New Microbes and New Infections最新文献

{"title":"A large-scale chikungunya outbreak in China: Implications for global health in the era of climate change","authors":"Ala'a B. Al-Tammemi , Ruba A. Al-Smadi , Tareq L. Mukattash","doi":"10.1016/j.nmni.2025.101632","DOIUrl":"10.1016/j.nmni.2025.101632","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101632"},"PeriodicalIF":5.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burden of dengue fever in travellers: a systematic literature review","authors":"Martin P. Grobusch ,&nbsp;Marta Díaz-Menéndez ,&nbsp;Eduardo Bittencourt de Gomensoro ,&nbsp;Caroline Mächler ,&nbsp;Bojana Milovanović","doi":"10.1016/j.nmni.2025.101631","DOIUrl":"10.1016/j.nmni.2025.101631","url":null,"abstract":"<div><h3>Background</h3><div>Dengue is a mosquito-borne viral infection with growing global impact, including international travellers travelling to and from endemic regions. This systematic literature review aimed to assess the clinical and economic burden of dengue in travellers from non-endemic countries.</div></div><div><h3>Methods</h3><div>This systematic review was conducted following the PRISMA guidelines to assess the incidence, prevalence, mortality, healthcare resource use, and costs of dengue fever in travellers between non-endemic and endemic regions. We systematically searched MEDLINE, Embase, Google Scholar, PubMed, and Epistemonikos. Due to heterogeneity, data were synthesised descriptively without quantitative analysis.</div></div><div><h3>Results</h3><div>Seventy unique studies were included. Heterogeneity in design, inconsistent reporting, and lack of denominator data limited the ability to calculate incidence rates or compare risks across regions. Two prospective studies provided incidence rates, reaching 58.7 cases per 1000 person-months of travel. No studies reported prevalence data. With three cases, reported mortality was rare. No cost data were identified, but limited data on healthcare resource use were identified from seven publications.</div></div><div><h3>Conclusions</h3><div>Findings highlight the challenges in quantifying individual risk and the need for improved surveillance, prospective data collection, and targeted prevention strategies. These results support improved travel health guidance and may inform vaccination strategies for travellers to endemic regions.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101631"},"PeriodicalIF":5.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local transmission of arboviral infections in the south of France and prevention paradigms - status quo August 2025","authors":"Philippe Gautret ,&nbsp;Patricia Schlagenhauf","doi":"10.1016/j.nmni.2025.101629","DOIUrl":"10.1016/j.nmni.2025.101629","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101629"},"PeriodicalIF":5.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmission dynamics and response strategies for the chikungunya outbreak in Southern China","authors":"Qinyue Zheng ,&nbsp;Jaffar A. Al-Tawfiq ,&nbsp;Qiuwei Pan","doi":"10.1016/j.nmni.2025.101630","DOIUrl":"10.1016/j.nmni.2025.101630","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101630"},"PeriodicalIF":5.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airport/seaport and autochthonous malaria in Europe from 1969 to 2022: A systematic review","authors":"Daniela Balzli ,&nbsp;Nejla Gültekin ,&nbsp;Zeno Stanga ,&nbsp;Ismail Ülgür ,&nbsp;Nadja Hedrich ,&nbsp;Jan Fehr ,&nbsp;Patricia Schlagenhauf","doi":"10.1016/j.nmni.2025.101627","DOIUrl":"10.1016/j.nmni.2025.101627","url":null,"abstract":"<div><h3>Background</h3><div>In the context of this paper, airport/seaport malaria denotes the accidental relocation by air or sea of a malaria infected mosquito to Europe, a non-endemic area, the survival of the transported mosquito and subsequent blood meal and infection of a local person. Autochthonous malaria refers to locally transmitted cases of malaria in Europe.</div></div><div><h3>Methods</h3><div>The systematic review followed PRISMA guidelines and was registered on PROSPERO (CRD42023444243). PubMed and Ovid MEDLINE electronic databases as well as EMBASE, Scopus and CINAHL were searched for eligible papers. The selection process followed strict inclusion and exclusion criteria.</div></div><div><h3>Results</h3><div>We included 68 papers describing 115 cases of airport, seaport or autochthonous malaria in Europe, with a total of 68 airport/seaport malaria cases and 47 autochthonous malaria cases. France, Germany, Italy and Spain reported both types of malaria cases. Cases of airport/seaport malaria only were reported from Belgium, Luxembourg, Switzerland and the United Kingdom. Cases of autochthonous malaria only were reported from Greece, Malta and the Netherlands. The case fatality rates for airport/seaport malaria were 13.24 % and for autochthonous malaria 2.13 % respectively.</div></div><div><h3>Conclusion</h3><div>The importance of airport/seaport and autochthonous malaria is related to the frequently delayed or missed diagnosis, leading to high case fatality rates. Rising temperature may facilitate the importation and proliferation of competent <em>Anopheles</em> vectors. Increased human migration and travel with malaria parasite carriage may contribute to the reemergence of autochthonous malaria in Europe.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101627"},"PeriodicalIF":5.4,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet dynamics and thrombocytopenia in dengue fever: A prospective cohort study from Shenzhen, China","authors":"Liping Guo ,&nbsp;Yuchen Gu ,&nbsp;Ying Zhang ,&nbsp;Haimei Zhang ,&nbsp;Weizhen Weng ,&nbsp;Shuai Wu ,&nbsp;Jing Yuan","doi":"10.1016/j.nmni.2025.101624","DOIUrl":"10.1016/j.nmni.2025.101624","url":null,"abstract":"<div><h3>Introduction</h3><div>Dengue fever, the most prevalent arthropod-borne viral disease, causes ∼400 million infections annually. Although thrombocytopenia is commonly associated with dengue, how it evolves in relation to viral load and immune responses remains poorly understood. This study aimed to elucidate platelet-virus-immune interactions in acute dengue by systematically tracking of viral load, platelet parameters, and leukocyte dynamics.</div></div><div><h3>Methods</h3><div>A prospective cohort study was conducted at Third People's Hospital in 2024, involving 135 confirmed dengue cases, supported by retrospective data from 2014 to 2023. Platelet counts, hematocrit (HCT), and cellular immunity markers (lymphocyte/neutrophil percentages) were longitudinally tracked. Viral load was quantified via NS5 gene Ct values. Statistical analyses involved LOESS regression and Pearson/Spearman correlations.</div></div><div><h3>Results</h3><div>Platelet counts exhibited a biphasic decline, reaching nadir levels (mean: 97.65 × 10⁹/L) at 6 days post-onset, with recovery by day 9. Thrombocytopenia severity was stratified as intermediate-low (50–99 × 10⁹/L; 50 %, 64/128) and very low (&lt;50 × 10⁹/L; 14.8 %, 19/128). Platelet decline correlated with elevated lymphocyte percentages (40 % vs. 17.8 % pre-decline; p &lt; 0.001) and suppressed neutrophils (46.6 % vs. 68.3 %; p &lt; 0.001). Critically, platelet counts inversely correlated with viral load (Ct values: R = 0.25, p = 0.028), HCT (R = −0.25), and platelet activation markers (MPV: R = −0.55; P-LCR: R = −0.57), while positively associating with platelet hematocrit (PCT: R = 0.97). No cases progressed to severe dengue despite extreme thrombocytopenia.</div></div><div><h3>Conclusions</h3><div>This study identifies distinct dengue thrombocytopenia kinetics driven by viral load. Predominant moderate thrombocytopenia (50–99 × 10⁹/L) challenges conventional risk stratification, advocating integrated monitoring of platelet indices and viral replication. These data advance both risk prediction and mechanistic knowledge of platelet-virus interactions.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101624"},"PeriodicalIF":5.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular characterization and phylogenetic analysis of cryptosporidium spp. in pediatric acute gastroenteritis: Epidemiological insights from northeastern Iran","authors":"Bibi Razieh Hosseini Farash ,&nbsp;Seyed Aliakbar Shamsian ,&nbsp;Fariba Berenji ,&nbsp;Mohammad Javad Najafzadeh ,&nbsp;Mehdi Zarean ,&nbsp;Behrouz Mahmoudi Gorgi ,&nbsp;Sahar Soleimanian ,&nbsp;Elnaz Nakhaei ,&nbsp;Lida Jarahi","doi":"10.1016/j.nmni.2025.101622","DOIUrl":"10.1016/j.nmni.2025.101622","url":null,"abstract":"<div><h3>Background</h3><div><em>Cryptosporidium</em> spp. are significant zoonotic pathogens causing gastroenteritis, particularly in pediatric populations. This study aimed to investigate the prevalence, molecular characterization, and phylogenetic analysis of <em>Cryptosporidium</em> species among children with acute gastroenteritis in northeastern Iran.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted on 138 children aged 3 months to 12 years at Dr. Sheikh Hospital, Mashhad, between January 2023 and June 2024. Stool samples were examined microscopically using Ziehl-Neelsen staining, and molecular analysis was performed targeting the 18S rRNA gene through PCR. Positive samples were sequenced, and phylogenetic trees were constructed to assess genetic diversity.</div></div><div><h3>Results</h3><div>Microscopic examination detected <em>Cryptosporidium</em> oocysts in 23.2 % of samples, while molecular analysis identified <em>Cryptosporidium</em> DNA in 26.8 %, demonstrating the superior sensitivity of PCR. Sequencing results revealed <em>Cryptosporidium parvum</em> as the predominant species (14/15 samples) with one <em>Cryptosporidium hominis</em> case. Phylogenetic analysis confirmed genetic diversity among isolates, highlighting potential zoonotic and environmental transmission routes. No significant associations were observed between infection prevalence and demographic factors such as age or gender (p &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study underscores the importance of molecular diagnostics in accurately identifying <em>Cryptosporidium</em> species and understanding their epidemiological significance. The findings contribute to regional knowledge on <em>Cryptosporidium</em> infections and highlight the need for targeted public health interventions to reduce disease burden in children.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101622"},"PeriodicalIF":5.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The discontinuation of the Fleming fund: Implications for global mitigation of antimicrobial resistance","authors":"Patrick Ashinze ,&nbsp;Oluwadamilare Olatunbosun ,&nbsp;Jasmine Kaur ,&nbsp;Maryam Olabisi Atofarati ,&nbsp;Abba Owoicho ,&nbsp;Toniloba Akingbola ,&nbsp;Daniel Olumuyiwa Ogunruku ,&nbsp;Folayemi Abiodun Iwaloye","doi":"10.1016/j.nmni.2025.101625","DOIUrl":"10.1016/j.nmni.2025.101625","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101625"},"PeriodicalIF":5.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-TB treatment outcomes in TB meningitis: A systematic review and meta-analysis","authors":"Samin Afazel ,&nbsp;Mohammad J. Nasiri ,&nbsp;Vishwanath Venketaraman","doi":"10.1016/j.nmni.2025.101623","DOIUrl":"10.1016/j.nmni.2025.101623","url":null,"abstract":"<div><h3>Introduction</h3><div>Tuberculous meningitis (TBM) remains a leading cause of mortality and neurological disability in both children and adults. This systematic review and meta-analysis aim to assess the treatment outcomes of anti-tuberculosis drugs in TBM patients, focusing on mortality and neurological disability.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive literature search on PubMed/MEDLINE, EMBASE, and Cochrane CENTRAL databases to identify articles reporting treatment outcomes in TBM up to December 15, 2024. Studies included in the analysis reported treatment outcomes for TBM patients. Pooled analyses were performed using random-effects model to assess mortality rates, neurological disability, and loss to follow-up.</div></div><div><h3>Results</h3><div>A total of 10 studies involving 2005 patients were included in the analysis. The pooled all-cause mortality rate across studies was 27.7 % (95 % CI: 22.6–33.4 %, <em>I</em>^<em>2</em>: 76 %), with higher mortality observed in HIV-positive individuals (40.3 %) compared to HIV-negative patients (17.1 %). The pooled rate of loss to follow-up was 6.6 % (95 % CI: 4.7–9.1 %). Subgroup analysis revealed that the mortality rate increased from 18.9 % at 3 months to 29.1 % at 6 months. The frequency of neurological disability was higher among studies using the Modified Rankin Scale (41.7 %) compared to the Barthel Index (14.1 %).</div></div><div><h3>Conclusions</h3><div>This study highlights the high mortality and significant neurological disability in TBM patients, particularly in HIV-positive individuals. Our findings emphasize the need for standardized outcome reporting and the incorporation of new therapeutic strategies, and improved diagnostic tools, to enhance clinical outcomes. Future research should focus on addressing these areas to optimize treatment protocols and reduce the burden of TBM.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101623"},"PeriodicalIF":5.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 in immunocompromised patients: proposed definition of a new entity with prolonged infection","authors":"Ivan Gentile ,&nbsp;Nicola Schiano Moriello ,&nbsp;Alberto Enrico Maraolo ,&nbsp;Rino Rappuoli","doi":"10.1016/j.nmni.2025.101626","DOIUrl":"10.1016/j.nmni.2025.101626","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"67 ","pages":"Article 101626"},"PeriodicalIF":5.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}