HardwareX最新文献_第4页

Development of a robotic-assisted handling and manipulation system for the high-scale bioproduction of 3D-bioprinted organ-on-a-chip devices 开发用于大规模生物生产三维生物打印片上器官设备的机器人辅助处理和操纵系统

IF 2

HardwareX Pub Date : 2024-08-22 DOI: 10.1016/j.ohx.2024.e00572

Nils Lindner , Andres Mejia-Wille , Anna Fritschen , Andreas Blaeser

{"title":"Development of a robotic-assisted handling and manipulation system for the high-scale bioproduction of 3D-bioprinted organ-on-a-chip devices","authors":"Nils Lindner , Andres Mejia-Wille , Anna Fritschen , Andreas Blaeser","doi":"10.1016/j.ohx.2024.e00572","DOIUrl":"10.1016/j.ohx.2024.e00572","url":null,"abstract":"<div><p>Organs-on-a-chip (OoCs) have proven to mimic the basic physiological behavior of organs and the influence of therapeutics on them in greater detail than conventional models, resulting in enormous projected market growth rates. However, the breakthrough to profitable commercialization of that technology has not yet been achieved, partly because the production process chain is characterized by a high proportion of manual laboratory work. The present work addresses this point. Utilizing affordable components, a demonstrator was developed that can be integrated into an existing 3D-bioprinting system and enables the automated production of perfusion-ready OoC devices starting from pre-fabricated injection-molded microfluidic chips. To this end, a corresponding process chain was first defined, and an expandable, configurable algorithm was developed and validated in the form of a finite state machine (FSM). This algorithm controls a modified 4-axis robot arm that covers the steps upstream and downstream of the printing process in the manufacturing process and achieves success rates of up to 100 %. A virtual interface between the robot and printer enables mutual communication and full integration of the algorithm into the process chain. Steps that pose a challenge for the automation of the process chain and appropriate countermeasures and optimizations were identified. This lays the foundation for scaling and standardizing the automated production of OoCs.</p></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S246806722400066X/pdfft?md5=9cc74006f150a61876809147fee64423&pid=1-s2.0-S246806722400066X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A customizable digital holographic microscope 可定制的数字全息显微镜

IF 2

HardwareX Pub Date : 2024-08-13 DOI: 10.1016/j.ohx.2024.e00569

Claudia Ravasio , Luca Teruzzi , Mirko Siano , Llorenç Cremonesi , Bruno Paroli , Marco A.C. Potenza

{"title":"A customizable digital holographic microscope","authors":"Claudia Ravasio , Luca Teruzzi , Mirko Siano , Llorenç Cremonesi , Bruno Paroli , Marco A.C. Potenza","doi":"10.1016/j.ohx.2024.e00569","DOIUrl":"10.1016/j.ohx.2024.e00569","url":null,"abstract":"<div><p>We propose a compact, portable, and low-cost holographic microscope designed for the characterization of micrometric particles suspended in a liquid. This system is built around a commercial optical microscope by substituting its illumination source (a light-emitting diode) with a collimated laser beam. Similarly, a quartz flow cell replaces the microscope glass slide using a 3D-printed custom mount. With the hardware presented in this paper, the holographic imaging of the electromagnetic fields emitted by the particles that intercept the laser beam achieves a resolution close to that of optical microscopes but with a greater depth of field. Several morphological and optical features can be extracted from the holograms, including particle projected section, aspect ratio, and extinction cross-section. Additionally, we introduce a remote system control that enables users to process the acquired holograms on a remote computational device. This work provides a comprehensive description of the methodology of image processing in holographic microscopy and a series of validation measurements conducted using calibrated particles. This technique is suitable for the characterization of airborne particles found in snow, firn, and ice; here we report experimental results obtained from Alpine ice cores.</p></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468067224000634/pdfft?md5=32242a7fc54507f92b0df2177c6c2c1f&pid=1-s2.0-S2468067224000634-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OpenHW3 – An open-source, low-cost temperature-controlled orbital shaker OpenHW3 - 一种开源、低成本的温控轨道振动器

IF 2

HardwareX Pub Date : 2024-08-13 DOI: 10.1016/j.ohx.2024.e00570

Matthew Hollingham, Yi Xiang, Titus Reed, Juan Pablo Gevaudan

{"title":"OpenHW3 – An open-source, low-cost temperature-controlled orbital shaker","authors":"Matthew Hollingham, Yi Xiang, Titus Reed, Juan Pablo Gevaudan","doi":"10.1016/j.ohx.2024.e00570","DOIUrl":"10.1016/j.ohx.2024.e00570","url":null,"abstract":"<div><p>The current lack of standardized testing methods to assess the binding isotherms of ions in cement and concrete research leads to uncontrolled variability in these results. In this study, an open-source and low-cost apparatus, named OpenHW3, is proposed to accurately measure the binding isotherms of ions in various cementitious material systems. OpenHW3 provides two main options, a temperature-controlled orbital shaker, as well as an option to retrofit a commercial orbital shaker for temperature control. The effectiveness of these device options is validated via comparison with conventional binding isotherms experiments. The binding isotherm results were comparable to conventional Waterbath shakers, while providing more reliable results compared to horizontal commercial shakers. It also provided accurate temperature control between 25 °C and 75 °C. The results here are critical for allowing open access to scientific equipment, and providing high-quality binding isotherm data for reliable service life models of urban infrastructure assets throughout the world.</p></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468067224000646/pdfft?md5=a9e5ffd97c71660aaf2bf133dcfc7023&pid=1-s2.0-S2468067224000646-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-cost, mobile EEG hardware for SSVEP applications 用于 SSVEP 应用的低成本移动脑电图硬件

IF 2

HardwareX Pub Date : 2024-08-10 DOI: 10.1016/j.ohx.2024.e00567

M. Kancaoğlu, M. Kuntalp

{"title":"Low-cost, mobile EEG hardware for SSVEP applications","authors":"M. Kancaoğlu, M. Kuntalp","doi":"10.1016/j.ohx.2024.e00567","DOIUrl":"10.1016/j.ohx.2024.e00567","url":null,"abstract":"<div><p>The global shortage of integrated circuits due to the COVID-19 pandemic has made it challenging to build biopotential acquisition devices like electroencephalography (EEG) hardware. To address this issue, a new hardware system using common ICs has been designed, which is cost-effective, precise, and easily accessible from global distributors. The hardware system comprises 8-channel inputs EEG hardware with a mobile headset capable of acquiring 5-30Hz EEG signals. First two channels of the design is enabled for steady-state visual evoked potential (SSVEP) operations, and the remaining channels can be powered up as needed. A small 3D-printable enclosure is also designed for the hardware board, which is attached to protective glasses to be used as a head-mounted device. The board includes an additional green LED, 4 pulse width modulation (PWM) outputs for general-purpose input/output (GPIO), 2 buttons for input, and exposed programming pins and digital-to-analog converter (DAC) output from the microcontroller unit (MCU). The proposed hardware system is expected to enable students and young researchers to experiment with EEG signals, especially SSVEP, before investing in professional equipment with the availability of programming codes.</p></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468067224000610/pdfft?md5=b46ca8b5f6ff44237844514be70a75d3&pid=1-s2.0-S2468067224000610-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Open-source cold and hot scientific sheet press for investigating polymer-based material properties 用于研究聚合物材料性能的开源冷热科学片材压机

IF 2

HardwareX Pub Date : 2024-08-08 DOI: 10.1016/j.ohx.2024.e00566

Morgan C. Woods , Cameron K. Brooks , Joshua M. Pearce

{"title":"Open-source cold and hot scientific sheet press for investigating polymer-based material properties","authors":"Morgan C. Woods , Cameron K. Brooks , Joshua M. Pearce","doi":"10.1016/j.ohx.2024.e00566","DOIUrl":"10.1016/j.ohx.2024.e00566","url":null,"abstract":"<div><p>To produce samples for both material testing and molded sheets/parts, this article details an open-source scientific cold and hot press design. It consists of two independent and modular upper and lower plate (929 cm<sup>2</sup>) assemblies each containing four 125 W insulated steel strip heaters. The steel housing for these heaters is entirely modular and designed for ease of manufacture, assembly, and customization. This system allows a researcher with access to a hydraulic press to repurpose existing equipment into a multipurpose hot and cold press, or if an independent machine is warranted, an additional welded support frame and commercially available bottle jack offer standalone operation. By utilizing this small-scale hot press either in conjunction with a hydraulic press or on its own, samples can be produced to determine the critical material properties of any polymer, composite, or polymer blend. A series of modular molds allow for the rapid production of flat sheet stock and solid testing samples adhering to the ASTM D695 standard for rigid plastics tested in compression and ASTM D638 standard for testing plastics in tension. The sheet mold offers the user the ability to produce stock sheets that can be cut and assembled into 2.5-D applications with post processing.</p></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468067224000609/pdfft?md5=fcdc3df69632c08ca4f761cf1e1b9b39&pid=1-s2.0-S2468067224000609-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and construction of a low-cost compressive loading and perfusion flow bioreactor 设计和建造低成本压缩加载和灌注流生物反应器

IF 2

HardwareX Pub Date : 2024-07-25 DOI: 10.1016/j.ohx.2024.e00565

Alexis Graham , Charlotte Thompson , Darrock Flynn , Honor Elchos , Jaydon Gibson , Lauren B. Priddy , Matthew W. Priddy

引用次数: 0

The Perry project: A versatile low-cost syringe pump for dispensing in automated synthesis systems 佩里项目：用于自动合成系统配料的多功能低成本注射泵

IF 2

HardwareX Pub Date : 2024-07-25 DOI: 10.1016/j.ohx.2024.e00562

Jakob Rørbæk Saugbjerg, Thorbjørn Bøgh Jensen, Martin Lahn Henriksen

引用次数: 0

Design and characterization of a low-cost particle image velocimetry system 低成本粒子图像测速系统的设计与鉴定

IF 2

HardwareX Pub Date : 2024-07-24 DOI: 10.1016/j.ohx.2024.e00563

Frederick Kojo Chaway Acquah, Jeremiah Paul Konadu Takyi, Heather R. Beem

{"title":"Design and characterization of a low-cost particle image velocimetry system","authors":"Frederick Kojo Chaway Acquah, Jeremiah Paul Konadu Takyi, Heather R. Beem","doi":"10.1016/j.ohx.2024.e00563","DOIUrl":"10.1016/j.ohx.2024.e00563","url":null,"abstract":"<div><p>Particle Image Velocimetry (PIV) is considered the gold standard technique for flow visualization. However, its cost (at least tens of thousands of dollars) can prove inhibitive in its standard form. This article presents an alternative design, leveraging off-the-shelf and open-source options for each key component involved: camera, laser module, optical components, tracer particles, and analysis software. Flow visualization is a crucial technique to connect theory to practice in teaching and researching fluid mechanics. Despite the ubiquity of this field within engineering curricula, many undergraduate institutions globally forego utilizing such equipment, given the barriers to setting it up. The availability of this low-cost alternative (∼$500) that can be built in-house offers a path forward. Characterization was done by visualizing the rotational flow generated by a magnetic stirrer in a cylindrical beaker. The velocity magnitude around the stirrer bar measured by the low-cost PIV system was compared to expected values calculated analytically. The percent difference was between 1–2% when the flow stayed two-dimensional but increased as the flow began developing into more of a 3-D flow. Repeatability varied no more than 6% between experiments. This platform holds the potential for reliable replication across institutions broadly.</p></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468067224000579/pdfft?md5=2c5df693befc5699c04626b9ebaa95a0&pid=1-s2.0-S2468067224000579-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Open-source design of low-cost sensorised elastic actuators for collaborative prosthetics and orthotics 用于协作假肢和矫形器的低成本传感器化弹性致动器的开源设计

IF 2

HardwareX Pub Date : 2024-07-23 DOI: 10.1016/j.ohx.2024.e00564

Filippo Sanfilippo, Martin Økter, Jørgen Dale, Hua Minh Tuan, Muhammad Hamza Zafar, Morten Ottestad

{"title":"Open-source design of low-cost sensorised elastic actuators for collaborative prosthetics and orthotics","authors":"Filippo Sanfilippo, Martin Økter, Jørgen Dale, Hua Minh Tuan, Muhammad Hamza Zafar, Morten Ottestad","doi":"10.1016/j.ohx.2024.e00564","DOIUrl":"10.1016/j.ohx.2024.e00564","url":null,"abstract":"<div><p>Collaborative robots, or cobots, have become popular due to their ability to safely operate alongside humans in shared environments. These robots use compliant actuators as a key design element to prevent damage during unintended collisions. In prosthetic and orthotic applications, compliant actuators are crucial for ensuring user safety and comfort. However, most compliant cobots for these applications are excessively expensive and complex to construct. Our study introduces an innovative, cost-effective, and sensorised elastic actuator design tailored for prosthetics and orthotics. The design uses a modular approach and leverages 3D printing technology for rapid customisation, enabling efficient and affordable fabrication. Both hardware and software components are open-source, facilitating unrestricted access for students, researchers, and practitioners. Our design supports impedance and admittance control techniques, enhancing the system’s capabilities. Validation results show a standard deviation of 9.67 Nm between calculated and measured torque in impedance control and 0.2563 radians between calculated and measured angles in admittance control. This allows for improved adaptability to varying operational requirements in prosthetics and orthotics. By introducing this educational framework encompassing a low-cost, sensorised elastic actuator design, we aim to address the need for accessible solutions in the field of collaborative robotics for prosthetics and orthotics.</p></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468067224000580/pdfft?md5=188ce0d1dd2fe332ff97f9f77a1b2443&pid=1-s2.0-S2468067224000580-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and implementation of a cost-effective, open-source, and programmable pulsatile flow system 设计并实现经济高效、开源和可编程的脉动流量系统

IF 2

HardwareX Pub Date : 2024-07-21 DOI: 10.1016/j.ohx.2024.e00561

Sanna E. Herwald , Daniel Y. Sze , Daniel B. Ennis , Alexander M. Vezeridis

引用次数: 0