New Microbes and New Infections最新文献

{"title":"Langya henipavirus (LayV) as an emerging zoonotic disease: a mini-review","authors":"Maryam Shafaati ,&nbsp;Milad Zandi","doi":"10.1016/j.nmni.2025.101643","DOIUrl":"10.1016/j.nmni.2025.101643","url":null,"abstract":"<div><div>Henipavirus is one of the genera in the <em>Orthoparamyxovirinae</em> subfamily, which includes several emerging viruses that pose a major public health threat. The predominant members of the virus genus, Hendra and Nipah viruses, are extremely virulent zoonotic viruses that cause neurological and respiratory infections and outbreaks in humans. The recently discovered Langya henipavirus, a new henipavirus phylogenetically related to Mojiang henipavirus (MojV), has been associated with febrile illness in patients from China who are mainly agricultural workers. Active surveillance must be conducted worldwide in an open and collaborative manner to reduce the likelihood of this new virus causing a health crisis. More research is needed to address the remaining difficulties.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101643"},"PeriodicalIF":5.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria vaccines: Current developments and immunological insights","authors":"Akanksha Verma ,&nbsp;Ritesh Ranjha ,&nbsp;Kuldeep Singh ,&nbsp;Vinod Yadav ,&nbsp;Ashima Bhaskar ,&nbsp;Ved Prakash Dwivedi ,&nbsp;Mradul Mohan","doi":"10.1016/j.nmni.2025.101646","DOIUrl":"10.1016/j.nmni.2025.101646","url":null,"abstract":"<div><div>Malaria is a parasitic disease of public health concern affecting nearly 263 million people globally. Majorly, poor and developing countries are prone to malaria. Children under 5 years are most susceptible to malaria morbidity and mortality. The emergence of drug-resistant parasites is posing a threat to the malaria control and elimination goals. There is a need of the hour to develop new <em>anti</em>-malarials along with novel malaria vaccines. The genetic complexity of the parasite and multiple life stages make it challenging to develop malaria vaccines. So far, the WHO has approved only two malaria vaccines. This review discusses the prospects of these two malaria vaccines and the future vaccine candidates targeting different life stages of <em>Plasmodium</em>. It also highlights the recent development in identifying the host's immune responses against malaria, novel vaccine candidates, and the ideal vaccine requirement.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101646"},"PeriodicalIF":5.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiological profile of sterile site organisms and culture positivity rates from a decade of paediatric admissions at a tertiary hospital in South Africa: A lower and middle-income country perspective","authors":"Prenika Jaglal ,&nbsp;Khine Swe-Swe Han ,&nbsp;Colin Menezes ,&nbsp;Sithembiso Velaphi","doi":"10.1016/j.nmni.2025.101644","DOIUrl":"10.1016/j.nmni.2025.101644","url":null,"abstract":"<div><h3>Background</h3><div>Sterile site (SS (blood and cerebrospinal fluid)) infections are formidable causes of childhood morbidity and fatality. This study aimed to determine aetiological organisms, antimicrobial resistance patterns and sepsis trend rates in paediatric inpatients from a low-and middle-income country.</div></div><div><h3>Methods</h3><div>A retrospective review of SS culture results of inpatients from the neonatal unit (NNU), general paediatric (GPW) and paediatric haematology-oncology wards (PHOW) at Chris Hani Baragwanath Academic Hospital, South Africa, from January 2013 to December 2022.</div></div><div><h3>Results</h3><div>A total of 58 053 SS specimens were submitted for analysis. Culture-positivity rate was 36.0 %, comprising 22.8 % and 13.2 % for pathogens and contaminants. Pathogen culture-positivity rate was higher in the NNU when compared to GPW (35.5 % vs 17.6 %; OR–5.38; 95 % CI 4.99–5.81) but lower than PHOW (35.5 % vs 46.6 %; OR-0.47; 95 % CI 0.39–0.52). Infection rates per 1000 patient-days increased from 1.74 in 2013 to 3.11 in 2022. Gram-negative bacteria (GNB) (66.0 % vs 18.7 %, OR-5.70; 95 % CI 5.23–6.19) and yeast (12.4 % vs 8.4 %, OR-7.66; 95 % CI 6.13–9.57) were more common in NNU than GPW. Multidrug-resistant (MDR) pathogen prevalence was 35.1 % with extended-spectrum beta-lactamase Enterobacterales contributing 40–50 %. Carbapenem-resistant <em>Acinetobacter</em> species increased from 40 % to 60 % from 2013 to 2022 (p = 0.004). MRSA prevalence decreased from 30 % to 10 % from 2013 to 2022 (p = 0.004).</div></div><div><h3>Conclusion</h3><div>The burden of paediatric MDR gram-negative SS infection was relatively high requiring ongoing surveillance, judicious antimicrobial use, while reinforcing infection control contact-based transmission precautions. Further studies on drivers of antimicrobial resistance such as unit specific antimicrobial consumption rates and prescriber practices, should be explored.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101644"},"PeriodicalIF":5.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual transmission of terbinafine-resistant Trichophyton indotineae among men who have sex with men","authors":"Liza Benzoni ,&nbsp;Matthieu Godinot ,&nbsp;Jean Berset de Vaufleury ,&nbsp;Victoire Reynaud ,&nbsp;Damien Dupont ,&nbsp;Pauline Tirard-Collet ,&nbsp;Jean Menotti ,&nbsp;François Durupt","doi":"10.1016/j.nmni.2025.101645","DOIUrl":"10.1016/j.nmni.2025.101645","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101645"},"PeriodicalIF":5.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial research productivity in Lebanon: A PubMed-Based bibliometric analysis","authors":"Aline Hajj ,&nbsp;Hala Sacre ,&nbsp;Maria Ounsi ,&nbsp;Mariam Nasser ,&nbsp;Sara Mohsen Meame ,&nbsp;Hussein Hazime ,&nbsp;Amal Al-Hajje ,&nbsp;Deema Rahme ,&nbsp;Nathalie Lahoud ,&nbsp;Jihan Safwan ,&nbsp;Marwan Akel ,&nbsp;Rony M. Zeenny ,&nbsp;Katia Iskandar ,&nbsp;Pascale Salameh","doi":"10.1016/j.nmni.2025.101642","DOIUrl":"10.1016/j.nmni.2025.101642","url":null,"abstract":"<div><h3>Background</h3><div>Antimicrobials have revolutionized medicine globally, but emerging antimicrobial resistance due to antimicrobial misuse might revert the world to the “pre-antibiotic era”. Research on the topic contributes to fighting antimicrobial resistance and developing related strategies. Hence, this bibliometric analysis aimed to assess antimicrobial research productivity in Lebanon.</div></div><div><h3>Methods</h3><div>Relevant publications were retrieved from PubMed, and data were assessed using the VOS viewer. The most research-active institutions, collaboration patterns, and various antimicrobial research areas were reported and discussed.</div></div><div><h3>Results</h3><div>Research productivity has exhibited an increasing trend over the past 20 years. Private institutions were the most active (90%), while international collaborations were moderate (40%), mainly with institutions in the United States and France. The only visible public-private partnership involved collaboration between the Lebanese University and other institutions. While immunology and molecular biology-related keywords were frequently used before 2012, more clinical (treatment outcome, antimicrobial stewardship, antimicrobial resistance) and environmental cluster-related keywords appeared later, with a low occurrence of resistance and the One Health concept.</div></div><div><h3>Conclusion</h3><div>This study assessed research productivity related to antimicrobials from Lebanese institutions; it showed the need for greater public sector involvement, expanded national and international research collaborations, and increased focus on critical concepts such as antimicrobial resistance and the One Health approach. Future studies should evaluate research quality and expand the search to additional research platforms other than PubMed for a more comprehensive understanding of the Lebanese research productivity in this field and further optimize strategic measures to combat antimicrobial resistance, optimize research agenda, and improve patient health outcomes.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101642"},"PeriodicalIF":5.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Febrile encephalopathy following a tick bite: A case report of Rickettsia conorii infection from Northeast Iran","authors":"Hamidreza Naderi ,&nbsp;Mahbubeh Haddad Nameghi ,&nbsp;Atefeh Vakilian ,&nbsp;Zeynab Barzegar ,&nbsp;Fatemeh Rajaei Ghannad ,&nbsp;Saber Esmaeili","doi":"10.1016/j.nmni.2025.101641","DOIUrl":"10.1016/j.nmni.2025.101641","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101641"},"PeriodicalIF":5.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunnel sign on magnetic resonance imaging in neuromelioidosis: A systematic literature review","authors":"Nitin Gupta ,&nbsp;Sonali Singh ,&nbsp;Tirlangi Praveen Kumar ,&nbsp;Sundeep Malla ,&nbsp;Astha Sethi ,&nbsp;Carl Boodman ,&nbsp;Steven Van Den Broucke ,&nbsp;Erika Vlieghe ,&nbsp;Emmanuel Bottieau ,&nbsp;Martin Peter Grobusch ,&nbsp;Chiranjay Mukhopadhyay","doi":"10.1016/j.nmni.2025.101639","DOIUrl":"10.1016/j.nmni.2025.101639","url":null,"abstract":"<div><h3>Background</h3><div>Neuromelioidosis can present with abscesses, meningitis, or encephalomyelitis, but can be missed on blood culture. Linear enhancement of the corticospinal tract (white matter motor pathway) on magnetic resonance imaging (MRI) in the form of a ‘tunnel sign’ is an essential clue for early diagnosis of neuromelioidosis. This systematic review (SR) explores the clinical profile and outcomes of neuromelioidosis patients with tunnel signs.</div></div><div><h3>Methods</h3><div>An SR was conducted to look for articles reporting individual details of neuromelioidosis patients with tunnel signs (reported or present on published images) on MRI. This review followed PRISMA guidelines and was prospectively registered with PROSPERO (CRD42024597199). After title-abstract and full-text screening, clinical profile and outcome data were extracted and analysed.</div></div><div><h3>Results</h3><div>Thirty cases (22 articles) with tunnel signs on MRI were included after screening 2985 articles. The traditional risk factors (diabetes mellitus, alcohol intake, steroids, etc.) for melioidosis were present in only 23 % (5/22) of patients. Limb weakness (89 %, 24/27) and cranial nerve involvement (46 %, 11/24) were commonly seen at presentation. Blood and cerebrospinal fluid (CSF) cultures for <em>B.pseudomallei</em> were only positive in 15 % (2/13) and 22 % (4/18). Due to low rates of clinical suspicion of neuromelioidosis (25 %, 6/24), empirical steroids and inappropriate antimicrobials were given in 47 % (8/17) and 65 % (9/17) of patients, respectively. A total of 30 % (n = 9) of the patients died.</div></div><div><h3>Conclusion</h3><div>In melioidosis-endemic areas with access to MRI, recognising the link between the presence of a tunnel sign and neuromelioidosis is crucial to initiate early adequate therapy.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101639"},"PeriodicalIF":5.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of the SARS-CoV-2 variant P.1 (Gamma) in Ecuador: A retrospective report of the first confirmed case","authors":"Katty Ojeda-Gutiérrez ,&nbsp;Fernando Serrano-Tamay ,&nbsp;David Zúñiga ,&nbsp;Sully Márquez ,&nbsp;Belén Prado-Vivar ,&nbsp;Mónica Becerra ,&nbsp;Juan José Guadalupe ,&nbsp;Patricio Rojas-Silva ,&nbsp;Verónica Barragán ,&nbsp;Paúl Cárdenas ,&nbsp;Paola Dalgo Aguilar","doi":"10.1016/j.nmni.2025.101638","DOIUrl":"10.1016/j.nmni.2025.101638","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"68 ","pages":"Article 101638"},"PeriodicalIF":5.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yellow fever in children and adolescents amid the South American outbreak, 2024/2025","authors":"Alfonso J. Rodriguez-Morales ,&nbsp;Daniela Torres-Hernández ,&nbsp;Maria Eugenia Guevara ,&nbsp;Alicia Chang-Cojulun ,&nbsp;Jose Brea-Del Castillo ,&nbsp;Romina Rios-Blanco ,&nbsp;Manuela Isbeth Mérida-Barrios ,&nbsp;Melissa Palmieri ,&nbsp;Maria L. Avila-Agüero","doi":"10.1016/j.nmni.2025.101635","DOIUrl":"10.1016/j.nmni.2025.101635","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101635"},"PeriodicalIF":5.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of armed conflict in eastern Democratic Republic of Congo on the risk of malaria outbreaks in children under five years old","authors":"Hermann Yokolo,&nbsp;Christian Tague,&nbsp;Joshua Ekouo,&nbsp;Dujardin Makeda,&nbsp;Aymar Akilimali","doi":"10.1016/j.nmni.2025.101636","DOIUrl":"10.1016/j.nmni.2025.101636","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101636"},"PeriodicalIF":5.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}