New Microbes and New Infections最新文献

{"title":"Novel and repurposed antiviral molecules for arbovirus infections with epidemic Potential: A systematic review","authors":"Jacopo Logiudice ,&nbsp;Giorgio Tiecco ,&nbsp;Alessandro Pavesi ,&nbsp;Francesca Bertoni ,&nbsp;Roberta Gerami ,&nbsp;Isabella Zanella ,&nbsp;Anna Artese ,&nbsp;Eugenia Quiros-Roldan","doi":"10.1016/j.nmni.2025.101614","DOIUrl":"10.1016/j.nmni.2025.101614","url":null,"abstract":"<div><h3>Background</h3><div>This systematic review investigates experimental and repurposed antiviral molecules for epidemic-potential arboviruses, including dengue (DENV), Zika (ZIKV), chikungunya (CHIKV), West Nile (WNV), and Usutu (USUV) viruses. Arboviral diseases pose a growing public health concern, exacerbated by climate change and increased global travel. Despite the absence of approved antiviral therapies for most arboviruses, numerous <em>in vitro</em>, <em>in vivo</em> and in human studies have evaluated candidate molecules targeting the different stages of viral replication. <strong>Methods</strong>: Our methods adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Pubmed, Embase, and Cochrane Library trials were searched. Studies published until March 2024 were included. After abstract review and duplication removal, full-text articles were obtained for further review, reviewed by two independent reviewers, and disagreements were resolved by a third reviewer. <strong>Results</strong>: Our analysis, based on 185 studies, highlights the antiviral role of molecules such as nucleoside analogs, protease inhibitors, and immune-modulators. No studies conducted in humans have been reported to demonstrate the antiviral efficacy of any molecule. Favipiravir, ribavirin, and sofosbuvir demonstrated viremia reduction and symptoms improvement <em>in vitro</em> and <em>in vivo</em> experiments. Cholesterol-lowering agents, such as atorvastatin and ezetimibe, showed promise in disrupting viral assembly. Montelukast and doxycycline exhibited anti-inflammatory effects, contributing to improved clinical outcomes. The cytokine modulation profiles varied, with notable reductions in pro-inflammatory markers in certain studies. <strong>Conclusions</strong>: Currently, there are no studies in humans demonstrating effective treatments against arboviral infections. Although some molecules have shown efficacy in reducing viral titters, further clinical evaluation of promising candidates and the exploration of combination therapies targeting viral replication and host immune-response are needed.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101614"},"PeriodicalIF":5.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shortage of praziquantel in Europe: a clarion call for urgent action","authors":"Andreas K. Lindner ,&nbsp;Corneliu Popescu ,&nbsp;José A. Perez-Molina ,&nbsp;Marta Díaz-Menéndez ,&nbsp;Camilla Rothe ,&nbsp;Hilmir Asgeirsson ,&nbsp;Jean-Marc Schwob ,&nbsp;Martin P. Grobusch ,&nbsp;Andreas Neumayr ,&nbsp;Thomas Weitzel ,&nbsp;Patricia Schlagenhauf","doi":"10.1016/j.nmni.2025.101613","DOIUrl":"10.1016/j.nmni.2025.101613","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101613"},"PeriodicalIF":5.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\" Listeria monocytogenes infection \": A report detailing multiple diagnostic approaches","authors":"Shujuan Zheng ,&nbsp;Yunyan Yu ,&nbsp;Jiumei Zhao,&nbsp;Dongmei Liu,&nbsp;Xiang Yang,&nbsp;Wenming Wang,&nbsp;Lin Chen","doi":"10.1016/j.nmni.2025.101612","DOIUrl":"10.1016/j.nmni.2025.101612","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101612"},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HKU5-CoV lineage 2 (HKU5-CoV-2): A novel bat-infecting coronavirus with likely ‘spillover’ risk","authors":"Hassan Karami","doi":"10.1016/j.nmni.2025.101611","DOIUrl":"10.1016/j.nmni.2025.101611","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101611"},"PeriodicalIF":2.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A letter in response to commentary provided on \"A case of <i>Flavobacterium lindanitolerans</i> meningitis and bacteraemia in an immunocompetent host\".","authors":"Amelia Benjamin","doi":"10.1016/j.nmni.2025.101609","DOIUrl":"10.1016/j.nmni.2025.101609","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"101609"},"PeriodicalIF":5.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"A case of <i>Flavobacterium lindanitolerans</i> meningitis and bacteraemia in an immunocompetent host\".","authors":"Asiyeh Dezhkam, Masoud Keikha","doi":"10.1016/j.nmni.2025.101608","DOIUrl":"10.1016/j.nmni.2025.101608","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"101608"},"PeriodicalIF":5.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oropouche Fever in Beni, Bolivia, 2024","authors":"Juan Pablo Escalera-Antezana ,&nbsp;Rodrigo Daniel Montesinos-Jove ,&nbsp;Carlos Eduardo Gonzales-Flores ,&nbsp;Claudia Nathaly Arauco-Gutierrez ,&nbsp;Jorge Luis Aviles-Sarmiento ,&nbsp;Claudia Marcela Montenegro-Narvaez ,&nbsp;Hugo Antonio Castro-Calderón ,&nbsp;Nestor Freddy Armijo-Subieta ,&nbsp;Alfonso J. Rodriguez-Morales","doi":"10.1016/j.nmni.2025.101610","DOIUrl":"10.1016/j.nmni.2025.101610","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101610"},"PeriodicalIF":2.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-border prevalence of putative-hypervirulent Klebsiella pneumoniae differs between tertiary hospitals in Austria and Germany","authors":"Bernd Neumann ,&nbsp;Sophie Wilhelm ,&nbsp;Jan Marco Kern ,&nbsp;Joerg Steinmann","doi":"10.1016/j.nmni.2025.101606","DOIUrl":"10.1016/j.nmni.2025.101606","url":null,"abstract":"<div><div>We conducted a prospective testing protocol for surveillance of putative hypervirulent <em>Klebsiella pneumoniae</em> in two tertiary hospitals in Germany and Austria, over a one year study period. In total, 45 (1.02 %) putative hvKp of around 4400 <em>K. pneumoniae</em> were identified. The study revealed a 3.3-times higher prevalence of putative hvKp in the German hospital.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101606"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening global health Equity: The imperative of the WHO pandemic agreement","authors":"Esam Ibraheem Azhar ,&nbsp;Sherif A. El-Kafrawy ,&nbsp;Ziad A. Memish","doi":"10.1016/j.nmni.2025.101607","DOIUrl":"10.1016/j.nmni.2025.101607","url":null,"abstract":"","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101607"},"PeriodicalIF":2.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First record of methicillin-resistant Staphylococcus aureus (MRSA) isolated from the Meia Ponte River and effluent in Brazil: an analysis of 1198 isolates","authors":"Igor Romeiro dos Santos ,&nbsp;Leandro Fonseca de Lima ,&nbsp;Marcelino Benvindo de Souza ,&nbsp;Isabela Náthaly Machado da Silva ,&nbsp;Adriano Roberto Vieira de Sousa ,&nbsp;Alexandre Melo Bailão ,&nbsp;Cátia Lira do Amaral ,&nbsp;Elisa Flávia Luiz Cardoso Bailão","doi":"10.1016/j.nmni.2025.101603","DOIUrl":"10.1016/j.nmni.2025.101603","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to detect environmental reservoirs of multidrug-resistant <em>Staphylococcus aureus</em> and methicillin-resistant <em>S. aureus</em> (MRSA) in Central Brazil.</div></div><div><h3>Methods</h3><div>Membrane filtration with growth on Baird-Parker agar base was used to recover <em>S. aureus</em> and MRSA from the effluents of a sewage treatment plant (STP) and surface water from an important Cerrado river. Effluent samples were collected at two points in the STP (pre- and post-treatment). Surface water was collected at six points along the Meia Ponte River, from its source to the mouth. Air samples were collected at all these collection points in 2022, totaling four campaigns between the dry and rainy seasons.</div></div><div><h3>Results</h3><div><em>S. aureus</em> was isolated at all collection points in all campaigns, totaling 87715 isolates. Of the 1198 selected isolates, 83 were cefoxitin (FOX)-resistant, indicating a methicillin-resistance phenotype. The antimicrobial profiles of the 83 FOX-resistant isolates were investigated, and 88 % could be considered multidrug-resistant <em>S. aureus</em>. Of the 83 FOX-resistant isolates, more than 70 % were resistant to clindamycin, erythromycin, and rifampicin. The presence of the <em>mecA</em> gene was confirmed in 18 isolates collected along the Meia Ponte River and inside the STP, with 15 exhibiting multidrug-resistant phenotypes. The results of the principal component analysis (PCA) revealed an association between <em>S. aureus</em> isolates and the urbanized environment/STP, as well as the presence of antimicrobials.</div></div><div><h3>Conclusion</h3><div>This study is a pioneer in identifying the presence of MRSA in Brazilian water bodies, highlighting the urgent need for monitoring antimicrobial resistance in urban rivers.</div></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"66 ","pages":"Article 101603"},"PeriodicalIF":2.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}