New Microbes and New Infections最新文献

{"title":"Quantitative microbial risk assessment of Legionella pneumophila in a drinking water distribution system: A case study","authors":"Seyed Mohammad Ranjdoost ,&nbsp;Mina Owrang","doi":"10.1016/j.nmni.2025.101584","DOIUrl":"10.1016/j.nmni.2025.101584","url":null,"abstract":"<div><h3>Background</h3><div><em>Legionella pneumophila</em> poses a significant health risk in hospital water systems. This study assessed the risk associated with <em>Legionella</em> contamination in a hospital drinking water system in Sari, Iran, over one year.</div></div><div><h3>Methods</h3><div>Water samples were collected seasonally from various hospital taps, including patient room showers and toilet faucets. Both cold and warm water sources were analyzed. Water quality parameters, including pH, chlorine levels, and temperature, were measured. <em>Legionella</em> spp. were isolated and enumerated using standard microbiological techniques, and species identification was confirmed via 16S rRNA gene sequencing. A Quantitative Microbial Risk Assessment (QMRA) model was employed to estimate the infection risk from shower and faucet use.</div></div><div><h3>Results</h3><div><em>Legionella</em> counts were significantly higher in warm water samples and during the summer season. A positive correlation was observed between <em>Legionella</em> counts and water pH, whereas negative correlations were found with chlorine levels and water temperature. QMRA results indicated that the estimated annual infection risk exceeded the acceptable limits set by the World Health Organization (WHO) and the United States Environmental Protection Agency (USEPA), particularly during summer.</div></div><div><h3>Conclusions</h3><div>The findings suggest that existing water management practices may be inadequate for controlling <em>Legionella</em> growth and transmission. Seasonal variations significantly impact infection risk, emphasizing the need for improved monitoring and control strategies. However, limitations related to sampling methodology, geographic specificity, and dose-response modeling should be considered when interpreting the results.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101584"},"PeriodicalIF":2.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reemergence of Oropouche virus infection in Venezuela, 2025","authors":"Alfonso J. Rodriguez-Morales ,&nbsp;Juan-Carlos Navarro ,&nbsp;Alberto Paniz-Mondolfi ,&nbsp;David A. Forero-Peña ,&nbsp;Daniel Romero-Alvarez ,&nbsp;Laura Naranjo-Lara ,&nbsp;Jose A. Suárez","doi":"10.1016/j.nmni.2025.101583","DOIUrl":"10.1016/j.nmni.2025.101583","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101583"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferritin's role in infectious diseases: Exploring pathogenic mechanisms and clinical implications","authors":"Yingying Liao ,&nbsp;Tao Zeng ,&nbsp;Xiaoyan Guo,&nbsp;Xinhua Li","doi":"10.1016/j.nmni.2025.101582","DOIUrl":"10.1016/j.nmni.2025.101582","url":null,"abstract":"<div><div>Ferritin, an iron storage protein, is crucial for maintaining iron metabolism balance throughout the body and serves as a key biomarker for evaluating the body's iron reserves. Reduced ferritin levels typically indicate iron deficiency, whereas elevated ferritin levels indicate an acute inflammatory response in infectious diseases. Recent research has established a significant link between elevated ferritin levels and disease severity and prognosis. The concept of hyperferritinemic syndrome has underscored ferritin's role as a pathogenic mediator. During infections, ferritin not only serves as a biomarker of inflammation but also exerts pro-inflammatory functions, which is a key factor in perpetuating the vicious pathogenic cycle. This review offers a comprehensive exploration of ferritin, covering its structural characteristics, regulatory mechanisms, and how diverse pathogens modulate ferritin. Understanding its pivotal role in infectious diseases is essential for identifying novel therapeutic prospects and enhancing disease management and prevention.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101582"},"PeriodicalIF":2.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of Flavobacterium lindanitolerans meningitis and bacteraemia in an immunocompetent host","authors":"Amelia Benjamin,&nbsp;Robert Gray,&nbsp;Madhuri Vidwans","doi":"10.1016/j.nmni.2025.101581","DOIUrl":"10.1016/j.nmni.2025.101581","url":null,"abstract":"<div><div><em>Flavobacterium lindanitolerans,</em> a gram-negative, non-spore forming predominantly aerobic rod, is an unusual cause of disease in humans. It has previously been described as an opportunistic pathogen in immunocompromised hosts. Here we described a case of meningitis and bacteraemia, in an immunocompetent individual who had undergone recent neurosurgical intervention.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101581"},"PeriodicalIF":2.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of tinea nigra in children","authors":"Tengteng Xin ,&nbsp;Jiahao Li ,&nbsp;Li Lin,&nbsp;Yijin Luo,&nbsp;Wenying Cai,&nbsp;Junmin Zhang","doi":"10.1016/j.nmni.2025.101577","DOIUrl":"10.1016/j.nmni.2025.101577","url":null,"abstract":"<div><div>A 6-year-old girl presented with brown patches on her right palm that had persisted for 5 years. Based on clinical manifestations, dermoscopy, and fungal microscopy, the child was diagnosed with tinea nigra. Molecular sequencing confirmed the pathogen as <em>Hortaea werneckii</em>. The patient was successfully treated with the topical application of an antifungal ointment.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101577"},"PeriodicalIF":2.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yellow fever outbreaks in South America: Current epidemiology, legacies of the recent past and perspectives for the near future","authors":"Rodrigo Nogueira Angerami ,&nbsp;Tania Do Socorro Souza Chaves ,&nbsp;Alfonso J. Rodríguez-Morales","doi":"10.1016/j.nmni.2025.101580","DOIUrl":"10.1016/j.nmni.2025.101580","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101580"},"PeriodicalIF":2.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights of public health measures to mitigate the growing threat of avian influenza in India","authors":"Eman Riaz ,&nbsp;Maria Riaz ,&nbsp;Muneeba Ali ,&nbsp;Stephen Awogbami ,&nbsp;Oforkansi Chioma Linda ,&nbsp;Malik Olatunde Oduoye","doi":"10.1016/j.nmni.2025.101573","DOIUrl":"10.1016/j.nmni.2025.101573","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101573"},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wolbachia: A bacterial weapon against dengue fever- a narrative review of risk factors for dengue fever outbreaks","authors":"Sahel Safaei ,&nbsp;Mozhgan Derakhshan-sefidi ,&nbsp;Amirmohammad Karimi","doi":"10.1016/j.nmni.2025.101578","DOIUrl":"10.1016/j.nmni.2025.101578","url":null,"abstract":"<div><div>Arboviruses constitute the largest known group of viruses and are responsible for various infections that impose significant socioeconomic burdens worldwide, particularly due to their link with insect-borne diseases. The increasing incidence of dengue fever in non-endemic regions underscores the urgent need for innovative strategies to combat this public health threat. <em>Wolbachia</em>, a bacterium, presents a promising biological control method against mosquito vectors, offering a novel approach to managing dengue fever. We systematically investigated biomedical databases (PubMed, Web of Science, Google Scholar, Science Direct, and Embase) using “AND” as a Boolean operator with keywords such as “dengue fever,” “dengue virus,” “risk factors,” “<em>Wolbachia</em>,” and “outbreak.” We prioritized articles that offered significant insights into the risk factors contributing to the outbreak of dengue fever and provided an overview of <em>Wolbachia</em>'s characteristics and functions in disease management, considering studies published until December 25, 2024.</div><div>Field experiments have shown that introducing <em>Wolbachia</em>-infected mosquitoes can effectively reduce mosquito populations and lower dengue transmission rates, signifying its potential as a practical approach for controlling this disease.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101578"},"PeriodicalIF":2.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mission of polio eradication in Pakistan- a review on challenges and future recommendations","authors":"Abdul Rehman Shah Syed ,&nbsp;Syeda Sadia Masood Raza ,&nbsp;Syeda Javeria Zakir ,&nbsp;Muhammad Abubakar Shahid Chishti ,&nbsp;Shahzaib Ahmad ,&nbsp;Hadin Darain Khan ,&nbsp;Asif Khaliq ,&nbsp;Muhammad Ali Muzammil ,&nbsp;Malik Olatunde Oduoye","doi":"10.1016/j.nmni.2025.101571","DOIUrl":"10.1016/j.nmni.2025.101571","url":null,"abstract":"<div><div>Poliomyelitis, commonly known as “polio” is a paralytic and perilous disease caused by the poliovirus. Due to its highly contagious nature, the virus was a challenge to the world in the late 1980s. Since 1988, the collective work of the Global Polio Eradication Initiative (GPEI), Centre for Disease Control and Prevention (CDC), and World Health Organization (WHO) through immunizations, communication awareness, and monitoring have helped the world exonerate polio. This article aims to review on challenges and future recommendations for polio eradication in Pakistan.</div><div>The mission of polio-free Pakistan was Herculean. It confronted enormous challenges in different ways but came out with positive results. In 2019, with only two remaining polio-endemic countries, Pakistan and Afghanistan, GPEI launched an “Endgame strategy 2019–2023,” aiming to eradicate polio globally, focusing on polio-endemic countries. The plan emphasizes the early detection of polio cases for complete eradication and to restrict the spread of polio. Pakistan has achieved a milestone in combating polio despite having a web of factors that have thwarted Pakistan's polio eradication efforts, but this is not the end. The struggle continues until we get an internationally verified certification of a polio-free nation; WHO has designed a multidisciplinary strategy for 2022–2026 to end this polio.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"64 ","pages":"Article 101571"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic and colistin resistance pattern of Salmonella spp. isolated from pediatric patients with diarrhea in the Southern region of Vietnam","authors":"Nga Thi Le ,&nbsp;Phuong Hoai Hoang ,&nbsp;Chinh Van Dang ,&nbsp;Tinh Huu Ho ,&nbsp;Phuc Le Hoang ,&nbsp;Dinh Quang Truong ,&nbsp;Ha Thi Thanh Nguyen ,&nbsp;Chuong Van Le ,&nbsp;Tuom Thi Tinh Truong ,&nbsp;Phuong Nhat Tran ,&nbsp;Trang Thi Phuong Phan","doi":"10.1016/j.nmni.2025.101576","DOIUrl":"10.1016/j.nmni.2025.101576","url":null,"abstract":"<div><h3>Background</h3><div><em>Salmonella</em> spp. is a prominent causative agent of pediatric diarrhea, with recent research emphasizing the rising concern regarding antimicrobial resistance (AMR), particularly involving colistin, a last-resort antibiotic.</div></div><div><h3>Methods</h3><div>This study involved the collection of 500 stool samples from children with diarrhea from two tertiary pediatric hospitals in Ho Chi Minh City. Conventional methods were used to isolate <em>Salmonella</em> spp., and antibiotic resistance profiling against seven antibiotics was conducted using the disk diffusion method. Colistin resistance was determined by the microdilution method. Colistin resistance (<em>mcr</em>) genes were detected by PCR assay. A conjugation experiment with a multidrug-resistant <em>Salmonella</em> strain and <em>E. coli</em> J53 was performed, and the plasmids from this <em>Salmonella</em> strain were analyzed using bioinformatics.</div></div><div><h3>Results</h3><div>The <em>Salmonella</em> spp. infection rate was found to be 74/500 (14.8 %). The predominant antibiotic resistance phenotype was ampicillin with 53/74 (71.6 %), followed by trimethoprim-sulfamethoxazole with 23/74 (31.1 %). Resistance rates to ceftazidime, cefotaxime and gentamicin were 14/74 (18.9 %), 13/74 (17.6 %) and 6/74 (8.1 %), respectively. Resistance to imipenem was not observed. Colistin resistance was exhibited in 3/74 (4.1 %) of isolates, all harboring the <em>mcr-1</em> gene. The plasmid carrying the <em>mcr-1</em> gene could transfer to <em>E. coli</em>, which belongs to the IncX4 type and contains IS26.</div></div><div><h3>Conclusion</h3><div>This study provides valuable insights into the antibiotic resistance profiles of <em>Salmonella</em> spp. isolated from pediatric patients, with particular emphasis on colistin resistance.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"65 ","pages":"Article 101576"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}