Journal of Cellular Neuroscience and Oxidative Stress最新文献_第4页

Reactive oxygen species and cancer 活性氧和癌症

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818606-0.00030-4

Hyewon Kong, N. Chandel

引用次数: 1

Copyright 版权

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818606-0.09995-8

引用次数: 0

Redox distress in organ fibrosis: The role of noncoding RNAs 器官纤维化中的氧化还原应激:非编码rna的作用

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818606-0.00037-7

V. Miguel, S. Lamas

引用次数: 1

Index 指数

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818606-0.09988-0

引用次数: 0

The effects of quercetin on antioxidant and cytokine levels in rat hippocampus exposed to acute cadmium toxicity 槲皮素对急性镉中毒大鼠海马抗氧化及细胞因子水平的影响

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2019-06-27 DOI: 10.37212/JCNOS.584684

I. Kisadere, N. Dönmez, H. H. Dönmez

{"title":"The effects of quercetin on antioxidant and cytokine levels in rat hippocampus exposed to acute cadmium toxicity","authors":"I. Kisadere, N. Dönmez, H. H. Dönmez","doi":"10.37212/JCNOS.584684","DOIUrl":"https://doi.org/10.37212/JCNOS.584684","url":null,"abstract":"The aim of this study was to determine cadmium neurotoxicity (Branca et al. 2018) and beneficial effect of quercetin (QE) (Kanter et al. 2016) against on neuronal damage in hippocampus exposed with acute cadmium (Cd). Adult male Wistar-Albino rats (n = 30) were used and divided into four groups as Control (C, n = 6), Cadmium (Cd, n = 8), Quercetin (Q, n = 8) and Cadmium + Quercetin (Cd + Q, n = 8). Cadmium (CdCl2, 4 mg kg-1 daily, s.c) were administrated to Cd and Cd+Q groups, and Quercetin (Q, 50 mg kg-1 daily, i.p) were administrated to Q and Cd + Q groups for 3 days, respectively. At 4th day after the treatments, hippocampal samples were taken from the four groups. Cadmium decreased superoxide dismutase (SOD) and reduced glutathione (GSH) levels and the SOD activity and GSH level were markedly (p< 0.05) lower in Cd group than in the Q and C groups. Lipid peroxidation (MDA) levels were higher in Cd group when compared to the control, Q and Cd+Q groups. IL1 levels were found statistically higher in Cd group than in the control, Q and Cd+Q groups. IL-6 and TNF-alfa levels were significantly (p< 0.05) higher in Cd and Cd+Q groups than the Q and C groups. In addition, IL10 levels were detected the lowest in Cd group when compared to other groups. In conclusion, our results show that quercetin can be beneficial against to neurotoxic effects of acute cadmium toxicity in the rat hippocampus through upregulation of antioxidant system but down regulation of cytokine levels.","PeriodicalId":37782,"journal":{"name":"Journal of Cellular Neuroscience and Oxidative Stress","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43548840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Aggregates of α-synuclein in brain tissue homogenates measured by newly designed Multimer-PAGE techniques 新设计的Multimer PAGE技术测定脑组织匀浆中α-突触核蛋白的聚集

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2019-06-27 DOI: 10.37212/JCNOS.584670

J. Saleh

引用次数: 1

Effect of stress on alteration of haematological parameters: A preliminary study on preclinical medical students in Malaysia 压力对血液学参数变化的影响：对马来西亚临床前医学生的初步研究

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2019-06-23 DOI: 10.37212/jcnos.683403

Mohammad A. I. Al-Hatamleh, Imilia Ismail, Omar Mahmoud Al-shajrawi, T. M. Ariff

{"title":"Effect of stress on alteration of haematological parameters: A preliminary study on preclinical medical students in Malaysia","authors":"Mohammad A. I. Al-Hatamleh, Imilia Ismail, Omar Mahmoud Al-shajrawi, T. M. Ariff","doi":"10.37212/jcnos.683403","DOIUrl":"https://doi.org/10.37212/jcnos.683403","url":null,"abstract":"The present study aimed to evaluate the effect of stress on haematological parameters among preclinical medical students. A cross-sectional study has been conducted on a total of 105 preclinical medical students at Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Terengganu, Malaysia. The validated depression anxiety stress scales-21 (DASS-21) questionnaire was distributed and blood samples were collected from the subjects on the same day to perform full blood count (FBC) test. There was no significant association between levels of stress with red blood cells (RBCs) count and indices. However, a significant negative association was identified between stress level and white blood cells (WBCs) count (r= - 0.204, p ≤ 0.05). Furthermore, no significant association was found between levels of stress and platelets count and indices, except the mean platelets volume (MPV); a significant positive association between students measured MPV and their perceived stress (r= 0.195, p ≤ 0.05) has been noted. Mean WBCs count was decreased, while mean MPV was increased with increasing stress levels. Furthermore, the structural equation model predicted that some parameters were near to be significantly associated with stress, which needs further investigation. This study provided novel insights about the potential effects of stress on blood cells and platelets. The results will help the researchers to uncover the critical areas of increasing ROS and oxidative stress caused by chronic life stress.","PeriodicalId":37782,"journal":{"name":"Journal of Cellular Neuroscience and Oxidative Stress","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45696638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Experimental cell culture models for investigating neurodegenerative diseases 研究神经退行性疾病的实验细胞培养模型

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2019-06-23 DOI: 10.37212/JCNOS.683400

A. Öz

{"title":"Experimental cell culture models for investigating neurodegenerative diseases","authors":"A. Öz","doi":"10.37212/JCNOS.683400","DOIUrl":"https://doi.org/10.37212/JCNOS.683400","url":null,"abstract":"Neurological disorders are an important cause of mortality and constitute 11.84% of total deaths globally according to WHO data 2015. It is estimated to increase up to 12.22% in year 2030. Most common NDs can be account for four main groups such as Alzheimer’s disease (AD), Amyotrophic Lateral Sclerosis (ALS), Huntington’s disease (HD) and Parkinson’s disease (PD). Among these diseases, only AD is the seventh common death cause worldwide and until recently the therapeutic approaches are still lack to decrease of prevalence. Hence, developing new strategies to understand molecular targets or break down to cascade of cellular degenerative process in the neurodegeneration should be investigated by future studies. In cell culture studies, many types of tissues and cells can be cultivated to be a minimized model to normal or pathophysiological status of disorders. There are lots of methodology or technique to compose efficient and respective neurodegenerative disease models in cell lines such as COS-7, HC2S2, HEK-293, HeLa, Neuro-2a, NSC-34, PC-12, and SH-SY5Y. We indicated best medium formula to growth of neuronal cells as well as differentiation chemicals and time/dosages. In the review it was aimed to summarize not only give information about cell lines, methodological procedures and molecular mechanisms of the diseases but also represent future perspective and offers to this field of neuroscience research.","PeriodicalId":37782,"journal":{"name":"Journal of Cellular Neuroscience and Oxidative Stress","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45247539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Microglia and its role in neurodegenerative diseases 小胶质细胞及其在神经退行性疾病中的作用

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2019-06-23 DOI: 10.37212/jcnos.683407

Kenan Yıldızhan, M. Nazıroğlu

{"title":"Microglia and its role in neurodegenerative diseases","authors":"Kenan Yıldızhan, M. Nazıroğlu","doi":"10.37212/jcnos.683407","DOIUrl":"https://doi.org/10.37212/jcnos.683407","url":null,"abstract":"Microglia are immune cells colonized in the central nervous system (CNS) during the development of the embryo. They make up about 12% of the glial cell population in the brain. These cells play an important role in eliminating the damage that may occur in the CNS or in carrying out normal functions. Microglia cells, which are in morphologically inactive form, are characterized by small cell body, small amounts of cytoplasm and cellular extensions that are released towards the environment. They undergo a significant morphological change and switch to the active form in a pathophysiological condition in the CNS, and they have the ability to migrate to the damaged area by ameboid movement. In today's studies, microglial cells in the active form has been stated to show neuroprotective and neurotoxic effects in neuronal structures in addition to carrying out phagocytosis of metabolic residues in the medium. It has also been mentioned in recent studies that microglial cells located in the CNS have a highly sensitive activation mechanism against inflammation and pathological conditions. Understanding the microglial activation mechanism in neurodegenerative diseases is thought to may contribute to the diagnosis / treatment of neurological diseases as well as being a diagnostic marker for the etiology of the diseases. In this review, the general characteristics and activation mechanism of microglial cells and their functional roles in Alzheimer's, Parkinson's, epilepsy and multiple sclerosis diseases were discussed in the current review.","PeriodicalId":37782,"journal":{"name":"Journal of Cellular Neuroscience and Oxidative Stress","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44385537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Ischemic stroke models in adult experimental animals 成年实验动物的缺血性脑卒中模型

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2019-06-21 DOI: 10.37212/jcnos.584699

A. Coşar

{"title":"Ischemic stroke models in adult experimental animals","authors":"A. Coşar","doi":"10.37212/jcnos.584699","DOIUrl":"https://doi.org/10.37212/jcnos.584699","url":null,"abstract":"Hypoxic-ischemia is containing complex physiological, molecular and biochemical pathways and it is induced by lack of oxygen supply to the brain. Hypoxic ischemia induces severe brain injury in adults and newborns. Pathophysiology of ischemic stroke involves oxidative stress, mitochondrial energy production failure, excessive Ca2+ influx and apoptosis (Akpinar, et al., 2016). Investigation of the traumatic brain injuries in the subject are difficult due to ethical restrictions. Therefore, the animal models have great importance for the clarifying etiology of the ischemic stroke-induced brain injuries. However, there are differences between human rodent brains. Notable difference between the human and rodent is presence of developing brain (Gennaro et al. 2019). In experimental animals, the best model of induction of hypoxic cerebral ischemic stroke is occlusion of the middle cerebral artery for 30-60 min (Gennaro et al. 2019). In addition to the best model, there are also other models of hypoxic cerebral stroke in rodents such as hypoxiaischemia, thrombotic ischemia, vasoconstriction. Endothelin 1 and the distal artery compression models (Gennaro et al. 2019; Hermann et al. 2019). In this presentation, I summarized the models currently used to investigate the human developmental ischemic stroke, describing their advantages and limitations.","PeriodicalId":37782,"journal":{"name":"Journal of Cellular Neuroscience and Oxidative Stress","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48862879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0