Gabrielle F Gloston, Katherine C Ward, G Carolina Rodriguez-Torres, Karen L Gamble, S Justin Thomas
{"title":"Integrating Assessment of Circadian Rhythmicity to Improve Treatment Outcomes for Circadian Rhythm Sleep-Wake Disorders: Updates on New Treatments.","authors":"Gabrielle F Gloston, Katherine C Ward, G Carolina Rodriguez-Torres, Karen L Gamble, S Justin Thomas","doi":"10.1007/s40675-025-00325-z","DOIUrl":"10.1007/s40675-025-00325-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>Despite advancements in basic circadian research, development of new diagnostic and treatment strategies for circadian rhythm sleep-wake disorders (CRSWDs) has been slow. Here, we review the most recent innovations in human circadian assessment and emerging new therapies for CRSWDs.</p><p><strong>Recent findings: </strong>Researchers have improved existing circadian assessment methods to overcome logistical barriers and developed novel circadian assessment methods. New treatments for CRSWDs involve pharmacological and behavioral treatments that modulate circadian phase, amplitude, and/or robustness of the central circadian clock.</p><p><strong>Summary: </strong>Commercialization of these emerging tools will require overcoming barriers, such as additional testing to confirm the underlying pathology and mechanism of action of potential treatments. Clinicians and scientists are also called to survey adjacent fields and adopt existing diagnostic tools that may offer diagnostic clarity in CRSWDs. Lastly, we must continue to advocate for medical insurance coverage of current and future tools and technologies to improve patient care.</p>","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"11 1","pages":"8"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nida T Qayyum, Andrew T Cole, Rami N Khayat, Anna Grosberg
{"title":"Improving the cardiovascular outcomes of obstructive sleep apnea: Towards more precise hypoxia-based models of disease severity.","authors":"Nida T Qayyum, Andrew T Cole, Rami N Khayat, Anna Grosberg","doi":"10.1007/s40675-024-00315-7","DOIUrl":"10.1007/s40675-024-00315-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>Obstructive sleep apnea (OSA) affects at least 1 billion people worldwide, and its increasing prevalence is alarming considering an association to comorbidities such as cardiovascular disease (CVD) and to demonstrated health disparities. This raises concerns regarding the current diagnostic standards, which are also impacted by disparities. The current review was aimed at identifying limitations in the apnea-hypopnea index (AHI), the primary clinical indicator of OSA severity, and analyzing recent alternatives. In addition, the association between OSA and CVD was discussed, and, considering the role of intermittent hypoxia, solutions were proposed for improving OSA diagnosis.</p><p><strong>Recent findings: </strong>Based on a review of current literature, alternative metrics to the AHI such as the hypoxia burden, sleep apnea-specific pulse rate, and oxygen desaturation rate were shown to be correlated with indicators of CVD in OSA patients. A recent mathematical study also presents the possibility of a model-based metric to eliminate existing bias in diagnostics and provide a more accurate quantification of tissue hypoxia.</p><p><strong>Summary: </strong>The analyzed studies give incentive to look beyond current clinical standards in OSA. Through this review, we motivate the use of mathematical modeling as a future avenue to improve OSA diagnosis with a hypoxia-based approach.</p>","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"11 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elyse R Thakur, Tran Tran, Brooke A Duarte, Jamie M Horrigan, Elizabeth W Lampe, Hyder Said, Jessica K Salwen-Deremer
{"title":"Mind-Body Interventions for Comorbid Sleep and Gastrointestinal Concerns.","authors":"Elyse R Thakur, Tran Tran, Brooke A Duarte, Jamie M Horrigan, Elizabeth W Lampe, Hyder Said, Jessica K Salwen-Deremer","doi":"10.1007/s40675-025-00348-6","DOIUrl":"10.1007/s40675-025-00348-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>Sleep disturbances are common in individuals with gastrointestinal (GI) disorders. The connection between sleep and GI symptoms is bidirectional and influenced by shared biopsychosocial mechanisms and cognitive-behavioral factors, including alterations in the stress response. Treating sleep disturbances can effectively manage coexisting symptoms. This review explores current research on sleep treatments for GI conditions, emphasizing mind-body interventions that target stress.</p><p><strong>Recent findings: </strong>Both pharmacological and non-pharmacological approaches (e.g., cognitive behavioral therapy for insomnia) benefit patients with sleep disturbance and concomitant GI symptoms; however, they have limitations. Other approaches, including mind-body interventions, may improve sleep quality, reduce GI symptoms, and enhance quality of life.</p><p><strong>Summary: </strong>Mind-body interventions can complement other evidence-based approaches for patients with co-morbid sleep disturbance and GI symptoms. However, more rigorous research is warranted to fully understand their benefit. As research evolves, healthcare professionals can guide patients on how to best integrate these approaches into their care.</p>","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"11 1","pages":"37"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12708811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katharine C Simon, Chelsea Cadle, Alessandra E Shuster, Paola Malerba
{"title":"Sleep Across the Lifespan: A Neurobehavioral Perspective.","authors":"Katharine C Simon, Chelsea Cadle, Alessandra E Shuster, Paola Malerba","doi":"10.1007/s40675-025-00322-2","DOIUrl":"10.1007/s40675-025-00322-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>Sleep is dynamic across the lifespan, influenced by brain maturation, neurophysiology, hormones, and cognitive processes. Sleep behaviors influenced by physiological and external factors can also impact sleep health. As sleep plays a mechanistic role in health across the lifespan, understanding when and how to intervene to benefit health is essential.</p><p><strong>Recent findings: </strong>Recent research has advanced our understanding of sleep across three domains: patterns, neurophysiology, and behaviors. Highlights include (1) Early childhood nap cessation is thought to relate to medial temporal lobe network maturation and underlie long-term hippocampal-dependent memory development. (2) Chronotype misalignment is a key factor in sleep deficits and social jetlag. (3) Older adult daytime sleep has complex effects on health, at times beneficial while others, potentially maladaptive. (4) Longitudinal sleep oscillation trajectories are starting to be investigated and indicate neurophysiology could be interpreted as indicative of brain maturation in development. (5) In adults, sleep quality and macrostructure trajectories show high variability, emphasizing distinctive traits in shaping sleep and its lifespan trajectories. (6) Neighborhood and socioeconomic factors influence sleep health across all ages. (7) In older adults, associations between loneliness and poor sleep are being unpacked.</p><p><strong>Summary: </strong>This recent research, while comprehensively describing our current understanding of sleep trajectories across the lifespan, emphasizes the need to expand current approaches to longitudinal measurement studies that cross age-spans. Expanding will enhance our ability to mechanistically determine the temporal and causal relations between the multiple dimensions of sleep (i.e., patterns, behaviors, and physiology) and outcomes in sleep health.</p>","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"11 1","pages":"7"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanjana Agarwal, Paige Monsod, Yoon-Sik Cho, Sharon MacRae, Justyna S Swierz, William J Healy, Younghoon Kwon, Xiaoyue Liu, Yeilim Cho
{"title":"Racial Disparity in Obstructive Sleep Apnea Care and its Impact on Cardiovascular Health.","authors":"Sanjana Agarwal, Paige Monsod, Yoon-Sik Cho, Sharon MacRae, Justyna S Swierz, William J Healy, Younghoon Kwon, Xiaoyue Liu, Yeilim Cho","doi":"10.1007/s40675-024-00308-6","DOIUrl":"10.1007/s40675-024-00308-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>Racial disparities in sleep health as well as the diagnosis and treatment of sleep disorders have emerged as a key driver of cardiovascular outcomes. Obstructive sleep apnea (OSA), is characterized by repeated airway obstructions during sleep and is associated with an increased risk of cardiovascular disease. While racial and ethnic minorities have disproportionately high OSA prevalence rates, diagnosis rates remain low. One explanation behind this phenomenon are structural environmental and lifestyle barriers that prevent access to OSA care. Additionally, there remains significantly limited understanding of OSA and its causes and symptoms within communities.</p><p><strong>Recent findings: </strong>In general, minorities have poorer sleep health due to systemic and environmental racism, which also causes an increased in conditions such as obesity that increases OSA risk. Disparities also persist within various types of OSA treatment. The most common form of treatment, continuous positive airway pressure (CPAP) has lower adherence among African Americans, as well as those living in areas with low socioeconomic status (SES), primarily minorities. There have been a small number of studies that have shown some initial success of educational campaigns about OSA within minority communities in increasing screenings and diagnoses. Peer based education has been an effective technique, and there is a need for such programs to be expanded.</p><p><strong>Summary: </strong>Disparities persist, with minority groups having worse sleep health and lower rates of adherence to OSA treatment. Some grassroots, peer-led educational campaigns show promise in increasing adherence. In light of these disparities, there remains a need for the field of sleep medicine to continue addressing the systemic barriers that hinder the timely evaluation and treatment in racial minorities.</p>","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"10 4","pages":"414-418"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stuti J. Jaiswal, Jeff B. Pawelek, Shiri Warshawsky, Giorgio Quer, Megan Trieu, Jay A. Pandit, Robert L. Owens
{"title":"Using New Technologies and Wearables for Characterizing Sleep in Population-based Studies","authors":"Stuti J. Jaiswal, Jeff B. Pawelek, Shiri Warshawsky, Giorgio Quer, Megan Trieu, Jay A. Pandit, Robert L. Owens","doi":"10.1007/s40675-023-00272-7","DOIUrl":"https://doi.org/10.1007/s40675-023-00272-7","url":null,"abstract":"","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"10 3","pages":"1-11"},"PeriodicalIF":1.8,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139124817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Barriers in Access to and Delivery of Behavioral Sleep Treatments","authors":"Sydneyjane Roberts, C. Ulmer","doi":"10.1007/s40675-023-00270-9","DOIUrl":"https://doi.org/10.1007/s40675-023-00270-9","url":null,"abstract":"","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"11 20","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138944447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expanding Access to CBT-I for Older Adults: Review and Expansion of Recent Recommendations","authors":"Jaime M. Hughes","doi":"10.1007/s40675-023-00271-8","DOIUrl":"https://doi.org/10.1007/s40675-023-00271-8","url":null,"abstract":"","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"95 24","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138954170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Habibolah Khazaie, Saeid Komasi, Reena Mehra, Sepideh Khazaie, A. Alipourian, Vijay Nambi, Amir Sharafkhaneh
{"title":"Insomnia and Incidence of Heart Failure in a Sample of Half a Million People: a Meta-analytic Review and Meta-regression of Prospective Studies","authors":"Habibolah Khazaie, Saeid Komasi, Reena Mehra, Sepideh Khazaie, A. Alipourian, Vijay Nambi, Amir Sharafkhaneh","doi":"10.1007/s40675-023-00269-2","DOIUrl":"https://doi.org/10.1007/s40675-023-00269-2","url":null,"abstract":"","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":"25 1","pages":"281-295"},"PeriodicalIF":1.8,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139238683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christina S. McCrae, Ashley F. Curtis, Melanie A. Stearns, Jason G. Craggs
{"title":"Fibromyalgia and the Brain: What’s Sleep got to do with it?","authors":"Christina S. McCrae, Ashley F. Curtis, Melanie A. Stearns, Jason G. Craggs","doi":"10.1007/s40675-023-00268-3","DOIUrl":"https://doi.org/10.1007/s40675-023-00268-3","url":null,"abstract":"","PeriodicalId":37449,"journal":{"name":"Current Sleep Medicine Reports","volume":" 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135241719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}