Medeniyet medical journal最新文献_第5页

Effects of Potentially Inappropriate Medications in Older Patients with Gastrointestinal System Cancer. 胃肠道系统癌症老年患者潜在不当用药的影响。

Medeniyet medical journal Pub Date : 2023-12-26 DOI: 10.4274/MMJ.galenos.2023.03063

Melike Ozkan, Irfan Karahan, Selim Yalcin, Gozde Sengul Aycicek

{"title":"Effects of Potentially Inappropriate Medications in Older Patients with Gastrointestinal System Cancer.","authors":"Melike Ozkan, Irfan Karahan, Selim Yalcin, Gozde Sengul Aycicek","doi":"10.4274/MMJ.galenos.2023.03063","DOIUrl":"10.4274/MMJ.galenos.2023.03063","url":null,"abstract":"Objective: Potentially inappropriate medications (PIM) is a crucial problem in the geriatric population. The amount of prescription and unadherence increase because of the different problems encountered in cancer patients. Our aim was to evaluate the effects of PIM in patients with gastrointestinal system cancer and to investigate its relationship with chemotherapy side effects, mortality, and progression.Methods: This retrospective cohort study assessed 154 patients with gastrointestinal system cancer. Demographics and disease features, the presence of PIM according to the \"TIME-to-STOP\" criteria and baseline laboratory parameters were recorded. The effects of PIM on survival and adverse treatment events were evaluated.Results: 66.9% of the cases were male and 33.1% were female. The mean age was 71.9±6.4 years. The most common side effects of chemotherapy are nausea, vomiting, kidney injury, and pain. The most frequently used prescriptions among the 98 PIMs were gliclazide, hyoscine N-butylbromide, simethicone, diphenoxylate atropine, and thiocolchicoside. PIM was detected in 68.1% of the participants. Chemotherapy side effects were more common in PIM group (p<0.001, odds ratio =5.6). PIM had no effect on mortality. Factors associated with mortality were age, stage, albumin, creatinine, operation history, and progression. A significant relationship was found between age, cancer stage, albumin, creatinine, operation history, and PIM in the regression model. There was no relationship between PIM and progression-free survival.Conclusion: Chemotherapy toxicity may increase with PIM detected on diagnosis. We suggest that PIM is an important factor in predicting the side effects of chemotherapy and minimizing the adverse effects.","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"38 4","pages":"284-290"},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10759939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Echocardiographic Findings of Pulmonary Hypertension-specific Therapy in Children 儿童肺动脉高压特异性治疗的早期超声心动图结果

Medeniyet medical journal Pub Date : 2023-12-18 DOI: 10.4274/mmj.galenos.2023.06706

Akif Kavgacı, F. Tunaoglu, S. Kula, A. Oguz, S. Terlemez, Fatma Incedere

引用次数: 0

Speech Perception as a Function of the Number of Channels and Channel Interaction in Cochlear Implant Simulation 人工耳蜗模拟中的语音感知与信道数量和信道相互作用的函数关系

Medeniyet medical journal Pub Date : 2023-12-18 DOI: 10.4274/mmj.galenos.2023.73454

Mustafa Yuksel, Sultan Nur Kaya

引用次数: 0

The Impact of Effective Vaccination on Clinical and Radiological Involvement in COVID-19 Patients 有效接种疫苗对 COVID-19 患者的临床和放射学影响

Medeniyet medical journal Pub Date : 2023-12-13 DOI: 10.4274/mmj.galenos.2023.88655

Coskun Dogan, Deniz Bilici, Burcu Arpınar Yiğitbaş, Omer Zengin, Orhan Zor, Oguzhan Akman, Ilyas Kocabag, Gonul Seven Yalcin, Esra Ertan Yazar

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Unusual Pattern of Coeliac Trunk and Its Branches: A Cadaveric Study of Two Cases with its Embryological and Clinical Correlation 腹腔干及其分支的异常形态：两例尸体研究及其胚胎学和临床相关性

Medeniyet medical journal Pub Date : 2023-12-04 DOI: 10.4274/mmj.galenos.2023.63993

Ariyanachi Kaliappan, Dr. Rohini Motwani, Mrudula Chandrupatla

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Comment on the “The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns” 关于 "甲状腺激素水平对新生儿动脉导管未闭的影响 "的评论

Medeniyet medical journal Pub Date : 2023-12-01 DOI: 10.4274/mmj.galenos.2023.36724

M. Al-Mendalawi

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Novel Predictor of the Development of AF in Patients with OSAS: Importance of Visceral Adipose Index OSAS患者房颤发展的新预测指标:内脏脂肪指数的重要性

Medeniyet medical journal Pub Date : 2023-11-07 DOI: 10.4274/mmj.galenos.2023.07455

Uğur OZKAN, Muhammet GURDOGAN

引用次数: 0

Vulnerabilities of Prostate Glandular Concretions Considered as Artefacts: A Cross-sectional Biopsy Slide Study 前列腺结块的脆弱性被认为是人工制品:一项横断切片活检研究

Medeniyet medical journal Pub Date : 2023-10-11 DOI: 10.4274/mmj.galenos.2023.34683

Surraj SUSAI, Rohini MOTWANI, Mrudula CHANDRUPATLA

引用次数: 0

Interatrial Block and Electrocardiographic Markers of Repolarization in Patients Hospitalized with COVID-19: Classical and Bayesian Analysis COVID-19住院患者房间传导阻滞和复极心电图标志物:经典和贝叶斯分析

Medeniyet medical journal Pub Date : 2023-10-09 DOI: 10.4274/mmj.galenos.2023.87400

Rengin CETIN GUVENC, Ali Kaan GUREN, Busra ENGUR, Selin CELİK, Refik DEMIRTUNC

引用次数: 0

Non-invasive Evaluation of Electromechanical Transmission in Patients with Hypertensive Response to Exercise Stress Test. 运动应激测试对高血压患者机电传导反应的无创评估。

Medeniyet medical journal Pub Date : 2023-09-28 DOI: 10.4274/MMJ.galenos.2023.42027

Ahmet Ferhat Kaya, Mehmet Hasan Ozdil, Cemalettin Yilmaz, Raif Kilic, Mehmet Ozbek, Hasan Kaya

{"title":"Non-invasive Evaluation of Electromechanical Transmission in Patients with Hypertensive Response to Exercise Stress Test.","authors":"Ahmet Ferhat Kaya, Mehmet Hasan Ozdil, Cemalettin Yilmaz, Raif Kilic, Mehmet Ozbek, Hasan Kaya","doi":"10.4274/MMJ.galenos.2023.42027","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.42027","url":null,"abstract":"Objective: Excessive hypertensive response to exercise testing is associated with adverse cardiovascular events such as left ventricular hypertrophy and atrial fibrillation (AF). In this study, we examined the relationship between electromechanical delay and excessive hypertensive response to exercise testing.Methods: Twenty-five people who had a hypertensive response to the exercise stress test and 28 people who were similar in age and gender with a normal blood pressure response in the exercise stress test as the control group were included in the study.Results: There was no statistical difference between the study groups in blood pressure holter values, conventional echocardiography findings, and exercise stress test findings. Lateral PA-TDI time (the time from the beginning of the P wave measured by tissue Doppler imaging to the beginning of the A' wave), left atrial electromechanical delay, and interatrial electromechanical delay were observed to be significantly longer in the hypertensive response group to exercise stress test compared with the control group (74.0±6.3 vs. 68.8±5.7, p=0.003; 24.7±7.0 vs. 19.6±7.1, p=0.013; 36.8±8.5 vs. 30.6±6.6, p=0.003, respectively).Conclusions: Early detection of electromechanical delay non-invasively may be useful in this patient group in predicting the development of new AF risk.","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":"38 3","pages":"180-186"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a1/4a/medj-38-180.PMC10542984.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41151608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0