Recent Progress in Omics Studies of Sleep and Circadian Phenotypes.

IF 1.5 Q4 CLINICAL NEUROLOGY

Current Sleep Medicine Reports Pub Date : 2025-12-01 Epub Date: 2025-04-15 DOI:10.1007/s40675-025-00335-x

Ziqing Wang, Tamar Sofer

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Abstract

Purpose of review: Sleep and circadian biology is fundamental to human health. Following the advancement in sleep medicine and availability of multi-omics technology, this review outlines the current knowledge regarding genetic basis and multi-omics research on circadian rhythm and the two most prevalent sleep disorders, obstructive sleep apnea (OSA) and insomnia.

Recent findings: Genome wide association analyses identified variants across circadian genes and genes pertinent to inflammation, obesity and neuronal function associated with OSA and insomnia. Multi-omics integration has led to novel breakthroughs in identifying systemic biomarkers and elucidating cascades, and causal associations underpinning these complex traits.

Summary: Multi-omics studies in sleep and circadian rhythm possess great potential in unveiling molecular mechanisms behind circadian rhythm and sleep, thereby advancing personalized medicine in the long term. Nevertheless, researchers should remain mindful of existing challenges in genetic and multi-omics sleep research, including data harmonization and existing racial and ethnic disparities in data collection and availability, limiting research generalizability.

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睡眠与昼夜表型组学研究进展。

综述目的：睡眠和昼夜节律生物学是人类健康的基础。随着睡眠医学的进步和多组学技术的可用性，本文概述了昼夜节律和两种最常见的睡眠障碍，阻塞性睡眠呼吸暂停（OSA）和失眠的遗传基础和多组学研究的现状。最近的发现：全基因组关联分析发现了与睡眠呼吸暂停和失眠相关的炎症、肥胖和神经元功能相关的昼夜节律基因和基因的变异。多组学整合在识别系统生物标志物和阐明级联以及支撑这些复杂特征的因果关系方面取得了新的突破。摘要：睡眠和昼夜节律的多组学研究在揭示昼夜节律和睡眠背后的分子机制方面具有巨大的潜力，从而长期推进个性化医疗。然而，研究人员应该注意到遗传和多组学睡眠研究中存在的挑战，包括数据协调和数据收集和可用性方面存在的种族和民族差异，限制了研究的普遍性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Sleep Medicine Reports Medicine-Pulmonary and Respiratory Medicine

CiteScore

2.50

自引率

5.60%

发文量

期刊介绍： Current Sleep Medicine Reports aims to review the most important, recently published articles in the field of sleep medicine. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of sleep conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as insomnia, narcolepsy, sleep apnea, circadian rhythm disorders, and parasomnias. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.