Current Sleep Medicine Reports最新文献

Recent Progress in Omics Studies of Sleep and Circadian Phenotypes. 睡眠与昼夜表型组学研究进展。

IF 1.5

Current Sleep Medicine Reports Pub Date : 2025-12-01 Epub Date: 2025-04-15 DOI: 10.1007/s40675-025-00335-x

Ziqing Wang, Tamar Sofer

{"title":"Recent Progress in Omics Studies of Sleep and Circadian Phenotypes.","authors":"Ziqing Wang, Tamar Sofer","doi":"10.1007/s40675-025-00335-x","DOIUrl":"https://doi.org/10.1007/s40675-025-00335-x","url":null,"abstract":"Purpose of review: Sleep and circadian biology is fundamental to human health. Following the advancement in sleep medicine and availability of multi-omics technology, this review outlines the current knowledge regarding genetic basis and multi-omics research on circadian rhythm and the two most prevalent sleep disorders, obstructive sleep apnea (OSA) and insomnia.Recent findings: Genome wide association analyses identified variants across circadian genes and genes pertinent to inflammation, obesity and neuronal function associated with OSA and insomnia. Multi-omics integration has led to novel breakthroughs in identifying systemic biomarkers and elucidating cascades, and causal associations underpinning these complex traits.Summary: Multi-omics studies in sleep and circadian rhythm possess great potential in unveiling molecular mechanisms behind circadian rhythm and sleep, thereby advancing personalized medicine in the long term. Nevertheless, researchers should remain mindful of existing challenges in genetic and multi-omics sleep research, including data harmonization and existing racial and ethnic disparities in data collection and availability, limiting research generalizability.","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"11 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daytime Napping in Adults: Benefits or Risks? Insights from Mendelian Randomization Studies. 成年人白天午睡：益处还是风险？孟德尔随机化研究的启示。

IF 1.5

Current Sleep Medicine Reports Pub Date : 2025-01-01 Epub Date: 2025-04-26 DOI: 10.1007/s40675-025-00333-z

Aarohi Gupta, Hassan S Dashti

{"title":"Daytime Napping in Adults: Benefits or Risks? Insights from Mendelian Randomization Studies.","authors":"Aarohi Gupta, Hassan S Dashti","doi":"10.1007/s40675-025-00333-z","DOIUrl":"10.1007/s40675-025-00333-z","url":null,"abstract":"Purpose of review: Daytime napping, a brief sleep episode during the day, has mixed health effects. This review explores the relationship between daytime napping frequency and health outcomes by synthesizing results from published Mendelian randomization (MR) studies, which help mitigate confounding and reverse causality commonly observed in traditional epidemiological research.Recent findings: A total of 35 studies spanning seven major disease categories were identified, with cardiovascular, neurological, and metabolic outcomes being the most frequently investigated in MR. Of the 89 tested outcomes, 36% of studies suggested increased disease risk with more frequent daytime napping, 54% reported no associations, and 10% suggested decreased disease risk with more frequent daytime napping. Not all MR findings align with existing epidemiological research.Summary: The current evidence from MR does not provide a definitive conclusion regarding the health effects of daytime napping. Future research should consider additional dimensions of napping beyond frequency and integrate both genetic and non-genetic approaches in diverse populations.","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"11 ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating Assessment of Circadian Rhythmicity to Improve Treatment Outcomes for Circadian Rhythm Sleep-Wake Disorders: Updates on New Treatments. 综合评估昼夜节律性以改善昼夜节律睡眠-觉醒障碍的治疗结果：新治疗方法的最新进展

IF 1.5

Current Sleep Medicine Reports Pub Date : 2025-01-01 Epub Date: 2025-02-17 DOI: 10.1007/s40675-025-00325-z

Gabrielle F Gloston, Katherine C Ward, G Carolina Rodriguez-Torres, Karen L Gamble, S Justin Thomas

{"title":"Integrating Assessment of Circadian Rhythmicity to Improve Treatment Outcomes for Circadian Rhythm Sleep-Wake Disorders: Updates on New Treatments.","authors":"Gabrielle F Gloston, Katherine C Ward, G Carolina Rodriguez-Torres, Karen L Gamble, S Justin Thomas","doi":"10.1007/s40675-025-00325-z","DOIUrl":"10.1007/s40675-025-00325-z","url":null,"abstract":"Purpose of review: Despite advancements in basic circadian research, development of new diagnostic and treatment strategies for circadian rhythm sleep-wake disorders (CRSWDs) has been slow. Here, we review the most recent innovations in human circadian assessment and emerging new therapies for CRSWDs.Recent findings: Researchers have improved existing circadian assessment methods to overcome logistical barriers and developed novel circadian assessment methods. New treatments for CRSWDs involve pharmacological and behavioral treatments that modulate circadian phase, amplitude, and/or robustness of the central circadian clock.Summary: Commercialization of these emerging tools will require overcoming barriers, such as additional testing to confirm the underlying pathology and mechanism of action of potential treatments. Clinicians and scientists are also called to survey adjacent fields and adopt existing diagnostic tools that may offer diagnostic clarity in CRSWDs. Lastly, we must continue to advocate for medical insurance coverage of current and future tools and technologies to improve patient care.","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"11 1","pages":"8"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving the cardiovascular outcomes of obstructive sleep apnea: Towards more precise hypoxia-based models of disease severity. 改善阻塞性睡眠呼吸暂停的心血管结果：迈向更精确的基于缺氧的疾病严重程度模型。

IF 1.5

Current Sleep Medicine Reports Pub Date : 2025-01-01 Epub Date: 2025-01-03 DOI: 10.1007/s40675-024-00315-7

Nida T Qayyum, Andrew T Cole, Rami N Khayat, Anna Grosberg

{"title":"Improving the cardiovascular outcomes of obstructive sleep apnea: Towards more precise hypoxia-based models of disease severity.","authors":"Nida T Qayyum, Andrew T Cole, Rami N Khayat, Anna Grosberg","doi":"10.1007/s40675-024-00315-7","DOIUrl":"10.1007/s40675-024-00315-7","url":null,"abstract":"Purpose of review: Obstructive sleep apnea (OSA) affects at least 1 billion people worldwide, and its increasing prevalence is alarming considering an association to comorbidities such as cardiovascular disease (CVD) and to demonstrated health disparities. This raises concerns regarding the current diagnostic standards, which are also impacted by disparities. The current review was aimed at identifying limitations in the apnea-hypopnea index (AHI), the primary clinical indicator of OSA severity, and analyzing recent alternatives. In addition, the association between OSA and CVD was discussed, and, considering the role of intermittent hypoxia, solutions were proposed for improving OSA diagnosis.Recent findings: Based on a review of current literature, alternative metrics to the AHI such as the hypoxia burden, sleep apnea-specific pulse rate, and oxygen desaturation rate were shown to be correlated with indicators of CVD in OSA patients. A recent mathematical study also presents the possibility of a model-based metric to eliminate existing bias in diagnostics and provide a more accurate quantification of tissue hypoxia.Summary: The analyzed studies give incentive to look beyond current clinical standards in OSA. Through this review, we motivate the use of mathematical modeling as a future avenue to improve OSA diagnosis with a hypoxia-based approach.","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"11 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial Disparity in Obstructive Sleep Apnea Care and its Impact on Cardiovascular Health. 阻塞性睡眠呼吸暂停护理中的种族差异及其对心血管健康的影响。

IF 1.5

Current Sleep Medicine Reports Pub Date : 2024-12-01 Epub Date: 2024-06-24 DOI: 10.1007/s40675-024-00308-6

Sanjana Agarwal, Paige Monsod, Yoon-Sik Cho, Sharon MacRae, Justyna S Swierz, William J Healy, Younghoon Kwon, Xiaoyue Liu, Yeilim Cho

{"title":"Racial Disparity in Obstructive Sleep Apnea Care and its Impact on Cardiovascular Health.","authors":"Sanjana Agarwal, Paige Monsod, Yoon-Sik Cho, Sharon MacRae, Justyna S Swierz, William J Healy, Younghoon Kwon, Xiaoyue Liu, Yeilim Cho","doi":"10.1007/s40675-024-00308-6","DOIUrl":"10.1007/s40675-024-00308-6","url":null,"abstract":"Purpose of review: Racial disparities in sleep health as well as the diagnosis and treatment of sleep disorders have emerged as a key driver of cardiovascular outcomes. Obstructive sleep apnea (OSA), is characterized by repeated airway obstructions during sleep and is associated with an increased risk of cardiovascular disease. While racial and ethnic minorities have disproportionately high OSA prevalence rates, diagnosis rates remain low. One explanation behind this phenomenon are structural environmental and lifestyle barriers that prevent access to OSA care. Additionally, there remains significantly limited understanding of OSA and its causes and symptoms within communities.Recent findings: In general, minorities have poorer sleep health due to systemic and environmental racism, which also causes an increased in conditions such as obesity that increases OSA risk. Disparities also persist within various types of OSA treatment. The most common form of treatment, continuous positive airway pressure (CPAP) has lower adherence among African Americans, as well as those living in areas with low socioeconomic status (SES), primarily minorities. There have been a small number of studies that have shown some initial success of educational campaigns about OSA within minority communities in increasing screenings and diagnoses. Peer based education has been an effective technique, and there is a need for such programs to be expanded.Summary: Disparities persist, with minority groups having worse sleep health and lower rates of adherence to OSA treatment. Some grassroots, peer-led educational campaigns show promise in increasing adherence. In light of these disparities, there remains a need for the field of sleep medicine to continue addressing the systemic barriers that hinder the timely evaluation and treatment in racial minorities.","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"10 4","pages":"414-418"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using New Technologies and Wearables for Characterizing Sleep in Population-based Studies 在人群研究中利用新技术和可穿戴设备描述睡眠特征

IF 1.8

Current Sleep Medicine Reports Pub Date : 2024-01-02 DOI: 10.1007/s40675-023-00272-7

Stuti J. Jaiswal, Jeff B. Pawelek, Shiri Warshawsky, Giorgio Quer, Megan Trieu, Jay A. Pandit, Robert L. Owens

引用次数: 0

Barriers in Access to and Delivery of Behavioral Sleep Treatments 获得和提供行为性睡眠治疗的障碍

IF 1.8

Current Sleep Medicine Reports Pub Date : 2023-12-22 DOI: 10.1007/s40675-023-00270-9

Sydneyjane Roberts, C. Ulmer

引用次数: 0

Expanding Access to CBT-I for Older Adults: Review and Expansion of Recent Recommendations 扩大老年人使用 CBT-I 的机会：近期建议的回顾与扩展

IF 1.8

Current Sleep Medicine Reports Pub Date : 2023-12-20 DOI: 10.1007/s40675-023-00271-8

Jaime M. Hughes

引用次数: 0

Insomnia and Incidence of Heart Failure in a Sample of Half a Million People: a Meta-analytic Review and Meta-regression of Prospective Studies 50 万人样本中的失眠与心力衰竭发病率：前瞻性研究的元分析回顾与元回归

IF 1.8

Current Sleep Medicine Reports Pub Date : 2023-11-24 DOI: 10.1007/s40675-023-00269-2

Habibolah Khazaie, Saeid Komasi, Reena Mehra, Sepideh Khazaie, A. Alipourian, Vijay Nambi, Amir Sharafkhaneh

引用次数: 0

Fibromyalgia and the Brain: What’s Sleep got to do with it? 纤维肌痛和大脑:睡眠与之有何关系?

Current Sleep Medicine Reports Pub Date : 2023-11-09 DOI: 10.1007/s40675-023-00268-3

Christina S. McCrae, Ashley F. Curtis, Melanie A. Stearns, Jason G. Craggs

引用次数: 0