importance of maintaining physical activity during recovery to mitigate these effects.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101598"},"PeriodicalIF":2.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emergence of oropouche fever: A potential new threat?","authors":"Shriyansh Srivastava ,&nbsp;Ranjit Sah ,&nbsp;Molakpogu Ravindra Babu ,&nbsp;Deepika Sharma ,&nbsp;Dheeraj Sharma ,&nbsp;Sachin Kumar ,&nbsp;Sathvik Belagodu Sridhar ,&nbsp;Tarun Wadhwa ,&nbsp;Javedh Shareef ,&nbsp;G.S.N. Koteswara Rao ,&nbsp;Jack Feehan ,&nbsp;Vasso Apostolopoulos ,&nbsp;Sanjit Sah ,&nbsp;Rachana Mehta ,&nbsp;Vini Mehta ,&nbsp;Aroop Mohanty ,&nbsp;Lysien Zambrano ,&nbsp;D. Katterine Bonilla-Aldana ,&nbsp;Camila Luna ,&nbsp;Tania do Socorro Souza Chaves ,&nbsp;Alfonso J. Rodriguez-Morales","doi":"10.1016/j.nmni.2025.101596","DOIUrl":"10.1016/j.nmni.2025.101596","url":null,"abstract":"<div><div>Oropouche fever, caused by the <em>Oropouche virus</em> (OROV), has become a significant public health concern. Recent outbreaks highlight its increasing global spread, driven by environmental, social, and ecological factors. The disease presents clinical similarities to other arboviral infections, making accurate diagnosis essential for effective management and prevention. This article examines the epidemiological patterns of Oropouche fever, including its geographic distribution and outbreak drivers. It explores the clinical manifestations of the disease, focusing on common symptoms, complications such as fatal cases and fetal abnormalities, and the necessity of differential diagnosis. The pathophysiology of OROV infection is analyzed, detailing viral entry mechanisms, immune responses, and the role of vectors in transmission. Additionally, we assess diagnostic challenges, comparing serological and molecular methods while identifying their limitations. Therapeutic strategies are also reviewed, including symptomatic treatments and potential antiviral candidates. Findings indicate that OROV infections mimic other arboviral diseases, complicating clinical diagnosis. Current diagnostic tools have limitations in accuracy and accessibility, particularly in resource-limited settings. Symptomatic treatment remains the primary approach, as no specific antiviral therapies or vaccines exist. The study identifies gaps in diagnostic development, vaccine research, and public health surveillance. Oropouche fever threatens global health, necessitating improved surveillance, diagnostic tools, and targeted research efforts. Enhancing epidemiological studies and developing effective vaccines will mitigate its impact. Strengthening public health strategies can help control the spread of OROV and reduce its burden on affected populations.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101596"},"PeriodicalIF":2.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of tick-borne infections in blood donors in Europe: a systematic review","authors":"Sophie Mathys ,&nbsp;Nejla Gültekin ,&nbsp;Zeno Stanga ,&nbsp;Ismail Ülgür ,&nbsp;Patricia Schlagenhauf","doi":"10.1016/j.nmni.2025.101597","DOIUrl":"10.1016/j.nmni.2025.101597","url":null,"abstract":"<div><h3>Background</h3><div>Tick-borne infections (TBIs) pose an increasing threat to public health and recent research shows a wide range of infections transmitted to humans by tick bite. This situation may have an impact on blood safety in the context of transfusion-transmitted TBIs. We aimed to assess the seroprevalence of TBIs in blood donors in Europe in the period 2000 to 2024.</div></div><div><h3>Methods</h3><div>This systematic review followed PRISMA guidelines. We searched PubMed, Embase, MEDLINE, Scopus, CINAHL, and national reporting systems up to April 2024 using keywords related to TBIs, Europe and epidemiology. Two reviewers independently screened and selected studies, focusing on seroprevalence of TBIs in European blood donors from 2000 to 2024. Data extraction and risk of bias assessment were performed.</div></div><div><h3>Results</h3><div>The search yielded 5304 articles, of which 56 met the inclusion criteria. We added one article after citation search. The included studies encompassed 19 European countries and 11 different TBIs. The most studied pathogen was <em>Borrelia</em> spp. The majority of studies used antibody detection as a diagnostic technique. The highest seroprevalence rates were observed for <em>Tick-Borne Encephalitis Virus</em> (<em>TBEV</em>), <em>Bartonella</em> spp., <em>Rickettsia</em> spp. and <em>Borrelia</em> spp. with pathogen seropositivity rates, in some studies, of over 20 % depending on the pathogen and the vaccination status of included individuals.</div></div><div><h3>Conclusions</h3><div>This study highlights the need to focus on a wider range of tick-borne pathogens to better understand the epidemiological landscape of TBIs. Additionally, incorporating Nucleic Acid Amplification Testing of donated blood will improve the ability to differentiate between past exposure and potential infectivity, to allow for an improved assessment of TBI transmission risk in transfusion medicine.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101597"},"PeriodicalIF":2.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}