综合评估昼夜节律性以改善昼夜节律睡眠-觉醒障碍的治疗结果：新治疗方法的最新进展

IF 1.5 Q4 CLINICAL NEUROLOGY

Current Sleep Medicine Reports Pub Date : 2025-01-01 Epub Date: 2025-02-17 DOI:10.1007/s40675-025-00325-z

Gabrielle F Gloston, Katherine C Ward, G Carolina Rodriguez-Torres, Karen L Gamble, S Justin Thomas

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引用次数: 0

摘要

综述目的：尽管基础昼夜节律研究取得了进展，但昼夜节律睡眠-觉醒障碍（CRSWDs）的新诊断和治疗策略发展缓慢。在这里，我们回顾了人类昼夜节律评估的最新创新和CRSWDs的新疗法。研究人员改进了现有的昼夜节律评估方法，以克服后勤障碍，并开发了新的昼夜节律评估方法。crswd的新治疗包括药物和行为治疗，可以调节昼夜节律的阶段、幅度和/或中央生物钟的稳健性。总结：这些新兴工具的商业化将需要克服障碍，例如额外的测试来确认潜在治疗的潜在病理和作用机制。临床医生和科学家也被要求调查邻近的领域，并采用现有的诊断工具，以明确crswd的诊断。最后，我们必须继续倡导医疗保险涵盖当前和未来的工具和技术，以改善患者护理。

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Integrating Assessment of Circadian Rhythmicity to Improve Treatment Outcomes for Circadian Rhythm Sleep-Wake Disorders: Updates on New Treatments.

Purpose of review: Despite advancements in basic circadian research, development of new diagnostic and treatment strategies for circadian rhythm sleep-wake disorders (CRSWDs) has been slow. Here, we review the most recent innovations in human circadian assessment and emerging new therapies for CRSWDs.

Recent findings: Researchers have improved existing circadian assessment methods to overcome logistical barriers and developed novel circadian assessment methods. New treatments for CRSWDs involve pharmacological and behavioral treatments that modulate circadian phase, amplitude, and/or robustness of the central circadian clock.

Summary: Commercialization of these emerging tools will require overcoming barriers, such as additional testing to confirm the underlying pathology and mechanism of action of potential treatments. Clinicians and scientists are also called to survey adjacent fields and adopt existing diagnostic tools that may offer diagnostic clarity in CRSWDs. Lastly, we must continue to advocate for medical insurance coverage of current and future tools and technologies to improve patient care.

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来源期刊

Current Sleep Medicine Reports Medicine-Pulmonary and Respiratory Medicine

CiteScore

2.50

自引率

5.60%

发文量

期刊介绍： Current Sleep Medicine Reports aims to review the most important, recently published articles in the field of sleep medicine. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of sleep conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as insomnia, narcolepsy, sleep apnea, circadian rhythm disorders, and parasomnias. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.