Systemic Immune-inflammation Index in Evaluation of Inflammation in Rheumatoid Arthritis Patients.

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL

Medeniyet medical journal Pub Date : 2024-09-30 DOI:10.4274/MMJ.galenos.2024.60533

Amela Dervisevic, Almir Fajkic, Elmedina Jahic, Lejla Dervisevic, Zurifa Ajanovic, Enisa Ademovic, Asija Zaciragic

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引用次数: 0

Abstract

Objective: To evaluate the systemic immune-inflammation (SII) index in patients with rheumatoid arthritis (RA) stratified by systemic inflammatory status.

Methods: Seropositive patients with RA (n=58) were divided into two groups based on serum hs-C-reactive protein (hs-CRP) levels: RA patients with hs-CRP levels of at or 3 mg/L or above (high systemic inflammatory status; n=38) and RA patients with hs-CRP levels of less than 3 mg/L (low systemic inflammatory status; n=20). The control group comprised 31 healthy individuals. Blood samples were tested for the next parameters: leukocytes, neutrophilic granulocytes, lymphocytes, thrombocytes [platelet (PLT)], high-sensitivity hs-CRP, sed rate [erythrocyte sedimentation rate (ESR)], neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR). The SII index was derived as Neu x PLT/Lym.

Results: In patients with RA, the SII index was elevated compared with that of healthy individuals and positively correlated with hs-CRP, erythrocyte sedimentation rate, NLR, MLR, PLR, tender joint count, and swollen-to-tender joint count ratio. Patients with RA who had hs-CRP levels of 3 mg/L above exhibited a statistically significant increase in the SII compared with those with hs-CRP levels below 3 mg/L. Additionally, within the cohort of RA patients with hs-CRP levels at or above 3 mg/L, a positive correlation was found between the SII index and both NLR and PLR. The SII index was positively correlated with NLR, MLR, and PLR in RA patients with hs-CRP levels below 3 mg/L. The cut-off point of the SII index for distinguishing between RA cases with hs-CRP levels 3 mg/L and those with hs-CRP levels 3 mg/L or higher was ≥323.4, with a sensitivity of 77.6% and a specificity of 54.8%.

Conclusions: The serum SII index can be a potentially useful marker for evaluating the inflammatory process and clinical progression of RA.

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评估类风湿性关节炎患者炎症的系统免疫炎症指数

目的：评估类风湿性关节炎（RA）患者的全身免疫炎症指数（SII）：评估类风湿性关节炎（RA）患者按全身炎症状态分层的全身免疫炎症（SII）指数：根据血清 hs-C 反应蛋白（hs-CRP）水平将血清阳性 RA 患者（58 人）分为两组：hs-CRP水平达到或超过3毫克/升的RA患者（高系统炎症状态；38人）和hs-CRP水平低于3毫克/升的RA患者（低系统炎症状态；20人）。对照组由 31 名健康人组成。对血样进行了以下参数检测：白细胞、中性粒细胞、淋巴细胞、血小板[血小板（PLT）]、高敏 hs-CRP、血沉[红细胞沉降率（ESR）]、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和单核细胞与淋巴细胞比值（MLR）。SII 指数的计算公式为 Neu x PLT/Lym：结果：与健康人相比，RA 患者的 SII 指数升高，并与 hs-CRP、红细胞沉降率、NLR、MLR、PLR、关节触痛计数和关节肿胀与触痛计数比呈正相关。与 hs-CRP 水平低于 3 毫克/升的患者相比，hs-CRP 水平高于 3 毫克/升的 RA 患者的 SII 有显著的统计学增长。此外，在 hs-CRP 水平达到或超过 3 毫克/升的 RA 患者队列中，SII 指数与 NLR 和 PLR 之间呈正相关。在 hs-CRP 水平低于 3 毫克/升的 RA 患者中，SII 指数与 NLR、MLR 和 PLR 呈正相关。区分 hs-CRP 水平为 3 毫克/升的 RA 病例和 hs-CRP 水平为 3 毫克/升或更高的 RA 病例的 SII 指数临界点为≥323.4，敏感性为 77.6%，特异性为 54.8%：结论：血清SII指数可能是评估RA炎症过程和临床进展的有用标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medeniyet medical journal Medicine-Medicine (all)

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

5 weeks

期刊介绍： The Medeniyet Medical Journal (Medeniyet Med J) is an open access, peer-reviewed, and scientific journal of Istanbul Medeniyet University Faculty of Medicine on various academic disciplines in medicine, which is published in English four times a year, in March, June, September, and December by a group of academics. Medeniyet Medical Journal is the continuation of Göztepe Medical Journal (ISSN: 1300-526X) which was started publishing in 1985. It changed the name as Medeniyet Medical Journal in 2015. Submission and publication are free of charge. No fees are asked from the authors for evaluation or publication process. All published articles are available online in the journal website (www.medeniyetmedicaljournal.org) without any fee. The journal publishes intradisciplinary or interdisciplinary clinical, experimental, and basic researches as well as original case reports, reviews, invited reviews, or letters to the editor, Being published since 1985, the Medeniyet Med J recognizes that the best science should lead to better lives based on the fact that the medicine should serve to the needs of society, and knowledge should transform society. The journal aims to address current issues at both national and international levels, start debates, and exert an influence on decision-makers all over the world by integrating science in everyday life. Medeniyet Med J is committed to serve the public and influence people’s lives in a positive way by making science widely accessible. Believing that the only goal is improving lives, and research has an impact on people’s lives, we select the best research papers in line with this goal.