Effect of stress on alteration of haematological parameters: A preliminary study on preclinical medical students in Malaysia

Q4 Biochemistry, Genetics and Molecular Biology

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2019-06-23 DOI:10.37212/jcnos.683403

Mohammad A. I. Al-Hatamleh, Imilia Ismail, Omar Mahmoud Al-shajrawi, T. M. Ariff

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引用次数: 5

Abstract

The present study aimed to evaluate the effect of stress on haematological parameters among preclinical medical students. A cross-sectional study has been conducted on a total of 105 preclinical medical students at Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Terengganu, Malaysia. The validated depression anxiety stress scales-21 (DASS-21) questionnaire was distributed and blood samples were collected from the subjects on the same day to perform full blood count (FBC) test. There was no significant association between levels of stress with red blood cells (RBCs) count and indices. However, a significant negative association was identified between stress level and white blood cells (WBCs) count (r= - 0.204, p ≤ 0.05). Furthermore, no significant association was found between levels of stress and platelets count and indices, except the mean platelets volume (MPV); a significant positive association between students measured MPV and their perceived stress (r= 0.195, p ≤ 0.05) has been noted. Mean WBCs count was decreased, while mean MPV was increased with increasing stress levels. Furthermore, the structural equation model predicted that some parameters were near to be significantly associated with stress, which needs further investigation. This study provided novel insights about the potential effects of stress on blood cells and platelets. The results will help the researchers to uncover the critical areas of increasing ROS and oxidative stress caused by chronic life stress.

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压力对血液学参数变化的影响：对马来西亚临床前医学生的初步研究

本研究旨在评估压力对临床前医学生血液学参数的影响。对马来西亚丁加奴苏丹·扎纳尔·阿比丁大学(UniSZA)医学院的105名临床前医学院学生进行了横断面研究。发放经验证的抑郁焦虑压力量表-21 (DASS-21)问卷，并于当日采血进行全血细胞计数(FBC)检测。应激水平与红细胞(rbc)计数和指标之间无显著相关性。应激水平与白细胞(wbc)计数呈显著负相关(r= - 0.204, p≤0.05)。此外，除了平均血小板体积(MPV)外，应激水平与血小板计数和其他指标之间没有显著关联;学生MPV测量值与压力感知呈显著正相关(r= 0.195, p≤0.05)。随着应激水平的升高，平均白细胞计数降低，而平均MPV升高。此外，结构方程模型预测某些参数与应力的关系接近显著，有待进一步研究。这项研究为应激对血细胞和血小板的潜在影响提供了新的见解。该结果将有助于研究人员揭示慢性生活压力引起的ROS和氧化应激增加的关键区域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cellular Neuroscience and Oxidative Stress Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Journal of Cellular Neuroscience and Oxidative Stress isan online journal that publishes original research articles, reviews and short reviews on themolecular basisofbiophysical,physiological and pharmacological processes thatregulate cellular function, and the control or alteration of these processesby theaction of receptors, neurotransmitters, second messengers, cation, anions,drugsor disease. Areas of particular interest are four topics. They are; 1. Ion Channels (Na+-K+Channels, Cl– channels, Ca2+channels, ADP-Ribose and metabolism of NAD+,Patch-Clamp applications) 2. Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) 3. Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD+ on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson’s and Alzheimer’s diseases) 4. Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)