Infection Ecology and Epidemiology最新文献

{"title":"Climate change and contagion: the emerging threat of zoonotic diseases in Africa.","authors":"Majani Edward, Amira M Heniedy, Abdullahi Saminu, J Jenifer Florence Mary, Duaa A Ahmed, Stephen T Engmann, Chizaram Onyeaghala, Safieh Shah","doi":"10.1080/20008686.2024.2441534","DOIUrl":"10.1080/20008686.2024.2441534","url":null,"abstract":"<p><p>This article investigates the escalating occurrence of zoonotic diseases in Africa, attributing their spread to climate change and human activities. Africa's unique combination of biodiversity, reliance on animal husbandry, and swift urbanization heightens its susceptibility. Climate change disrupts ecosystems and animal habitats, intensifying human-wildlife interactions. Urbanization, inadequate sanitation, and insufficient healthcare infrastructure further facilitate disease spread. Climate-induced displacement adds another layer of complexity. Mitigation strategies include improving surveillance systems, fostering early detection via point-of-care diagnostics and digital contact tracing, and investing in vaccines and therapeutics. Our purpose of this is to advocate for sustainable land use, robust community-level public health systems, international cooperation, and resource-sharing. We also emphasize the need for effective vector-control policies, dedicated research funding, and annual awareness, vaccination, and early detection campaigns in endemic regions.</p>","PeriodicalId":37446,"journal":{"name":"Infection Ecology and Epidemiology","volume":"15 1","pages":"2441534"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Hepatitis E virus transmission risks: a comprehensive review of cases among blood transfusion recipients and blood donors.","authors":"Sangthang Singson, Shamee Shastry, N Sudheesh, Kiran Chawla, Mridula Madiyal, Dhivya Kandasamy, Chiranjay Mukhopadhyay","doi":"10.1080/20008686.2024.2406834","DOIUrl":"https://doi.org/10.1080/20008686.2024.2406834","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis E Virus is a major cause of acute and fulminant hepatitis, particularly in developing countries. While the virus is commonly spread through the fecal-oral route, numerous cases of transfusion transmitted Hepatitis E Virus (TT-HEV) have been reported, raising concerns about its transmission via blood transfusions, especially in industrialized countries. The high prevalence of antibodies and viremia among asymptomatic blood donors further heightens the risk of transfusion-related transmission. However, there is still debate about the best strategy to minimize TT-HEV.</p><p><strong>Objective: </strong>The review was conducted to Summarize the literature on TT-HEV infection cases and the prevalence of HEV among blood donors.</p><p><strong>Methods: </strong>The databases PubMed, Scopus, Web of Science, Embase, and CINAHL were searched for relevant studies from 2000 to 2022.Serological and molecular screening data of HEV in blood donors were used to gather prevalence and incidence rates.TT-HEV cases were reviewed by examining evidence of HEV infection before and after transfusion.</p><p><strong>Results: </strong>A total of 121 manuscripts reports the prevalence and incidence of HEV among blood donors and cases of TT-HEV. Twenty-six articles reported confirmed cases of TT-HEV and 101 articles reported on HEV prevalence or incidence among blood donors.</p><p><strong>Conclusion: </strong>TT-HEV transmission through blood products is a real concern, especially for immunocompromised patients.The risk and severity of infection could vary between immunocompetent and immunosuppressed patients.To increase transfusion safety, the evaluation recommends HEV screening protocols, especially in endemic region.</p>","PeriodicalId":37446,"journal":{"name":"Infection Ecology and Epidemiology","volume":"14 1","pages":"2406834"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untangling the role of environmental and host-related determinants for on-farm transmission of verotoxin-producing <i>Escherichia coli</i> O157.","authors":"Lena-Mari Tamminen, Johan Dicksved, Erik Eriksson, Linda J Keeling, Ulf Emanuelson","doi":"10.1080/20008686.2024.2406852","DOIUrl":"10.1080/20008686.2024.2406852","url":null,"abstract":"<p><p><b>Background:</b> Cattle colonised by the zoonotic pathogen verotoxin-producing Escherichia coli of serotype O157 (VTEC O157) can shed high levels of the pathogen in their faeces. A suggested key for controlling VTEC O157 is preventing colonisation of individuals. <b>Aim:</b> In this study the role of individual super-shedders and factors related to susceptibility and environmental exposure in the transmission of VTEC O157 among dairy calves are explored. <b>Methods:</b> The association between sex, age, pen hygiene, pen type and stocking density and colonisation of individual calves, established by recto-anal mucosal swabs, on farms where pathogenic VTEC O157 had been confirmed was investigated. In a follow-up sampling, the consistency of previously identified risk factors and the role of shedding pen mates was assessed by studying the risk of new/re-colonisation. <b>Results:</b> The results suggest an important role of stocking density that decreases with age, possibly due to increased resistance to colonisation following exposure. However, previous colonisation did not influence the risk of being colonised in the second sampling. Super-shedders (shedding >103 colony forming units/g faeces) significantly increased the risk of colonisation in peers (OR = 10, CI 4.2-52). In addition, environmental factors associated with survival of the bacteria, affected risk. <b>Conclusion:</b> The results confirm the suggested importance of super-shedders but also emphasises the importance of considering the combined exposure from peers and the environment.</p>","PeriodicalId":37446,"journal":{"name":"Infection Ecology and Epidemiology","volume":"14 1","pages":"2406852"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Literature review on micro-organisms from domestic goats potentially causing human pneumonia.","authors":"Wouter Lokhorst, Inge Roof, Marieke Opsteegh, Alex Bossers, Manon Swanenburg, Wim H M van der Poel, Thomas J Hagenaars, Joke W B van der Giessen","doi":"10.1080/20008686.2024.2406835","DOIUrl":"10.1080/20008686.2024.2406835","url":null,"abstract":"<p><p><b>Background:</b> In the Netherlands, living in proximity to goat farms has been consistently associated with an increased incidence of community-acquired pneumonia (CAP). The cause remains largely unknown though airborne microbial agents could play a role. <b>Objective:</b> The aim of this study is to explore micro-organisms present in goats that can cause human pneumonia. <b>Methods:</b> An extensive literature review was conducted to identify all micro-organisms detected in goats that are associated with human pneumonia. Additionally, the identified micro-organisms were prioritized using a self-developed scoring system and expert opinion. <b>Results:</b> Through extensive literature review, 4309 references describing 302 different micro-organisms in goats or on goat farms were identified. Additional searches and reviews for human respiratory disease caused by each of these micro-organisms yielded a final list of 76 bacteria, 7 viruses, 7 fungi, and 6 protozoa. They were assigned scores based on pneumonia type, diagnosis of respiratory disease, patient immune status, and evidence strength. Based on these scores, the most likely potential causal micro-organisms included Moraxella spp. Chlamydia psittaci, Staphylococcus aureus, and Streptococcus pneumoniae. Subsequently, the list of micro-organisms was reviewed by external experts on their perceived likelihood of the organism causing this CAP. <b>Conclusion:</b> Results of this literature study can give insight into the possible causes of pneumonia. Nonetheless, no unambiguous conclusion on the actual cause of the increased CAP risk around goat farms can be drawn solely based on these results.</p>","PeriodicalId":37446,"journal":{"name":"Infection Ecology and Epidemiology","volume":"14 1","pages":"2406835"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global stability analysis and modelling onchocerciasis transmission dynamics with control measures.","authors":"Musah Konlan, Baaba Abassawah Danquah, Eric Okyere, Shaibu Osman, Justice Amenyo Kessie, Elvis Kobina Donkoh","doi":"10.1080/20008686.2024.2347941","DOIUrl":"10.1080/20008686.2024.2347941","url":null,"abstract":"<p><p><b>Background:</b> Onchocerciasis infection is one of the neglected tropical diseases targeted for eradication by 2030. The disease is usually transmitted to humans through the bites of black flies. These black flies mostly breed near well-oxygenated fast-running water bodies. The disease is common in mostly remote agricultural villages near rivers and streams. <b>Objective:</b> In this study, a deterministic model describing the infection dynamics of human onchocerciasis disease with control measures is presented. <b>Methods:</b> We derived the model's reproductive number and used a stability theorem of a Metzler matrix to show that disease-free equilibrium is both locally and globally asymptotically stable whenever the reproductive number is less than one. Parameter contribution was conducted using sensitivity analysis. The model endemic equation is shown to be a cubic polynomial in the presence of infected immigrants and a quadratic form in their absence. <b>Results:</b> When the inflow of infected immigrants is null, the model endemic equation may admit a unique equilibrium if the reproductive number is greater than one, or admits multiple endemic equilibria if the reproductive number is less than unity. We carried out a sensitivity analysis to identify the significant parameters that contribute to onchocerciasis spread. <b>Conclusion:</b> Onchocerciasis disease can be eradicated if the importation of infected immigrants is properly monitored. The integration of the One Health concept in the public health system is key in tackling the emergence and spread of diseases.</p>","PeriodicalId":37446,"journal":{"name":"Infection Ecology and Epidemiology","volume":"14 1","pages":"2347941"},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic Leptospira contamination in the environment: a systematic review.","authors":"Yulia Sayanthi, Dewi Susanna","doi":"10.1080/20008686.2024.2324820","DOIUrl":"10.1080/20008686.2024.2324820","url":null,"abstract":"<p><strong>Background: </strong>The pathogenic Leptospira is maintained in renal tubules of certain animals, mostly rodents, and excreted in the urine which can contaminate the environment. It is necessary to detect pathogenic Leptospira in environmental samples. Knowing the survival of Leptospira in the environment (water and soil) can provide an overview of where and how they can be transmitted to humans.</p><p><strong>Objective: </strong>Therefore, this study aimed to provide a systematic overview of pathogenic Leptospira presence in water and soil environment, the various species of pathogenic Leptospira that are harmful for human, and the ability to survive using a systematic review method.</p><p><strong>Methods: </strong>The search process used four databases: PubMed, Science Direct, Scopus, and ProQuest. Furthermore, the articles sought were published from 2000 to July 2021, and 38 were analysed.</p><p><strong>Results: </strong>The pathogenic Leptospira contamination in water was higher in urban areas, while soil samples were higher in rural areas. Various pathogenic Leptospira detected in the environment were L. alstonii, L. kmetyi, L. noguchii, and L. interrogans. Those pathogenic Leptospira can survive in water at 4-30°C and at pH < 7; in soil, it can survive at a humidity of < 20% and a pH < 6.</p><p><strong>Conclusion: </strong>Urban and rural areas have the same risk for leptospirosis disease because pathogenic Leptospira (P1).</p>","PeriodicalId":37446,"journal":{"name":"Infection Ecology and Epidemiology","volume":"14 1","pages":"2324820"},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of antibiotic-resistant bacteria and antibiotic resistance genes within the one health framework.","authors":"Ayodele Oluwaseun Ajayi, Adebowale Toba Odeyemi, Olajide Joseph Akinjogunla, Akinwole Babafenwa Adeyeye, Ibiwumi Ayo-Ajayi","doi":"10.1080/20008686.2024.2312953","DOIUrl":"10.1080/20008686.2024.2312953","url":null,"abstract":"<p><p><b>Background:</b> The interdisciplinary One Health (OH) approach recognizes that human, animal, and environmental health are all interconnected. Its ultimate goal is to promote optimal health for all through the exploration of these relationships. Antibiotic resistance (AR) is a public health challenge that has been primarily addressed within the context of human health and clinical settings. However, it has become increasingly evident that antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) that confer resistance are transmitted and circulated within humans, animals, and the environment. Therefore, to effectively address this issue, antibiotic resistance must also be considered an environmental and livestock/wildlife problem. <b>Objective:</b> This review was carried out to provide a broad overview of the existence of ARB and ARGs in One Health settings. <b>Methods:</b> Relevant studies that placed emphasis on ARB and ARGs were reviewed and key findings were accessed that illustrate the importance of One Health as a measure to tackle growing public and environmental threats. <b>Results:</b> In this review, we delve into the complex interplay of the three components of OH in relation to ARB and ARGs. Antibiotics used in animal husbandry and plants to promote growth, treat, and prevent infectious diseases lead to the development of antibiotic-resistant bacteria in animals. These bacteria are transmitted from animals to humans through food and environmental exposure. The environment plays a critical role in the circulation and persistence of antibiotic-resistant bacteria and genes, posing a significant threat to human and animal health. This article also highlights how ARGs are spread in the environment through the transfer of genetic material between bacteria. This transfer can occur naturally or through human activities such as the use of antibiotics in agriculture and waste management practices. <b>Conclusion:</b> It is important to integrate the One Health approach into the public health system to effectively tackle the emergence and spread of ARB and genes that code for resistance to different antibiotics.</p>","PeriodicalId":37446,"journal":{"name":"Infection Ecology and Epidemiology","volume":"14 1","pages":"2312953"},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10868463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between steroid use and superinfections in SARS-CoV-2 patients. A systematic review and meta-analysis.","authors":"Melissa González Ramírez, Jaime Andrés Hoyos Muñoz, Germán Alberto Moreno Gómez, Mateo Aguirre Flórez, José Fernando Gómez González","doi":"10.1080/20008686.2023.2277000","DOIUrl":"10.1080/20008686.2023.2277000","url":null,"abstract":"<p><p><b>Introduction:</b> The use of steroids has been proposed as a pharmacological approach to treat the SARS-CoV-2 infection to improve outcomes. However, there are doubts about safety against the development of superinfections and their worse outcomes. <b>Objective:</b> To establish the relative frequency of superinfection associated with using steroids in patients with SARS-CoV-2 infection. <b>Materials and methods:</b> We conducted a systematic literature review and meta-analysis using PRISMA standards in 5 databases (PubMed/Scopus/Cochrane/EMBASE/Google Scholar). The search was carried out between February 2020 and May 2023. The search terms were 'steroids' or 'superinfection' 'and' followed by 'SARS-CoV-2' or 'COVID-19'. <b>Results:</b> We found 77 studies, but only 10 with 3539 patients were included in the systematic review. All patients developed severe disease. The documented OR for superinfection through the meta-analysis was 1.437 (95% IC 0.869-2.378) with a p-value of 0.158 without showing a risk attributed to steroids and the development of superinfections. In the Funnel-plot analysis, no publication biases were found. <b>Conclusion:</b> No relationship was found between using steroids and superinfection in patients with SARS-CoV-2.</p>","PeriodicalId":37446,"journal":{"name":"Infection Ecology and Epidemiology","volume":"13 1","pages":"2277000"},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10769522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection rates of norovirus gastroenteritis and factors associated with the infection before and during COVID-19 pandemic: a secondary analysis of surveillance data in Guangxi Zhuang Autonomous Region, Southern China.","authors":"Yanxu Zhong, Huan Lu, Yuyan Jiang, Dongmei Tan, Yuli Pan, Tippawan Liabsuetrakul","doi":"10.1080/20008686.2023.2278246","DOIUrl":"10.1080/20008686.2023.2278246","url":null,"abstract":"<p><p><b>Background:</b> Changes in oral and hand hygiene behaviors have been reported during the COVID-19 pandemic in 2020 which may be associated with the incidence of the norovirus infection, a common cause of gastroenteritis. <b>Objective:</b> To estimate the trends of detection rates of norovirus gastroenteritis and associated factors before COVID-19 in 2015-2019 and during the COVID-19 in 2020 in Guangxi, China. <b>Methods:</b> A secondary analysis of Guangxi surveillance data of gastroenteritis patients was conducted. The detection rate in 2020 was predicted using an autoregressive integrated moving average modeland associated factors were analyzed using multiple logistic regression adjusted for interaction effects. <b>Results:</b> Of 7,903 gastroenteritis patients, the overall detection rate of norovirus gastroenteritis was 12.8%, (14.3% before and 6.1% during COVID-19). Detection rates gradually decreased from 2015 to 2020, of which the slope of predicted line was slightly flatter than the actual line. The odds ratios of detection were double to triple increase during COVID-19 in the younger age group and having food intake outside their homes. Tourist city, season, and types of food were independent associated factors. <b>Conclusion:</b> The detection rates were higher during the COVID-19 year among the population aged 45 years or less and those who consumed food outside their home.</p>","PeriodicalId":37446,"journal":{"name":"Infection Ecology and Epidemiology","volume":"13 1","pages":"2278246"},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10769525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outdoor recreation, tick borne encephalitis incidence and seasonality in Finland, Norway and Sweden during the COVID-19 pandemic (2020/2021).","authors":"Solveig Jore, Hildegunn Viljugrein, Marika Hjertqvist, Timothée Dub, Henna Mäkelä","doi":"10.1080/20008686.2023.2281055","DOIUrl":"10.1080/20008686.2023.2281055","url":null,"abstract":"<p><p>During the pandemic outdoor activities were encouraged to mitigate transmission risk while providing safe spaces for social interactions. Human behaviour, which may favour or disfavour, contact rates between questing ticks and humans, is a key factor impacting tick-borne encephalitis (TBE) incidence. We analyzed annual and weekly TBE cases in Finland, Norway and Sweden from 2010 to 2021 to assess trend, seasonality, and discuss changes in human tick exposure imposed by COVID-19. We compared the pre-pandemic incidence (2010-2019) with the pandemic incidence (2020-2021) by fitting a generalized linear model (GLM) to incidence data. Pre-pandemic incidence was 1.0, 0.29 and 2.8 for Finland, Norway and Sweden, respectively, compared to incidence of 2.2, 1.0 and 3.9 during the pandemic years. However, there was an increasing trend for all countries across the whole study period. Therefore, we predicted the number of cases in 2020/2021 based on a model fitted to the annual cases in 2010-2019. The incidences during the pandemic were 1.3 times higher for Finland, 1.7 times higher for Norway and no difference for Sweden. When social restrictions were enforced to curb the spread of SARS-CoV-2 there were profound changes in outdoor recreational behavior. Future consideration of public health interventions that promote outdoor activities may increase exposure to vector-borne diseases.</p>","PeriodicalId":37446,"journal":{"name":"Infection Ecology and Epidemiology","volume":"13 1","pages":"2281055"},"PeriodicalIF":0.0,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10769561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139379122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}