eNeurologicalSciPub Date : 2025-03-01Epub Date: 2025-01-05DOI: 10.1016/j.ensci.2025.100548
Wolfgang Grisold, Stephen L. Lewis
{"title":"The world federation of neurology digital neurology update (WNU)","authors":"Wolfgang Grisold, Stephen L. Lewis","doi":"10.1016/j.ensci.2025.100548","DOIUrl":"10.1016/j.ensci.2025.100548","url":null,"abstract":"","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100548"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
eNeurologicalSciPub Date : 2025-03-01Epub Date: 2025-01-09DOI: 10.1016/j.ensci.2025.100549
Abdullah M. Al-Qudah , Pooja S. Tallapaneni , Donald J. Crammond , Jeffrey Balzer , Katherine M. Anetakis , Varun Shandal , Jingyuan Biaesch , Malik Ghannam , Neelesh Nadkarni , Bradley A. Gross , Michael Lang , Kathirvel Subramanium , Senthilkumar Sadhasivam , Parthasarathy D. Thirumala
{"title":"Intraoperative neuromonitoring as an independent predictor for postoperative delirium in ICU following aneurysm clipping","authors":"Abdullah M. Al-Qudah , Pooja S. Tallapaneni , Donald J. Crammond , Jeffrey Balzer , Katherine M. Anetakis , Varun Shandal , Jingyuan Biaesch , Malik Ghannam , Neelesh Nadkarni , Bradley A. Gross , Michael Lang , Kathirvel Subramanium , Senthilkumar Sadhasivam , Parthasarathy D. Thirumala","doi":"10.1016/j.ensci.2025.100549","DOIUrl":"10.1016/j.ensci.2025.100549","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to evaluate the diagnostic accuracy of significant intraoperative neurophysiological monitoring (IONM) changes as an independent predictor of postoperative delirium (POD) in patients undergoing aneurysm clipping.</div></div><div><h3>Methods</h3><div>IONM and clinical data from 273 patients who underwent craniotomy for aneurysm clipping from 2019 until 2021 were retrospectively reviewed. Significant IONM changes and POD were respectively evaluated based on visual review of data and clinical documentation. POD was assessed multiple times in the ICU using the Intensive Care Delirium Screening Checklist (ICDSC).</div></div><div><h3>Results</h3><div>Of the 273 patients undergoing craniotomy with IONM, 83 had POD (30.4 %). Significant IONM changes were noted in 42 patients, of which 19 patients had POD (45.2 %). In contrast, 231 patients had no IONM changes during surgery, of which 64 (27.7 %) patients had POD. Multivariable analysis showed that significant IONM changes were associated with POD, OR: 2.09 (95 % CI 1.01–4.43, <em>p</em>-value: 0.046). Additionally, somatosensory evoked potentials (SSEP) changes were significantly associated with POD (p-value: 0.044).</div></div><div><h3>Conclusion</h3><div>Significant IONM changes are associated with an increased risk of POD in patients undergoing craniotomy for aneurysm clipping. Our findings offer a strong basis for future research and analysis of EEG and SSEP monitoring to detect and possibly prevent POD.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100549"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early diagnosis of cryptococcal meningoencephalitis in HIV-negative patients: Integration of brain MRI and clinical findings","authors":"Kosei Nakamura, Masato Kanazawa, Yuka Koike, Takuya Konno, Osamu Onodera","doi":"10.1016/j.ensci.2025.100552","DOIUrl":"10.1016/j.ensci.2025.100552","url":null,"abstract":"<div><h3>Purpose</h3><div>Cryptococcal meningoencephalitis (CM) in human immunodeficiency virus (HIV)-negative patients are often diagnosed later than in HIV-infected patients, which increases mortality rates concerning the former. Consequently, early diagnosis and treatment are crucial for improving clinical prognosis in HIV-negative patients. This study investigated the utility of magnetic resonance imaging (MRI) in combination with clinical and laboratory findings for early diagnosis of CM in HIV-negative patients.</div></div><div><h3>Methods</h3><div>This retrospective cohort analysis included consecutive patients diagnosed with central nervous system (CNS) infections. Demographic profiles, laboratory findings, admission symptoms, and MRI findings were assessed. A comparative analysis between CM and other CNS infections was performed.</div></div><div><h3>Results</h3><div>Twelve HIV-negative patients were diagnosed with CM, while 38 exhibited other CNS infections (two fungal, 23 bacterial, 12 viral, one parasitic). Pseudocysts on MRI (<em>p</em> = 0.002), absence of fever (<em>p</em> = 0.001), headache (<em>p</em> = 0.005), and normal C-reactive protein (CRP) levels (<em>p</em> = 0.020) were specific findings in CM. By applying a cut-off value of one point in combination of pseudocysts, absence of fever, headache, and normal CRP levels in differentiating CM from other CNS infections, the sensitivity and specificity were calculated as 76.3 % and 91.7 %, respectively.</div></div><div><h3>Conclusion</h3><div>Integrating pseudocysts, absence of fever, headache, and normal CRP levels predicts early CM diagnosis, potentially improving outcomes.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100552"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
eNeurologicalSciPub Date : 2025-03-01Epub Date: 2025-01-10DOI: 10.1016/j.ensci.2025.100554
Armin Adibi , Iman Adibi , Saeed Bahramian , Saba Naghavi , Fatemeh Gholami
{"title":"Bilateral optic neuritis as an atypical presentation of juvenile Behcet syndrome: A case report","authors":"Armin Adibi , Iman Adibi , Saeed Bahramian , Saba Naghavi , Fatemeh Gholami","doi":"10.1016/j.ensci.2025.100554","DOIUrl":"10.1016/j.ensci.2025.100554","url":null,"abstract":"<div><div>Behcet syndrome is a systemic vasculitis characterized by relapsing uveitis, oral aphthous, and genital ulcers. We present a rare case of a 14-year-old male with juvenile Behcet syndrome (JBS) presenting as bilateral optic neuritis with oral aphthous. Initial treatment with methylprednisolone did not improve the patient's condition. Serum plasmapheresis was performed, resulting in improved visual acuity and papillitis. The patient was discharged with azathioprine, which led to symptom regression. This case highlights the atypical neurologic presentation of JBS and the potential efficacy of plasma exchange in refractory cases.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100554"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
eNeurologicalSciPub Date : 2025-03-01Epub Date: 2025-01-06DOI: 10.1016/j.ensci.2025.100550
Sara Samadzadeh , Roy D. Sleator
{"title":"The role of Neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in MS and AQP4-NMOSD: Advancing clinical applications.","authors":"Sara Samadzadeh , Roy D. Sleator","doi":"10.1016/j.ensci.2025.100550","DOIUrl":"10.1016/j.ensci.2025.100550","url":null,"abstract":"<div><div>Fluid biomarkers such as Glial Fibrillary Acidic Protein (GFAP) and Neurofilament Light (NfL) play important roles in the diagnosis, monitoring, and evaluation of therapeutic responses in conditions such as Multiple Sclerosis (MS) and Aquaporin-4 Neuromyelitis Optica Spectrum Disorder (AQP4-NMOSD). These biomarkers offer key insights into the underlying pathophysiological mechanisms of these diseases, enabling effective follow-up and personalized treatment approaches, which are essential for improving patient outcomes. Herein, we synthesize the structural attributes, functional roles, and clinical significance of GFAP and NfL in the context of MS and AQP4-NMOSD. We explore the critical implications of these biomarkers in disease manifestation and progression, emphasizing the necessity to develop standardized methodologies and multicentric studies to confirm their clinical applicability.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100550"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
eNeurologicalSciPub Date : 2025-03-01Epub Date: 2025-01-21DOI: 10.1016/j.ensci.2025.100555
{"title":"Erratum regarding missing conflict of interests statements in previously published articles","authors":"","doi":"10.1016/j.ensci.2025.100555","DOIUrl":"10.1016/j.ensci.2025.100555","url":null,"abstract":"","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100555"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
eNeurologicalSciPub Date : 2025-03-01Epub Date: 2025-02-01DOI: 10.1016/j.ensci.2025.100559
Matthew C. Kiernan
{"title":"Recent developments in consensus diagnostic criteria for amyotrophic lateral sclerosis","authors":"Matthew C. Kiernan","doi":"10.1016/j.ensci.2025.100559","DOIUrl":"10.1016/j.ensci.2025.100559","url":null,"abstract":"","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"38 ","pages":"Article 100559"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thalamic deep brain stimulation for postural tremor caused by hyperthermia-induced cerebellar dysfunction: A case report","authors":"Mitsuyoshi Tamura , Shigeki Hirano , Yoshihisa Kitayama , Marie Morooka , Tomoki Suichi , Kazumoto Shibuya , Yoshinori Higuchi , Satoshi Kuwabara","doi":"10.1016/j.ensci.2024.100536","DOIUrl":"10.1016/j.ensci.2024.100536","url":null,"abstract":"<div><h3>Background</h3><div>The efficacy of deep brain stimulation (DBS) in treating tremor symptoms in cerebellar disorders remains unclear.</div></div><div><h3>Case presentation</h3><div>A 47-year-old woman presented with neck and arm tremor and ataxic speech/gait after four days of >40 °C fever due to septic shock attributed to lithiasis-pyelonephritis. Left ventral intermediate nucleus thalamus DBS alleviated contralateral postural arm tremor, although the action tremor and terminal oscillation remained unchanged.</div></div><div><h3>Discussion</h3><div>To our knowledge, this is the first report of thalamic DBS for hyperthermia-induced cerebellar dysfunction. Patients with postural tremor resulting from cerebellar damage can benefit from thalamic DBS, leading to improved activities of daily living.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"37 ","pages":"Article 100536"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}