Maliha Khalid, Muhammad Saad Khan, Erum Siddiqui, Aminath Waafira
{"title":"Exploring the potential of Carica Papaya Leaf Extract: a perspective on its effectiveness in ameliorating thrombocytopenia in dengue patients.","authors":"Maliha Khalid, Muhammad Saad Khan, Erum Siddiqui, Aminath Waafira","doi":"10.1080/20008686.2025.2456055","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Dengue fever (DF) is endemic in Pakistan, posing health risks. Recent flooding in 2022 and strong monsoon rains in 2024 have increased the possibility of an epidemic. It is an infectious disease having potentially severe outcomes including thrombocytopenia.</p><p><strong>Discussion: </strong>Carica Papaya Leaf Extract (CPLE) has emerged as an off-label treatment option, showing promising results in increasing platelet counts and reducing hospital stays. However, a critical assessment of existing research reveals methodological flaws, hindering specific recommendations.</p><p><strong>Conclusion: </strong>This perspective advocates for comprehensive research to evaluate the risks and benefits of CPLE as a potential remedy for thrombocytopenia associated with dengue fever. A robust investigation will inform clinical practice and guide healthcare decisions, contributing to improved patient outcomes in dengue-endemic areas.</p>","PeriodicalId":37446,"journal":{"name":"Infection Ecology and Epidemiology","volume":"15 1","pages":"2456055"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758791/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection Ecology and Epidemiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/20008686.2025.2456055","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Environmental Science","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Dengue fever (DF) is endemic in Pakistan, posing health risks. Recent flooding in 2022 and strong monsoon rains in 2024 have increased the possibility of an epidemic. It is an infectious disease having potentially severe outcomes including thrombocytopenia.
Discussion: Carica Papaya Leaf Extract (CPLE) has emerged as an off-label treatment option, showing promising results in increasing platelet counts and reducing hospital stays. However, a critical assessment of existing research reveals methodological flaws, hindering specific recommendations.
Conclusion: This perspective advocates for comprehensive research to evaluate the risks and benefits of CPLE as a potential remedy for thrombocytopenia associated with dengue fever. A robust investigation will inform clinical practice and guide healthcare decisions, contributing to improved patient outcomes in dengue-endemic areas.
期刊介绍：
Infection Ecology & Epidemiology aims to stimulate inter-disciplinary collaborations dealing with a range of subjects, from the plethora of zoonotic infections in humans, over diseases with implication in wildlife ecology, to advanced virology and bacteriology. The journal specifically welcomes papers from studies where researchers from multiple medical and ecological disciplines are collaborating so as to increase our knowledge of the emergence, spread and effect of new and re-emerged infectious diseases in humans, domestic animals and wildlife. Main areas of interest include, but are not limited to: 1.Zoonotic microbioorganisms 2.Vector borne infections 3.Gastrointestinal pathogens 4.Antimicrobial resistance 5.Zoonotic microbioorganisms in changing environment
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
