eNeurologicalSci最新文献

{"title":"Internal carotid artery dissection in a patient with Parkinson's disease after COVID-19 infection","authors":"Takanobu Okubo ,&nbsp;Hidehiro Ishikawa ,&nbsp;Keita Matsuura ,&nbsp;Asako Tamura ,&nbsp;Koichi Miyashita ,&nbsp;Maki Umino ,&nbsp;Masayuki Maeda ,&nbsp;Akihiro Shindo","doi":"10.1016/j.ensci.2024.100529","DOIUrl":"10.1016/j.ensci.2024.100529","url":null,"abstract":"<div><h3>Background</h3><div>Internal carotid artery (ICA) dissection is a relatively rare cause of acute ischemic stroke. Stretching and compression of ICA due to sudden acceleration, deceleration, and rotational forces are risk factors for ICA dissection. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is believed to trigger an inflammatory response that exacerbates endothelial dysfunction and leads to arterial dissection. Although levodopa-induced cervical dyskinesia in Parkinson's disease often manifests as choreiform movement, dissection has not been reported in such patients.</div></div><div><h3>Case presentation</h3><div>A 51-year-old man with Parkinson's disease (PD) presented with gradually worsening neck pain and transient aphasia 1 week after mild coronavirus disease 2019 (COVID-19) infection. The patient already had neck pain due to cervical spondylosis and presented with levodopa-induced cervical dyskinesia. Magnetic resonance imaging revealed acute ischemic stroke in the left parietal lobe and an intramural hematoma with an area of stenosis in the left ICA. The patient was diagnosed with left ICA dissection.</div></div><div><h3>Conclusions</h3><div>COVID-19 infection can cause vessel wall vulnerability. Although patients with PD often have neck pain, ICA dissection should be considered a differential diagnosis if the patient has a recent history of COVID-19.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"37 ","pages":"Article 100529"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142421597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of physical activity on quality of life in patients with epilepsy in a developing country: A cross-sectional, survey-based study","authors":"Daniel San-Juan ,&nbsp;Miguel Benjamín Cervera-Sánchez ,&nbsp;Miguel Angel Morales-Morales ,&nbsp;Emilio Israel Wong-Valenzuela ,&nbsp;Dara Lizeth Torres-Rodríguez ,&nbsp;Daniela Carolina Pimentel-Saona","doi":"10.1016/j.ensci.2024.100533","DOIUrl":"10.1016/j.ensci.2024.100533","url":null,"abstract":"<div><h3>Rationale</h3><div>Patients with epilepsy face different barriers based on ignorance and fear of themselves and others while exercising, this situation complicates attempts at exercise and promotes discrimination against patients. Physical activity has been associated with favorable results in the health of this population and can be used as a non-pharmacological treatment seeking to increase the health and improve living conditions of patients. Our study aims to explore how physical activity impacts quality-of-life perception in these patients.</div></div><div><h3>Methods</h3><div>We performed a cross-sectional, survey-based study conducted at the outpatient Epilepsy Clinic in the National Institute of Neurology and Neurosurgery “Manuel Velasco Suárez”. Patients between 17 and 65 years of age and with an established diagnosis of epilepsy were considered for participation. A 31-item questionnaire was administered to all participants face-to-face or by telephone. The questions included in the survey were selected from the Global Physical Activity Questionnaire and the Quality of Life in Epilepsy Inventory to assess the level of exercise and perceived quality of life of participants. Descriptive and inferential Mann-Whitney <em>U</em> test statistical analysis was done using IBM SPSS Statistics 23.0 software.</div></div><div><h3>Results</h3><div>Participants' mean age was 35.69 ± 11.93 years, 45 % were male and 55 % female. Significant differences were found in the domain of perceived quality of life in the self-reported physically active participants (<em>p</em> = 0.0256; 95 % IC: 1.00–15.22), with a mean score of 75.78 ± 16.64 in the active group vs. 67.66 ± 15.86 in the sedentary group. In those who complied with the exercise recommendations according to the WHO, there was significant evidence of improvement in the general quality of life (<em>p</em> = 0.0032; 95 % IC:4.9–23.9), with a mean score of 75.22 ± 15.92 in the active group vs. 60.76 ± 17.836 in the sedentary group.</div></div><div><h3>Conclusions</h3><div>Physical activity is associated with a significant impact on how patients with epilepsy perceive their quality of life. In addition, it improves memory and concentration in the tasks they perform in their daily lives.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"37 ","pages":"Article 100533"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tiny infarction of rostral cerebellum manifested by contralesional body lateropulsion","authors":"Obay Alalousi ,&nbsp;Mickael Bonnan","doi":"10.1016/j.ensci.2024.100523","DOIUrl":"10.1016/j.ensci.2024.100523","url":null,"abstract":"<div><p>Body lateropulsion (BLP) has been reported several times after cerebellar infarction. It is usually ipsilateral to the cerebellar infarction, particularly when limited to the rostral cerebellum. In contrast, contralesional BLP after cerebellar infarction has been reported in more caudal regions of the cerebellum (such as the nodulus or the tonsil).</p><p>We report the case of a small infarction of the left anterior paravermis of the rostral cerebellum which resulted in bilateral symptoms: ipsilesional limb ataxia and, unexpectedly, contralesional BLP.</p><p>Several neurological pathways were potentially involved. Both right and left dorsal spinocerebellar tracts may have been damaged by the infarction of the left anterior paravermis. On the other hand, the proximity of the infarct to the superior cerebellar peduncle may have caused damage to the vestibular pathways (fastigio-vestibular or dentato-vestibular tracts), as they exit the cerebellum by the superior cerebellar peduncle. A lesion of the cerebellum close to the superior cerebellar peduncle could result in a contralesional BLP.</p></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"37 ","pages":"Article 100523"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405650224000303/pdfft?md5=457b524f5d4cb98e5d9b00ed240d40b0&pid=1-s2.0-S2405650224000303-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IIH, SIH and headache: Diagnosis and treatment update","authors":"Shuu-Jiun Wang","doi":"10.1016/j.ensci.2024.100532","DOIUrl":"10.1016/j.ensci.2024.100532","url":null,"abstract":"<div><div>Idiopathic intracranial hypertension (IIH) and spontaneous intracranial hypotension (SIH) are two major secondary headache disorders resulting from abnormal intracranial pressure (ICP). This short communication outlines the pathophysiology, diagnostic criteria, and management strategies for IIH and SIH. IIH predominantly affects obese women of childbearing age and presents with daily headaches, visual disturbances, and papilledema. It is characterized by elevated cerebrospinal fluid (CSF) pressure, with diagnosis supported by imaging and lumbar puncture. Treatment includes weight reduction, medications, and surgical interventions in refractory cases. SIH, conversely, is caused by spontaneous spinal CSF leaks and presents with acute orthostatic headaches. Diagnosis is supported by neuroimaging and lumbar puncture, revealing low CSF pressure. Treatment includes supported care, (targeted) epidural blood patch, with surgical repair considered in refractory cases. Advances in imaging and treatment have significantly improved outcomes for both conditions.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"37 ","pages":"Article 100532"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular parkinsonism showing dopamine transporter scan findings mimicking those of Parkinson's disease","authors":"Hirotaka Sakuramoto,&nbsp;Hiroaki Fujita,&nbsp;Keitaro Ogaki,&nbsp;Keisuke Suzuki","doi":"10.1016/j.ensci.2024.100528","DOIUrl":"10.1016/j.ensci.2024.100528","url":null,"abstract":"<div><p>Dopamine transporter (DAT) scan is important in the diagnosis of Parkinson's disease (PD). We herein report a patient with vascular parkinsonism (VP) who showed dopamine transporter (DAT) scan findings which mimicked those typically seen in patients with Parkinson's disease (PD). DAT scan findings in patients with VP are characterized by a lower striatal asymmetry index than in patients with PD and decreased uptake in the area consistent with old cerebral infarction or hemorrhage. However, we should be aware that, as in our patient, VP patients with asymmetric basal ganglia lesions, may show increased striatal asymmetry index and asymmetric DAT scan findings.</p></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"37 ","pages":"Article 100528"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405650224000352/pdfft?md5=b1aab43d71f875ab19a490bb60a4b217&pid=1-s2.0-S2405650224000352-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of nerve fiber layer and ganglion cell complex changes in patients with migraine using optical coherence tomography","authors":"Yasmin Walha ,&nbsp;Mona Rekik ,&nbsp;Khadija Sonda Moalla ,&nbsp;Sonda Kammoun ,&nbsp;Omar Ayadi ,&nbsp;Chokri Mhiri ,&nbsp;Mariem Dammak ,&nbsp;Amira Trigui","doi":"10.1016/j.ensci.2024.100525","DOIUrl":"10.1016/j.ensci.2024.100525","url":null,"abstract":"<div><h3>Purpose</h3><p>To analyze changes in peripapillary retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness in migraine patients with and without aura compared to healthy controls and to identify factors influencing the occurrence of these anomalies.</p></div><div><h3>Methods</h3><p>This is a cross-sectional case-control study including migraine patients and control subjects. All patients and controls underwent a complete ophthalmological examination, RNFL and GCC thickness measurements using a spectral domain-OCT device.</p><p>The duration of migraine, the frequency and duration of migraine attacks, the migraine disability assessment (MIDAS) and migraine severity scale (MIGSEV) questionnaire scores were recorded.</p></div><div><h3>Results</h3><p>One hundred and twenty eyes from 60 patients (60 eyes in the migraine without aura (MWoA) group and 60 eyes in the migraine with aura (MWA) group) were included. Control group included 30 age and gender matched healthy participants (60 eyes). OCT revealed that RNFL and GCC thickness were significantly reduced in the migraine without aura (MWoA) and in the migraine with aura (MWA) groups compared to the control group and in the migraine with aura (MWA) group compared to the migraine without aura (MWoA) group. Prolonged disease duration was associated to decreased GCC thickness. RNFL and GCC thickness were correlated to disease severity, attack frequency and duration. In the multivariate study, duration of migraine and attack frequency were the main determinant factors of nasal GCC thickness. Disease severity was the main determinant of RNFL and GCC thickness, with the exception of the nasal sector.</p></div><div><h3>Conclusion</h3><p>Our study emphasize the significant impact of both types of migraine on retinal structures. OCT would serve as a valuable biomarker in migraine.</p></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"37 ","pages":"Article 100525"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405650224000327/pdfft?md5=c10cd63368bef8fc8e2711e33ab5ed0b&pid=1-s2.0-S2405650224000327-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplastic myelitis associated with Waldenström macroglobulinemia responsive to treatment with ibrutinib – venetoclax: A case report","authors":"Sathya Narasimhan ,&nbsp;Kristin M. Galetta ,&nbsp;Jorge J. Castillo ,&nbsp;Shamik Bhattacharyya","doi":"10.1016/j.ensci.2024.100527","DOIUrl":"10.1016/j.ensci.2024.100527","url":null,"abstract":"<div><p>Waldenström macroglobulinemia (WM) is a B-cell lymphoproliferative malignancy characterized by IgM paraproteinemia and presence of lymphoplasmacytic cells in the bone marrow. Isolated longitudinally extensive transverse myelitis (LETM) is a rare manifestation of WM. We report a rare case of paraneoplastic LETM in a 68-year-old male with treatment-naïve WM (MYD88 L265P mutation in bone marrow aspirate), who responded to ibrutinib and venetoclax therapy. Our patient presented with a two-month history of unsteadiness, tingling, and numbness in both hands and feet, that progressed to bilateral leg and arm weakness. Based on radiographic findings, a diagnosis of paraneoplastic LETM was made and he was treated acutely with IV methylprednisolone followed by a quick oral prednisone taper. However, he subsequently relapsed and symptomatically worsened while on rituximab therapy. Accounting for worsening anemia, our patient was enrolled in a Phase II trial evaluating the effects of ibrutinib-venetoclax therapy in treatment naïve WM. After three months of study therapy, he had a complete response of myelopathy symptoms and MRI lesions. Our observation of sustained disease response in this patient may support a role for concurrent BTK and BCL2 inhibition in paraneoplastic myelitis associated with B-cell lymphoproliferative disorders. However, this observation needs to be validated in larger cohort studies and potentially in clinical trials if further data are supportive.</p></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"37 ","pages":"Article 100527"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405650224000340/pdfft?md5=43afc1ecba5891cbfde9596c785398c2&pid=1-s2.0-S2405650224000340-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the clinical landscape of artery of Percheron infarction: A systematic review","authors":"Oday Atallah ,&nbsp;Yasser F. Almealawy ,&nbsp;Arwa Salam Alabide ,&nbsp;Minaam Farooq ,&nbsp;Vivek Sanker ,&nbsp;Suraa N. Alrubaye ,&nbsp;Rami Darwazeh ,&nbsp;Wireko Andrew Awuah ,&nbsp;Toufik Abdul-Rahman ,&nbsp;Ahmed Muthana ,&nbsp;Aalaa Saleh ,&nbsp;Jack Wellington ,&nbsp;Amr Badary","doi":"10.1016/j.ensci.2024.100521","DOIUrl":"10.1016/j.ensci.2024.100521","url":null,"abstract":"<div><h3>Introduction</h3><p>Infarction of the artery of Percheron (AOP) is a rare vascular condition where a single arterial branch supplies blood to the thalamic and midbrain regions, leading to neurological deficits. The challenge lies in its often-delayed diagnosis due to its rarity and diverse clinical presentations, necessitating heightened awareness among clinicians for expedited diagnosis and appropriate therapeutic interventions.</p></div><div><h3>Materials and methods</h3><p>All relevant studies involving patients diagnosed with infarction of AOP were retrieved from PubMed, Google Scholar, Web of Science, and Scopus. Only human studies that were published in full English-language reports were included. Included in the search were the terms “Artery of Percheron,” “infarction,” “stroke,” and “demarcation”. Age, gender, presenting symptoms, treatment, recovery time, and outcome of patients with AOP infarction were all recorded.</p></div><div><h3>Results</h3><p>A systematic review was conducted on a total of 530 articles, out of which 130 articles met the specified requirements. The average age is 59, with men comprising 57.7% of the population. The symptoms reported were visual disturbance in 43.9% of cases and changed mental state in 77.2% of cases. Treatment options include conservative management (85.4%), thrombolysis (11.3%), and other approaches. The optimal age range for recovery is between 41 and 50 years old.</p></div><div><h3>Conclusion</h3><p>Our study on acute AOP infarction highlights male predominance, common comorbidities like hypertension and diabetes, and prevalent symptoms including visual disturbance and altered mental state. Early recognition is crucial, with thrombolytic therapy within the critical time window showing promising outcomes. These findings offer insights for enhanced clinical management of AOP infarction.</p></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"37 ","pages":"Article 100521"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405650224000285/pdfft?md5=254de266619eecf40f4fc4ea54192342&pid=1-s2.0-S2405650224000285-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double trouble: The intersection of neurobrucellosis and systemic lupus erythematosus in a 24-year-old female","authors":"Hashim Talib Hashim ,&nbsp;Aws Murad Frhood ,&nbsp;Ahmed Abdulhussain Shahatta ,&nbsp;Ahmed Dheyaa Al-Obaidi ,&nbsp;Arshed Shakir Kadim","doi":"10.1016/j.ensci.2024.100531","DOIUrl":"10.1016/j.ensci.2024.100531","url":null,"abstract":"<div><h3>Background</h3><div>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs, while brucellosis is a zoonotic infection prevalent in endemic areas. Neurobrucellosis, a severe complication of brucellosis, can mimic or coexist with autoimmune conditions like SLE, complicating diagnosis and treatment. This case report highlights the diagnostic challenges and management strategies for such overlapping diseases.</div></div><div><h3>Case presentation</h3><div>In this case report, we present a 24-year-old female who initially presented with symptoms that were misleadingly attributed to a simple vaginal ulcer. Her clinical course evolved to include migratory polyarthralgia, nocturnal fevers, and significant weight loss, eventually culminating in severe headaches and dizziness that led to a diagnosis of meningitis. Comprehensive diagnostic work-up, including the presence of a malar rash, positive anti-dsDNA antibodies, and elevated inflammatory markers, pointed towards SLE. However, the identification of bacterial infection markers in the cerebrospinal fluid (CSF) and her history of animal contact in an endemic area led to the diagnosis of neurobrucellosis. The patient's remarkable response to doxycycline and rifampicin confirmed the infectious etiology, highlighting the complex interplay between these two diseases.</div></div><div><h3>Conclusion</h3><div>The intersection of SLE and neurobrucellosis in this patient underscores the importance of a multidisciplinary approach to diagnosis and treatment, ensuring that both the autoimmune and infectious aspects of the patient's condition are adequately addressed. This case contributes valuable insights into the management of such rare and complex presentations, emphasizing the need for vigilance and adaptability in clinical practice.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"37 ","pages":"Article 100531"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142421598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobehavioral features in medication-overuse headache","authors":"Franz Riederer ,&nbsp;Roberto Pirrotta ,&nbsp;Chantal Martin Soelch ,&nbsp;Andreas R. Gantenbein ,&nbsp;Adrian Scutelnic ,&nbsp;Antonia Klein ,&nbsp;Christoph J. Schankin ,&nbsp;Peter S. Sándor","doi":"10.1016/j.ensci.2024.100538","DOIUrl":"10.1016/j.ensci.2024.100538","url":null,"abstract":"<div><h3>Background</h3><div>Medication-overuse headache (MOH) has been related to the spectrum of dependence behavior and impaired orbitofrontal cortex function. Alexithymia is a trait comprising deficits in identifying self-emotions and perception. It was the aim of the study to investigate impulsivity and alexithymia, in patients with MOH and perform correlations with cerebral grey matter.</div></div><div><h3>Material and methods</h3><div>Patients with chronic migraine and MOH according to ICHD criteria from a tertiary headache clinic and healthy controls were investigated by a single psychiatrist, using clinical scales for self-control (BIS-11) and alexithymia (TAS-20) and screened for dependence based on DSM-IV criteria. Correlations of BIS-11 and TAS-20 with cerebral grey matter were analysed with the SPM based toolbox CAT12, using high resolution T1weighted MRI-Sequences acquired on a 3 T scanner.</div></div><div><h3>Results</h3><div>MRI data were available from 30 MOH patients (24 women) and 47 healthy controls (26 women). MOH patients had increased impulsivity (62.2 ± 11.1 vs. 55.7 ± 7.2; <em>p</em> = 0.007) and alexithymia (49.8 ± 14.8 vs. 38.0 ± 6.5; <em>p</em> &lt; 0.001). Analyzing only women, the results remained significant. Ninety percent of patients fulfilled DSM-IV criteria for substance dependence. There was a positive correlation between impulsivity and grey matter in the left middle orbital gyrus in healthy controls but not in patients (<em>p</em> &lt; 0.05, corrected). No correlations with alexithymia and cerebral grey matter were found.</div></div><div><h3>Conclusions</h3><div>The present study suggests a neurobehavioral basis for MOH, consisting of impaired impulse control, and self-perception along with features of substance dependence. Although decreased orbitofrontal cortex volume was confirmed in this MOH cohort, impulsivity and alexithymia were not correlated with this structural abnormality.</div></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"37 ","pages":"Article 100538"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}