New Microbes and New Infections最新文献

{"title":"First human infection with influenza A(H1N1) variant virus in Vietnam","authors":"Nitin Kumar Bansal, Sanjit Sah, Muhammed Shabil, Amogh Verma, Rodrigue Ndabashinze","doi":"10.1016/j.nmni.2024.101519","DOIUrl":"10.1016/j.nmni.2024.101519","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101519"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fighting the Monkeypox in Rwanda, An overview of current state and future recommendations","authors":"Amos Kipkorir Langat, Maher Ali Rusho, Elysée Byiringiro, Godfred Yawson Scott, Amidu Alhassan, Vérité K. Cyubahiro, Christian Tague, Elie Kihanduka, Menelas Nkeshimana, Aymar Akilimali","doi":"10.1016/j.nmni.2024.101518","DOIUrl":"10.1016/j.nmni.2024.101518","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101518"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteria vs bacteria; the future of antibiotics?","authors":"Muhammad Sohaib Khan, Kamran Ahmed Khan, Muhammad Jansher","doi":"10.1016/j.nmni.2024.101523","DOIUrl":"10.1016/j.nmni.2024.101523","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101523"},"PeriodicalIF":2.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-emergence of Eastern equine encephalitis: A looming threat in the era of climate change","authors":"Amogh Verma, Vinay Suresh, Manvinder Brar, Amit Varma, Sanjit Sah, Mahendra Pratap Singh, Rachana Mehta, Ashok Kumar Balaraman, Sakshi Pandey, Sai Gautham Kanagala","doi":"10.1016/j.nmni.2024.101521","DOIUrl":"10.1016/j.nmni.2024.101521","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101521"},"PeriodicalIF":2.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real world effectiveness of early ensitrelvir treatment in patients with SARS-CoV-2, a retrospective case series","authors":"Shuichi Abe ,&nbsp;Dhammika Leshan Wannigama ,&nbsp;Yu Suzuki ,&nbsp;Daisuke Akaneya ,&nbsp;Junko Igarashi ,&nbsp;Mayu Suto ,&nbsp;Kazunori Moriya ,&nbsp;Daisuke Ishizawa ,&nbsp;Yoshikazu Okuma ,&nbsp;Parichart Hongsing ,&nbsp;Cameron Hurst ,&nbsp;Thammakorn Saethang ,&nbsp;Paul G. Higgins ,&nbsp;Stephen M. Stick ,&nbsp;Anthony Kicic","doi":"10.1016/j.nmni.2024.101522","DOIUrl":"10.1016/j.nmni.2024.101522","url":null,"abstract":"<div><h3>Background</h3><div>Ensitrelvir, a 3C-like protease inhibitor, received emergency approval in Japan in November 2022 for treating non-hospitalized patients with mild-to-moderate COVID-19. However, confirmation of its real-world clinical effectiveness is limited.</div></div><div><h3>Methods</h3><div>This retrospective study evaluated 18 vaccinated outpatients (15 men; median age, 39.5 years; range, 26–56), treated with a 5-day oral ensitrelvir regimen (375 mg loading dose, followed by 125 mg daily) between December 1, 2022, and January 31, 2023. Nasal swabs were collected on days 0, 3, 6, and 9 for RT-qPCR to assess viral load. Variants were identified by Sanger sequencing, and outcomes were compared to historical controls. Patients were followed for 60 days to monitor for post-acute sequelae of COVID-19 (PASC).</div></div><div><h3>Results</h3><div>Symptoms such as mild fever and sore throat improved rapidly after one day of ensitrelvir treatment, with 66 % of patients recovering within six days. All individuals were infected with the BA.5 Omicron variant. Viral loads, as measured by Ct values, increased significantly from 21.82 at symptom onset to 37.65 b y day 6, with SARS-CoV-2 RNA undetectable in most patients by day 9. Those treated within 48 h of symptom onset showed the viral load reduction. Compared to historical controls, where symptom resolution took 8.5 days, ensitrelvir shortened recovery time to as little as 1.4 days for over 66 % of patients.</div></div><div><h3>Conclusion</h3><div>Ensitrelvir treatment resulted in rapid symptom relief and significant viral load reduction, with no adverse events, viral rebound, or PASC symptoms, demonstrating its potential efficacy and safety. Larger studies are needed for further confirmation.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101522"},"PeriodicalIF":2.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variability of the recombinant SARS-CoV-2 XEC: Is it a new evolutionary dead-end lineage?","authors":"Francesco Branda,&nbsp;Massimo Ciccozzi,&nbsp;Fabio Scarpa","doi":"10.1016/j.nmni.2024.101520","DOIUrl":"10.1016/j.nmni.2024.101520","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101520"},"PeriodicalIF":2.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new and more contagious XEC subvariant of SARS-CoV-2 may lead to massive increase in COVID-19 cases","authors":"Aminath Waafira,&nbsp;Kannan Subbaram,&nbsp;Razana Faiz,&nbsp;Zeba Un Naher,&nbsp;Punya Laxmi Manandhar,&nbsp;Sheeza Ali","doi":"10.1016/j.nmni.2024.101517","DOIUrl":"10.1016/j.nmni.2024.101517","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101517"},"PeriodicalIF":2.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of clade-defining single nucleotide polymorphisms for improved rabies virus surveillance","authors":"Ankeet Kumar,&nbsp;Sheetal Tushir,&nbsp;Yashas Devasurmutt,&nbsp;Sujith S. Nath,&nbsp;Utpal Tatu","doi":"10.1016/j.nmni.2024.101511","DOIUrl":"10.1016/j.nmni.2024.101511","url":null,"abstract":"<div><h3>Background</h3><div>Rabies is an ancient disease that remains endemic in many countries. It causes many human deaths annually, predominantly in resource-poor countries. Over evolutionary timelines, several rabies virus (RABV) genotypes have stabilised, forming distinct clades. Extensive studies have been conducted on the origin, occurrence and spread of RABV clades. Single nucleotide polymorphisms (SNPs) distribution across the RABV genome and its clades remains largely unknown, highlighting the need for comprehensive whole-genome analyses.</div></div><div><h3>Methods</h3><div>We accessed whole genome sequences for RABV from public databases and identified SNPs across the whole genome sequences. Then, we annotated these SNPs using an R script, and these SNPs were categorised into different categories; universal, clade-specific, and clade-defining, based on the frequency of occurrence.</div></div><div><h3>Results</h3><div>In this study, we present the SNPs occurring in the RABV based on whole genome sequences belonging to 8 clades isolated from 7 different host species likely to harbour dog-related rabies. We classified mutations into several classes based on their location within the genome and assessed the effect of SNP mutations on the viral glycoprotein.</div></div><div><h3>Conclusions</h3><div>The clade-defining mutations have implications for targeted surveillance and classification of clades. Additionally, we investigated the effects of these mutations on the Glycoprotein of the virus. Our findings contribute to expanding knowledge about RABV clade diversity and evolution, which has significant implications for effectively tracking and combatting RABV transmission.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101511"},"PeriodicalIF":2.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pakistan's first MERS-CoV case: A wake up call for global health authorities","authors":"Keita Wagatsuma","doi":"10.1016/j.nmni.2024.101516","DOIUrl":"10.1016/j.nmni.2024.101516","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101516"},"PeriodicalIF":2.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Murine typhus outbreak: Emergence of a new public health concerns in India","authors":"Mahendra Singh ,&nbsp;Ashok Kumar Balaraman ,&nbsp;Rachana Mehta,&nbsp;Sanjit Sah","doi":"10.1016/j.nmni.2024.101514","DOIUrl":"10.1016/j.nmni.2024.101514","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101514"},"PeriodicalIF":2.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}